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Search Results: 1 - 10 of 40726 matches for " Ji Eun Lee "
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The Application of the Korean Dietary Pattern Score; KNHANES (Korean National Health and Nutrition Examination Survey) 2007  [PDF]
Kyung Won Lee, Ji Eun Oh, Mi Sook Cho
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.312221
Abstract: The aim of this study was to apply the Korean Dietary Pattern Score (KDPS) to Korean subjects based on traditional Korean-style meals. The KDPS is based on the 3-Chup Bansang (the traditional Korean daily table setting) and considers the intake of 6 major food groups according to the Korean Dietary Reference Intakes (KDRIs). The KDPS consists of 2 parts: the Korean-Style Meal Score (KSMS) and the Food Group Score (FGS). The KDPS was applied dietary data collected during the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007. Socio-demographic status, gender, age, and body mass index are all factors that have been shown to be meaningful predictors for the KDPS. When the effect of the KDPS on risk of disease was evaluated, a higher total KDPS was associated with a decreased risk of elevated systolic blood pressure (p < 0.05) and hypercholesterolemia (p < 0.05). In addition, as the KSMS increased, the risk of central obesity (p < 0.05) and hypertension (p < 0.01) significantly decreased. A higher total KDPS suggests a greater diversity of food intake, and therefore greater dietary diversity appears to lower the risk of disease. The KDPS is relevant because it integrates scores for Korean-style meal patterns and meal evaluation from a nutritional perspective. In conclusion, the KDPS is appropriate for evaluating the quality of diet, adherence to Korean-style meal patterns, and risk of related diseases. These results will be useful for evaluating the nation’s dietary patterns, nutrition, and health status when planning nutrition policies and programs.
Power Law Exponents for Vertical Velocity Distributions in Natural Rivers  [PDF]
Hae-Eun Lee, Chanjoo Lee, Youg-Jeon Kim, Ji-Sung Kim, Won Kim
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.512114

While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponents such as 1/6 and 1/7 are generally applied. However, exponent of power law is an index representing bed resistance related with relative roughness and furthermore influences the shapes of vertical velocity distribution. The purpose of this study is to investigate characteristics of vertical velocity distribution of the natural rivers by testing and optimizing previous methods used for determination of power law exponent with vertical velocity distribution data collected with ADCPs during the years of 2005 to 2009 from rivers in South Korea. Roughness coefficient has been calculated from the equation of Limerinos. And using theoretical and empirical formulae, and representing relationships between bed resistance and power law exponent, it has been evaluated whether the exponents suggested by these equations appropriately reproduce vertical velocity distribution of actual rivers. As a result, it has been confirmed that there is an increasing trend of power law exponent as bed resistance increases. Therefore, in order to correctly predict vertical velocity distribution in the natural rivers, it is necessary to use an exponent that reflects flow conditions at the field.

A systems-biology approach to understanding the ciliopathy disorders
Ji Eun Lee, Joseph G Gleeson
Genome Medicine , 2011, DOI: 10.1186/gm275
Abstract: Motile cilia (flagella) arose in the eukaryotic lineage in single-celled protists, where they took on signaling capacities, and it was only with the emergence of the multicellular animal kingdom that their non-motile cousins (primary cilia) appeared. Motile cilia in multi-ciliated organisms beat in coordinated waves and are found in various tissues, where they perform a variety of functions. For example, motile cilia in the trachea function in sweeping mucus and particulates out of the lungs and in the fallopian tubes they assist in moving the ovum from the fallopian tube to the uterus. Primary cilia, on the other hand, have a role in sensory detection. In worms, for example, they are present exclusively in a handful of neurons used to detect food. Although there are some cells with motile and primary cilia in vertebrates, most cells have primary cilia whereas only a handful of cells have motile cilia. Both types of cilia have a protruding microtubule structure called the axoneme emerging from a basal body that contains the pair of centrioles (Figure 1). Structurally, the axonemes in both motile and primary cilia comprise nine doublet microtubules, but primary cilia differ in that they lack the two central microtubules (9 + 0) that motile cilia have (9 + 2).Cilia maintain separate cytoplasmic and membrane compartments, but are completely lacking vesicles. Instead cilia rely on specialized modes of transportation called intraflagellar transport (IFT) to deliver cargo proteins and lipids along the axoneme. IFT can operate in the anterograde direction (towards the ciliary tip) using complex B factors, or in the retrograde direction (towards the ciliary base) using complex A factors; together these factors regulate the transport speed and net cargo flux. An important, recently emerged aspect of cilia is the gatekeeper role of the septin family of proteins, regulating initial entry and exit of ciliary factors at the base of the cilium [1]. The transition zone, where the
The clinical utility of tuberculin skin test and interferon-γ release assay in the diagnosis of active tuberculosis among young adults: a prospective observational study
Ji Eun Lee, Hee-Jin Kim, Sei Won Lee
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-96
Abstract: We prospectively enrolled 166 young participants 20-29 years of age with suspected active TB in a military hospital of South Korea. The TST and QFT-IT were performed for all participants.Of the 143 patients included in the analysis, active TB was diagnosed in 100 (69.9%). There were 141 male patients, none of whom had immunosuppressive disease. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of TST were 94% (95% CI, 87-98%), 88% (95% CI, 74-96%), 95% (95% CI, 88-98%), and 86% (95% CI, 72-94%), respectively. The sensitivity, specificity, PPV, and NPV of the QFT-IT were 93% (95% CI, 86-97%), 95% (95% CI, 81-99%), 98% (95% CI, 92-99%), and 84% (95% CI, 69-93%), respectively. No significant differences were found between the TST and QFT-IT in any statistic.Both the TST and QFT-IT showed high sensitivity and specificity in differentiating active TB from other diseases. The diagnostic accuracy of these two tests did not differ significantly when applied to this clinical population of young, immunocompetent adults in whom neonatal BCG vaccination was common, there was no history of previous TB and in whom suspicion of TB was high.ClinicalTrials.gov: NCT00982969Tuberculosis (TB) is an important public health problem worldwide. In 2007, there were 9.27 million cases of TB, and 1.3 million deaths occurred among HIV-negative TB cases [1]. South Korea has an intermediate TB burden; the incidence of new cases is 90 per 100 000 people per year despite an intensive effort for disease control [2]. A prompt and accurate diagnosis is critical for effective control and management of TB, but conventional diagnostic methods have their limitations. Completion of mycobacteria culture takes 3-8 weeks on solid medium and 7-21 days in liquid medium [3,4]. The sensitivity of acid-fast bacilli (AFB) smears is low [3]. The polymerase chain reaction test is often used for rapid microbiological diagnosis of TB, but its sensitivity for smear-negat
Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets  [PDF]
Yun-Jung Lee, Young-Hye Moon, Kyeong Eun Hyung, Jong-Sun Yoo, Mi Ji Lee, Ik Hee Lee, Byung Sung Go, Kwang Woo Hwang
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.48A3003

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

Cyanidine-3-O-Galactoside Enriched Aronia melanocarpa Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells  [PDF]
Su-Min Lim, Jae In Jung, Nam Young Kim, Jung-Shik Bae, Hyun Sook Lee, Eun Ji Kim
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.102011
Abstract: Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.
Expression of Adenine Nucleotide Translocator Correlates with the IL-4-induced lymphocyte survival: Role of PI3K and MAPK
Ji-Young Jang,Choong-Eun Lee
The Scientific World Journal , 2001, DOI: 10.1100/tsw.2001.193
Comparison of Perinatal Outcomes in Late Preterm Spontaneous and Indicated Preterm Birth Neonates  [PDF]
Dasom Chun, Eun Hye Yoo, Ji Young Lee, Hyun Mi Kim, Mi Ju Kim, Won Joon Seong, Hyun-Hwa Cha
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.612083
Abstract: Objective: We aimed to compare the perinatal outcomes in late preterm spontaneous and indicated birth neonates. Methods: We studied 289 late preterm births, classified as either aspontaneous late preterm birth (sLPTB) group (preterm labor with intact membranes and preterm premature rupture of membranes) or an indicated late preterm birth (iLPTB) group (hypertensive disorder in pregnancy, placental causes, and maternal diseases), according to the delivery indication. We then compared the maternal and neonatal characteristics and perinatal outcomes, including the Apgar score, admission to the neonatal intensive care unit (NICU) or special care nursery (SCN), duration of NICU stay, and the rate of composite morbidity (antibiotic use, hypoglycemia, hypocalcemia, hyperbilirubinemia requiring phototherapy, respiratory support, and respiratory distress syndrome). Results: A total of 198 neonates were in the sLPTB group and 91 were in the iLPTB group. In spite of greater gestational age at the time of delivery in the iLPTB group, the mean birth weight was lower than that in the sLPTB group. Additionally, the iLPTB group showed lower Apgar scores, and higher rates of NICU or SCN admission, respiratory support, and hypoglycemia, but there was no difference in the rate of composite morbidity between the two groups. Conclusion: iLPTB neonates had lower birth weights despite greater gestational age than those in the sLPTB group, but there was no difference in the rate of composite morbidity between the two groups.
Anti-inflammatory effect of ethanolic extract from Myagropsis myagroides on murine macrophages and mouse ear edema
Joung Eun-Ji,Lee Min-Sup,Choi Ji-Woong,Kim Jong-Soon
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-171
Abstract: Background This study aims to investigate anti-inflammatory effect of ethanolic extract of Myagropsis myagroides (EMM) in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and the phorbol 12-myristate 13-acetate (PMA)-induced ear edema in mice, and to clarify its underlying molecular mechanisms. Methods The levels of nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines were measured by Griess assay and enzyme linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), mitogen-activated protein kinases (MAPKs), and Akt were measured using Western blotting. Nuclear translocation and transcriptional activation of nuclear factor-κB (NF-κB) were determined by immunocytochemistry and reporter gene assay, respectively. PMA-induced mouse ear edema was used as the animal model of inflammation. Anti-inflammatory compounds in EMM were isolated using high-performance liquid chromatography and identified by nuclear magnetic resonance. Results EMM significantly inhibited the production of NO, PGE2, and pro-inflammatory cytokines in a dose-dependent manner and suppressed the expression of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells. EMM strongly suppressed nuclear translocation of NF-κB by preventing degradation of inhibitor of κB-α as well as by inhibiting phosphorylation of Akt and MAPKs. EMM reduced ear edema in PMA-induced mice. One of the anti-inflammatory compounds in EMM was identified as 6,6’-bieckol. Conclusions These results suggest that the anti-inflammatory properties of EMM are associated with the down-regulation of iNOS, COX-2, and pro-inflammatory cytokines through the inhibition of NF-κB pathway in LPS-stimulated macrophages.
Protective Effects of Purple Sweet Potato Added to Bacillus subtilis-Fermented Soymilk against Amyloid beta-Induced Memory Impairment
Ji Hyun Kim,Ji Myung Choi,Sanghyun Lee,Eun Ju Cho
Journal of Agricultural Science , 2012, DOI: 10.5539/jas.v4n4p223
Abstract: The present study focused on the protective effects of 5% purple sweet potato added to Bacillus subtilis-fermented soymilk (PFSM) under an Alzheimer’s disease (AD) model using ICR mice induced by amyloid beta (Ab), which showed strong antioxidative activity against cognition impairment in a previous study. To observe memory and cognition abilities, T-maze, object cognition, and Morris water-maze tests were carried out. The A? injected groups showed impairments of cognition and memory. However, the oral administration of PFSM extract (100 and 200 mg/kg body weight/day for 7 days) improved cognition and memory. Furthermore, nitric oxide (NO) formation and lipid peroxidation were significantly elevated by Ab, whereas PFSM treatment significantly decreased NO formation and lipid peroxidation in the brain, liver, and kidneys. The present study suggests that PFSM improves memory deficit and cognition ability following Ab induction. The protective effects of PFSM against A?-induced impairments of memory and cognition are closely related to the attenuation of oxidative stress.
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