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Search Results: 1 - 10 of 126945 matches for " Jiana Li "
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Gene Silencing of BnTT10 Family Genes Causes Retarded Pigmentation and Lignin Reduction in the Seed Coat of Brassica napus
Kai Zhang, Kun Lu, Cunmin Qu, Ying Liang, Rui Wang, Yourong Chai, Jiana Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061247
Abstract: Yellow-seed (i.e., yellow seed coat) is one of the most important agronomic traits of Brassica plants, which is correlated with seed oil and meal qualities. Previous studies on the Brassicaceae, including Arabidopsis and Brassica species, proposed that the seed-color trait is correlative to flavonoid and lignin biosynthesis, at the molecular level. In Arabidopsis thaliana, the oxidative polymerization of flavonoid and biosynthesis of lignin has been demonstrated to be catalyzed by laccase 15, a functional enzyme encoded by the AtTT10 gene. In this study, eight Brassica TT10 genes (three from B. napus, three from B. rapa and two from B. oleracea) were isolated and their roles in flavonoid oxidation/polymerization and lignin biosynthesis were investigated. Based on our phylogenetic analysis, these genes could be divided into two groups with obvious structural and functional differentiation. Expression studies showed that Brassica TT10 genes are active in developing seeds, but with differential expression patterns in yellow- and black-seeded near-isogenic lines. For functional analyses, three black-seeded B. napus cultivars were chosen for transgenic studies. Transgenic B. napus plants expressing antisense TT10 constructs exhibited retarded pigmentation in the seed coat. Chemical composition analysis revealed increased levels of soluble proanthocyanidins, and decreased extractable lignin in the seed coats of these transgenic plants compared with that of the controls. These findings indicate a role for the Brassica TT10 genes in proanthocyanidin polymerization and lignin biosynthesis, as well as seed coat pigmentation in B. napus.
Deletion and Down-Regulation of HRH4 Gene in Gastric Carcinomas: A Potential Correlation with Tumor Progression
Chao Zhang, Yi Xiong, Jiana Li, Yang Yang, Li Liu, Wen Wang, Luo Wang, Manhui Li, Zhengyu Fang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031207
Abstract: Background Histamine is an established growth factor for gastrointestinal malignancies. The effect of histamine is largely determined locally by the histamine receptor expression pattern. Histamine receptor H4 (HRH4), the newest member of the histamine receptor family, is positively expressed on the epithelium of the gastrointestinal tract, and its function remains to be elucidated. Previously, we reported the decreased expression of HRH4 in colorectal cancers and revealed its correlation with tumor proliferation. In the current study, we aimed to investigate the abnormalities of HRH4 gene in gastric carcinomas (GCs). Methodology/Principal Findings We analyzed H4R expression in collected GC samples by quantitative PCR, Western blot analysis, and immunostaining. Our results showed that the protein and mRNA levels of HRH4 were reduced in some GC samples, especially in advanced GC samples. Copy number decrease of HRH4 gene was observed (17.6%, 23 out of 131), which was closely correlated with the attenuated expression of H4R. In vitro studies, using gastric cancer cell lines, showed that the alteration of HRH4 expression on gastric cancer cells influences tumor growth upon exposure to histamine. Conclusions/Significance We show for the first time that deletion of HRH4 gene is present in GC cases and is closely correlated with attenuated gene expression. Down-regulation of HRH4 in gastric carcinomas plays a role in histamine-mediated growth control of GC cells.
Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression
Zhengyu Fang, Wantong Yao, Yi Xiong, Jiana Li, Li Liu, Lei Shi, Wei Zhang, Chao Zhang, Liping Nie, Jun Wan
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-195
Abstract: Immunoblotting, real-time PCR, immunofluorescence and immunohistochemistry assays were adopted to examine HRH4 expression in case-matched CRC samples (n = 107) and adjacent normal tissues (ANTs). To assess the functions of HRH4 in CRC cells, we established stable HRH4-transfected colorectal cells and examined cell proliferation, colony formation, cell cycle and apoptosis in these cells.The protein levels of HRH4 were reduced in most of the human CRC samples regardless of grade or Dukes classification. mRNA levels of HRH4 were also reduced in both early-stage and advanced CRC samples. In vitro studies showed that HRH4 over-expression caused growth arrest and induced expression of cell cycle proteins in CRC cells upon exposure to histamine through a cAMP -dependent pathway. Furthermore, HRH4 stimulation promoted the 5-Fu-induced cell apoptosis in HRH4-positive colorectal cells.The results from the current study supported previous findings of HRH4 abnormalities in CRCs. Expression levels of HRH4 could influence the histamine-mediated growth regulation in CRC cells. These findings suggested a potential role of abnormal HRH4 expression in the progression of CRCs and provided some new clues for the application of HRH4-specific agonist or antagonist in the molecular therapy of CRCs.Colorectal cancer is the uncontrolled growth of malignant cells in the colon or rectum. It is currently the third most common cancer in the Chinese population, responsible for about 130,000 deaths per year. The growth of CRC cells is influenced by various factors such as insulin-like growth factors (IGF) [1], endothelial growth factor [2,3] and epidermal growth factor receptor [4-6].Histamine and histamine receptors, previously identified as critical molecules during inflammation, are also involved in the control of CRC growth [7-10]. Histamine is a ubiquitous chemical messenger that exhibits numerous functions and may act as ans [7,11,12]. Histamine levels in cells and tissues are regulated by
A High-Density SNP Map for Accurate Mapping of Seed Fibre QTL in Brassica napus L
Liezhao Liu, Cunmin Qu, Benjamin Wittkop, Bin Yi, Yang Xiao, Yajun He, Rod J. Snowdon, Jiana Li
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083052
Abstract: A high density genetic linkage map for the complex allotetraploid crop species Brassica napus (oilseed rape) was constructed in a late-generation recombinant inbred line (RIL) population, using genome-wide single nucleotide polymorphism (SNP) markers assayed by the Brassica 60 K Infinium BeadChip Array. The linkage map contains 9164 SNP markers covering 1832.9 cM. 1232 bins account for 7648 of the markers. A subset of 2795 SNP markers, with an average distance of 0.66 cM between adjacent markers, was applied for QTL mapping of seed colour and the cell wall fiber components acid detergent lignin (ADL), cellulose and hemicellulose. After phenotypic analyses across four different environments a total of 11 QTL were detected for seed colour and fiber traits. The high-density map considerably improved QTL resolution compared to the previous low-density maps. A previously identified major QTL with very high effects on seed colour and ADL was pinpointed to a narrow genome interval on chromosome A09, while a minor QTL explaining 8.1% to 14.1% of variation for ADL was detected on chromosome C05. Five and three QTL accounting for 4.7% to 21.9% and 7.3% to 16.9% of the phenotypic variation for cellulose and hemicellulose, respectively, were also detected. To our knowledge this is the first description of QTL for seed cellulose and hemicellulose in B. napus, representing interesting new targets for improving oil content. The high density SNP genetic map enables navigation from interesting B. napus QTL to Brassica genome sequences, giving useful new information for understanding the genetics of key seed quality traits in rapeseed.
DNA Methylation Alterations at 5′-CCGG Sites in the Interspecific and Intraspecific Hybridizations Derived from Brassica rapa and B. napus
Wanshan Xiong, Xiaorong Li, Donghui Fu, Jiaqin Mei, Qinfei Li, Guanyuan Lu, Lunwen Qian, Yin Fu, Joseph Onwusemu Disi, Jiana Li, Wei Qian
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065946
Abstract: DNA methylation is an important regulatory mechanism for gene expression that involved in the biological processes of development and differentiation in plants. To investigate the association of DNA methylation with heterosis in Brassica, a set of intraspecific hybrids in Brassica rapa and B. napus and interspecific hybrids between B. rapa and B. napus, together with parental lines, were used to monitor alterations in cytosine methylation at 5′-CCGG sites in seedlings and buds by methylation-sensitive amplification polymorphism analysis. The methylation status of approximately a quarter of the methylation sites changed between seedlings and buds. These alterations were related closely to the genomic structure and heterozygous status among accessions. The methylation status in the majority of DNA methylation sites detected in hybrids was the same as that in at least one of the parental lines in both seedlings and buds. However, the association between patterns of cytosine methylation and heterosis varied among different traits and between tissues in hybrids of Brassica, although a few methylation loci were associated with heterosis. Our data suggest that changes in DNA methylation at 5′-CCGG sites are not associated simply with heterosis in the interspecific and intraspecific hybridizations derived from B. rapa and B. napus.
Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population
Nan Zhao, Xin Liu, Yongqin Wang, Xiaoqiu Liu, Jiana Li, Litian Yu, Liyuan Ma, Shuyu Wang, Hongye Zhang, Lisheng Liu, Jingbo Zhao, Xingyu Wang
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-162
Abstract: A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model.We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group.Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.
Research on hybrid control methods of aluminum reduction on neural network
基于神经网络的铝电解混合控制模型研究*

WANG Cheng-liang,PANG Xu,LU Zhi-jiana,
汪成亮
,庞栩,陆志坚a

计算机应用研究 , 2010,
Abstract: 铝电解优化控制生产过程的实质是将可控参数尽量控制在工艺要求的目标值范围内。传统的基于神经网络的控制方法或直接判断氧化铝浓度,缺乏对历史浓度的有效追踪,致使判断准确率下降;或对铝电解生产状况进行宏观识别,并调整,但缺乏实时性、及时性。针对上述问题,将神经网络和关联规则库、专家知识库、控制策略相结合,提出了一种新的氧化铝浓度识别及控制方法,从而将神经网络上升为一种混合控制模型HC-NN (hybrid control- neural network)。该模型以控制参数(自变量)为神经网络输入,和其输出共同作为
Cross-Cultural Color-Odor Associations
Carmel A. Levitan, Jiana Ren, Andy T. Woods, Sanne Boesveldt, Jason S. Chan, Kirsten J. McKenzie, Michael Dodson, Jai A. Levin, Christine X. R. Leong, Jasper J. F. van den Bosch
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101651
Abstract: Colors and odors are associated; for instance, people typically match the smell of strawberries to the color pink or red. These associations are forms of crossmodal correspondences. Recently, there has been discussion about the extent to which these correspondences arise for structural reasons (i.e., an inherent mapping between color and odor), statistical reasons (i.e., covariance in experience), and/or semantically-mediated reasons (i.e., stemming from language). The present study probed this question by testing color-odor correspondences in 6 different cultural groups (Dutch, Netherlands-residing-Chinese, German, Malay, Malaysian-Chinese, and US residents), using the same set of 14 odors and asking participants to make congruent and incongruent color choices for each odor. We found consistent patterns in color choices for each odor within each culture, showing that participants were making non-random color-odor matches. We used representational dissimilarity analysis to probe for variations in the patterns of color-odor associations across cultures; we found that US and German participants had the most similar patterns of associations, followed by German and Malay participants. The largest group differences were between Malay and Netherlands-resident Chinese participants and between Dutch and Malaysian-Chinese participants. We conclude that culture plays a role in color-odor crossmodal associations, which likely arise, at least in part, through experience.
Beneficial Experience from Teaching and Education to Research and Development  [PDF]
Li Li
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.37B039
Abstract:

Teaching and Education (T&E) constitute the most important activity in knowledge transfer from generation to generation. This can explain why government organizations consider the training of highly qualified personnel as one of the most important criteria in the selection of research and development (R&D) grant applications. A university professor should thus not only play the role of researcher, but also that of teacher. T&E and R&D combine to form an inseparable relationship for university professors. By shooting for excellence in T&E, we could get a new perception of a familiar field or initiate a brand new field altogether, which would in turn enhance our research. The quest for excellence in R&D leads to deeper and better understanding of materials taught, and progress in R&D enriches our T&E endeavors. Here, the author shares a beneficial experience from T&E to R&D.

A Causality Analysis of Coal Consumption and Economic Growth for China and India  [PDF]
Jinke Li, Zhongxue Li
Natural Resources (NR) , 2011, DOI: 10.4236/nr.2011.21007
Abstract: China and India are the two countries with the strongest economic growth in the world. Meanwhile they consume much of the global coal to fuel their economic development. With coal burning as a major factor contributing to global greenhouse gas emissions, China and India are confronted with a dilemma of economic growth and environment protection. Will coal consumption reduction cause economic shocks? Is there a causal relationship between coal consumption and economic growth in China and India? In this paper Granger causality tests were used to examine the relationship between coal consumption and GDP in China and India, using data for the period from 1965 to 2006. It was found that a unidirectional causality from GDP to coal consumption existed in China while a unidirectional causality from coal consumption to GDP did in India. Therefore, developing cleaner and more efficient technologies is essential to reduce their CO2 emissions to reach sustainable development.
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