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Search Results: 1 - 10 of 469924 matches for " Jeong-A Park "
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ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function
Sanghoon Kwon, Dongbum Kim, Jae Rhee, Jeong-A Park, Dae-Won Kim, Doo-Sik Kim, Younghee Lee, Hyung-Joo Kwon
BMC Biology , 2010, DOI: 10.1186/1741-7007-8-23
Abstract: We found that a variant of ASB9 that lacks the SOCS box (ASB9ΔSOCS) was naturally detected in human cell lines but not in peripheral blood mononuclear cells or normal hepatocytes. We also identified ubiquitous mitochondrial creatine kinase (uMtCK) as a new target of ASB9 in human embryonic kidney 293 (HEK293) cells. The ankyrin repeat domains of ASB9 can associate with the substrate binding site of uMtCK in a SOCS box-independent manner. The overexpression of ASB9, but not ASB9ΔSOCS, induces ubiquitination of uMtCK. ASB9 and ASB9ΔSOCS can interact and colocalise with uMtCK in the mitochondria. However, only expression of ASB9 induced abnormal mitochondrial structure and a decrease of mitochondrial membrane potential. Furthermore, the creatine kinase activities and cell growth were significantly reduced by ASB9 but not by ASB9ΔSOCS.ASB9 interacts with the creatine kinase system and negatively regulates cell growth. The differential expression and function of ASB9 and ASB9ΔSOCS may be a key factor in the growth of human cell lines and primary cells.The largest family of suppressor of cytokine signalling (SOCS) box-containing superfamily proteins are the ankyrin repeat and SOCS box proteins (Asbs; ASBs in humans). Although 18 members of the Asb family have been identified in mice and humans, the function of Asbs has not been clearly defined. The Asbs have two functional domains, a SOCS box and a variable number of N-terminal ankyrin (ANK) repeats [1]. The SOCS box of Asb proteins has two subdomains: a BC box and a Cul2/Cul5 box. Highly conserved amino acid sequences of the BC box and the Cul5 box, which are essential for ensuring that the interaction with elongins B/C and Cullin 5-Rbx2 forms E3 ubiquitin (Ub) ligase complexes, are important in a ubiquitination-mediated proteolysis pathway [2-6]. While SOCS family members use the SH2 domain to recruit substrates, the ANK repeat regions of Asb family members serve as specific protein-protein interaction platforms to recr
Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4
Bokyung Son, Jiae Yun, Jeong-A Lim, Hakdong Shin, Sunggi Heu, Sangryeol Ryu
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-33
Abstract: The endolysin from B. cereus phage B4, designated LysB4, was identified and characterized. In silico analysis revealed that this endolysin had the VanY domain at the N terminus as the catalytic domain, and the SH3_5 domain at the C terminus that appears to be the cell wall binding domain. Biochemical characterization of LysB4 enzymatic activity showed that it had optimal peptidoglycan hydrolase activity at pH 8.0-10.0 and 50°C. The lytic activity was dependent on divalent metal ions, especially Zn2+. The antimicrobial spectrum was relatively broad because LysB4 lysed Gram-positive bacteria such as B. cereus, Bacillus subtilis and Listeria monocytogenes and some Gram-negative bacteria when treated with EDTA. LC-MS analysis of the cell wall cleavage products showed that LysB4 was an L-alanoyl-D-glutamate endopeptidase, making LysB4 the first characterized endopeptidase of this type to target B. cereus.LysB4 is believed to be the first reported L-alanoyl-D-glutamate endopeptidase from B. cereus-infecting bacteriophages. The properties of LysB4 showed that this endolysin has strong lytic activity against a broad range of pathogenic bacteria, which makes LysB4 a good candidate as a biocontrol agent against B. cereus and other pathogenic bacteria.Bacillus cereus is a Gram-positive, spore-forming, rod-shape bacterium that grows well in aerobic and anaerobic environments [1]. It causes food poisoning by producing two different types of toxins: an emetic toxin and a diarrheal toxin [2]. Although the symptoms caused by B. cereus food poisoning are relatively mild, the incidence of the disease is gradually increasing, and it can develop into severe disease [3]. In addition, B. cereus can survive at a wide temperature range and form spores in harsh environments, especially during food processing; therefore, measures to control B. cereus effectively in the food industry are necessary [4,5].Recently, endolysins have been explored as promising antibacterial agents. Endolysins are
Impact of de-escalation therapy on clinical outcomes for intensive care unit-acquired pneumonia
Mi Kyong Joung, Jeong-a Lee, Soo-youn Moon, Hae Cheong, Eun-Jeong Joo, Young-Eun Ha, Kyung Sohn, Seung Chung, Gee Suh, Doo Chung, Jae-Hoon Song, Kyong Peck
Critical Care , 2011, DOI: 10.1186/cc10072
Abstract: This was a retrospective observational cohort study of ICU patients who developed pneumonia more than 48 hours after admission to the ICU at Samsung Medical Center from September 2004 to December 2007.The 137 patients comprised 44 (32.1%) who received de-escalation therapy and 93 in the non-de-escalation group. The de-escalation group showed a lower pneumonia-related mortality rate than the non-de-escalation group by day 14 (2.3% vs. 10.8%, respectively; P = 0.08) and by day 30 (2.3% vs. 14%, respectively; P = 0.03) after the diagnosis of pneumonia. The variables independently associated with ICU-acquired pneumonia-related mortality included the Acute Physiology and Chronic Health Evaluation II (APACHE II) score and the modified Clinical Pulmonary Infection Score (CPIS) after 5 days with pneumonia. The non-de-escalation group had significantly higher APACHE II score and modified CPIS after 5 days with ICU-acquired pneumonia compared to the de-escalation group. Among all patients, 20.4% (28 of 137) had negative cultures for pathogens, and 42.9% (12 of 28) received de-escalation therapy. The latter 12 patients received de-escalation therapy and survived 30 days after the diagnosis of pneumonia.Patients in the de-escalation group showed a significantly lower mortality rate compared to patients in the non-de-escalation group. De-escalation therapy can be safely provided to patients with ICU-acquired pneumonia if they are clinically stable by day 5, even in those whose respiratory specimen cultures yield no specific pathogens.Nosocomial pneumonia accounts for almost one-half of all intensive care unit (ICU) mortality and approximately 60% of mortality due to all nosocomial infections. The initial choice of antimicrobial therapy is critical to the clinical outcome of patients with nosocomial pneumonia. Early and aggressive empirical therapy with broad-spectrum agents targeted at the likely pathogens has been associated with a reduction in the ventilator-associated pneumon
Anti-Tumoral Effect of the Mitochondrial Target Domain of Noxa Delivered by an Engineered Salmonella typhimurium
Jae-Ho Jeong, Kwangsoo Kim, Daejin Lim, Kwangjoon Jeong, Yeongjin Hong, Vu H. Nguyen, Tae-Hyoung Kim, Sangryeol Ryu, Jeong-A Lim, Jae Il Kim, Geun-Joong Kim, Sun Chang Kim, Jung-Joon Min, Hyon E. Choy
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0080050
Abstract: Bacterial cancer therapy relies on the fact that several bacterial species are capable of targeting tumor tissue and that bacteria can be genetically engineered to selectively deliver therapeutic proteins of interest to the targeted tumors. However, the challenge of bacterial cancer therapy is the release of the therapeutic proteins from the bacteria and entry of the proteins into tumor cells. This study employed an attenuated Salmonella typhimurium to selectively deliver the mitochondrial targeting domain of Noxa (MTD) as a potential therapeutic cargo protein, and examined its anti-cancer effect. To release MTD from the bacteria, a novel bacterial lysis system of phage origin was deployed. To facilitate the entry of MTD into the tumor cells, the MTD was fused to DS4.3, a novel cell-penetrating peptide (CPP) derived from a voltage-gated potassium channel (Kv2.1). The gene encoding DS4.3-MTD and the phage lysis genes were placed under the control of PBAD, a promoter activated by L-arabinose. We demonstrated that DS4.3-MTD chimeric molecules expressed by the Salmonellae were anti-tumoral in cultured tumor cells and in mice with CT26 colon carcinoma.
Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; Consortium for Improving Survival of Lymphoma (CISL) study
Ho-Young Yhim, Hye Kang, Yoon Choi, Seok Kim, Won Kim, Yee Chae, Jin Kim, Chul Choi, Sung Oh, Hyeon Eom, Jeong-A Kim, Jae Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Sung, Hyo Kim, Dae Lee, Cheolwon Suh, Jae-Yong Kwak
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-321
Abstract: We retrospectively analyzed data from 68 patients, newly diagnosed with DLBCL and breast involvement at 16 Korean institutions between January 1994 and June 2009.Median age at diagnosis was 48 years (range, 20-83 years). Forty-three (63.2%) patients were PBL according to previous arbitrary criteria, sixteen (23.5%) patients were high-intermediate to high risk of international prognostic index. The patients with one extranodal disease in the breast (OED) with or without nodal disease were 49 (72.1%), and those with multiple extranodal disease (MED) were 19 (27.9%). During median follow-up of 41.5 months (range, 2.4-186.0 months), estimated 5-year progression-free survival (PFS) was 53.7 ± 7.6%, and overall survival (OS) was 60.3 ± 7.2%. The 5-year PFS and OS was significantly higher for patients with the OED group than those with the MED group (5-year PFS, 64.9 ± 8.9% vs. 27.5 ± 11.4%, p = 0.001; 5-year OS, 74.3 ± 7.6% vs. 24.5 ± 13.0%, p < 0.001). In multivariate analysis, MED (hazard ratio [HR], 3.61; 95% confidence interval [CI], 1.07-12.2) and fewer than four cycles of systemic chemotherapy with or without local treatments (HR, 4.47; 95% CI, 1.54-12.96) were independent prognostic factors for worse OS. Twenty-five (36.8%) patients experienced progression, and the cumulative incidence of progression in multiple extranodal sites or other than breasts and central nervous system was significantly different between the OED group and the MED group (5-year cumulative incidence, 9.7 ± 5.4% vs. 49.0 ± 15.1%, p = 0.001).Our results show that the patients included in OED group, reflecting different treatment outcome, prognosis and pattern of progression, should be considered as PBL in the future trial. Further studies are warranted to validate our suggested criteria.Approximately one-third of non-Hodgkin lymphoma (NHL) arises primarily from sites other than lymph nodes; for this reason, they are usually named as primary extranodal lymphoma [1]. The definition of primary ext
Topological entropy and AF subalgebras of graph C*-algebras
Ja A Jeong,Gi Hyun Park
Mathematics , 2004,
Abstract: Let A_E be the canonical AF subalgebra of a graph C*-algebra C*(E) associated with a locally finite directed graph E. For Brown-Voiculescu's topological entropy ht(\Phi_E) of the canonical completely positive map \Phi_E on C*(E), ht(\Phi_E)=ht(\Phi_E|_{A_E})=h_l(E)=h_b(E) is known to hold for a finite graph E, where h_l(E) is the loop entropy of Gurevic and h_b(E) is the block entropy of Salama. For an irreducible infinite graph E, the inequality h_l(E)\leq ht(\Phi_E|_{A_E}) has been known recently. It is shown in this paper that ht(\Phi_E|_{A_E})\leq max{h_b(E), h_b(tE)}, where tE is the graph E with the direction of the edges reversed. Some irreducible infinite graphs E_p(p>1) with ht(\Phi_E|_{A_{E_p}})=log p are also examined.
Saturated actions by finite dimensional Hopf *-algebras on C*-algebras
J. A. Jeong,G. H. Park
Mathematics , 2007,
Abstract: If a finite group action $\alpha$ on a unital $C^*$-algebra $M$ is saturated, the canonical conditional expectation $E:M\to M^\alpha$ onto the fixed point algebra is known to be of index finite type with $Index(E)=|G|$ in the sense of Watatani. More generally if a finite dimensional Hopf $*$-algebra $A$ acts on $M$ and the action is saturated, the same is true with $Index (E)=\dim(A)$. In this paper we prove that the converse is true. Especially in case $M$ is a commutative $C^*$-algebra $C(X)$ and $\alpha$ is a finite group action, we give an equivalent condition in order that the expectation $E:C(X)\to C(X)^\alpha$ is of index finite type, from which we obtain that $\alpha$ is saturated if and only if $G$ acts freely on $X$. Actions by compact groups are also considered to show that the gauge action $\gamma$ on a graph $C^*$-algebra $C^*(E)$ associated with a locally finite directed graph $E$ is saturated.
Dynamics of ripple formation in sputter erosion: nonlinear phenomena
S. Park,B. Kahng,H. Jeong,A. -L. Barabasi
Physics , 1999, DOI: 10.1103/PhysRevLett.83.3486
Abstract: Many morphological features of sputter eroded surfaces are determined by the balance between ion induced linear instability and surface diffusion. However, the impact of the nonlinear terms on the morphology is less understood. We demonstrate that while at short times ripple formation is described by the linear theory, after a characteristic time the nonlinear terms determine the surface morphology by either destroying the ripples, or generating a new rotated ripple structure. We show that the morphological transitions induced by the nonlinear effects can be detected by monitoring the surface width and the erosion velocity.
The structure of gauge-invariant ideals of labelled graph $C^*$-algebras
Ja A Jeong,Sun Ho Kim,Gi Hyun Park
Mathematics , 2011,
Abstract: In this paper, we consider the gauge-invariant ideal structure of a $C^*$-algebra $C^*(E,\mathcal{L},\mathcal{B})$ associated to a set-finite, receiver set-finite and weakly left-resolving labelled space $(E,\mathcal{L},\mathcal{B})$, where $\mathcal{L}$ is a labelling map assigning an alphabet to each edge of the directed graph $E$ with no sinks. Under the assumption that an accommodating set $\mathcal{B}$ is closed under taking relative complement, it is obtained that there is a one to one correspondence between the set of all hereditary saturated subsets of $\mathcal{B}$ and the gauge-invariant ideals of $C^*(E,\mathcal{L},\mathcal{B})$. For this, we introduce a quotient labelled space $(E,\mathcal{L},[\mathcal{B}]_R)$ arising from an equivalence relation $\sim_R$ on $\mathcal{B}$ and show the existence of the $C^*$-algebra $C^*(E,\mathcal{L},[\mathcal{B}]_R)$ generated by a universal representation of $(E,\mathcal{L},[\mathcal{B}]_R)$. Also the gauge-invariant uniqueness theorem for $C^*(E,\mathcal{L},[\mathcal{B}]_R)$ is obtained. For simple labelled graph $C^*$-algebras $C^*(E,\mathcal{L},\bar{\mathcal{E}})$, where $\bar{\mathcal{E}}$ is the smallest accommodating set containing all the generalized vertices, it is observed that if for each vertex $v$ of $E$, a generalized vertex $[v]_l$ is finite for some $l$, then $C^*(E,\mathcal{L},\bar{\mathcal{E}})$ is simple if and only if $(E,\mathcal{L},\bar{\mathcal{E}})$ is strongly cofinal and disagreeable. This is done by examining the merged labelled graph $(F,\mathcal{L}_F)$ of $(E,\mathcal{L})$ and the common properties that $C^*(E,\mathcal{L},\bar{\mathcal{E}})$ and $C^*(F,\mathcal{L},\bar{\mathcal{F}})$ share.
Spontaneous Spinal Subdural Hematoma Developed After Weightlifting: A case Report and Review of Literature  [PDF]
JiEun Park, SooMi Lim, Jeong Hyun Yoo
Open Journal of Clinical Diagnostics (OJCD) , 2011, DOI: 10.4236/ojcd.2011.12002
Abstract: Spontaneous spinal subdural hematoma is a rare disease. Several predisposing factors are reported including impaired clotting due to therapeutic anti-coagulation or hematologic disorder, vascular anom-aly, intraspinal tumor, and iatrogenic causes such as lumbar puncture or spinal anesthesia.We report a rare case of spontaneous spinal subdural hematoma developed after weightlifting in a healthy young man treated with conservative treatment.
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