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Search Results: 1 - 10 of 155602 matches for " Jin-Hui Wang "
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Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency
Jun Zhao, Dangui Wang, Jin-Hui Wang
Molecular Brain , 2012, DOI: 10.1186/1756-6606-5-12
Abstract: With two-photon imaging and electrophysiology to record cellular functions in the barrel cortex in vivo, we analyzed the activity patterns of neurons and astrocytes in response to whisker stimuli with increasing frequency, an environmental stimulus pattern that rodents experience in the accelerated motion. Compared to the resting state, whisker stimulation caused barrel neurons and astrocytes to be activated more synchronously. An increased stimulus frequency up-regulated the activity strength of neurons and astrocytes as well as coordinated their interaction. The coordination among the barrel neurons and astrocytes was fulfilled by increasing their functional connections.Our study reveals that the nerve cells in the barrel cortex encode frequency messages in whisker tactile inputs through setting their activity coordination.
Quantal Glutamate Release Is Essential for Reliable Neuronal Encodings in Cerebral Networks
Jiandong Yu, Hao Qian, Na Chen, Jin-Hui Wang
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025219
Abstract: Background The neurons and synapses work coordinately to program the brain codes of controlling cognition and behaviors. Spike patterns at the presynaptic neurons regulate synaptic transmission. The quantitative regulations of synapse dynamics in spike encoding at the postsynaptic neurons remain unclear. Methodology/Principal Findings With dual whole-cell recordings at synapse-paired cells in mouse cortical slices, we have investigated the regulation of synapse dynamics to neuronal spike encoding at cerebral circuits assembled by pyramidal neurons and GABAergic ones. Our studies at unitary synapses show that postsynaptic responses are constant over time, such as glutamate receptor-channel currents at GABAergic neurons and glutamate transport currents at astrocytes, indicating quantal glutamate release. In terms of its physiological impact, our results demonstrate that the signals integrated from quantal glutamatergic synapses drive spike encoding at GABAergic neurons reliably, which in turn precisely set spike encoding at pyramidal neurons through feedback inhibition. Conclusion/Significance Our studies provide the evidences for the quantal glutamate release to drive the spike encodings precisely in cortical circuits, which may be essential for programming the reliable codes in the brain to manage well-organized behaviors.
8-Hydroxyquinoline Dansylates Modified with PAMAM Dendrimer as Fluorescent Fe3+ Sensors
Qi Zhang,Yaowu Sha,Jin-Hui Wang
Molecules , 2010, DOI: 10.3390/molecules15052962
Abstract: A series of fluorescent sensors based on 8-hydroxyquinoline dansylate as core and dendritic PAMAM as shell were synthesized. Their fluorescence characteristic and fluorescent sensing behavior toward metal ions were studied in water/methanol (1: 1, v/v). The sensors exhibit good selectivity and sensitivity for Fe3+ ion and to some extent for Cr3+ ion. The third generation dendrimer has the better sensitivity than the first and second generations.
Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons
Rongjing Ge, Hao Qian, Jin-Hui Wang
Molecular Brain , 2011, DOI: 10.1186/1756-6606-4-19
Abstract: The neurons are one of basic units to fulfill the brain functions, and their events are executed at different subcellular compartments, such as the reception of synaptic inputs, the integration of these synaptic signals, the production of action potentials and the secretion of neurotransmitters [1,2]. In terms of the sources for firing action potentials, the current belief is that action potentials are generated at axon hillock [3-11]. In these studies, short-time square pulses are given and a single spike is induced. However, the regulations and mechanisms for the physiological signals integrated from synaptic inputs to trigger the spikes remains unknown.The neurons integrate the signals from numerous synapses and produce sequential spikes as the digital codes to carry various messages under the physiological conditions [12,13]. These integrated signals in vivo are long-time in nature, and their depolarization pulses induce sequential spikes [14-18] and Figure 1). A source for these in vivo signals to initiate sequential spikes has not been documented, which we have investigated at cortical pyramidal neurons by dual- recording their soma and axonal bleb simultaneously.The physiological sources of firing action potentials are ideally identified by using in vivo signals, which has not been documented yet. In order to address this issue, we have analyzed these signals that were intracellularly recorded from cortical pyramidal neurons in living mice.In vivo signals including those inducing sequential spikes (Figure 1A) and subthreshold pulses (Figure 1B) appear long time. Figure 1C illustrates that these depolarization pulses integrated in vivo fall into a range of 50~1600 ms in their durations. These in vivo signals are generally classified into steady-state pulses (an extended waveform in left panel of Figure 1B) and fluctuation ones (in right). The former is similar to direct-current pulses used to induce spikes in the most of electrophysiological experiments, and t
Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes
Yu Jiandong,Qian Hao,Wang Jin-Hui
Molecular Brain , 2012, DOI: 10.1186/1756-6606-5-26
Abstract: Action potentials at the neurons and graded signals at the synapses are primary codes in the brain. In terms of their functional interaction, the studies were focused on the influence of presynaptic spike patterns on synaptic activities. How the synapse dynamics quantitatively regulates the encoding of postsynaptic digital spikes remains unclear. We investigated this question at unitary glutamatergic synapses on cortical GABAergic neurons, especially the quantitative influences of release probability on synapse dynamics and neuronal encoding. Glutamate release probability and synaptic strength are proportionally upregulated by presynaptic sequential spikes. The upregulation of release probability and the efficiency of probability-driven synaptic facilitation are strengthened by elevating presynaptic spike frequency and Ca2+. The upregulation of release probability improves spike capacity and timing precision at postsynaptic neuron. These results suggest that the upregulation of presynaptic glutamate release facilitates a conversion of synaptic analogue signals into digital spikes in postsynaptic neurons, i.e., a functional compatibility between presynaptic and postsynaptic partners.
Human umbilical cord blood-derived mononuclear cell transplantation for umbilical hernia and hepatic hydrothorax in primary biliary cirrhosis  [PDF]
Ying-Mei Tang, Yun Zhang, Li-Ying You, Wei-Min Bao, Hong-Wei Wang, Jin-Hui Yang, Xiang Hu
Stem Cell Discovery (SCD) , 2012, DOI: 10.4236/scd.2012.22005
Abstract: Cell therapy was proposed as a potential treatment intervention for liver cirrhosis recently due to the fact that the therapeutic protocol for primary biliary cirrhosis (PBC)-associated refractory umbilical hernia and hepatic hydrothorax is not well defined currently. We report herein the case of a 58-year-old woman who received routine treatments for PBC, which developed into an incarcerated hernia and uncontrolled hydrothorax. This subject’s condition was significantly improved and maintained stable condition after receiving human umbilical cord blood-derived mononuclear cell (CBMC) transplantation. Consequently, this new strategy may be a potential treatment option for the refractory umbilical hernia and hydrothorax caused by PBC. However, sufficient data from large-scale controlled and double-blinded clinical trials are needed to further confirm the treatment efficacy and longterm safety before this cell transplantation can be used as a regular therapy for liver cirrhosis.
Jin-hui Yang,Yan-xue Chen,Shao-hui Wang,Jian-lei Wang
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536808038488
Abstract: The complete molecule of the title compound, C4H8N2O2, is generated by a crystallographic inversion center. The occurence of N—H...O hydrogen bonds results in the formation of a two-dimensional infinite network parallel to the (010) plane. In this plane, the hydrogen bonds define graph-set motif R44(22) in a centrosymmetric array by the association of four molecules.
Pilot study on the treatment of ultrafiltration for laundry wastewater recycling and reuse

Wang Jin,Jiang Jin-Hui,
Wang J
,Jiang JH

环境科学 , 2007,
Abstract: A pilot study of the treatment for laundry wastewater recycling and reuse on the spot was carried out by ultrafiltration (UF) with different membrane material of PAN, PS and PP. According to the analysis of membrane fouling combined with UF effluent quality, PAN membrane was superior to the others. It removed the turbidity, suspended solid, fat oil and grease effectively, but kept anionic surfactant (LAS) to a certain degree in the UF effluent which is beneficial to recycling and reuse. By correlation analysis, it was found the high COD concentration of effluent was caused by LAS remained. The whiteness and softness of cotton cloth washed by UF effluent for a long-term was not different with that washed by tap water. The removal of bacteria and E. coli by UF membrane was not very high, and so UF effluent was disinfected by ultraviolet (UV) further. As the dosage of UV was not less than 3 750 J/m2, the microbial level reached the China national standard of drinking water. The optimal UF operation condition is to backwash two minutes every thirty minutes' filtration. Adopted alkali liquor of pH 11 to 13 to carry out chemical cleaning, the membrane flux was recovered completely.
Dynamical effects of the four-wave mixing enhancement induced by constructive quantum interference

Xue Yan,Wang Gang,Wu Jin-Hui,Zhang Bing,Gao Jin-Yue,

中国物理 B , 2011,
Relationship between clinical characteristics and survival of gastroenteropancreatic neuroendocrine neoplasms: A single-institution analysis (1995–2012) in South China
Wang Yu-hong,Lin Yuan,Xue Ling,Wang Jin-hui
BMC Endocrine Disorders , 2012, DOI: 10.1186/1472-6823-12-30
Abstract: Background Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine tumors accounting for 65–75% of neuroendocrine neoplasms (NENs). Given the fact that there are few studies on GEP-NENs among Chinese patients, we performed a retrospective study in South China. Methods Totally 178 patients with GEP-NENs treated at the First Affiliated Hospital of Sun Yat-sen University between January 1995 and May 2012 were analyzed retrospectively. Results Pancreas was found the most common site of involvement (34.8%). 149 patients (83.7%) presented as non-functional tumors with non-specific symptoms such as abdominal pain (33.7%); carcinoid syndrome was not found in this study. Several methods are useful for localization of GEP-NENs, yielding varied detection rates from 77.8% to 98.7%. Positive rates of chromogranin A (CgA) and synaptophysin (Syn) immunhistochemically were 69.1% and 90.2%, respectively. 87 patients (51.5%) had G1 tumors, 31(18.3%) G2 tumors and 51 (30.2%) G3 tumors. Neuroendocrine tumor (NET), neuroendocrine carcinoma (NEC) and mixed adenoendocrine carcinoma (MANEC) were 69.8%, 27.2% and 3.0%, respectively. 28.1% of patients presented with distant disease. Surgery was performed in 152 (85.4%) patients, and overall 5-year survival rate was 54.5%. Functionality, G1 grading and NET classification were associated with favorable prognosis in univariate analysis. Distant metastasis contributed to unfavorable prognosis of these tumors. Conclusions Nonfunctional tumors with non-specific symptoms account for the majority of GEP-NENs. Diagnosis depends on pathological classification. Multidisciplinary treatments could help improve the outcome.
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