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Search Results: 1 - 10 of 23203 matches for " Jeong-Yoon Song "
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Laparoscopic resection of an adrenal pseudocyst mimicking a retroperitoneal mucinous cystic neoplasm
Bum-Soo Kim, Sun-Hyung Joo, Sung-Il Choi, Jeong-Yoon Song
World Journal of Gastroenterology , 2009,
Abstract: Adrenal pseudocysts are rare cystic masses that arise within the adrenal gland and are usually non-functional and asymptomatic. Adrenal pseudocysts consist of a fibrous wall without a cellular lining. We report a patient with a 9 cm, left-sided suprarenal cystic mass who presented with abdominal discomfort of 2 years’ duration. A 38-year-old woman was referred to our service for evaluation of abdominal discomfort and gastrointestinal symptoms. Routine laboratory tests were within normal limits. An abdominal computed tomography scan showed a 9 cm × 8 cm × 8 cm well-defined cystic lesion displacing the left kidney. Magnetic resonance imaging showed a cystic lesion with low signal intensity on the T1-weighted image and high signal intensity on the T2-weighted image. A laparoscopic left adrenalectomy was performed to diagnose the lesion. The final pathology showed an adrenal pseudocyst without a cellular lining. The patient had no postoperative complications and she was discharged four days after surgery.
Risk Points of Flame Retardant Textiles by Halogen and Halogen-Free Laminating Film  [PDF]
Yoon Jeong Baek, Jeoung Hwa Shin
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.511083
Abstract: This study was to develop the flame retardant (FR) protective clothing which had multifunction such anti-bacterial, UV cut, FR function with water repellent and water vapor permeable laminating textiles for industrial workers. First of all, the FR yarn and FR textiles were developed for this purpose. Second, the comparison analysis between the halogen laminating textiles and halogen-free laminating textiles were tested to figure out the eco-friendly laminating method. Third, the flame retardant ability was compared the halogen laminated textiles to halogen-free laminated textiles. LOI, UV protection ratio, antibiosis after 50 laundry test, water proof pressure, and moisture permeability of developed textiles were tested. GC-HR-TOF-MS was used for analysis of laminating film (halogen and halogen-free). 4.1 wt% TiO2 yarn showed antibacterial function (Pneumococcus & Staphylococcus aureus: 99.9%), UV Protection (UVA: 90.8, UVB: 92.1), and LOI (33.6). The chosen optimal compounding ratio for PU compound of HRF and HFFR were as followed: PU resin 58.3%, DMF (Dimethyl formamide, δ = 12.2) 8.3%, MEK (Methylethylketone) 8.3% and FR (flame retardants) 25.0%. Binder for laminating should not be included over 10% of FRs because of adhesion between textiles and FR laminating film. There were detected phosphorus compounds in the textiles treated by halogenated type flame retardants and halogenated-free type flame retardants. There were not any detected harmful compounds from all textile samples.
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways
Jeong Song, Chun Kang, Moon Yoo, Seung Kim, Hyung Yoon, Young Kim, Kwan Kim, Hwa Moon, Sung Park
Respiratory Research , 2007, DOI: 10.1186/1465-9921-8-28
Abstract: Nitric oxide was donated to the A549 cells by NOR-1. MUC5AC mucin levels were assayed by enzyme-linked immunosorbent assay (ELISA). MUC5AC promoter activity was determined by measuring luciferase activity after the lysing the transfected cells. Activation of PKC isoforms were measured by assessing the distribution of the enzyme between cytosolic and membrane fractions using immunoblotting. Immunoblotting experiments using a monoclonal antibody specific to PKC isoforms were performed in the cytosol and membrane fractions from A549 cells. Western blot analysis for pERK and p38 were performed using the corresponding antibodies from the cell lysates after donating NO to the A549 cells by NOR-1.The transcriptional activity of MUC5AC promoter was maximal at the concentration of 0.1 mM NOR-1 for 1 hour incubation in transfected A549 cells. (±)-(E)-methyl-2-((E)-hydroxyimino)-5-nitro-6-methoxy-3-hexenamide (NOR-1) markedly displaced the protein kinase C (PKC)α and PKCδ from the cytosol to the membrane. Furthermore, the PKC-α,βinhibitors, G?6976 (10 nM) and PKCδ inhibitors, rottlerin (4 μM) inhibited the NOR-1 induced migration of PKCα and PKCδ respectively. NOR-1 also markedly increased the MUC5AC promoter activity and mRNA expression, mucin synthesis and ERK1/2 phosphorylation. The PKC inhibitors also inhibited the NOR-1 induced MUC5AC mRNA and MUC5AC protein synthesis by inhibiting the activation of PKCα and PKCδ with ERK1/2 pathways.Exogenous NO induced the MUC5AC mucin gene and protein through the PKCα and PKCδ – ERK pathways in A549 cells. Inhibition of PKC attenuated NO-mediated MUC5AC mucin synthesis. In view of this findings, PKC inhibitors might be useful in the treatment of bronchial asthma and chronic bronchitis patients where NO and mucus are increased in the bronchial airways.Production of NO is generally increased during inflammatory airway diseases such as asthma or bronchiectasis, or after exposure to irritant gases such as ozone [1]. NO is produced by the a
Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib
Changhoon Yoo,Jeong-Eun Kim,Shin-Kyo Yoon,Song Cheol Kim,Jin-Hee Ahn,Tae Won Kim,Cheolwon Suh,Jae-Lyun Lee
Sarcoma , 2009, DOI: 10.1155/2009/360875
Abstract: A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angiosarcomas. When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma.
Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies
Chin Rhee, Ji Kang, Yong Kim, Jin Kim, Hyung Yoon, Seok Kim, Soon Kwon, Young Kim, Kwan Kim, Hwa Moon, Sung Park, Hee Kim, Seok Lee, Jeong Song
Critical Care , 2009, DOI: 10.1186/cc8149
Abstract: We studied critically ill patients with hematologic malignancies with the dual objectives of describing patients with ARDS during neutropenia recovery and identifying risk factors for ARDS during neutropenia recovery. A cohort of consecutive neutropenic patients with hematologic malignancies who were admitted to the intensive care unit (ICU) was studied. During a 6-year period, 71 patients recovered from neutropenia, of whom 38 (53.5%) developed ARDS during recovery.Compared with non-ARDS patients, patients who experienced ARDS during neutropenia recovery were more likely to have pneumonia, be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. The in-ICU mortality was significantly different between the two groups (86.8% versus 51.5%, respectively, for patients who developed ARDS during neutropenia recovery versus those who did not during neutropenia recovery). In multivariate analysis, only occurrence of pneumonia during the neutropenic episode was associated with a marked increase in the risk of ARDS (odds ratio, 4.76).Patients with hematologic malignancies complicated by pneumonia during neutropenia are at increased risk for ARDS during neutropenia recovery.Over the past two decades, the survival of patients with a hematologic malignancy has substantially improved as a result of new and intensive chemotherapeutic regimens, which may be followed by hematopoietic stem cell transplantation (HSCT) [1]. Unfortunately, the use of aggressive chemotherapeutic regimens frequently results in life-threatening complications, requiring transfer to the intensive care unit (ICU) for monitoring or advanced support [2]. Respiratory failure is the most common reason for ICU admission in critically ill patients with hematologic malignancies [3].Intensive chemotherapeutic treatment results in an increase in the number of patients with neutropenia. In cancer patients, neutropenia recovery may be associated with a deterioration in oxygenation and e
Gene expression profile of the skin in the 'hairpoor' (HrHp) mice by microarray analysis
Bong-Kyu Kim, In-Cheol Baek, Hwa-Young Lee, Jeong-Ki Kim, Hae-Hiang Song, Sungjoo K Yoon
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-640
Abstract: From 45,282 mouse probes, differential expressions in 43 (>2-fold), 306 (>1.5-fold), and 1861 genes (>1.2-fold) in skin from HrHp/HrHp mice were discovered and compared with skin from wild-type mice. Among the 1861 genes with a > 1.2-fold increase in expression, further analysis showed that the expression of eight genes known to have a close relationship with hair follicle development, ascertained by conducting real-time PCR on skin RNA produced during hair follicle morphogenesis (P0-P14), indicated that four genes, Wif1, Casp14, Krt71, and Sfrp1, showed a consistent expression pattern with respect to HR overexpression in vivo.Wif1 and Casp14 were found to be upregulated, whereas Krt71 and Sfrp1 were downregulated in cells overexpressing HR in transient transfection experiments on keratinocytes, suggesting that HR may transcriptionally regulate these genes. Further studies are required to understand the mechanism of this regulation by the HR cofactor.With a complex and dynamic structure, hair is generated by hair-producing follicles and has a patterned cycle of growth and remodeling, which consists of growth (anagen), regression (catagen), and rest (telogen) stages. There are many genes involved in mature hair follicle (HF) regulation [1].One of these genes, hairless (Hr), is expressed in skin, specifically in the suprabasal cell layer of the interfollicular epidermis and in the lower portion of the HF epithelium; its expression is dependent on the hair cycle. Hr encodes a 130 kDa protein (HR), which contains a zinc finger domain and is localized in the nucleus [2], and acts as a transcriptional corepressor that regulates transcription through directly binding to the thyroid hormone receptor [3,4], vitamin D receptor [5], and retinoic acid-like orphan receptor α [6].Various Hr mutant mice have been studied to understand the function of HR, and most Hr mutant mice are created by causing the loss of HR function in their cells, giving them a typical phenotype with a re
Preparation of Thiophene-Fused and Tetrahydroquinoline-Linked Cyclopentadienyl Titanium Complexes for Ethylene/α-Olefin Copolymerization
Sung Hun Kim,Ji Hae Park,Bo Geun Song,Seung-Woong Yoon,Min Jeong Go,Junseong Lee,Bun Yeoul Lee
Catalysts , 2013, DOI: 10.3390/catal3010104
Abstract: A synthetic scheme was developed for the large-scale preparation of a dimethylthiophene-fused and tetrahydroquinaldine-linked dimethylcyclopentadienyl titanium complex ( 2), which is a high-performance homogeneous Ziegler catalyst. 2,3,4,5-Tetramethyl-4,5-dihydrocyclopenta[ b]thiophen-6-one was prepared without chromatography purification on the 40-g scale in a laboratory setting, from which the ligand precursor for 2 was obtained in 65% yield on a 50-g scale in a one-pot without the need for chromatography purification. Metallation was achieved in a high yield (78%) through reaction of the dilithiated compound with TiCl 4. Many derivatives were prepared by employing the same synthetic scheme as applied for 2. Among them, the titanium complex prepared from 2-methyl-4,5-dimethyl-6-(2- n-butyl-2,3,4,5-tetrahydroquinolin-8-yl)-4 H-cyclopenta[ b]thiophene exhibited an exceptionally high activity. Under commercially relevant high-temperature polymerization conditions (160 °C), this compound showed a higher activity than 2 (126 × 10 6 g/molTi?h versus 72 × 10 6 g/molTi?h), albeit with the formation of a polymer of slightly lower molecular weight ( M w, 159,000 versus 218,000) and with a slightly lower 1-octene content (9.3 mol% versus 12 mol%).
Immobilization of antibodies on the self-assembled monolayer by antigen-binding site protection and immobilization kinetic control  [PDF]
Myungok Yoon, Hyun Jin Hwang, Jeong Hee Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.44033
Abstract: The orientation of the biological molecule immobi-lized on a solid surface has been critical in devel-opment of various applications. In this study, ori-entation of antibody was retained by protecting the antigen-binding site of the antibody prior to immo-bilization to -functionalized mixed self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 1-heptanethiol. More importantly, the number of immobilization bonds formed between each an-tigen-binding site protected antibody molecule and the solid surface was controlled by optimizing the mole fraction of the activated carboxyl group of the linker molecules in the mixed SAM. The amount of antibody used in this study was approximately equivalent to the amount for one monolayer surface coverage. The resulting activity of protected immo-bilized antibody was about 10 fold higher than that of random immobilized antibody
Outer Membrane Vesicles Derived from Escherichia coli Up-Regulate Expression of Endothelial Cell Adhesion Molecules In Vitro and In Vivo
Ji Hyun Kim, Yae Jin Yoon, Jaewook Lee, Eun-Jeong Choi, Namwoo Yi, Kyong-Su Park, Jaesung Park, Jan L?tvall, Yoon-Keun Kim, Yong Song Gho
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059276
Abstract: Escherichia coli, as one of the gut microbiota, can evoke severe inflammatory diseases including peritonitis and sepsis. Gram-negative bacteria including E. coli constitutively release nano-sized outer membrane vesicles (OMVs). Although E. coli OMVs can induce the inflammatory responses without live bacteria, the effect of E. coli OMVs in vivo on endothelial cell function has not been previously elucidated. In this study, we show that bacteria-free OMVs increased the expression of endothelial intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1, and enhanced the leukocyte binding on human microvascular endothelial cells in vitro. Inhibition of NF-κB and TLR4 reduced the expression of cell adhesion molecules in vitro. OMVs given intraperitoneally to the mice induced ICAM-1 expression and neutrophil sequestration in the lung endothelium, and the effects were reduced in ICAM-1-/- and TLR4-/- mice. When compared to free lipopolysaccharide, OMVs were more potent in inducing both ICAM-1 expression as well as leukocyte adhesion in vitro, and ICAM-1 expression and neutrophil sequestration in the lungs in vivo. This study shows that OMVs potently up-regulate functional cell adhesion molecules via NF-κB- and TLR4-dependent pathways, and that OMVs are more potent than free lipopolysaccharide.
Comparison of Measured and Dynamic Analysis Vertical Accelerations of High-Speed Railway Bridges Crossed by KTX Train  [PDF]
Hyejin Yoon, Won Jong Chin, Jeong-Rae Cho, Jae Yoon Kang, Jongwon Kwark
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.59091
Abstract:

Since high-speed railway bridges are subjected to cyclic loading by the continuous wheel loads traveling at high speed and regular spacing, their dynamic behavior is of extreme importance and has significant influence on the riding safety of the trains. To secure the riding safety of the trains, advanced railway countries have limited the vertical acceleration of the bridge slab below critical values at specific frequency domains. Since these limitations of the vertical acceleration constitute the most important factors in securing the dynamic safety of the bridges, these countries have opted for a conservative approach. However, the Korean specifications limit only the size of the peak acceleration without considering the frequency domain, which impede significantly rational evaluation of the high-speed railway bridges in Korea. In addition, the evaluation of the acceleration without consideration of the frequency domain is the cause of disagreement between the dynamic analysis and measurement results. This study conducts field monitoring and dynamic analysis on high-speed railway bridges to gather the acceleration signals and compare them. Significant difference in the size of the vertical acceleration was observed between the measured and dynamic analysis accelerations when discarding the frequency domain as done in the current specifications. The comparison of the accelerations considering only low frequencies below 30 Hz showed that the dynamic analysis reflected accurately the measured vertical acceleration.

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