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Search Results: 1 - 10 of 25151 matches for " Ji Qian "
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Evaluation of RNA-Seq software in gene expression quantification  [PDF]
Yan Ji, Ziliang Qian, Jia Wei
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.64059

High-throughput RNA sequencing (RNA-Seq) promises a complete annotation and quantification of all genes and their isoforms across samples. Because sequencing reads from this new technology are shorter than transcripts from which they are derived, expression estimation with RNA-Seq requires increasingly complex computational methods. In recent years, a number of expression quantification methods have been published from both public and commercial sources. Here we presented an overview of these attempts on quantifying gene expression. We then defined a set of criteria and compared the performance of several programs based on these criteria, and we further provided advices on selecting suitable tools for different biological applications.

Information Aggregation of Group Decision-Making in Emergency Events  [PDF]
Kefan Xie, Qian Wu, Gang Chen, Chao Ji
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.28057
Abstract: Information is a key factor in emergency management, which helps decision makers to make effective decisions. In this paper, aiming at clarifying the information aggregation laws, and according to the characteristic of emergency information, information relative entropy is applied in the information aggregation to establish the information aggregation model of emergency group decision-making. The analysis shows that support and credibility of decision rule are the two factors in information aggregation. The results of four emergency decision-making groups in case study support the analysis in the paper.
Research on the Seepage Safety Monitoring Indexes of the High Core Rockfill Dam  [PDF]
Bo Chen, Li Zhang, Qiupei Qian, Yanhong Dou, Zhuohao Ji
World Journal of Engineering and Technology (WJET) , 2017, DOI: 10.4236/wjet.2017.53B006
The study on developing the reasonable safety monitoring indexes plays a most importantly role in the health monitoring of high core rockfill dams. However, researches on this topic are relatively scarce both at home and abroad. In this paper, the characteristics and failure modes of seepage in high core rockfill dam are analyzed firstly. Then, a safety monitoring index based on seepage quantity, which reflects the overall seepage behavior, is developed, using the real-time monitoring data and its safety monitoring model. Moreover, another safety monitoring index based on seepage gradient, reflecting the local seepage behavior, is proposed, combining the spatial layout of osmo- meters and local failure mechanisms of core wall. Additionally, one more safety monitoring index based on permeability coefficient, which considers the overall and local seepage behaviors, is developed, on the basis of establishing the finite element analysis model and real-time seepage coefficient inversion analysis model of high core rockfill dam. A case study on these indexes of Nuozhadu high core rockfill dam is developed, which improves the reliability of seepage safety evaluation of the dam.
Study of an Interactive System of Sight-Singing and Ear-Training  [PDF]
Qian Lin, Shan-Ji Chen, Wei Jiang, Guo-Qing Jia
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.59005
Abstract: This paper introduces an interactive system of sight-singing and ear-training which combines the technology of single chip microprocessor (SCM) with learning music. It contains the functions of scanning keyboard, reading the key value, interruption service, reading file and displaying file. In order to strengthen the commonality and practicability of the system, SD card is used to store the materials and the ZNFAT32 file system is transplanted to organize the materials in the form of file directory. This interactive system can recognize and perform music automatically for the users and play significant role in education and entertainment.
Resolution of Symptoms after Parent Artery Occlusion Treatment for Giant Cavernous Carotid Artery Aneurysms  [PDF]
Zenghui Qian, Tangming Peng, Wenjun Ji, Jing Wu, Huibin Kang, Xiaolong Wen, Wenjuan Xu, Aihua Liu, Youxiang Li
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.44038

Background and Objective: Giant cavernous carotid artery aneurysms (CCAAs) often produce a variety of neurological deficits, primarily those related to ophthalmoplegia/paresis and headache. This study was designed to evaluate the resolution of symptoms after parent artery occlusion (PAO) treatment for giant CCAAs. Methods: We retrospectively reviewed a series of 17 consecutive giant CCAAs treated with PAO treatment. All patients were evaluated by balloon occlusion test (BOT) before treatment. Patients who could tolerate BOT were treated by PAO. The following outcomes were analyzed: angiographic assessment, evolution of symptoms and outcome at clinical follow-up using modified Rankin Scale (mRS). Results: A total number of 17 giant CCAAs were treated by PAO. The initial post-procedure and follow-up angiogram revealed complete occlusion in all patients, no new lesion was detected. Periprocedural infarcts occurred in 1 patient (5.9%). Procedure-related mortality and morbidity were 0% and 5.9%, respectively. At mean 31.8 months clinical follow-up, symptoms had disappeared in 7 (41.2%) of the patients, partially improved in 5 (29.4%), remained unchanged in 4 (23.5%) and worsened in 1 (5.9%) of cases. Sixteen (94.1%) patients presented a good clinical outcome (mRS 0 - 1). Conclusion: Most patients in our series improved or remained stable after PAO. The results of this study indicate that PAO can improve the outcome of those symptomatic giant CCAAs if BOT can be tolerated.

Estimate of Heavy Metals in Soil with Non-Soil Removed  [PDF]
Ji Jian, Yao Fang, Wei-Le Li, Qian-Yu Chen, Heng-Yu Tian, Shuang-Lin You
Journal of Data Analysis and Information Processing (JDAIP) , 2017, DOI: 10.4236/jdaip.2017.54011
Abstract: Quantifying and mapping heavy metals’ concentrations in the soil are important in monitoring and managing heavy metal pollution in the mining areas. However, the cover on the soil acts as a balk when retrieving information from soil. In order to retrieve heavy metal pollution precisely and quickly from hyperspectral images, this study presents a new method to remove non-soil information based NDVI from hyper-spectral and multi-spectral images. The method assumed that the mixed objects in each pixel of remote sensing images are composed only of soil and vegetation-based non-soil end-generational endmembers, then, the soil information of each pixel can be compensated with the non-soil information removed based on its NDVI. Thus, the soil DN value can be corrected to retrieve soil information more precisely. The method has been used on the Hyperion image in June 8, 2002 and the Gaofen-2 (GF-2) image in February 14, 2016 to retrieve the heavy metals’ contents in Bai-ma and De-sheng mining areas, Miyi County, Sichuan Province. From the non-soil information removed images, the R2 and RMSE of the models of estimating Cr, Ag, Cu and Ba in soil are 0.68, 0.724, 0.71, 0.695 and 75.96, 0.03, 52.88, 284.70 respectively. From the original images, the R2 and RMSE of the models of estimating Cr, Ag, Cu and Ba in soil are 0.67, 0.385, 0.425, 0.406 and 80.11, 0.18, 53.43, 396.49 respectively. The retrieval results show that the non-soil information removed images are superior to original images in soil heavy metals’ contents retrieval. This indicates that this method is feasible, and it can be used in soil information retrieval.
Evidence-based obstetrics in four hospitals in China: An observational study to explore clinical practice, women's preferences and provider's views
Xu Qian, Helen Smith, Li Zhou, Ji Liang, Paul Garner
BMC Pregnancy and Childbirth , 2001, DOI: 10.1186/1471-2393-1-1
Abstract: Observational study. Using the Cochrane Library, we identified six procedures that should be avoided as routine and two that should be encouraged. Procedure rate determined by exit interviews with women, verified using hospital notes. Views of women and providers explored with in depth interviews.The study sites were three hospitals in Shanghai and one in neighbouring province of Jiangsu. 150 women at each centre for procedure rate, and 48 in-depth interviews with women and providers.Vaginal births were 50% (303/599) of the total. Of the six practices where evidence suggests they should be avoided as routine, three were performed with rates above 70%: pubic shaving (3 hospitals), rectal examination (3 hospitals), and episiotomy (3 hospitals). Most women delivered lying down, pain relief was rarely given, and only in the urban district hospital did women routinely have a companion. Most women wanted support or companionship during labour and to be given pain relief; but current practice is insufficient to meet women's needs.Obstetric practice is not following best available evidence in the hospitals studied. There is a need to adjust hospital policy to support the use of interventions proven to be of benefit to women during childbirth, and develop approaches that ensure clinical practice changes.In China, over 60% of women deliver in health facilities. Even in rural areas, institutional births account for over half the births in some provinces, with a national urban average of 76%. Shanghai has the highest rate of institutional deliveries, with virtually all women delivering in hospital [1]. Over the last few years there have been efforts to improve the quality of care in hospitals throughout China. Some tertiary hospitals in Shanghai have been promoting evidence-based care [2, 3]. The World Health Organization (WHO) and UNICEF have promoted baby friendly hospitals. However, mechanisms to encourage evidence-based obstetric care that is humane and women-friendly have
Evidence-informed obstetric practice during normal birth in China: trends and influences in four hospitals
Xu Qian, Helen Smith, Hong Liang, Ji Liang, Paul Garner
BMC Health Services Research , 2006, DOI: 10.1186/1472-6963-6-29
Abstract: Sample surveys of women at postnatal discharge in three government hospitals in Shanghai and one in neighbouring Jiangsu province carried out in 1999, repeated in 2003, and compared. Main outcome measures were changes in obstetric practice and influences on provider behaviour. "Routine practice" was defined as more than 65% of vaginal births. Semi-structured interviews with doctors explored influences on practice.In 1999, episiotomy was routine at all four hospitals; pubic shaving, rectal examination (to monitor labour) and electronic fetal heart monitoring were routine at three hospitals; and enema on admission was common at one hospital. In 2003, episiotomy rates remained high at all hospitals, and actually significantly increased at one; pubic shaving was less common at one hospital; one hospital stopped rectal examination for monitoring labour, and the one hospital where enemas were common stopped this practice. Mobility during labour increased in three hospitals. Continuous support was variable between hospitals at baseline and showed no change with the 2003 survey.Provider behaviour was mainly influenced by international best practice standards promoted by hospital directors, and national legislation about clinical practice.Obstetric practice became more evidence-informed in this selected group of hospitals in China. Change was not directly related to the promotion of evidence-based practice in the region. Hospital directors and national legislation seem to be particularly important influences on provider behaviour at the hospital level.Evidence-based practice is widely promoted, but actual obstetric practice is often not evidence-informed. Research has shown large practice variations across facilities in the same country in China [1], South Africa [2] and the UK [3]; in particular, unnecessary obstetric procedures during normal birth are common and may actually be increasing in some countries [4-6]. Increased numbers of reliable summaries of scientific eviden
Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy
Quan Wen, Yide Hu, Fuyun Ji, Guisheng Qian
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-133
Abstract: Peripheral blood lymphocytes were isolated from 26 ALL patients 24 hours after TBI preconditioning (4.5 and 9 Gy, respectively). Extracted DNA was analyzed by real-time PCR method.Average 2.31 times mtDNA and 0.53 fold CD levels were observed after 4.5 Gy exposure compared to their basal levels. 9 Gy TBI produced a greater response of both mtDNA and CD levels than 4.5 Gy. Significant inverse correlation was found between mtDNA content and CD level at 4.5 and 9 Gy (P = 0.037 and 0.048). Moreover, mtDNA content of lymphocytes without irradiation was found to be correlated to age.mtDNA and CD content may be considered as predictive factors to radiation toxicity.Breakage of cellular DNA following radiation is a dose dependent phenomenon and occurs in both the nuclear and extra-nuclear DNA. Thus, besides nuclear nDNA, mitochondrial DNA (mtDNA) is equally affected as an only extra-nuclear genome [1,2]. Numerous investigations showed that mtDNA can be an easily available target for endogenous reactive oxygen species (ROS) and free radicals caused by ionizing radiation (IR), which resulted in mtDNA copy number alteration and mtDNA damage (such as mutation and depletion) [3,4].The mechanisms of cellular response to radiation with regard to mtDNA alterations were mainly involved in the following two ways. On one hand, mtDNA has few repair mechanisms and continued mitochondrial function is preserved primarily due to its high copy number. One of possible radio-protective mechanism is that enhanced replication of mtDNA reduces the mutation frequency of total mtDNA and delays the onset of lethal radiation damage to the mitochondria [5,6]. This hypothesis has been recently supported by Zhang et al with exhibiting increased mtDNA copy number in gut and bone marrow of total body irradiated rats [7]. On the other hand, IR usually prompts cell apoptosis by displaying an accumulation of large scale mtDNA deletions, especially the specific 4977 bp deletion, referred to as the "common de
Optimization in Pretreatment Conditions for Determination of Heterotrophic Bacteria from Freshwater and Marine Sediments Using Flow Cytometry

JI Qian,ZHANG Jing,

生态毒理学报 , 2008,
Abstract: The Flow Cytometry (FCM) has been widely used to determine the heterotrophic bacteria in water environment presently. Also, it can be used to determine the heterotrophic bacteria in benthos environment after the appropriate pretreatment. The treatment of extracting sediment-attached bacteria to water environment is the key point of applying the FCM to the study of benthos. This paper discussed the methods of pretreatment for the FCM to detect the heterotrophic bacteria both in freshwater and marine sediments. Results showed that the relatively preferable pretreatment conditions for sediments were: sodium pyrophosphate as the dispersant with the final concentration of 1mmol·L-1 and incubated 10min in dark; sonicate 1min in water bath at 20w, 40KHz power with a manual shake every 30s; and centrifugal extraction 3 times with 2800 r·min-1 at room temperature.
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