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Search Results: 1 - 10 of 79310 matches for " Ji-Young Yang "
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1H NMR-Based Metabolite Profiling of Planktonic and Biofilm Cells in Acinetobacter baumannii 1656-2
Jinki Yeom, Ji-Hyun Shin, Ji-Young Yang, Jungmin Kim, Geum-Sook Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057730
Abstract: Acinetobacter baumannii is an aerobic and gram-negative pathogenic bacterium that is resistant to most antibiotics. Recently, A. baumannii 1656-2 exhibited the ability to form biofilms under clinical conditions. In this study, global metabolite profiling of both planktonic and biofilm forms of A. baumannii 1656-2 was performed using high-resolution nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis to investigate the metabolic patterns leading to biofilm formation. Principal components analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) score plots showed a distinct separation between planktonic and biofilm cells. Metabolites including acetates, pyruvate, succinate, UDP-glucose, AMP, glutamate, and lysine were increasingly involved in the energy metabolism of biofilm formation. In particular, the ratio of N-acetyl-D-glucosamine (GlcNAc) to D-glucosamine (GlcNH2) was significantly higher during biofilm formation than under the planktonic condition. This study demonstrates that NMR-based global metabolite profiling of bacterial cells can provide valuable insight into the metabolic changes in multidrug resistant and biofilm-forming bacteria such as A. baumannii 1656-2.
Investigation of the SH3BP2 Gene Mutation in Cherubism
Lee,Ji-Young,Jung,Yang-Seok,Kim,Soo-A,Lee,Sang-Ho
Acta Medica Okayama , 2008,
Abstract: Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients. In this study, we examined a 6-year-old Korean boy and his family. We found a Pro418Arg mutation in the SH3BP2 gene of the patient and his mother. A father and his 30-month-old younger brother had no mutations. Immunohistochemically, the multinucleated giant cells proved positive for CD68 and tartrate-resistant acid phosphatase (TRAP). Numerous spindle-shaped stromal cells expressed a ligand for receptor activator of nuclear factor kB (RANKL), but not in multinucleated giant cells. These results provide evidence that RANKL plays a critical role in the differentiation of osteoclast precursor cells to multinucleated giant cells in cherubism. Additionally, genetic analysis may be a useful method for differentiation of cherubism.
Acanthopanax koreanum Fruit Waste Inhibits Lipopolysaccharide-Induced Production of Nitric Oxide and Prostaglandin E2 in RAW 264.7 Macrophages
Eun-Jin Yang,Ji-Young Moon,Jung-Soon Lee,Jaesook Koh,Nam Ho Lee,Chang-Gu Hyun
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/715739
Abstract: The Acanthopanax koreanum fruit is a popular fruit in Jeju Island, but the byproducts of the alcoholic beverage prepared using this fruit are major agricultural wastes. The fermentability of this waste causes many economic and environmental problems. Therefore, we investigated the suitability of using A. koreanum fruit waste (AFW) as a source of antiinflammatory agents. AFWs were extracted with 80% EtOH. The ethanolic extract was then successively partitioned with hexane, CH2Cl2, EtOAc, BuOH, and water. The results indicate that the CH2Cl2 fraction (100 g/mL) of AFW inhibited the LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells by 79.6% and 39.7%, respectively. These inhibitory effects of the CH2Cl2 fraction of AFWs were accompanied by decreases in the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and iNOS and COX-2 mRNA in a dose-dependent pattern. The CH2Cl2 fraction of AFWs also prevented degradation of IB- in a dose-dependent manner. Ursolic acid was identified as major compound present in AFW, and CH2Cl2 extracts by high performance liquid chromatography (HPLC). Furthermore using pure ursolic acid as standard and by HPLC, AFW and CH2Cl2 extracts was found to contain 1.58 mg/g and 1.75 mg/g, respectively. Moreover, we tested the potential application of AFW extracts as a cosmetic material by performing human skin primary irritation tests. In these tests, AFW extracts did not induce any adverse reactions. Based on these results, we suggest that AFW extracts be considered possible anti-inflammatory candidates for topical application.
Residue patterns of buprofezin and teflubenzuron in treated peaches  [PDF]
Ji-Young Yoon, Jae-Hun Park, Ye-hoon Han, Kyu-Seung Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2012, DOI: 10.4236/jacen.2012.11002
Abstract: The biological half-life and final residue levels of buprofezin and teflubenzuron were examined in peaches over a 14-day cultivation period. The residue levels of buprofezin and teflubenzuron were analyzed by chromatographic method with recovery ranging from 84.0% to 96.6%. The biological half-lives of buprofezin andteflubenzuron were 4.88 and 11.49 days at the standard dose, and 4.40 and 10.86 days at a triple dose, respectively. The initial concentration of buprofezin exceeded the maximum residue limit (MRL) set in Korea, but the concentration decreased to below the MRL within 6 days after application. The initial and persisting concentrations of teflubenzuron were all below the prescribed MRL. The final residue levels of buprofezin and teflubenzuron were 0.17 and 0.10 mg·kg﹣1 following a standard single dose, and 0.20 and 0.23 mg·kg﹣1 following a triple dose, respectively. The final re-sidue levels of buprofezin and teflubenzuron were also compared with the good agricultural practices standards of the United States and Italy.


Borel-Pade vs Borel-Weniger method: a QED and a QCD example
G. Cvetic,Ji-Young Yu
Physics , 2000, DOI: 10.1142/S0217732300001596
Abstract: Recently, Weniger (delta sequence) method has been proposed by the authors of Ref. [1] (Jentschura et al.) for resummation of truncated perturbation series in quantum field theories. Those authors presented numerical evidence suggesting that this method works better than Pade approximants when we resum a function with singularities in the Borel plane but not on the positive axis. We present here numerical evidence suggesting that in such cases the combined method of Borel-Pade works better than its analog Borel-Weniger, and that it may work better or comparably well in some of the cases when there are singularities on the positive axis in the Borel plane.
Nonperturbative dispersive sector in strong (quasi-)Abelian fields
G. Cvetic,Ji-Young Yu
Physics , 1999, DOI: 10.1016/S0217-751X(01)00285-0
Abstract: In strong (quasi-)Abelian fields, even at the one-loop level of the coupling constant, quantum fluctuations of fermions induce an effective Lagrangian density whose imaginary (absorptive) part is purely nonperturbative and known to be responsible for the fermion-antifermion pair creation. On the other hand, the induced real (dispersive) part has perturbative and nonperturbative contributions. In the one-loop case, we argue how to separate the two contributions from each other for any strength of the field. We show numerically that the nonperturbative contributions are in general comparable with or larger than the induced perturbative ones. We arrive at qualitatively similar conclusions also for the induced energy density. Further, we investigate numerically the quasianalytic continuation of the perturbative results into the nonperturbative sector, by employing (modified) Borel-Pade. It turns out that in the case at hand, we have to integrate over renormalon singularities, but there is no renormalon ambiguity involved.
The volume of hyperbolic cone-manifolds of the knot with Conway's notation $C(2n, 3)$
Ji-Young Ham,Joongul Lee
Mathematics , 2015,
Abstract: Let $C(2n, 3)$ be the family of two bridge knots of slope $(4n+1)/(6n+1)$. We calculate the volumes of the $C(2n, 3)$ cone-manifolds using the Schl\"{a}fli formula. We present the concrete and explicit formula of them. We apply the general instructions of Hilden, Lozano, and Montesinos-Amilibia and extend the Ham, Mednykh, and Petrov's methods. As an application, we give the volumes of the cyclic coverings over those knots. For the fundamental group of $C( 2n, 3)$, we take and tailor Hoste and Shanahan's. As a byproduct, we give an affirmative answer for their question whether their presentation is actually derived from Schubert's canonical 2-bridge diagram or not.
The minimum dilatation of pseudo-Anosov 5-braids
Ji-Young Ham,Won Taek Song
Mathematics , 2005,
Abstract: The minimum dilatation of pseudo-Anosov 5-braids is shown to be the largest zero $\lambda_5 \approx 1.72208$ of $x^4 - x^3 - x^2 - x + 1$ which is attained by $\sigma_1\sigma_2\sigma_3\sigma_4\sigma_1\sigma_2$.
Residue patterns of indoxacarb and pyridalyl in treated cauliflower  [PDF]
Ji-Young Yoon, Jae-Hun Park, Hye-Ree Moon, Guk-Tak Han, Kyu-Seung Lee
Agricultural Sciences (AS) , 2013, DOI: 10.4236/as.2013.43017
Abstract:

The biological half-life and final residue levels of indoxacarb and pyridalyl were determined in cauliflower over a 10-day cultivation period following applications of a standard (100 g a.i.ha–1 and 200 g a.i.·ha–1, respectively) and double dose (200 g a.i.·ha–1 and 400 g a.i.·ha–1, respectively). The residue levels were analyzed by gas chromatography with recovery ranging from 92.1% to 109.7%. The biological half-lives of indoxacarb and pyridalyl were 6.33 and 7.74 days for the standard dose, and 6.26 and 7.44 days for the double dose, respectively. The initial and persisting concentrations of indoxacarb and pyridalyl were all below the Korean maximum residue limits for broccoli of 1.0 mgkg–1 and 3.0 mgkg–1, respectively.

Essential Oil from Cryptomeria japonica Induces Apoptosis in Human Oral Epidermoid Carcinoma Cells via Mitochondrial Stress and Activation of Caspases
Jeong-Dan Cha,Ji-Young Kim
Molecules , 2012, DOI: 10.3390/molecules17043890
Abstract: Cryptomeria japonica D. Don (C. japonica) has been used in traditional medicines from Asia for a variety of indications, including liver ailments, and an antitussive, and for its antiulcer activities. We examined the cell viability and apoptosis of KB cells treated with C. japonica essential oil at several concentrations for 12 h by MTT assay, Hoechst-33258 dye staining, DNA fragmentation, flow cytometry (cell cycle), and Western blotting for mitochondria stress, activation of caspases, and poly (ADP-ribose) polymerase. The essential oil induced the apoptosis of KB cells in a dose-dependent manner, which was verified by DNA fragmentation, appearance of apoptotic bodies, and the sub-G1 ratio. The essential oil also induced rapid and transient caspase-3 activity and cleavage of PARP of the KB cells. Treating the cells with the oil also caused changes in the mitochondrial level of the Bcl-2 family proteins such as Bcl-2 and Bax, thereby inducing the release of cytochrome c into the cytosol. The essential oil of C. japonica may have potential as a cancer chemopreventive and therapeutic agent.
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