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Search Results: 1 - 10 of 161919 matches for " Jian-Yong Li "
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Xi-Wang Liu,Jian-Yong Li,Han Zhang,Ya-Jun Yang
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812022477
Abstract: The title compound, C10H5ClF2N2OS, was obtained by linking an amino heterocycle and a substituted benzoyl chloride. The dihedral angle between the two rings is 41.2 (2)° and the equalization of the amide C—N bond lengths reveals the existence of conjugation between the benzene ring and the thiazole unit. In the crystal, pairs of N—H...N hydrogen bonds link molecules into inversion dimers. Non-classical C—H...F and C—H...O hydrogen bonds stabilize the crystal structure.
4-Allyl-2-methoxyphenyl 2-acetoxybenzoate
Xi-Wang Liu,Jian-Yong Li,Ya-Jun Yang,Ji-Yu Zhang
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811021416
Abstract: In the title compound, C19H18O5, the ester group is twisted with respect to the acetylsalicylic acid and eugenol rings at dihedral angles of 22.48 (2) and 81.07 (1)°, respectively. The dihedral angle between the two benzene rings is 60.72 (1)°. The crystal packing exhibits no significantly short intermolecular contacts.
Efficient Mining of Frequent Closed XML Query Pattern
Jian-Hua Feng,Qian Qian,Jian-Yong Wang,Li-Zhu Zhou,
Jian-Hua Feng
,Qian Qian,Jian-Yong Wang,and Li-Zhu Zhou

计算机科学技术学报 , 2007,
Abstract: Previous research works have presented convincing arguments that a frequent pattern mining algorithm should not mine all frequent but only the closed ones because the latter leads to not only more compact yet complete result set but also better efficiency.Upon discovery of frequent closed XML query patterns,indexing and caching can be effectively adopted for query performance enhancement.Most of the previous algorithms for finding frequent patterns basically introduced a straightforward generate-and-test strategy.In this paper,we present SOLARIA*,an efficient algorithm for mining frequent closed XML query patterns without candidate maintenance and costly tree-containment checking.Efficient algorithm of sequence mining is involved in discovering frequent tree-structured patterns,which aims at replacing expensive containment testing with cheap parent-child checking in sequences.SOLARIA* deeply prunes unrelated search space for frequent pattern enumeration by parent-child relationship constraint.By a thorough experimental study on various real-life data,we demonstrate the efficiency and scalability of SOLARIA* over the previous known alternative.SOLARIA* is also linearly scalable in terms of XML queries' size.
The Efficacy and Adverse Reaction of Bleeding of Clopidogrel plus Aspirin as Compared to Aspirin Alone after Stroke or TIA: A Systematic Review
Yan Huang, Man Li, Jian-Yong Li, Min Li, Yuan-Peng Xia, Ling Mao, Bo Hu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065754
Abstract: Background and Purpose Given the high risk of stroke after TIA (transient ischemia attack) or stroke and the adverse reaction of bleeding of antiplatelets, we undertook a meta-analysis, reviewed randomized controlled trials (RCTs) comparing aspirin plus clopidogrel with aspirin alone to determine the efficacy and adverse reaction of bleeding of the two protocols in the prevention of stroke. Methods We analyzed the incidences of stroke, bleeding and severe bleeding by using fixed-effect model or random-effect model on the basis of the result of heterogeneity test. Results Five qualified RCTs satisfied the inclusion criteria. We found that treatment with aspirin plus clopidogrel was associated with lower incidence of stroke (Risk Ratio (RR), 0.66, 95% confidence interval (CI), 0.47 to 0.93), higher incidence of bleeding (RR, 1.75, 95% CI, 1.48 to 2.05) as compared with aspirin-alone treatment. In terms of severe bleeding, no statistical difference existed between them (RR, 2.21, 95% CI, 0.25 to 19.52). Conclusion The combined use of aspirin and clopidogrel is more effective than aspirin alone for patients with previous TIA or stroke for the prevention of stroke, with risk of bleeding being higher. No statistical difference was found in severe bleeding between the two treatment protocols.
LATS2 is De-methylated and Overexpressed in Nasopharyngeal Carcinoma and Predicts Poor Prognosis
Yan Zhang, Chun-Fang Hu, Jing Chen, Li-Xu Yan, Yi-Xin Zeng, Jian-Yong Shao
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-538
Abstract: Using quantitative real time PCR and immunoblotting, the expression of LATS2 was detected in nasopharyngeal carcinoma cell lines and in the immortalized nasopharyngeal epithelial cell line NP69. Using immunohistochemistry, we analyzed LATS2 protein expression in 220 nasopharyngeal carcinoma cases. The association of LATS2 protein expression with the clinicopathological characteristics and the prognosis of nasopharyngeal carcinoma were subsequently assessed. Using methylation specific PCR, we detected the methylation status of the LATS2 promoter. RNA interference was performed by transfecting siRNA to specifically knock down LATS2 expression in 5-8F and CNE2.LATS2 protein was detected in 178 of 220 (80.91%) cases of nasopharyngeal carcinoma. LATS2 overexpression was a significant, independent prognosis predictor (P = 0.037) in nasopharyngeal carcinoma patients. Methylation specific PCR revealed that 36.7% (11/30) of nasopharyngeal carcinoma tissues and all of the chronic nasopharyngeal inflammation samples were methylated. Functional studies showed that the suppression of LATS2 expression in nasopharyngeal carcinoma (5-8F and CNE2) cell lines by using specific small interfering (siRNA) resulted in the inhibition of growth, induction of apoptosis and S-phase cell cycle increase. Overexpression of LATS2 in NP69 stimulated cell proliferation.Our results indicate that LATS2 might play a role in the tumorigenesis of nasopharyngeal carcinoma by promoting the growth of nasopharyngeal carcinoma cells. Transfection with specific siRNA might be feasible for the inhibition of growth, induction of apoptosis and S phase increase in nasopharyngeal carcinoma.Nasopharyngeal carcinoma (NPC) is endemic to certain areas of Southern China, South-Asia and North Africa. In Southern China in the Guandong and Guangxi provinces, the incidence rate of NPC is up to 25-40 per 100,000 person-years [1,2]. A dominant clinicopathological characteristic of NPC is the involvement of cervical lymph no
Overexpression of Osteopontin, αvβ3 and Pim-1 Associated with Prognostically Important Clinicopathologic Variables in Non-Small Cell Lung Cancer
Yi Jin, Da-yue Tong, Jian-ning Chen, Zhi-ying Feng, Jian-yong Yang, Chun-kui Shao, Jia-ping Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048575
Abstract: In this study, we examined the expression of osteopontin (OPN), αvβ3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC. Immunohistochemical assays were used to examine the protein expression of OPN, αvβ3 and Pim-1 in 208 NSCLC samples and their adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the relationships between OPN, αvβ3 and Pim-1 expression patterns, and their association with the clinical-pathological parameters of NSCLC patients. In NSCLC tissues, the positive rates of OPN, αvβ3 and Pim-1 expression were 67.8% (141/208), 76.0% (158/208) and 58.7% (122/208), respectively. However, in the adjacent normal lung tissues, the positive rates of OPN, αvβ3 and Pim-1 were 20.2% (42/208), 24.0% (50/208) and 14.9% (31/208), respectively. The differences in the positive expression rates of OPN, αvβ3 and Pim-1 between NSCLCs and the adjacent normal lung tissues were all significant (P<0.01). Additionally, the positive expression of OPN, αvβ3 and Pim-1 in NSCLCs was associated with an increase in pathological grade, lymph node metastasis and advanced clinical stage (all P<0.01). Furthermore, associations between the expression of OPN and αvβ3, OPN and Pim-1, and αvβ3 and Pim-1 were also observed in our NSCLC cohort (all P<0.01). The OPN, αvβ3 and Pim-1 proteins are frequently overexpressed in NSCLC and are associated with some clinicopathologic variables that are of known prognostic importance in NSCLC, suggesting that they may play an important role in the development and/or progression of NSCLC.
The Configuration and Process Route Optimization of FMS Based on Hybrid GA

LI Jian-yong,CHA Jian-zhong,E Ming-cheng,

系统工程理论与实践 , 2004,
Abstract: Hybrid genetic algorithms (HGA) was proposed for configuration of FMS based on Closed Queueing Networks (CQN). The monotonicity of throughput function and cost function in the CQN model was fully utilized to design an operator called as Maximum Gradient of Throughput-Cost. This operator can guide new populations into feasible region from infeasible region. The algorithms for process route optimization imbedded an operator called as Operator Distributing Remainder Randomly in GA to resolve the constraint optimal problem. The operator distributed equation constraints over individuals randomly and makes all individuals feasibility by heuristic rules. Accordingly, HGA are capable of solving the fconstraint optimal problem and enhancing their ability of local search. An illustration of the method showed that the solution quality by the HGA is better than that by Implicit Enumeration most in use.
Notes on Paphiopedilum wardii and its related species

ZHANG Jian-Yong,LIU Zhong-Jian,LEI Si-Peng,CHEN Li-Jun,

植物分类学报 , 2001,
Abstract: The relationships between Paphiopedilum wardii and its related species are briefly discussed. Two new species: Paph. burmanicum J. Y. Zhang et Z. J. Liu and Paph. brevilabium Z. J. Liu et J. Y. Zhang are described and illustrated. A key to the five species treated is provided.
Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A
Zi-Ming Du,Li-Fu Hu,Hai-Yun Wang,Li-Xu Yan,Yi-Xin Zeng,Jian-Yong Shao,Ingemar Ernberg
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019137
Abstract: The role of microRNA-155 (miR-155) has been associated with oncogenesis of several human tumors. However the expression pattern of miR-155 has not been investigated in nasopharyngeal carcinoma (NPC). The present study was to assess miR-155 expression pattern and its possible function in NPC, to identify its targets and evaluate their clinical applications in NPC. MiR-155 was found to be upregulated in two Epstein-Barr virus (EBV) negative NPC derived cell lines CNE1 and TW03, as well as in NPC clinical samples by quantitative Real-time PCR and in situ hybridization detection. EBV encoded LMP1 and LMP2A could further enhance the expression of miR-155 in NPC CNE1 and TW03 cells. JMJD1A and BACH1 were identified as putative targets of miR-155 in a bioinformatics screen. Overexpression of miR-155 downregulated a luciferase transcript fused to the 3′UTR of JMJD1A and BACH1. MiR-155 mimic could downregulate the expression of JMJD1A and BACH1, while miR-155 inhibitor could upregulate JMJD1A expression in NPC cell lines. Moreover, downregulation of JMJD1A was significantly correlated with N stage in TNM classification (p = 0.023), a lower five-year survival rate (p = 0.021), and a lower five-year disease-free survival rate (p = 0.049) of NPC patients. Taken together, up-regulation of miR-155 in NPC is partly driven by LMP1 and LMP2A, and results in downregulation of JMJD1A, which is associated with N stage and poor prognosis of NPC patients. The potential of miR-155 and JMJD1A as therapeutic targets in NPC should be further investigated.
Methylation status of DDIT3 gene in Chronic Myeloid Leukemia
Ya-li Wang, Jun Qian, Jiang Lin, Dong-ming Yao, Zhen Qian, Zhao-hui Zhu, Jian-yong Li
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-54
Abstract: The methylation status of DDIT3 promoter was detected in the bone marrow mononuclear cells from 53 patients with CML using methylation-specific PCR (MSP). The expression levels of DDIT3 and bcr/abl transcript were determined by real-time quantitative PCR (RQ-PCR). Clinical data of these patients were collected and analyzed.The aberrant methylation of DDIT3 gene promoter was found in 35 of 53 (66%) CML cases. Correlation was not found between DDIT3 promoter hypermethylation and the age, sex, hemoglobin concentration, platelet counts, chromosomal abnormalities, bcr/abl transcript, and staging of CML patients (P > 0.05), but found between DDIT3 promoter hypermethylation and WBC counts of CML cases (R = 0.781, P < 0.001). The level of DDIT3 transcript in CML patients was significantly lower than that in controls (median 3.28 vs 19.69, P < 0.001), however, there was no difference in the level of DDIT3 transcript between methylation-positive CML cases (0.05-65.32, median 2.13) and methylation- negative CML cases (0.12-126.04, median 3.92) (P > 0.05).Our results demonstrate that aberrant methylation of DDIT3 occurs in CML frequently.Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive accumulation of clonal myeloid cells in hematopoietic tissues. Almost all patients with CML present the common cytogenetic abnormality of the t(9;22) and the bcr/abl fusion gene which is generated by the translocation. Clinically CML can be divided into three phases: the chronic phase (CP), the accelerated phase (AP), the blast crisis (BC) [1,2]. BC is the last stage of CML disease progress, in which hematopoietic differentiation become arrested and immature blasts accumulate in the bone marrow and spill into the circulation. The mechanisms responsible for transition of CP into BC remain poorly understood [3].In the pathogenesis of leukemias and other cancers, gene silencing by aberrant DNA methylation is a frequent event [4,5]. The methylation of several tumor sup
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