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Search Results: 1 - 10 of 1877 matches for " Jiin-Yuh Jang "
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Numerical Study of a Confined Axisymmetric Jet Impingement Heat Transfer with Nanofluids  [PDF]
Jun-Bo Huang, Jiin-Yuh Jang
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.51B013
Abstract: A numerical simulation on confined impinging circular jet working with a mixture of water and Al2O3 nanoparticles is investigated. The flow is turbulent and a constant heat flux is applied on the heated plate. A two-phase mixture model approach has been adopted. Different nozzle-to-plate distance, nanoparticle volume concentrations and Reynolds number have been considered to study the thermal performances of the system in terms of local, average and stagnation point Nusselt number. The local Nusselt number profiles show that the highest values within the stagnation point region, and the lowest at the end of the heated plate. It is observed that the average Nusselt number increases for increasing nanoparticle concentrations, moreover, the highest values are observed for H/D=5, and a maximum increase of 10% is obtained at a concentration equal to 5%.
Sequences Located within the N-Terminus of the PD-Linked LRRK2 Lead to Increased Aggregation and Attenuation of 6-Hydroxydopamine-Induced Cell Death
Neeraj Pandey, Mark T. Fahey, Yuh-Jiin I. Jong, Karen L. O'Malley
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045149
Abstract: Clinical symptoms of Parkinson's disease (PD) arise from the loss of substantia nigra neurons resulting in bradykinesia, rigidity, and tremor. Intracellular protein aggregates are a pathological hallmark of PD, but whether aggregates contribute to disease progression or represent a protective mechanism remains unknown. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been linked to PD in both familial cases and idiopathic cases and aggregates of the LRRK2 protein are present in postmortem PD brain samples. To determine whether LRRK2 contains a region of protein responsible for self-aggregation, two independent, bioinformatic algorithms were used to identify an N-terminal amino acid sequence as being aggregation-prone. Cells subsequently transfected with a construct containing this domain were found to have significantly increased protein aggregation compared to wild type protein or a construct containing only the last half of the molecule. Finally, in support of the hypothesis that aggregates represent a self-protection strategy, aggregated N-terminal LRRK2 constructs significantly attenuated cell death induced by the PD-mimetic, 6-hydroxydopamine (6-OHDA).
Characteristics of Nickel Thin Film and Formation of Nickel Silicide by Remote Plasma Atomic Layer Deposition using Ni(iPr-DAD)2
Jinho Kim,Woochool Jang,Jingyu Park,Heeyoung Jeon,Hyunjung Kim,Junhan Yuh,Hyeongtag Jeon
Physics , 2014, DOI: 10.3938/jkps.66.821
Abstract: In this study, the characteristics of nickel thin film deposited by remote plasma atomic layer deposition (RPALD) on p-type Si substrate and formation of nickel silicide using rapid thermal annealing were determined. Bis(1,4-di-isopropyl-1,3-diazabutadienyl)nickel, Ni(iPr-DAD)2, was used as a Ni precursor and ammonia plasma was used as a reactant. This was the first attempt to deposit Ni thin film using Ni(iPr-DAD)2 as a precursor for the ALD process. The RPALD Ni film was deposited with a growth rate of around 2.2{\AA}/cycle at 250 {\deg}C and showed significant low resistivity of 33 {\mu}{\Omega}cm with a total impurity concentration of around 10 at. %.The impurities of the thin film, carbon and nitrogen, were existent by the forms of C-C and C-N in a bonding state. The impurities removal tendency was investigated by comparing of experimental conditions, namely process temperature and pressure. Nitrogen impurity was removed by thermal desorption during each ALD cycle and carbon impurity was reduced by the optimizing of the process pressure which is directly related with a mean free path of NH3 plasma. After Ni deposition, nickel silicide was formed by RTA in a vacuum ambient for 1 minute. A nickel silicide layer from ALD Ni and PVD Ni was compared at the annealing temperature from 500 to 900 {\deg}C. NiSi from ALD Ni showed better thermal stability due to the contribution of small amounts of carbon and nitrogen in the asdeposited Ni thin film. Degradation of the silicide layer was effectively suppressed with a use of ALD Ni.
α-Siphons of a Suboptimal Control Model of a Subclass of Petri Nets  [PDF]
Daniel Yuh Chao
Intelligent Control and Automation (ICA) , 2011, DOI: 10.4236/ica.2011.21003
Abstract: It has been a hot research topic to synthesize maximally permissive controllers with fewest monitors. So far, all maximally permissive control models for a well-known benchmark are generalized Petri net, which com-plicates the system. In addition, they all relied on time-consuming reachability analysis. Uzam and Zhou ap-ply First-met-bad-marking (FBM) method to the benchmark to achieve a near maximal permissive control policy with the advantage of no weighted control (WC) arcs. To improve the state of the art, it is interesting to synthesize optimal controller with as few weighted arcs as possible since it is unclear how to optimize the control for siphon involving WC arcs, This paper explores the condition to achieve optimal controller with-out WC and defining a new type of siphon, called α-siphon. If the condition is not met, one can apply the technique by Piroddi et al. to synthesize optimal controllers with WC.
Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats
David HT Yen, Lih-Chi Chen, Yuh-Chiang Shen, Ying-Chen Chiu, I-Chun Ho, Ya-Jou Lou, I-Chin Chen, Jiin-Cherng Yen
Journal of Biomedical Science , 2011, DOI: 10.1186/1423-0127-18-32
Abstract: Intravenous injection of phenylephrine was administered to evoke the BRR before and at 10, 30, and 60 min after microinjection of the test agents into NTS of Sprague-Dawley rats. Western blotting analysis was used to measure the level and phosphorylation of proteins that involved in BRR-enhancing effects of ADM (0.2 pmol) in NTS. The colocalization of PKA and nNOS was examined by immunohistochemical staining and observed with a laser confocal microscope.We found that ADM-induced enhancement of BRR response was blunted by microinjection of NPLA or Rp-8-Br-cGMP, a selective inhibitor of nNOS or protein kinase G (PKG) respectively, into NTS. Western blot analysis further revealed that ADM induced an increase in the protein level of PKG-I which could be attenuated by co-microinjection with the ADM receptor antagonist ADM22-52 or NPLA. Moreover, we observed an increase in phosphorylation at Ser1416 of nNOS at 10, 30, and 60 min after intra-NTS administration of ADM. As such, nNOS/PKG signaling may also account for the enhancing effect of ADM on BRR response. Interestingly, biochemical evidence further showed that ADM-induced increase of nNOS phosphorylation was prevented by co-microinjection with Rp-8-Br-cAMP, a PKA inhibitor. The possibility of PKA-dependent nNOS activation was substantiated by immunohistochemical demonstration of co-localization of PKA and nNOS in putative NTS neurons.The novel finding of this study is that the signal transduction cascade that underlies the enhancement of BRR response by ADM in NTS is composed sequentially of cAMP/PKA and nNOS/PKG pathways.Adrenomedullin (ADM), a 52-amino acid peptide, was originally isolated from human pheochromocytoma and initially shown to have potent vasodilatory activity [1]. The physiologic and pharmacologic functions of ADM have been intensively investigated after its discovery (for review see [2]). ADM exerts multiple biological activities by acting on its specific receptors, composed of calcitonin receptor-lik
The Distribution of Multiple Shot Noise Process and Its Integral  [PDF]
Jiwook Jang
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.53047
Abstract:

In this paper, we study multiple shot noise process and its integral. We analyse these two processes systematically for their theoretical distributions, based on the piecewise deterministic Markov process theory developed by Davis [1] and the martingale methodology used by Dassios and Jang [2]. The analytic expressions of the Laplace transforms of these two processes are presented. We also obtain the multivariate probability generating function for the number of jumps, for which we use a multivariate Cox process. To derive these, we assume that the Cox processes jumps, intensity jumps and primary event jumps are independent of each other. Using the Laplace transform of the integral of multiple shot noise process, we obtain the tail of multivariate distributions of the first jump times of the Cox processes, i.e. the multivariate survival functions. Their numerical calculations and other relevant joint distributions numerical values are also presented.

Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling
Mu-Jang Lee,Han-Min Chen,Bor-Show Tzang,Chiu-Wen Lin,Chau-Jong Wang,Jer-Yuh Liu,Shao-Hsuan Kao
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/578060
Abstract: Increased cell death of cardiomyocyte by oxidative stress is known to cause dysfunction of the heart. O. gratissimum is one of the more well-known medicinal plants among the Ocimum species and widely used in treatment of inflammatory diseases. In this study, we hypothesized that aqueous extract of O. gratissimum leaf (OGE) may protect myocardiac cell H9c2 from oxidative injury by hydrogen peroxide (H2O2). Our results revealed that OGE pretreatment dose-dependently protects H9c2 cells from cell death when exposed to H2O2. Additionally, DNA condensation induced by H2O2 was also reduced by OGE pretreatment, suggesting that Ocimum gratissimum extract may attenuate H2O2-induced chromosome damage. Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8. Additionally, OGE pretreatment significantly upregulated Bcl-2 expression and Akt phosphorylation, and slightly affected the phosphorylation of mitogen-activated protein kinases including p38 MAPK and JNK. Taken together, our findings revealed that Ocimum gratissimum extract effectively inhibited the mitochondrial pathway and upregulated Bcl-2 expression, which may be important in protecting H9c2 cells from H2O2-induced cell death.
Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549
Han-Min Chen,Mu-Jang Lee,Cheng-Yi Kuo,Pei-Lin Tsai,Jer-Yuh Liu,Shao-Hsuan Kao
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/739093
Abstract: Ocimum gratissimum (OG) is widely used as a traditional herb for its antibacterial activity in Taiwan. Recently, antitumor effect of OG on breast cancer cell is also reported; however, the effects of OG on human pulmonary adenocarcinoma cell A549 remain unclear. Therefore, we aimed to investigate whether aqueous OG extract (OGE) affects viability of A549 cells and the signals induced by OGE in A549 cells. Cell viability assays revealed that OGE significantly and dose-dependently decreased the viability of A549 cell but not that of BEAS-2B cell. Morphological examination and DAPI staining indicated that OGE induced cell shrinkage and DNA condensation for A549 cells. Further investigation showed that OGE enhanced activation of caspase-3, caspase-9 and caspase-8 and increased protein level of Apaf-1 and Bak, but diminished the level of Bcl-2. Additionally, OGE inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) yet enhanced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAP kinase (p38). In conclusion, our findings indicate that OGE suppressed the cell viability of A549 cells, which may result from the activation of apoptotic signaling and the inhibition of anti-apoptotic signaling, suggesting that OGE might be beneficial to lung carcinoma treatment.
Comparison between Neural Network and Adaptive Neuro-Fuzzy Inference System for Forecasting Chaotic Traffic Volumes  [PDF]
Jiin-Po Yeh, Yu-Chen Chang
Journal of Intelligent Learning Systems and Applications (JILSA) , 2012, DOI: 10.4236/jilsa.2012.44025
Abstract: This paper applies both the neural network and adaptive neuro-fuzzy inference system for forecasting short-term chaotic traffic volumes and compares the results. The architecture of the neural network consists of the input vector, one hidden layer and output layer. Bayesian regularization is employed to obtain the effective number of neurons in the hidden layer. The input variables and target of the adaptive neuro-fuzzy inference system are the same as those of the neural network. The data clustering technique is used to group data points so that the membership functions will be more tailored to the input data, which in turn greatly reduces the number of fuzzy rules. Numerical results indicate that these two models have almost the same accuracy, while the adaptive neuro-fuzzy inference system takes more time to train. It is also shown that although the effective number of neurons in the hidden layer is less than half the number of the input elements, the neural network can have satisfactory performance.
Application of the Adaptive Neuro-Fuzzy Inference System for Optimal Design of Reinforced Concrete Beams  [PDF]
Jiin-Po Yeh, Ren-Pei Yang
Journal of Intelligent Learning Systems and Applications (JILSA) , 2014, DOI: 10.4236/jilsa.2014.64013
Abstract: Using a genetic algorithm owing to high nonlinearity of constraints, this paper first works on the optimal design of two-span continuous singly reinforced concrete beams. Given conditions are the span, dead and live loads, compressive strength of concrete and yield strength of steel; design variables are the width and effective depth of the continuous beam and steel ratios for positive and negative moments. The constraints are built based on the ACI Building Code by considering the strength requirements of shear and the maximum positive and negative moments, the development length of flexural reinforcement, and the serviceability requirement of deflection. The objective function is to minimize the total cost of steel and concrete. The optimal data found from the genetic algorithm are divided into three groups: the training set, the checking set and the testing set for the use of the adaptive neuro-fuzzy inference system (ANFIS). The input vector of ANFIS consists of the yield strength of steel, compressive strength of concrete, dead load, span, width and effective depth of the beam; its outputs are the minimum total cost and optimal steel ratios for positive and negative moments. To make ANFIS more efficient, the technique of Subtractive Clustering is applied to group the data to help streamline the fuzzy rules. Numerical results show that the performance of ANFIS is excellent, with correlation coefficients between the three targets and outputs of the testing data being greater than 0.99.
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