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Search Results: 1 - 10 of 119985 matches for " Jianghao Wang "
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Big Models: From Beijing to the whole China
Ying Long,Kang Wu,Jianghao Wang,Zhenjiang Shen
Computer Science , 2014,
Abstract: This paper propose the concept of big model as a novel research paradigm for regional and urban studies. Big models are fine-scale regional/urban simulation models for a large geographical area, and they overcome the trade-off between simulated scale and spatial unit by tackling both of them at the same time enabled by emerging big/open data, increasing computation power and matured regional/urban modeling methods. The concept, characteristics, and potential applications of big models have been elaborated. We addresse several case studies to illustrate the progress of research and utilization on big models, including mapping urban areas for all Chinese cities, performing parcel-level urban simulation, and several ongoing research projects. Most of these applications can be adopted across the country, and all of them are focusing on a fine-scale level, such as a parcel, a block, or a township (sub-district), which is not the same with the existing studies using conventional models that are only suitable for a certain single or two cities or regions, or for a larger area but have to significantly sacrifice the data resolution. It is expected that big models will mark a promising new era for the urban and regional study in the age of big data.
Synthesis and Bioactivity of Natural Occurring Petasin-Like Derivatives as Antitumor Agents  [PDF]
Xiaolong Shi, Saiyang Zhang, Jianghao Wang, Tingyu Li, Junju Liu, Yi Hou, Lei Liu, Dongjun Fu, Haiwei Xu, Hongmin Hongmin, Yanbing Zhang
Open Journal of Medicinal Chemistry (OJMC) , 2015, DOI: 10.4236/ojmc.2015.52003
Abstract: Petasin is a potential antitumor against human neuroblastoma cell SK-N-SH by inhibiting the ERK1/2 phosphorylation. In view of its great activity and new antiproliferative mechanisms, a series of petasin derivatives were designed and synthesized, which showed great antiproliferative activity. Among them compounds 1h and 1f were more effective against SK-N-SH cells than petasin with the IC50 values of 0.87 and 2.63 μM, respectively.
Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer
Jianghao Chen, Ling Wang, Qing Yao, Rui Ling, Kaizong Li, Hui Wang
Breast Cancer Research , 2004, DOI: 10.1186/bcr819
Abstract: Sixty patients with breast carcinoma confirmed by preoperative puncture-biopsy were divided into two groups at random. The LC group (n = 30) received a subcutaneous injection of 4 ml of carboplatin-activated carbon suspension, containing 20 mg of carboplatin, adjacent to the primary tumour. The VC group (n = 30) received an intravenous administration of an equal dose of aqueous carboplatin. At 1, 12, 24, 36 and 48 hours after administration, modified radical mammectomies were performed on 12 patients at each time point, with 6 from each group. Axillary lymph nodes were removed for pathological examination. The platinum concentrations in nodes were determined by Zeeman atomic absorption spectrometry.A total of 275 axillary lymph nodes were resected, with 154 in the LC group and 121 in the VC group. Of the 275 lymph nodes, 136 (49.5%) from 23 patients (38.3%) had histopathologically detected metastases. At 1, 12, 24, 36 and 48 hours after injection, the carboplatin concentrations in the LC group were 11.82 ± 3.50, 23.58 ± 7.34, 18.22 ± 4.93, 16.70 ± 5.15 and 14.62 ± 4.29 μg/g (means ± SD), respectively, whereas those in the VC group were 0.06 ± 0.02, 0.11 ± 0.05, 0.10 ± 0.02, 0.05 ± 0.02 and 0 μg/g, respectively. Significant differences were found in each corresponding comparison (P < 0.001). Lymph node metastasis was uncorrelated with drug concentration (P > 0.05).LC can effectively and continuously improve the drug concentrations in axillary lymph nodes in patients with breast cancer, in comparison with VC.Regional lymph nodes are a common site for the postoperative relapse of advanced breast carcinoma. To improve the prognosis, axillary lymph nodes are routinely resected in radical mammectomy. However, there are several paths through which lymph drains from the breast to adjacent tissues, as shown in recent studies on sentinel lymph node [1,2]. Radical mammectomy fails in excising lymph nodes located in the mediastinum, internal mammary or hepatic portal. A similar
General multidimensional cloud model and its application on spatial clustering in Zhanjiang, Guangdong

DENG Yu,LIU Shenghe,ZHANG Wenting,WANG Li,WANG Jianghao,

地理学报 , 2010,
Abstract: Traditional spatial clustering methods have the disadvantage of “hardware division”, and can not describe the physical characteristics of spatial entity effectively. In view of the above, this paper sets forth a general multi-dimensional cloud model, which describes the characteristics of spatial objects more reasonably according to the idea of non-homogeneous and non-symmetry. Based on infrastructures’ classification and demarcation in Zhanjiang, a detailed interpretation of clustering results is made from the spatial distribution of membership degree of clustering, the comparative study of Fuzzy C-means and a coupled analysis of residential land prices. General multi-dimensional cloud model reflects the integrated characteristics of spatial objects better, reveals the spatial distribution of potential information, and realizes spatial division more accurately in complex circumstances. However, due to the complexity of spatial interactions between geographical entities, the generation of cloud model is a specific and challenging task.
Zero-Mode Contribution in Nucleon-Delta Transition
Yu, Jianghao;Wang, Teng;Ji, Chueng-Ryong;Ma, Bo-Qiang
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevD.76.074009
Abstract: We investigate the transition form factors between nucleon and $\Delta$(1232) particles by using a covariant quark-spectator-diquark field theory model in (3+1) dimensions. Performing a light-front calculation in parallel with the manifestly covariant calculation in light-front helicity basis, we examine the light-front zero-mode contribution to the helicity components of light-front good ("+") current matrix elements. Choosing the light-front gauge ($\epsilon^+_{h=\pm}=0$) with circular polarization in Drell-Yan-West frame, we find that only the helicity components $({1\over 2}, {1\over 2})$ and $({1\over 2},-{1\over 2})$ of the good current receive the zero-mode contribution. Taking into account the zero-mode, we find the prescription independence in obtaining the light-front solution of form factors from any three helicity matrix elements with smeared light-front wavefunctions. The angular condition, which guarantees the full covariance of different schemes, is recovered.
Dynamic Contrast-Enhanced MR Imaging in a Phase Ⅱ Study on Neoadjuvant Chemotherapy Combining Rh-Endostatin with Docetaxel and Epirubicin for Locally Advanced Breast Cancer
Qianxin Jia, Junqing Xu, Weifeng Jiang, Minwen Zheng, Mengqi Wei, Jianghao Chen, Ling Wang, Yi Huan
International Journal of Medical Sciences , 2013,
Abstract: Background: Anti-angiogenesis is a promising therapeutic strategy for locally advanced breast cancer. We performed this phase II trial to evaluate the anti-angiogenesis and anti-tumor effect of rh-endostatin combined with docetaxel and epirubicin in patients with locally advanced breast cancer by dynamic contrast-enhanced magnetic resonance imaging in 70 previously untreated locally advanced breast cancer patients. Methods: The study population was randomly assigned to neoadjuvant chemotherapy with docetaxel and epirubicin (neoadjuvant chemotherapy group) or neoadjuvant chemotherapy combining rh-endostatin with docetaxel and epirubicin (neoadjuvant chemotherapy+rh-endostatin group). The anti-angiogenic and anti-tumor effects of both regimens were evaluated by serial dynamic contrast-enhanced magnetic resonance imaging and microvessel density measurements after final surgery. Results: The results suggested a higher clinical objective response (90.9% vs. 67.7%, P = 0.021) and greater reductions in tumor size (67.2% vs. 55.9%, P = 0.000), Ki-67 proliferation index (32.79% vs. 12.47%, P = 0.000), tumor signal enhanced ratio (64% vs. 48%, P = 0.018), and Ktrans (67% vs. 39%, P = 0.026) in neoadjuvant chemotherapy+rh-endostatin group than those in neoadjuvant chemotherapy group. In addition, the microvessel density value in the neoadjuvant chemotherapy+rh-endostatin group was significantly lower than in the neoadjuvant chemotherapy group (18.67 ± 6.53 vs. 36.05 ± 9.64, P = 0.000). Moreover, the microvessel density value was significantly correlated with Ktrans after neoadjuvant chemotherapy+rh-endostatin treatment (r=0.88, P = 0.00). Conclusions: The neoadjuvant chemotherapy+rh-endostatin treatment significantly repressed angiogenesis in locally advanced breast cancer and synergistically enhanced the anti-tumor effect of neoadjuvant chemotherapy. Serial dynamic contrast-enhanced magnetic resonance imaging data including reductions in tumor size and Ktrans, could provide non-invasive evaluation for chemotherapeutic efficacy and, consequently, optimization of individual chemotherapy for locally advanced breast cancer patients.
Spatial Clustering Method Based on General Multidimensional Cloud Model
广义多维云模型及在空间聚类中的应用

DENG Yu,LIU Shenghe,ZHANG Wenting,WANG Li,WANG Jianghao,
邓羽
,刘盛和,张文婷,王丽,王江浩

地理学报 , 2009,
Abstract: Traditional spatial clustering methods can not avoid the disadvantage of "hardware division", and can not describe the physical characteristics of spatial entity effectively. One-dimensional cloud model can not accurately reflect multi-attribute characteristics of the real-world. Besides, essential information of spatial objects might be lost during procedure of simple fusion. Standard two-dimensional cloud model overcomes some shortcomings of one-dimensional cloud, but it still can not meet the needs of simulating the non-homogeneous and non-symmetry characteristics of complex geographical phenomena. In view of the above, this paper sets forth a general multi-dimensional cloud model, which describes the characteristics of spatial objects more reasonably. Based on the empirical research, a detailed interpretation of clustering results is made from the spatial distribution of membership degree of clustering, the comparative study of Fuzzy C-means and a coupled analysis of residential land prices. It is found that general multi-dimensional cloud model can reflect the integrated characteristics of spatial objects better, reveal the spatial distribution of potential information, and realize spatial division more accurately in complex circumstances. However, due to the complexity of spatial interactions among geographical entities, the construction of cloud model is a specific and challenging task.
地铁隧道活塞风实测及特征分析
Subway piston wind measurement and analysis of Xi’an metro Line 2

齐江浩,赵蕾,王君,李德辉,郭永桢,邓保顺
QI Jianghao
,ZHAO Lei,WANG Jun,LI Dehui,GUO Yongzhen,DENG Baoshun

- , 2016,
Abstract: 对西安地铁2号线某站上、下行线隧道以及活塞风道中的风速和温度进行监测,分析冬季最冷月和夏季最热月列车行驶过程中隧道与活塞风道内气流的运动特性及其动态变化规律。研究结果表明:对于安装有屏蔽门的车站,列车活塞风对隧道空间和活塞风道环境影响巨大,活塞风大小主要受室外与地下温度差异、隧道结构、列车运行状况、行驶空气阻力、空气与壁面之间的摩擦及列车会车情况等因素影响。
A station of Xi’an Metro Line 2 is selected as study object. The wind speed and temperature in running tunnel and piston ventilation shafts of uplink and downlink is analyzed. The airflow movement, piston wind regular pattern of running tunnel and piston ventilation shafts during train running in the coldest month of winter and the hottest month of summer is also studied. According to the result,for the station with platform screen doors,piston wind greatly influence the surroundings of tunnel and piston ventilation shaft. The subway piston wind is significantly influenced by indoor and outdoor difference in temperature,structure of tunnel,the workings of train,air resistance,trains meeting and so on
西安地铁车站环境实测及公共区空调负荷计算分析
Field measurement of Xi''an Metro station environment and analysis of air conditioning load for the public zone

齐江浩,赵蕾,王君,李德辉,郭永桢,邓保顺
QI Jianghao
,ZHAO Lei,WANG Jun,LI Dehui,GUO Yongzhen,DENG Baoshun

- , 2016,
Abstract: 基于对西安地铁2号线纬一街站车站公共区、站台隧道、活塞风井、排热风道和室外空气的温度和相对湿度的逐时监测,通过负荷计算及理论分析车站公共区空调负荷逐时变化规律并提出负荷计算建议。通常负荷计算中是按照规范中的规定,以晚高峰为基础取定常值。研究结果表明:虽然早高峰温度低但相对湿度大,加之早高峰客流量常常大于晚高峰,致使地铁实际运营中车站公共早高峰空调负荷时常大于晚高峰。建议空调负荷计算中综合考虑早晚高峰的峰值负荷。
According to the monitoring data of temp rature and relative humidity of Xian Metro line 2 Wei Street Station ( i.e. public zone, station tunnel, piston shaft, heat exhaust duct and externalair), the load of air-conditioning and theoretical analysis are calculated. This paper reveals the hourly change rule of the public zone air-conditioning load,and put forward some suggestions. We calculate the public zone air-conditioning load according to the regulations in design specification,based on evening peak get the constant value.In reality,morning peak’s passenger flow is bigger and the air relative humidity is higher. Then the load of morning peak and evening should be rationally considered in the calculation of public zone air-conditioning load
Detection and Analysis of Human Papillomavirus (HPV) DNA in Breast Cancer Patients by an Effective Method of HPV Capture
Ting Wang, Xi Zeng, Weiyang Li, Haijun Zhu, Guan Wang, Xiao Liu, Yonggang Lv, Jinghua Wu, Xuehan Zhuang, Juliang Zhang, Yi Zhao, Haodong Huang, Jing Fan, Qing Yao, Chenyang He, Xiuqing Zhang, Chen Huang, Jianghao Chen, Ling Wang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090343
Abstract: Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between human papillomavirus (HPV) and the risk of breast carcinoma, these studies remain inconclusive. Here we aim to detect HPV DNA in various tissues from patients with breast carcinoma using the method of HPV capture combined with massive paralleled sequencing (MPS). To validate the confidence of our methods, 15 cervical cancer samples were tested by PCR and the new method. Results showed that there was 100% consistence between the two methods.DNA from peripheral blood, tumor tissue, adjacent lymph nodes and adjacent normal tissue were collected from seven malignant breast cancer patients, and HPV type 16(HPV16) was detected in 1/7, 1/7, 1/7and 1/7 of patients respectively. Peripheral blood, tumor tissue and adjacent normal tissue were also collected from two patients with benign breast tumor, and 1/2, 2/2 and 2/2 was detected to have HPV16 DNA respectively. MPS metrics including mapping ratio, coverage, depth and SNVs were provided to characterize HPV in samples. The average coverage was 69% and 61.2% for malignant and benign samples respectively. 126 SNVs were identified in all 9 samples. The maximum number of SNVs was located in the gene of E2 and E4 among all samples. Our study not only provided an efficient method to capture HPV DNA, but detected the SNVS, coverage, SNV type and depth. The finding has provided further clue of association between HPV16 and breast cancer.
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