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Search Results: 1 - 10 of 31886 matches for " Ji Su Bae "
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Korean Atmospheric Environmental Impact Assessment for Thermal Power Plant  [PDF]
Young Soo Lee, Ji Su Bae, Yu Jin Kang, Yu Jin Kang
Journal of Geoscience and Environment Protection (GEP) , 2014, DOI: 10.4236/gep.2014.24004
Abstract:

Korea has adopted Environmental Impact Assessment (hereafter “EIA”) system for more than 3 decades. There are 74 big projects subject to EIA according to (Environmental Impact Assessment Law (No. 10892). For thermal power plant of which output is more than 10 MW, EIA must be done by proponents. To assess impact on atmospheric environment, proponents utilize air dispersion models and to minimize the adverse impact on air quality, state-of-the-art add-on control technology is applied.

Cyanidine-3-O-Galactoside Enriched Aronia melanocarpa Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells  [PDF]
Su-Min Lim, Jae In Jung, Nam Young Kim, Jung-Shik Bae, Hyun Sook Lee, Eun Ji Kim
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.102011
Abstract: Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.
Development of Multiplexed Bead-Based Immunoassays for the Detection of Early Stage Ovarian Cancer Using a Combination of Serum Biomarkers
Yong-Wan Kim, Su Mi Bae, Hyunsun Lim, Yoon Ji Kim, Woong Shick Ahn
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044960
Abstract: CA125 as a biomarker of ovarian cancer is ineffective for the general population. The aim of this study was to evaluate multiplexed bead-based immunoassay of multiple ovarian cancer-associated biomarkers such as transthyretin and apolipoprotein A1, together with CA125, to improve the identification and evaluation of prognosis of ovarian cancer. We measured the serum levels of CA125, transthyretin, and apolipoprotein A1 from the serum of 61 healthy individuals, 84 patients with benign ovarian disease, and 118 patients with ovarian cancer using a multiplex liquid assay system, Luminex 100. The results were then analyzed according to healthy and/or benign versus ovarian cancer subjects. When CA125 was combined with the other biomarkers, the overall sensitivity and specificity were significantly improved in the ROC curve, which showed 95% and 97% sensitivity and specificity, respectively. At 95% specificity for all stages the sensitivity increased to 95.5% compared to 67% for CA125 alone. For stage I+II, the sensitivity increased from 30% for CA125 alone to 93.9%. For stage III+IV, the corresponding values were 96.5% and 91.6%, respectively. Also, the three biomarkers were sufficient for maximum separation between noncancer (healthy plus benign group) and stage I+II or all stages (I?IV) of disease. The new combination of transthyretin, and apolipoprotein A1 with CA125 improved both the sensitivity and the specificity of ovarian cancer diagnosis compared with those of individual biomarkers. These findings suggest the benefit of the combination of these markers for the diagnosis of ovarian cancer.
Intracranial hemorrhage and cerebellar infarction caused by acupuncture
Heo Jae-Hyeok,Bae Myoung-Hoon,Lee Su-Ji
Neurology India , 2011,
Abstract:
C16 Saturated Fatty Acid Induced Autophagy in A549 Cells through Topoisomerase I Inhibition  [PDF]
Sandeep Karna, Won Bong Lim, Ji Sun Kim, Sang Woo Kim, Kum Hue Bae, Min Sung Cho, Hee Kyun Oh, Ok Su Kim, Hong Ran Choi, Ok Joon Kim, Hui Zheng
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.39160
Abstract: C16 saturated fatty acid (Palmitic acid) is one of the most common dietary fatty acids which played an important role in the cellular biological functions. Palmitic acid (PA) was tested for potential inhibition of DNA topoisomerase I (topo I) and it exhibited inhibitory activity in the nanomolar range. Treatment of lung adenocarcinoma cell line A549 with PA resulted in a decrease in cell viability in a concentration-dependent manner, and PA showed cytotoxicity with an IC50 value of 150 μM. DNA fragmentation assay and caspase activity indicated that PA does not induce apoptotic cell death in A549 cells. Finally, we found that PA was able to cause an increase in autophagic flux in a time-dependent manner, evidenced by the accumulation of LC3 through monodansylcadaverine (MDC) staining. More importantly, inhibition of autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K), by 3-Methyladenine (3-MA) was able to effectively suppress PA-induced autophagy. We showed that inhibition of autophagy sensitized the cells signal to PA-induced apoptosis, suggesting the pro-survival function of autophagy induced by PA. Taken together, results from this study reveal that PA as a topo I inhibitor induced autophagic cell death in A549 cells.
The Traditional Herbal Medicine, Dangkwisoo-San, Prevents Cerebral Ischemic Injury through Nitric Oxide-Dependent Mechanisms
Ji Hyun Kim,Sun Haeng Park,Young Whan Kim,Jung Min Ha,Sun Sik Bae,Guem San Lee,Su In Cho,Byung Tae Choi,Hwa Kyoung Shin
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/718302
Abstract: Dangkwisoo-San (DS) is an herbal extract that is widely used in traditional Korean medicine to treat traumatic ecchymosis and pain by promoting blood circulation and relieving blood stasis. However, the effect of DS in cerebrovascular disease has not been examined experimentally. The protective effects of DS on focal ischemic brain were investigated in a mouse model. DS stimulated nitric oxide (NO) production in human brain microvascular endothelial cells (HBMECs). DS (10–300 μg/mL) produced a concentration-dependent relaxation in mouse aorta, which was significantly attenuated by the nitric oxide synthase (NOS) inhibitor L-NAME, suggesting that DS causes vasodilation via a NO-dependent mechanism. DS increased resting cerebral blood flow (CBF), although it caused mild hypotension. To investigate the effect of DS on the acute cerebral injury, C57/BL6J mice received 90 min of middle cerebral artery occlusion followed by 22.5 h of reperfusion. DS administered 3 days before arterial occlusion significantly reduced cerebral infarct size by 53.7% compared with vehicle treatment. However, DS did not reduce brain infarction in mice treated with the relatively specific endothelial NOS (eNOS) inhibitor, N5-(1-iminoethyl)-L-ornithine, suggesting that the neuroprotective effect of DS is primarily endothelium-dependent. This correlated with increased phosphorylation of eNOS in the brains of DS-treated mice. DS acutely improves CBF in eNOS-dependent vasodilation and reduces infarct size in focal cerebral ischemia. These data provide causal evidence that DS is cerebroprotective via the eNOS-dependent production of NO, which ameliorates blood circulation.
Functional and Molecular Changes of the Bladder in Rats with Crushing Injury of Nerve Bundles from Major Pelvic Ganglion to the Bladder: Role of RhoA/Rho Kinase Pathway
Su Jin Kim,Dong Sup Lee,Woong Jin Bae,Seol Kim,Sung Hoo Hong,Ji Youl Lee,Tae-Kon Hwang,Sae Woong Kim
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140917511
Abstract: Voiding dysfunction is a common complication after radical pelvic surgery. To reduce this complication, nerve-sparing radical pelvic surgery was introduced. However, several patients experienced voiding difficulty despite nerve-sparing radical pelvic surgery. Thus, we investigated the functional and molecular changes of the bladder in rats, which demonstrated voiding dysfunction induced by nerve damage during nerve-sparing radical pelvic surgery. Male rats were used and assigned to normal, sham-operated, and bilateral crushing nerve bundles from major pelvic ganglion (MPG) to bladder group. After one, two, and four-week crushing injury, significantly decreased contractile response and increased connective tissue of the detrusor were observed and these results were reliable findings with voiding difficulty following nerve-sparing radical pelvic surgery. After crushing injury, significantly increased M2 muscarinic receptor expression was observed and this might be regarded as the compensatory response. However, M3 muscarinic receptor expression was not significantly changed. The expression of RhoA, ROCK-α, and ROCK-β was significantly increased after one, two, and four-week crushing injury. From these results, the down-regulation of RhoA/Rho kinase pathway might lead to the decreased bladder contractility after crushing injury of nerve bundles from MPG to the bladder despite of the compensated up-regulation of M2 muscarinic receptor.
Evaluation of various Deformable Image Registrations for Point and Volume Variations
Su Chul Han,Sang Hyun Choi,Seungwoo Park,Soon Sung Lee,Haijo Jung,Mi-Sook Kim,Hyung Jun Yoo,Young Hoon Ji,Chul Young Yi,Kum Bae Kim
Physics , 2015,
Abstract: The accuracy of deformable image registration (DIR) has a significant dosimetric impact in radiation treatment planning. We evaluated accuracy of various DIR algorithms using variations of the deformation point and volume. The reference image (Iref) and volume (Vref) was first generated with virtual deformation QA software (ImSimQA, Oncology System Limited, UK). We deformed Iref with axial movement of deformation point and Vref depending on the types of deformation that are the deformation1 is to increase the Vref (relaxation) and the deformation 2 is to decrease . The deformed image (Idef) and volume (Vdef) acquired by ImSimQA software were inversely deformed to Iref and Vref using DIR algorithms. As a result, we acquired deformed image (Iid) from Idef and volume (Vid) from Vdef. The DIR algorithms were the Horn Schunk optical flow (HS), Iterative Optical Flow (IOF), Modified Demons (MD) and Fast Demons (FD) with the Deformable Image Registration and Adaptive Radiotherapy Toolkit (DIRART) of MATLAB. The image similarity between Iref and Iid was calculated using the metrics that were Normalized Mutual Information (NMI) and Normalized Cross Correlation (NCC). When moving distance of deformation point was 4 mm, the value of NMI was above 1.81 and NCC was above 0.99 in all DIR algorithms.When the Vref increased or decreased about 12%, the difference between Vref and Vid was within 5% regardless of the type of deformation.The value of Dice Similarity Coefficient (DSC) was above 0.95 in deformation1 except for the MD algorithm. In case of deformation 2, that of DSC was above 0.95 in all DIR algorithms. The Idef and Vdef have not been completely restored to Iref and Vref and the accuracy of DIR algorithms was different depending on the degree of deformation. Hence, the performance of DIR algorithms should be verified for the desired applications.
Effects of Carbon Dioxide Treatment and Modified Atmosphere Packaging on the Quality of Long Distance Transporting “Maehyang” Strawberry  [PDF]
Hyun Jin Choi, Yeong Seuk Bae, Jung Soo Lee, Me Hea Park, Ji Gang Kim
Agricultural Sciences (AS) , 2016, DOI: 10.4236/as.2016.712074
Abstract: This study was conducted to investigate the effects of carbon dioxide (CO2) and modified atmosphere (MA) packaging on the quality of strawberry during long distance transportation. “Maehyang” strawberries (Fragaria x ananassa Duch.) with red color on 70% of the fruit surface were harvested in Gyeongnam province, Korea. The samples were placed in gas-tight chamber with 30% CO2 concentration for 3 hours at 3°C. Strawberry samples were then packaged with modified atmosphere-modified humidity (MA/MH) packaging film. Samples treated with CO2 alone and combined CO2 with MA packaging were stored for one day at 1°C, transported for 10 days at 1°C, and distributed for 3 days at 4°C. Carbon dioxide alone or combination with MA packaging was effective in maintaining quality of “Maehyang” strawberries. Carbon dioxide treatment significantly increased firmness and reduced softening index and decay rate during 14 day transportation and distribution. Samples treated with CO2 + MA had higher overall score with low softening index and weight loss after 14 days of transportation and low temperature distribution compared to CO2 treatment only. The results indicated that a short term application of CO2 or combination treatment of CO2 and MA could be good postharvest handling for maintaining freshness of “Maehyang” strawberries during long distance vessel export.
Created N-ideals of BCK/BCI-algebras
Young Bae Jun,Min Su Kang
Applied Mathematical Sciences , 2012,
Abstract:
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