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Search Results: 1 - 10 of 211779 matches for " Jessica L. Mason "
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Hepatitis C Virus Core Protein Inhibits Interferon Production by a Human Plasmacytoid Dendritic Cell Line and Dysregulates Interferon Regulatory Factor-7 and Signal Transducer and Activator of Transcription (STAT) 1 Protein Expression
Amy E. L. Stone, Angela Mitchell, Jessica Brownell, Daniel J. Miklin, Lucy Golden-Mason, Stephen J. Polyak, Michael J. Gale, Hugo R. Rosen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095627
Abstract: Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell population in the defense against viruses. pDCs detect viral pathogen associated molecular patterns (PAMPs) through pattern recognition receptors (PRR). PRR/PAMP interactions trigger signaling events that induce interferon (IFN) production to initiate local and systemic responses. pDCs produce Type I and Type III (IFNL) IFNs in response to HCV RNA. Extracellular HCV core protein (Core) is found in the circulation in chronic infection. This study defined how Core modulates PRR signaling in pDCs. Type I and III IFN expression and production following exposure to recombinant Core or β-galactosiade was assessed in human GEN2.2 cells, a pDC cell line. Core suppressed type I and III IFN production in response to TLR agonists and the HCV PAMP agonist of RIG-I. Core suppression of IFN induction was linked with decreased IRF-7 protein levels and increased non-phosphorylated STAT1 protein. Circulating Core protein interferes with PRR signaling by pDCs to suppress IFN production. Strategies to define and target Core effects on pDCs may serve to enhance IFN production and antiviral actions against HCV.
Mutational and Topological Analysis of the Escherichia coli BamA Protein
Douglas F. Browning, Sophie A. Matthews, Amanda E. Rossiter, Yanina R. Sevastsyanovich, Mark Jeeves, Jessica L. Mason, Timothy J. Wells, Catherine A. Wardius, Timothy J. Knowles, Adam F. Cunningham, Vassiliy N. Bavro, Michael Overduin, Ian R. Henderson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084512
Abstract: The multi-protein β-barrel assembly machine (BAM) of Escherichia coli is responsible for the folding and insertion of β-barrel containing integral outer membrane proteins (OMPs) into the bacterial outer membrane. An essential component of this complex is the BamA protein, which binds unfolded β-barrel precursors via the five polypeptide transport-associated (POTRA) domains in its N-terminus. The C-terminus of BamA contains a β-barrel domain, which tethers BamA to the outer membrane and is also thought to be involved in OMP insertion. Here we mutagenize BamA using linker scanning mutagenesis and demonstrate that all five POTRA domains are essential for BamA protein function in our experimental system. Furthermore, we generate a homology based model of the BamA β-barrel and test our model using insertion mutagenesis, deletion analysis and immunofluorescence to identify β-strands, periplasmic turns and extracellular loops. We show that the surface-exposed loops of the BamA β-barrel are essential.
Palaeolithic-Mesolithic Day Meeting, British Museum, 17th March 1995
Sarah L. R. Mason
Papers from the Institute of Archaeology , 1995, DOI: 10.5334/pia.71
Abstract:
Neolithic Studies Group Autumn Meeting: Domestic Settlement and the Landscape, British Museum, 14th November 1994
Sarah L. R. Mason
Papers from the Institute of Archaeology , 1995, DOI: 10.5334/pia.75
Abstract:
AT THE INTERSECTION OF ECONOMICS AND CULTURE: THE THRIFT INDUSTRY AND PROGRESSIVE ERA SOCIAL REFORM
David L. Mason
Essays in Economic & Business History , 2000,
Abstract: Although America’s thrift industry originated in 1831, it did not truly grow until the 1880s when the country was entering the Second Industrial Revolution. By then thrifts were becoming an important source of home finance for the urban working class, who were attracted to it by promoters who emphasized the practical benefits of home ownership. These same industry promoters, however, also gained the support of Progressive Era elites by positioning the industry as a solution to urban problems created by industrialization. The success of these efforts is seen quantitatively in terms of industry growth, and qualitatively in the diversity of support in terms of race, gender and ethnicity.
Global anti-self-dual Yang-Mills fields in split signature and their scattering
L. J. Mason
Physics , 2005,
Abstract: We consider solutions to the anti-self-dual Yang Mills (ASDYM) equations in split signature that are global on the double cover of the appropriate conformally compactified Minkowski space $\widetilde\M$. Ward's ASDYM twistor construction is adapted to this geometry by using a correspondence between points of $\widetilde\M$ and holomorphic discs in $\CP^3$, twistor space, with boundary on the real slice $\RP^3$. A 1-1 correspondence is obtained between smooth global $\U(n)$ solutions to the ASDYM equations on $\widetilde\M$ and pairs consisting of an arbitrary holomorphic vector bundle $E$ over $\CP^3$ together with a smooth positive definite hermitian metric $H$ on $E|_{\RP^3}$. There are no topological or other restrictions on the bundle $E$. The description generalises the result of the scattering transform for 1+1 dimensional integrable systems in which solutions are encoded into a combination of algebraic data, here $E$, and a reflection coefficient, here $H:\RP^3\to E\otimes\bar E$. For trivial $E$, the twistor data consists of the smooth Hermitian matrix function $H$ on $\RP^3$ up to constants; the correspondence then provides a nonlinear generalisation of the X-ray transform. Explicit examples are given with different topologies of $E$. A scattering problem for ASDYM fields in split signature is set up and it is shown that sufficiently small data at past infinity uniquely determines data at future infinity by taking a family of holonomies followed by a sequence of two Birkhoff factorizations. The scattering map is simple on the holonomies, but non-trivial at the level of the connection in the non-abelian case.
Twistor actions for non-self-dual fields; a new foundation for twistor-string theory
L. J. Mason
Mathematics , 2005, DOI: 10.1088/1126-6708/2005/10/009
Abstract: Twistor space constructions and actions are given for full Yang-Mills and conformal gravity using almost complex structures that are not, in general, integrable. These are used as the basis of a derivation of the twistor-string generating functionals for tree level perturbative scattering amplitudes of Yang-Mills and conformal gravity. The derivation follows by expanding and resumming the classical approximation to the path integral obtained from the twistor action. It provides a basis for exploring whether the equivalence can be made to extend beyond tree level and allows one to disentangle conformal supergravity modes from the Yang-Mills modes.
Above and Below Ground Interactions in Monoculture and Intercropping of Onion and Lettuce in Greenhouse Conditions  [PDF]
Jessica L. de Haan, Liette Vasseur
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.521347
Abstract: Intercropping has been seen as an advantageous strategy in sustainable agriculture. Plants however interact with one another both above and below ground with members of the same species (intraspecific) or members of a different species (interspecific) for nutrients, water and light. It is therefore essential to understand these interactions when intercropped. The objective was to examine the above and below ground interactions between onion and lettuce in monocrop and intercrop systems. We examined the various possible interactions (no competition, above ground, below ground, or full) using a full factorial randomized design under greenhouse conditions. Onion yield was highest in intraspecific above ground competition and lowest in below ground and full interspecific competition with lettuce. Dry weight of onions in above ground competition with lettuce was significantly greater than that of the control group. Fresh weight of lettuce leaves were highest in below ground and full interspecific competition treatments. The hectare model and yield results suggest that there is strong below ground competitive effect between onion and lettuce in intercrop. Asymetric interspecific facilitation was found: facilitation by onion led to increased lettuce yield but a negative effect of lettuce on onion yield was observed. Knowledge of competitive interactions between component crops can have several applications in sustainable agricultural as it helps to match the most efficient species under specific conditions.
The Einstein-Weyl Equations, Scattering Maps, and Holomorphic Disks
Claude LeBrun,L. J. Mason
Mathematics , 2008,
Abstract: We show that conformally compact, globally hyperbolic, Lorentzian Einstein-Weyl 3-manifolds are in natural one-to-one correspondence with orientation-reversing diffeomorphisms of the 2-sphere. The proof hinges on a holomorphic-disk analog of Hitchin's mini-twistor correspondence.
Zoll Manifolds and Complex Surfaces
Claude LeBrun,L. J. Mason
Mathematics , 2002,
Abstract: We classify compact surfaces with torsion-free affine connections for which every geodesic is a simple closed curve. In the process, we obtain completely new proofs of all the major results concerning the Riemannian case. In contrast to previous work, our approach is twistor-theoretic, and depends fundamentally on the fact that, up to biholomorphism, there is only one complex structure on CP2.
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