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Search Results: 1 - 10 of 3633 matches for " Jens Nee "
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Serial measurement of neuron specific enolase improves prognostication in cardiac arrest patients treated with hypothermia: A prospective study
Christian Storm, Jens Nee, Achim J?rres, Christoph Leithner, Dietrich Hasper, Christoph J Ploner
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-6
Abstract: In a prospective study of 35 patients resuscitated from cardiac arrest, NSE was measured daily for four days following admission. Outcome was assessed at ICU discharge using the CPC score. All patients received hypothermia treatment for 24 hours at 33°C with a surface cooling device according to current guidelines.The cutoff for absolute NSE levels in patients with unfavourable outcome (CPC 3-5) 72 hours after cardiac arrest was 57 μg/l with an area under the curve (AUC) of 0.82 (sensitivity 47%, specificity 100%). The cutoff level for NSE kinetics in patients with unfavourable outcome (CPC 3-5) was an absolute increase of 7.9 μg/l (AUC 0.78, sensitivity 63%, specificity 100%) and a relative increase of 33.1% (AUC 0.803, sensitivity 67%, specificity 100%) at 48 hours compared to admission.In cardiac arrest patients treated with hypothermia, prognostication of unfavourable outcome by NSE kinetics between admission and 48 hours after resuscitation may be superior to prognostication by absolute NSE levels.The recommended examinations proposed by the American Academy of Neurology (AAN) for prognostication in patients after cardiac arrest have mainly been evaluated in the era prior to hypothermia [1]. However, recent studies indicate that mild therapeutic hypothermia modifies the prognostic significance of clinical findings, NSE levels, and electrophysiological testing in patients resuscitated from cardiac arrest [2-6]. This has generated the necessity to re-evaluate all prognostic markers in patients treated with hypothermia. In particular, NSE cutoff levels and their temporal dynamics have only rarely been investigated in these patients so far. In this study, we prospectively investigated serum NSE levels and NSE kinetics in 35 cardiac arrest patients treated with hypothermia.The study protocol was approved by the local ethics committee on human research and was conducted in accordance with the guidelines of the Declaration of Helsinki. Written informed consent to the
2-year survival of patients undergoing mild hypothermia treatment after ventricular fibrillation cardiac arrest is significantly improved compared to historical controls
Christian Storm, Jens Nee, Anne Krueger, Joerg C Schefold, Dietrich Hasper
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2010, DOI: 10.1186/1757-7241-18-2
Abstract: Clinical and outcome data of 107 consecutive patients undergoing therapeutic hypothermia after cardiac arrest due to VF were compared with 98 historical controls. Neurological outcome was assessed at ICU discharge according to the Pittsburgh cerebral performance category (CPC). A Kaplan-Meier analysis of follow-up data concerning mortality after 24 months as well as a Cox-regression to adjust for confounders were calculated.Neurological outcome significantly improved after mild hypothermia treatment (hypothermia group CPC 1-2 59.8%, control group CPC 1-2 24.5%; p < 0.01). In Kaplan-Meier survival analysis hypothermia treatment was also associated with significantly improved 2-year probability for survival (hypothermia 55% vs. control 34%; p = 0.029). Cox-regression analysis revealed hypothermia treatment (p = 0.031) and age (p = 0.013) as independent predictors of 24-month survival.Our study demonstrates that the early survival benefit seen with therapeutic hypothermia persists after two years. This strongly supports adherence to current recommendations regarding postresuscitation care for all patients after cardiac arrest due to VF and maybe other rhythms as well.Patients surviving cardiac arrest still have a poor prognosis with regard to both mortality and neurological outcome. Current guidelines recommend mild hypothermia treatment after cardiac arrest due to ventricular fibrillation (VF) as well as for other initial rhythms[1,2]. These recommendations are based on published data demonstrating a significantly improved outcome with therapeutic hypothermia, especially after VF cardiac arrest. In these studies follow-up time ranged between 3 and 6 months[3,4].Recent studies show that neurological performance does not change markedly from the time of ICU discharge to six months after cardiac arrest in the majority of patients [5]. In a few patients functional outcomes improved over time, while deterioration was rarely seen [6]. Mortality of course is also an importan
Extinction, Slime, and Bottoms
Sean Nee
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0020272
Almost periodic solutions to systems of parabolic equations
Janpou Nee
International Journal of Stochastic Analysis , 1994, DOI: 10.1155/s1048953394000456
Abstract: In this paper we show that the second-order differential solution is 2-almost periodic, provided it is 2-bounded, and the growth of the components of a non-linear function of a system of parabolic equation is bounded by any pair of con-secutive eigenvalues of the associated Dirichlet boundary value problems.
Extinction, Slime, and Bottoms
Sean Nee
PLOS Biology , 2004, DOI: 10.1371/journal.pbio.0020272
The peak of the solution of elliptic equations
Janpou Nee
Mathematics , 2015,
Abstract: The location of critical points corresponding to both Dirichlet and Neumann boundary condition are concerned. A counter example of inheritance of convexity of domain is given, then using Pohozeav identity locally, the location of critical points of Neumann boundary value problem and the uniqueness of local extrema of Dirichlet boundary value problem are studied.
生物多样性 , 2002,
Abstract: ?:了解外来入侵物种(alieninvasivespecies,ais)的生物学涉及纯生物学及应用生物学的问题。但是靠预先设计的实验来加深人们的了解显然是不可能的。然而我们可以研究现有的入侵,这也是一个很好的途径。本文利用新西兰历史上的一些记录,探讨了物种在新环境中成功定居的因素。令人惊奇的是,物种间的生物学差异对成功的定居几乎没有什么作用,相反,真正起作用的是一个物种被引入新环境的频率及数量。
Correlates of invasion success:evidence from New Zealand

Sean Nee,

生物多样性 , 2002,
Abstract: Understanding the biology of alien invasive species (AIS) is a problem for pure, as well as applied biology. However, it is obviously not possible to conduct designed experiments to further our understanding. We can, however, study actual invasions; the next best thing. We used historical data from New Zealand to explore the correlates of successful establishment of species in a new environment. Surprisingly, biological differences between species explained little of the variation in establishment success. Instead, what matters is how often, and in what numbers, a species is introduced into the new environment.
Mild therapeutic hypothermia alters neuron specific enolase as an outcome predictor after resuscitation: 97 prospective hypothermia patients compared to 133 historical non-hypothermia patients
Ingo G Steffen, Dietrich Hasper, Christoph J Ploner, Joerg C Schefold, Ekkehart Dietz, Frank Martens, Jens Nee, Anne Krueger, Achim J?rres, Christian Storm
Critical Care , 2010, DOI: 10.1186/cc8975
Abstract: In this prospective observational cohort study the data of patients after cardiac arrest receiving MTH (n = 97) were consecutively collected and compared with a retrospective non-hypothermia (NH) group (n = 133). Serum NSE was measured 72 hours after admission to ICU. Neurological outcome was classified according to the Pittsburgh cerebral performance category (CPC 1 to 5) at ICU discharge.NSE serum levels were significantly lower under MTH compared to NH in univariate analysis. However, in a linear regression model NSE was affected significantly by time to return of spontaneous circulation (ROSC) and ventricular fibrillation rhythm but not by MTH. The model for neurological outcome identified NSE, NSE*MTH (interaction) as well as time to ROSC as significant predictors. Receiver Operating Characteristic (ROC) analysis revealed a higher cutoff value for unfavourable outcome (CPC 3 to 5) with a specificity of 100% in the hypothermia group (78.9 μg/l) compared to the NH group (26.9 μg/l).Recommended cutoff levels for NSE 72 hours after ROSC do not reliably predict poor neurological outcome in cardiac arrest patients treated with MTH. Prospective multicentre trials are required to re-evaluate NSE cutoff values for the prediction of neurological outcome in patients treated with MTH.Early prediction of neurological outcome in patients surviving cardiac arrest is a challenging problem. A combined approach using clinical assessment, electrophysiological studies and biochemical markers has been proven reliable in predicting poor outcome and is currently used in most centres [1-3].Neuron specific enolase (NSE) is a gamma isomer of enolase that is located in neurons and neuroectodermal cells. Several studies have evaluated the significance of NSE to predict neurological outcome in patients after cardiac arrest. However, the results are not unanimous regarding outcome prediction and the best cutoff value for NSE [3-5]. Most authors agree that the NSE serum level after 72 hours
Melothria domingensis (Cucurbitaceae), an endangered Caribbean endemic, is a Cayaponia
Hanno Schaefer,Michael Nee
PhytoKeys , 2012, DOI: 10.3897/phytokeys.18.3914
Abstract: The Neotropical genus Melothria (Benincaseae, Cucurbitaceae) is a small group of yellow- or white-flowered climbers with small to medium-sized fruits. In 1899, Alfred Cogniaux described a species from montane rainforest in Haiti as Melothria domingensis, presumably based on the overall similarity in habit, leaf shape, and fruit morphology of his incomplete herbarium material to other Central American Melothria species. Melothria domingensis is still rare in European and American herbaria and the species has never been studied in detail. We here present molecular and morphological analyses, which show that the species is misplaced in Melothria and instead belongs in the distantly related tribe Cucurbiteae in the genus Cayaponia. We illustrate the species, provide the formal transfer and an extended description, and discuss the phylogenetic, biogeographic and ecological implications, including the finding that most likely bee- and not bat-pollination is ancestral in Cayaponia.
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