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Search Results: 1 - 10 of 30109 matches for " Jian Suo "
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Genotoxic and Biological Evaluation of a Nano Silica Cross Linked Composite Specifically Used for Intra-Vas Device  [PDF]
Shu-Jian Chen, Yao Bai, Xun-Bin Huang, Jin-Ping Suo, Juan Li
Soft Nanoscience Letters (SNL) , 2012, DOI: 10.4236/snl.2012.23005
Abstract: The Context: Aims: To evaluate the biocompatibility and in vitro genotoxicity of a non-copper nano silica polymer modified composite for filtering-type intra-vas devices. Settings and Design: Academic research laboratory, Huazhong University of Science and Technology. Prospective experimental study. Methods and Material: Non-copper nano silica polymer modified composite rods were implanted into the back muscle of rabbits for biocompatibility evaluation. Comet assay was applied to the determination of DNA damage, while, Mutagenic activity was tested by means of Ames test using Salmonella typhimurium TA98 and TA 100 tester strains with and without metabolic activation. Statistical analysis used: qualitative and quantitative data were tested using the Chi-square test and Student’s test. Results: Only mild inflammatory reaction was observed in the surrounding tissues of the implanted nano-silica modified polymer composite in the early implantation stage, which was similar to that of the sham-operated group. The inflammatory reaction was completely disappeared after 12 weeks. No significant DNA damage (P > 0.05) were tested on the nano-silica modified polymer composite in Comet assay. In Ames test, the extracts from non-copper composite did not exert mutagenic effect on the bacterial. Conclusions: The non-copper nano silica modified composite did not exhibit in vitro genotoxicity and obvious inflammation in tissue, it would be a safe biomaterial for further clinical trial.
Visceral Myopathy Presenting as Acute Appendicitis and Ogilvie Syndrome
Punyaram Kharbuja,Raghvendra Thakur,Jian Suo
Case Reports in Surgery , 2013, DOI: 10.1155/2013/906457
Abstract: Background. Visceral myopathy is rare pathological condition of gastrointestinal tract with uncertain clinical presentation and unknown etiology. It often presents with symptoms of chronic intestinal pseudoobstruction of colon. We report a case of visceral myopathy which presented to us as acute appendicitis and Ogilvie syndrome, and we managed it surgically. Method and Result. A case report of 20-year female clinically presented as acute appendicitis and we performed laparoscopic exploration which revealed inflamed appendix with grossly dilated ascending colon. We performed laparoscopic appendectomy and postoperatively managed the patients with IV fluids, antibiotics, neostigmine, and extended length rectal tube for enema and decompression. During postoperative period, she developed abdomen distension and peritonitis, and we ordered abdomen CT which revealed colon pseudo- obstruction. We performed right hemicolectomy with permanent ileostomy, and the histopathology reports of resected colon were visceral myopathy. Conclusion. Visceral myopathy is very rare group of disease and poorly understood condition that may present with chronic or acute intestinal pseudo-obstruction and often mimic other more common gastrointestinal disease. VM should be considered as differential diagnosis whenever the patient presents with acute appendicitis, uncharacteristic abdominal symptoms, recurrent attacks of abdominal distention, and pain with no radiological evidence of intestinal obstruction. 1. Introduction Visceral myopathy (VM) is rare pathologic conditions of gastrointestinal tract that can mimic various causes of acute abdomen. Patients with VM often present with symptoms of chronic intestinal pseudo-obstruction (CIP) of colon like recurrent episodes of abdominal pain, vomiting, and abdominal distension due to recurrent disturbance of motility in gastrointestinal tract and often causes misdiagnosis of acute abdomen including acute appendicitis. Unlike the classical symptoms, we report a rare and atypical case of VM presenting as acute appendicitis and acute pseudo-obstruction and perforation of colon clinically and pathologically. 2. Case Report 20 years, female with 2 days of abdominal pain, pain migrating to right iliac fossa and feverish with temperature 38°C. She denied history of abdominal and gynecological disease or symptoms. Clinically diagnosed acute appendicitis (Alvarado Score 7) and we performed diagnostic laparoscopy which revealed inflamed appendix and grossly dilated ascending colon. As the patient had no history and signs of constipation and
The spatial distribution of dark-matter-annihilation originated gamma-ray line signal
Tong-Suo Lu,Tie-Kuang Dong,Jian Wu
Physics , 2013, DOI: 10.1088/1674-4527/14/5/002
Abstract: The GeV$-$TeV $\gamma-$ray line signal is the smoking gun signature of the dark matter annihilation or decay. The detection of such a signal is one of the main targets of some space-based telescopes, including Fermi-LAT and the upcoming CALET, DAMPE and Gamma-400. An important feature of the dark-matter-annihilation originated $\gamma-$ray line photons is their concentration at the center of the Galaxy. So far no reliable $\gamma-$ray line has been detected by Fermi-LAT and the upper limits on the cross section of annihilation into $\gamma-$rays have been reported. We use these upper limits to estimate the "maximal" number of $\gamma-$ray line photons detectable for Fermi-LAT, DAMPE and Gamma-400 and then investigate the spatial distribution of these photons. We show that usually the center of the distribution region will be offset from the Galactic centre (Sgr A$^{\star}$) due to the limited statistics. Such a result is almost independent of the dark matter distribution models and renders the reconstruction of the dark matter distribution with the $\gamma-$ray line signal very challenging for the foreseeable space-based detectors.
Accelerating Alzheimer’s pathogenesis by GRK5 deficiency via cholinergic dysfunction  [PDF]
William Z. Suo
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.24020
Abstract: G protein-coupled receptors (GPCRs) mediate a wide variety of physiological function. GPCR signaling is negatively regulated by the receptor desensitization, a procedure initiated by a group of kinases, including GPCR kinases (GRKs). Studies using genetargeted mice revealed that deficiency of a particular GRK member led to dysfunction of a highly selective group of GPCRs. In particular, for example, GRK5 deficiency specifically disrupts M2/M4-mediated muscarinic cholinergic function. Emerging evidence indicates that ?-amyloid accumulation may lead to GRK5 deficiency, while the latter impairs desensitization of M2/M4 receptors. Within memory circuits, M2 is primarily presynaptic autoreceptor serving as a negative feedback to inhibit acetylcholine release. The impaired desensitization of M2 receptor by GRK5 deficiency leads to hyperactive M2, which eventually suppresses acetylcholine release and results in an overall cholinergic hypofunctioning. Since the cholinergic hypofunctioning is known to cause ?-amyloid accumulation, the GRK5 deficiency appears to connect the cholinergic hypofunctioning and ?-amyloid accumulation together into a self-amplifying cycle, which accelerates both changes. Given that the ? -amyloid accumulation and the cholinergic hypofucntioning are the hallmark changes in the ?-amyloid hypothesis and the cholinergic hypothesis, respectively, the GRK5 deficiency appears to bring the two major hypotheses in Alzheimer’s disease together, whereas the GRK5 deficiency is the pivotal link. Therefore, any strategies that can break this cycle would be therapeutically beneficial for Alzheimer’s patients.
Polymorphisms of the DNA Methyltransferase 1 Associated with Reduced Risks of Helicobacter pylori Infection and Increased Risks of Gastric Atrophy
Jing Jiang, Zhifang Jia, Donghui Cao, Mei-Shan Jin, Fei Kong, Jian Suo, Xueyuan Cao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046058
Abstract: Introduction DNA methyltransferase-1(DNMT1) is an important enzyme in determining genomic methylation patterns in mammalian cells. We investigated the associations between SNPs in the DNMT1 gene and risks of developing H. pylori seropositivity, gastric atrophy and gastric cancer in the Chinese population. Methods The study consisted of 447 patients with gastric cancer; 111 patients with gastric atrophy; and 961 healthy controls. Five SNPs, rs10420321, rs16999593, rs8101866, rs8111085 and rs2288349 of the DNMT1 gene were genotyped. Anti-H.pylori IgG was detected by ELISA. Gastric atrophy was screened by the level of serum pepsinogen Ιand II and then confirmed by endoscopy and histopatholgical examinations. Results The age- and sex-adjusted OR of H. pylori seropositivity was 0.67 (95%CI: 0.51–0.87) for rs8111085 TC/CC genotypes, significantly lower than the TT genotype in healthy controls. The adjusted OR of H.pylori seropositivity was 0.68 (95%CI: 0.52–0.89) for rs10420321 AG/GG genotypes. In addition, patients carrying rs2228349 AA genotype have a significantly increased risk for H.pylori seropositivity (OR = 1.67; 95%CI: 1.02–2.75). Further haplotype analyses also showed that the ATTTG and ATCTA are significantly associated with increased risks in H.pylori infection compared to the GTCCG haplotype (OR = 1.38, 95%CI: 1.08–1.77; OR = 1.40, 95% CI: 1.09–1.80). The adjusted ORs of gastric atrophy were 1.66 (95%CI: 1.06–2.61) for rs10420321 GG genotype, and 1.67 (95%CI 1.06–2.63, P = 0.03) for rs8111085 CC genotype, but no association was found between SNPs in the DNMT1 gene and risk of developing gastric cancer. Conclusions Individuals with rs10420321 GG and rs8111085 CC genotype of the DNMT1 gene were associated with reduced risks for H.pylori infection. On the other hand, higher risks of gastric atrophy were found in the carriers with these two genotypes compared to other genotypes. Our results suggested that SNPs of DNMT1 could be used as genotypic markers for predicting genetic susceptibilities to H.pylori infection and risks in gastric atrophy.
The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells
Dongming Liang, Yuanyuan Ma, Jian Liu, Claes Goran Trope, Ruth Holm, Jahn M. Nesland, Zhenhe Suo
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-201
Abstract: Ovarian cancer cell lines ES-2 and OVCAR-3 were cultivated in different oxygen tensions for proliferation, cell cycling and invasion analyses. The clonogenic potential of cells was examined by colony formation and sphere formation assays. Stem cell surface markers, SP and CD44bright and CD44dim cells were analyzed by flow cytometry. Protein expression of HIF-1α, HIF-2α, Ot3/4 and Sox2 were investigated by Western blotting.Both cell lines cultivated at hypoxic condition grew relatively slowly with extended G0/G1 phase. However, if the cells were pre-treated under 1% O2 for 48?hrs before brought back to normoxia, the cells showed significantly higher proliferation rate with higher infiltration capability, and significant more colonies and spheres, in comparison to the cells always cultivated under normoxia. CD44bright cells expressed significantly higher levels of Oct3/4 and Sox2 than the CD44dim cells and formed significantly more clones and spheres examined in vitro. Hypoxic treatment of the cells resulted in stronger CD44 expression in both cell lines, and stronger CD133 expression in the OVCAR-3 cell line. In parallel with these findings, significantly increased number of side population (SP) cells and up-regulated expression of Oct3/4 and Sox2 in both ES-2 and OVCAR-3 cell lines were observed.We conclude that ovarian cancer cells survive hypoxia by upgrading their stem-like properties through up-regulation of stemness-related factors and behave more aggressively when brought back to higher oxygen environment.
Effects of nitrogen fertilizer input on the composition of mineral elements in corn grain
Yu-kui, Rui;Shi-ling, Jiang;Fu-suo, Zhang;Jian-bo, Shen;
Agrociencia , 2009,
Abstract: excessive and inappropriate application of industrial n fertilizer can result in severe environmental and ecological problems, but whether the input of n fertilizer could affect the composition of mineral elements in corn has not been reported. effects of input of n fertilizer on the composition of mineral elements (se, mo, i, mn, fe, cu, zn, ca, cr, k, na, and mg), in corn grain were investigated by icp-ms (inductive coupling plasma-mass spectrometry). se, i, mn, fe, zn, cr, k and ca were significantly lower in the treatments with n fertilizer compared to a control without n fertilizer. there was a significant negative conrrelation (r) between four mineral elements and n fertilizer input: i, -0.71; zn, -0.65; ca, -0.75; k, -0.89. therefore appropriate reduction of n fertilizer input cannot only prevent environmental problems from excessive application of industrial n fertilizer, besides it might reduce the problem of malnutrition induced by mineral elements deficiency.
Effects of nitrogen fertilization on heavy metal content of corn grains
Rui,Yu-kui; Zhang,Fu-suo; Shen,Jian-bo;
Phyton (Buenos Aires) , 2009,
Abstract: nitrogen fertilization has played a significant role in increasing crop yield, and solving problems of hunger and malnutrition worldwide. however, excessive nitrogen inputs do not significantly increase crop yields but may lead to many serious environmental problems. the effects of nitrogen fertilization rate were studied on heavy metal content of corn grains. our results show that nitrogen fertilization management is beneficial for reducing production costs, protecting the environment, and improving the quality of farm products.
Facile synthesis of hollow urchin-like gold nanoparticles and their catalytic activity
Wei Wang,Yujia Pang,Jian Yan,Guibao Wang,Hui Suo,Chun Zhao,Shuangxi Xing
Gold Bulletin , 2012, DOI: 10.1007/s13404-012-0052-y
Abstract: The galvanic replacement reaction between Ag nanoparticles (NPs) and HAuCl4 followed by addition of ascorbic acid led to the formation of AuNPs sharing both urchin-like and hollow structures. The AgNPs took as sacrificial templates to guide the hollow structure and the intermediates provided rough surface and active sites for the further deposition of AuNPs, which originated from the reduction of excess HAuCl4 by ascorbic acid. These unique structured AuNPs presented excellent optical properties and great advantages in catalysis applications.
Wu-Lan Zeng,Jin-Long Suo,Fang-fang Jian
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810040675
Abstract: In the title molecule, C17H18O5, which was prepared by the reaction of (R)-1,5-dioxaspiro[5.5]undecane-2,4-dione and 4-methoxybenzaldehyde with ethanol, the 1,3-dioxane ring is in a distorted envelope conformation with the spiro C atom forming the flap. The crystal structure is stabilized by weak intermolecular C—H...O hydrogen bonds.
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