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Search Results: 1 - 10 of 15788 matches for " Ji Hoe Heo "
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Therapeutic Effects of Water Soluble Danshen Extracts on Atherosclerosis
Yoon Hee Cho,Cheol Ryong Ku,Zhen-Yu Hong,Ji Hoe Heo
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/623639
An Objective Pronator Drift Test Application (iPronator) Using Handheld Device
Soojeong Shin, Eunjeong Park, Dong Hyun Lee, Ki-Jeong Lee, Ji Hoe Heo, Hyo Suk Nam
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041544
Abstract: Background The pronator drift test is widely used to detect mild arm weakness. We developed an application that runs on a handheld device to objectify the pronator drift test and investigated its feasibility in stroke patients. Methods The iPronator application, which uses the built-in accelerometer in handheld devices, was developed. We enrolled acute ischemic stroke patients (n = 10) with mild arm weakness and healthy controls (n = 10) to validate the iPronator. In addition to conventional neurological examinations, the degree of average, maximum, and oscillation in drift and pronation were measured and compared using the iPronator. Follow-up tests using the iPronator were also conducted in the patient group one week later. Results There was a strong correlation between the average degree of pronation and drift measured by the iPronator (r = 0.741, p<0.001). The degrees of average and maximum in pronation were greater in the patient group than in the control group [in average, 28.9°, interquartile range (IQR) 18.7–40.3 vs. 3.8° (IQR 0.3–7.5), p<0.001], in maximum, 33.0° (IQR 24.0–52.1) vs. 6.2° (IQR 1.4–9.4), p<0.001]. The degree of oscillation in pronation was not different between the groups (p = 0.166). In drift, the degrees of average, maximum, and oscillation were greater in the patient group. In stroke patients, a follow-up study at one week revealed improvements in the degrees of pronation and drift compared with baseline parameters. Conclusions The iPronator can reliably detect mild arm weakness of stroke patients and was also useful in detecting functional recovery for one week in patients with acute stroke.
Lack of Association between Stroke and Left Atrial Out-Pouching Structures: Results of a Case-Control Study
Ji Young Ko, Young Dae Kim, Yoo Jin Hong, Hye-Jeong Lee, Jin Hur, Byoung Wook Choi, Ji Hoe Heo, Young Jin Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076617
Abstract: Background and Purpose Clinical significance of out-pouching structures of the left atrium (LA) as potential embolic sources remains unclear. We sought to evaluate the association between stroke and LA out-pouching structures. Methods A case-control study was conducted to assess the prevalence of LA out-pouching structures in subjects with and without stroke. Case subjects were 270 stroke patients who had undergone cardiac CT. Control subjects were 270 age- and sex-matched patients without a history of stroke and who had undergone cardiac CT. Presence of LA out-pouching structures was determined by ECG-gated cardiac CT. The location of out-pouching structures was categorized as near Bachmann bundle, anterior, inferoseptal, inferior, and lateral. The prevalence, number and location of out-pouching structures and clinical characteristics were compared between the two groups. Results One hundred sixty eight out-pouching structures were identified in 139 stroke patients (51%), while a total of 169 out-pouching structures were found in 155 control patients (57%) (p=0.1949). The prevalence of LA out-pouching structures with different locations was not significantly different between the stroke group and control group. In the stroke group, the prevalence of out-pouching structures was not significantly different by subtypes of ischemic stroke and the prevalence of LA out-pouching structures was not different between patients with atrial fibrillation (AF) and without AF. Conclusion The left atrial out-pouching structures are commonly seen in a population with and without stroke with similar prevalence. Our study suggests that LA out-pouching structures are not significant risk factors of stroke.
Thrombolytic Effects of the Snake Venom Disintegrin Saxatilin Determined by Novel Assessment Methods: A FeCl3-Induced Thrombosis Model in Mice
Il Kwon, Sung-Yu Hong, Young Dae Kim, Hyo Suk Nam, Sungsoo Kang, Seung-Hee Yang, Ji Hoe Heo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081165
Abstract: Saxatilin, a novel disintegrin purified and cloned from the venom of the Korean snake Gloydius saxatilis, strongly inhibits activation and aggregation of platelets. Glycoprotein (GP) IIb/IIIa receptor antagonists can resolve thrombus, so saxatilin might also have thrombolytic effects. We investigated the thrombolytic effects of saxatilin in mice using a ferric chloride-induced carotid arterial thrombosis model. Thrombotic occlusion and thrombus resolution were evaluated quantitatively by measuring blood flow in the carotid artery with an ultrasonic flow meter and calculating the degree of flow restoration on a minute-by-minute basis; results were confirmed by histological examination. Saxatilin dissolved thrombi in a dose-dependent manner. Saxatilin at 5 mg/kg restored blood flow to baseline levels. As saxatilin dose increased, time to recanalization decreased. A bolus injection of 10% of a complete dose with continuous infusion of the remaining dose for 60 minutes resulted in effective recanalization without reocclusion. The thrombolytic effect of saxatilin was also demonstrated in vitro using platelet aggregometry by administering saxatilin in preformed thrombi. Bleeding complications were observed in 2 of 71 mice that received saxatilin. Fibrin/fibrinogen zymography and platelet aggregometry studies indicated that saxatilin does not have fibrinolytic activity, but exerted its action on platelets. Integrin-binding assays showed that saxatilin inhibited multiple integrins, specifically α2bβ3 (GP IIb/IIIa), α5β1, αvβ3, αvβ1, and αvβ5, which act on platelet adhesion/aggregation. Saxatilin inhibited multiple integrins by acting on platelets, and was safe and effective in resolving thrombi in mice.
AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair
Jong-Ho Cha, Hee-Jun Wee, Ji Hae Seo, Bum Ju Ahn, Ji-Hyeon Park, Jun-Mo Yang, Sae-Won Lee, Eun Hee Kim, Ok-Hee Lee, Ji Hoe Heo, Hyo-Jong Lee, Irwin H. Gelman, Ken Arai, Eng H. Lo, Kyu-Won Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094695
Abstract: The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic scar surrounding the lesion site. The fibrotic scar is known as an obstacle for axonal regeneration in the remodeling stage. However, the role of the fibrotic scar in the new tissue formation stage remains largely unknown. We found that the number of A-kinase anchoring protein 12 (AKAP12)-positive cells in the fibrotic scar was increased over time, and the cells formed a structure which traps various immune cells. Furthermore, the AKAP12-positive cells strongly express junction proteins which enable the structure to function as a physical barrier. In in vivo validation, AKAP12 knock-out (KO) mice showed leakage from a lesion, resulting from an impaired structure with the loss of the junction complex. Consistently, focal brain injury in the AKAP12 KO mice led to extended inflammation and more severe tissue damage compared to the wild type (WT) mice. Accordingly, our results suggest that AKAP12-positive cells in the fibrotic scar may restrict excessive inflammation, demonstrating certain mechanisms that could underlie the beneficial actions of the fibrotic scar in the new tissue formation stage during the CNS repair process.
The Relationship between Thyroid Hormone Levels and Corrected QT Interval and QT Dispersion in Non-Diabetic Hemodialysis Patients  [PDF]
Heo-Yeong Kim, Ji Soo Kim, Seung Eun Suh, Yu Kyung Hyun, Kyeong Mi Park, Hyung-Jong Kim
Open Journal of Nephrology (OJNeph) , 2014, DOI: 10.4236/ojneph.2014.41003

Background: Cardiovascular disease and sudden cardiac death are common in hemodialysis patients. These cardiac complications are often associated with prolonged QTc interval (QTc) and QTc dispersion (QTcd). Subclinical hypothyroidism (SH) can alter autonomic modulation of heart rate and cause increased inhomogeneity of ventricular recovery time. We aimed to evaluate the relationship between thyroid hormone levels and QTc and QTcd in non-diabetic hemodialysis patients. Methods: We enrolled 29 non-diabetic hemodialysis patients without thyroid disease. After each hemodialysis session, a 12-lead ECG was recorded. Before each hemodialysis session, routine laboratory tests and measurement of thyroid hormone levels were performed. Patients were divided into 2 groups according to QTc (group 1 QTc < 430 ms, group 2 QTc ≥ 430 ms). We examined the relationship between QTc or QTcd and thyroid hormone in the respective groups and then compared the results from the 2 groups. Results: The mean age was 54.06 ± 14.72 years and the means of QTc and QTcd were 433.82 ± 22.03 ms, 59.10 ± 28.29 ms, respectively. Homocysteine levels were significant higher in group 2 than group 1 (p < 0.05) and QTcd was comparable between groups. In group 1, QTc and QTcd were not significant correlated with TSH, T3, fT4 and biochemical parameters. In group 2, QTc was significant positively correlated with TSH (p < 0.05) and QTcd was

A Novel Gaze Tracking Method Based on the Generation of Virtual Calibration Points
Ji Woo Lee,Hwan Heo,Kang Ryoung Park
Sensors , 2013, DOI: 10.3390/s130810802
Abstract: Most conventional gaze-tracking systems require that users look at many points during the initial calibration stage, which is inconvenient for them. To avoid this requirement, we propose a new gaze-tracking method with four important characteristics. First, our gaze-tracking system uses a large screen located at a distance from the user, who wears a lightweight device. Second, our system requires that users look at only four calibration points during the initial calibration stage, during which four pupil centers are noted. Third, five additional points (virtual pupil centers) are generated with a multilayer perceptron using the four actual points (detected pupil centers) as inputs. Fourth, when a user gazes at a large screen, the shape defined by the positions of the four pupil centers is a distorted quadrangle because of the nonlinear movement of the human eyeball. The gaze-detection accuracy is reduced if we map the pupil movement area onto the screen area using a single transform function. We overcame this problem by calculating the gaze position based on multi-geometric transforms using the five virtual points and the four actual points. Experiment results show that the accuracy of the proposed method is better than that of other methods.
Three-year caregiver’s reports on driving performance: A divination or diagnostic tool for fitness to drive in Parkinson Disease patients  [PDF]
Hoe C. Lee
Advances in Parkinson's Disease (APD) , 2013, DOI: 10.4236/apd.2013.22009
Abstract: Objectives: This study aims to examine whether information provided by spouse or relatives can be employed to identify PD patients with deteriorated driving performance, using three-year caregiver’s reports on their driving ability as the outcome measure. Methods: Fifty-three idiopathic PD subjects were assessed on open roads. Prior to the driving assessment, participants were examined by a geriatrician with various clinical assessments. The caregivers filled out a questionnaire, the scores of which is a reflection of their concern on driving performanceof their PD relatives. The same measurements were collected for the subsequent two years. Hierarchical Poisson regression analysis, adjusting for gender, age and driving exposure (hours of driving per week), was then undertaken to determine whether the measures of driving assessment were associated with the score of the questionnaire. Results: During the three-year period, all PD participants were rated at least 3 questions positive in the caregiver’s questionnaire; the worst participant was rated positive eight times. Except the assessment criteria to gauge thetraffic rulesandregulations compliance,all other measures of the driving assessment were found to be significantly associated with the information provided by the caregivers. Conclusions: This study demonstrated that the information provided by caregivers was useful to identify PD patients with deteriorated driving performance. If adopted as part of the off-road driving assessment for PD patients, the questionnaire can provide reliable information to clinicians.
The Fission Yeast GATA Factor, Gaf1, Modulates Sexual Development via Direct Down-Regulation of ste11+ Expression in Response to Nitrogen Starvation
Lila Kim, Kwang-Lae Hoe, Yeong Man Yu, Ji-Hyun Yeon, Pil Jae Maeng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042409
Abstract: Gaf1 is the first GATA family zinc-finger transcription factor identified in Schizosaccharomyces pombe. Here, we report that Gaf1 functions as a negatively acting transcription factor of ste11+, delaying the entrance of cells exposed to transient nitrogen starvation into the meiotic cycle. gaf1Δ strains exhibited accelerated G1-arrest upon nitrogen starvation. Moreover, gaf1Δ mutation caused increased mating and sporulation frequency under both nitrogen-starved and unstarved conditions, while overexpression of gaf1+ led to a significant impairment of sporulation. By microarray analysis, we found that approximately 63% (116 genes) of the 183 genes up-regulated in unstarved gaf1Δ cells were nitrogen starvation-responsive genes, and furthermore that 25 genes among the genes up-regulated by gaf1Δ mutation are Ste11 targets (e.g., gpa1+, ste4+, spk1+, ste11+, and mei2+). The phenotype caused by gaf1Δ mutation was masked by ste11Δ mutation, indicating that ste11+ is epistatic to gaf1+ with respect to sporulation efficiency, and accordingly that gaf1+ functions upstream of ste11+ in the signaling pathway governing sexual development. gaf1Δ strains showed accelerated ste11+ expression under nitrogen starvation and increased ste11+ expression even under normal conditions. Electrophoretic mobility shift assay analysis demonstrated that Gaf1 specifically binds to the canonical GATA motif (5′-HGATAR-3′) spanning from ?371 to ?366 in ste11+ promoter. Consequently, Gaf1 provides the prime example for negative regulation of ste11+ transcription through direct binding to a cis-acting motif of its promoter.
Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition
Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo, Woo Kyung Moon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038053
Abstract: Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc. Recombinant Nkx2.5 (myc-Nkx2.5) proteins were reduced by treatment with the O-GlcNAcase inhibitors STZ and O-(2-acetamido-2-deoxy-D-glucopyroanosyli?dene)-amino-N-phenylcarbamate; PUGNAC) as well as the overexpression of recombinant O-GlcNAc transferase (OGT-flag). Co-immunoprecipitation analysis revealed that myc-Nkx2.5 and OGT-flag proteins interacted and myc-Nkx2.5 proteins were modified by O-GlcNAc. In addition, Nkx2.5 proteins were reduced in the heart tissue of streptozotocin (STZ)-induced diabetic mice and O-GlcNAc modification of Nkx2.5 protein increased in diabetic heart tissue compared with non-diabetic heart. Thus, excessive O-GlcNAcylation causes downregulation of Nkx2.5, which may be an underlying contributing factor for the development of diabetic cardiomyopathy.
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