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Search Results: 1 - 10 of 5421 matches for " Jeoung Hwa Shin "
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Risk Points of Flame Retardant Textiles by Halogen and Halogen-Free Laminating Film  [PDF]
Yoon Jeong Baek, Jeoung Hwa Shin
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.511083
Abstract: This study was to develop the flame retardant (FR) protective clothing which had multifunction such anti-bacterial, UV cut, FR function with water repellent and water vapor permeable laminating textiles for industrial workers. First of all, the FR yarn and FR textiles were developed for this purpose. Second, the comparison analysis between the halogen laminating textiles and halogen-free laminating textiles were tested to figure out the eco-friendly laminating method. Third, the flame retardant ability was compared the halogen laminated textiles to halogen-free laminated textiles. LOI, UV protection ratio, antibiosis after 50 laundry test, water proof pressure, and moisture permeability of developed textiles were tested. GC-HR-TOF-MS was used for analysis of laminating film (halogen and halogen-free). 4.1 wt% TiO2 yarn showed antibacterial function (Pneumococcus & Staphylococcus aureus: 99.9%), UV Protection (UVA: 90.8, UVB: 92.1), and LOI (33.6). The chosen optimal compounding ratio for PU compound of HRF and HFFR were as followed: PU resin 58.3%, DMF (Dimethyl formamide, δ = 12.2) 8.3%, MEK (Methylethylketone) 8.3% and FR (flame retardants) 25.0%. Binder for laminating should not be included over 10% of FRs because of adhesion between textiles and FR laminating film. There were detected phosphorus compounds in the textiles treated by halogenated type flame retardants and halogenated-free type flame retardants. There were not any detected harmful compounds from all textile samples.
Tip60 Tumor Suppressor Requires Its NLS Motif to Interact with Importin α  [PDF]
Eun Jeoung Lee, Sung Hwa Shin, Sang Sun Kang
CellBio (CellBio) , 2019, DOI: 10.4236/cellbio.2019.81001
Abstract: Tip60 is a specific member of MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of nuclear histone acetyltransferases (HAT). It is essential for cellular survival, differentiation, and metabolism. A putative canonical NLS motif between the chromo domain and the zinc finger of Tip60 was identified. Here we show evidence that Tip60 is associated with importin α as its substrate and transported from cytoplasm to the nucleus. Pull down assay revealed that Tip60 was physically associated with importin α both in vivo and in vitro. Confocal microscopic observation showed that Tip60 and importin α were co-localized with each other. The localization of Tip60 to the nuclear and its interaction with importin α was disrupted when its putative NLS motif for binding to importin α was mutated (219RKRK222 219AAAA222). However, attachment of this putative NLS motif to a cytoplasmic protein (YAP 1-210 fragment) promoted its nuclear localization. Based on transient transfection, Tip60 NLS motif mutant showed a substantial reduction in self-acetylation, HAT activity, and apoptotic ability whereas wild type Tip60 did not show such reduction. Taken together, our results demonstrate that importin α transports Tip60 from the cytoplasm to the nucleus through binding to the putative NLS motif of Tip60 for its tumor suppressing function.
The interaction between Fe65 and Tip60 is regulated by S-nitrosylation on 440 cystein residue of Fe65  [PDF]
Eun Jeoung Lee, Sung Hwa Shin, Sunghee Hyun, Jaesun Chun, Sang Sun Kang
Advances in Biological Chemistry (ABC) , 2011, DOI: 10.4236/abc.2011.13013
Abstract: The S-Nitrosylation of protein thiol groups by NO is a widely recognized protein modification. The treat-ment of cells with NOBF4 induces the S-nitrosylation of FE65. In this study, we present evidence showing that FE65 modified by NO (Nitric Oxide) via S-nitrosylation induces functional changes in the protein that inhibits the HAT activity of Tip60. The results of mutational analysis of FE65 demonstrated further that the cysteine residue of FE65 (Cys440) is critical to the process of S-nitrosylation. The mutation of the cysteine residue which completely ablated the S-nitrosylation of FE65 also lost its inhibitory effects on Tip60 HAT activity. Thus, our findings show, for the first time, that the novel regulation mechanism of Tip60 activity may operate via FE65 binding, which is enhanced by S-nitrosylation on the FE65 Cys440 residue. This study describes the interaction between FE65 and Tip60, which is enhanced by a posttransla-tional modification of FE65 (through S-nitrosylation) by NO, promoting the association of the FE65-Tip60 protein complex and inhibiting both the HAT activity of Tip60 and cell death.
Phosphorylation on TRPV4 Serine Residue 824 Enhances Its Association with PGM1  [PDF]
Sung Hwa Shin, Eun Jeoung Lee, Sunghee Hyun, Sang Sun Kang
American Journal of Molecular Biology (AJMB) , 2016, DOI: 10.4236/ajmb.2016.61004
Abstract: The TRPV4 cation channel is expressed in a broad range of tissues and participates in the generation of a Ca2+ signal and/or depolarization of membrane potential. Here, human phosphoglucomutase- 1 (PGM1), an enzyme that converts glucose-6 phosphate to glucose-1 phosphate in the glycolysis pathway, as the first auxiliary protein of TRPV4 Ca2+ channels, is identified with yeast two hybrid system, coimmunoprecipitation, confocal microscopy, and GST pull-down assays. TRPV4 forms a complex with PGM1 through its C-terminal cytoplasmic domain. Because it is demonstrated that TRPV4 serine residue 824 (S824) is phosphorylated by serum/glucocorticoid regulated kinase 1, we elucidate the effect of TRPV4 S824 phosphorylation on TRPV association with PGM1. Even an inactivated mutant version of TRPV4, S824A, exhibited a decreased ability to bind PGM1, an activated phosphomimetic mutant version of TRPV4, S824D, exhibited enhanced binding to PGM1. Thus, formation of the TRPV4/PGM1 complex and localization of this complex to the plasma membrane appear to be regulated by the phosphorylation status of residue S824 in TRPV4. The newly identified interactor of TRPV4 may help the molecular pathways modulating transport activity or glucose metabolism, respectively.
SGK1 Inhibits ULK2 Autophagy Activity  [PDF]
Sung Hwa Shin, Eun Jeoung Lee, Sunghee Hyun, Sang Sun Kang
American Journal of Molecular Biology (AJMB) , 2020, DOI: 10.4236/ajmb.2020.101002
Abstract: Serum- and glucocorticoid-induced kinase 1 (SGK1) is known to have consensus sequence of phosphorylation site R-x-R-x-x-(S/T)-Φ, where Φ is any hydrophobic amino acid and arginine residues are conserved at positions −5 and −3 relative to positions of Ser/Thr residues that are phosphorylated in the presence of SGK1. UNC-21-like kinase 2 (ULK2) also harbors putative SGK1 phosphorylation sites at both Ser507 (502RsRnsSG508) and Ser750 (745RtRttSV751) residues. Thus, the objective of this study was to determine whether Ser507 and Ser750 residues of ULK2 could be phosphorylation sites of SGK1 as one of its authentic substrate proteins. Using ULK2 507 and 750 serine residue un- or phosphorylation analog (S507AS750A or 507DS750D), we observed that modification of Ser507 or Ser750 residue was required to activate the kinase activity of ULK2 and sensitize ULK2 to stress or starvation while simultaneously enhancing its active state and autophagy characteristics, suggesting that phosphorylation at Ser750 or Ser507 residue could modulate its subcellular localization and protein interaction with AMPK1α to activate ULK2. We also observed that ULK2 autophagy activity was enhanced by GSK650394 (an SGK1 inhibitor) to compensate survival capacity through increasing its association with LC3 and phosphorylation. When SGK1 known to be associated with cell survival was inhibited by GSK650394, ULK2 autophagy pathway was activated to avoid cell death alternatively. Thus, our observations indicate that phosphorylation of ULK2 by SGK1 can regulate cell survival as an alternative modulation of ULK2 functions.
Effect of Meridian Massage for Cancer Related Fatigue

In sook Jeoung,Hwa-Seung Yoo,

世界科学技术-中医药现代化 , 2008,
Abstract:
Electrokinetics Technology to Improve Acidizing of Carbonate Reservoir Rocks  [PDF]
Sanghee Shin, George V. Chilingar, Mohammed Haroun, Kenneth Wittle, Najmedin Meshkati, Sibel Pamukcu, Jaehyeung Jeoung, Hobon Koo
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.44A001
Abstract:

A novel technology (electrokinetics) is proposed to improve acidizing operations, i.e., increase the penetration distance. The acid dissolves the carbonates (limestones/dolomites), enlarging the pores and increasing the width of pre-existing fractures. This gives rise to an increase in permeability. The principal acid commonly used is hydrochloric (HCl), which is pumped through tubing. Aqueous solutions of hydrochloric acid (usually 15%) are pumped into the carbonate formations to enlarge the pores and pre-existing fractures. Without application of D.C. current, the penetration distance is usually very short, especially in tight rocks. However, the penetration distance of acid is very short. By applying D.C. current, one can drive the acid for long distances into the formation being acidized.

Generation of class fields by Siegel-Ramachandra invariants
Dong Hwa Shin
Mathematics , 2010,
Abstract: We show that the Siegel-Ramachandra invariants could be primitive generators of the ray class fields of imaginary quadratic fields. By using Shimura's reciprocity law we give a modern explanation of the solution of class number one problem given by Heegner and Stark.
Malicious Node Detection Using Confidence Level Evaluation in a Grid-Based Wireless Sensor Network  [PDF]
Min-Cheol Shin, Yoon-Hwa Choi
Wireless Sensor Network (WSN) , 2013, DOI: 10.4236/wsn.2013.53007
Abstract:

In this paper, we present a malicious node detection scheme using confidence-level evaluation in a grid-based wireless sensor network. The sensor field is divided into square grids, where sensor nodes in each grid form a cluster with a cluster head. Each cluster head maintains the confidence levels of its member nodes based on their readings and reflects them in decision-making. Two thresholds are used to distinguish between false alarms due to malicious nodes and events. In addition, the center of an event region is estimated, if necessary, to enhance the event and malicious node detection accuracy. Experimental results show that the scheme can achieve high malicious node detection accuracy without sacrificing normal sensor nodes.

First Record of a Hyalid Species, Protohyale pumila (Crustacea: Amphipoda: Hyalidae), from Korea
Myung-Hwa Shin,Won Kim
Animal Systematics, Evolution and Diversity , 2012, DOI: http://dx.doi.org/10.5635/ased.2012.28.4.312
Abstract: A hyalid amphipod, Protohyale pumila (Hiwatari and Kajihara, 1981), collected from Jeju Island is reported for the first time in the Korean fauna. The species is characterized by the presence of a short apical spine on the palp article 4 of maxilliped, a distinctly large and blunt cusp on the propodus of male gnathopod 1, and a distal truncate process on the palm of male gnathopod 2. Herein, the present species is described and illustrated. Korean hyalid amphipods now are composed of four species belonging to three genera. Voucher specimens were deposited in the Marine Arthropod Depository Bank of Korea, Seoul National University.
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