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Search Results: 1 - 10 of 3571 matches for " Jens Kordelle "
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Collagen Metabolism of Human Osteoarthritic Articular Cartilage as Modulated by Bovine Collagen Hydrolysates
Saskia Schadow, Hans-Christian Siebert, Günter Lochnit, Jens Kordelle, Markus Rickert, Jürgen Steinmeyer
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053955
Abstract: Destruction of articular cartilage is a characteristic feature of osteoarthritis (OA). Collagen hydrolysates are mixtures of collagen peptides and have gained huge public attention as nutriceuticals used for prophylaxis of OA. Here, we evaluated for the first time whether different bovine collagen hydrolysate preparations indeed modulate the metabolism of collagen and proteoglycans from human OA cartilage explants and determined the chemical composition of oligopeptides representing collagen fragments. Using biophysical techniques, like MALDI-TOF-MS, AFM, and NMR, the molecular weight distribution and aggregation behavior of collagen hydrolysates from bovine origin (CH-Alpha?, Peptan? B 5000, Peptan? B 2000) were determined. To investigate the metabolism of human femoral OA cartilage, explants were obtained during knee replacement surgery. Collagen synthesis of explants as modulated by 0–10 mg/ml collagen hydrolysates was determined using a novel dual radiolabeling procedure. Proteoglycans, NO, PGE2, MMP-1, -3, -13, TIMP-1, collagen type II, and cell viability were determined in explant cultures. Groups of data were analyzed using ANOVA and the Friedman test (n = 5–12). The significance was set to p≤0.05. We found that collagen hydrolysates obtained from different sources varied with respect to the width of molecular weight distribution, average molecular weight, and aggregation behavior. None of the collagen hydrolysates tested stimulated the biosynthesis of collagen. Peptan? B 5000 elevated NO and PGE2 levels significantly but had no effect on collagen or proteoglycan loss. All collagen hydrolysates tested proved not to be cytotoxic. Together, our data demonstrate for the first time that various collagen hydrolysates differ with respect to their chemical composition of collagen fragments as well as by their pharmacological efficacy on human chondrocytes. Our study underscores the importance that each collagen hydrolysate preparation should first demonstrate its pharmacological potential both in vitro and in vivo before being used for both regenerative medicine and prophylaxis of OA.
Double Quantum Entanglement to Understand Superconductivity  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2013, DOI: 10.4236/wjcmp.2013.34032
Abstract:

The feature of quantum entanglement in doublet and multiplet systems is briefly described and used to create a new model for the superconducting phase.

Superconductivity  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2014, DOI: 10.4236/wjcmp.2014.44026
Abstract: The feature of quantum entanglement is used to create a new model for the superconducting state.
Entanglement: A Modern Aspect of Nature  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2015, DOI: 10.4236/wjcmp.2015.53025
Abstract: The intention of this paper is to provide an easy to understand introduction to the peculiarities of entangled systems. A novel description for strong (mass entanglement) and weak (spin-or-bital and thermal entanglement) quantum entangled particles is discussed and applied to the phenomena of superconductivity, superfluidity and ultracold gases. A brief statement about how to represent the physical reality of quantum-entanglement as Quantum-Field-Theory (QFT) is noted.
Microstrip Ultra-Wideband Filter with Flexible Notch Characteristics  [PDF]
Marjan Mokhtaari, Jens Bornemann
Wireless Engineering and Technology (WET) , 2012, DOI: 10.4236/wet.2012.31002
Abstract: A microstrip ultra-wideband (UWB) filter with unique shape, compactness, simplicity of operation and flexible notch characteristics is introduced. It is based on the fundamental and harmonic characteristics of a 50 Ohm transmission line that is grounded at both ends. The filter possesses design flexibility in the sense that it can operate as a stand-alone UWB component or include simple additional circuitry to create one or two notches within the ultra-wideband frequency range. The basic design principles are highlighted and verified using the results of two commercially available field solver packages. Individual filter structures with single and double notches are validated through measurements of a number of filter prototypes.
Broadband Feed for Low Cross-Polarization Uniplanar Tapered Slot Antennas on Low-Permittivity Substrate  [PDF]
Jan Schorer, Jens Bornemann
Wireless Engineering and Technology (WET) , 2013, DOI: 10.4236/wet.2013.41003
Abstract:

A broadband feeding technique for the uniplanar tapered slot antenna (TSA) is presented. The TSA operates at a center frequency of 6.5 GHz with a 7 GHz bandwidth (107 percent). The antenna and feed are realized with a broadband microstrip-to-slotline transition on a low permittivity high frequency substrate, Rogers RT/Duroid 5880. The input impedance of the system is designed for 50 Ω compatibility with other system components, and the cross polarization is kept below 30 dB. The developed TSA system was simulated with commercially available electromagnetic software and manufactured. Measured results validate the design process and the antenna’s performance.

Use of Mineral Liberation Analysis (MLA) in the Characterization of Lithium-Bearing Micas  [PDF]
Dirk Sandmann, Jens Gutzmer
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2013, DOI: 10.4236/jmmce.2013.16043
Abstract: The capabilities and opportunities of the application of automated mineralogy for the characterization of lithium-bearing zinnwaldite-micas are critically assessed. Samples of a crushed greisen-type ore comprising mostly of quartz, topaz and zinnwaldite (Li-rich mica) were exposed to further comminution by cone crusher and high voltage pulse power fragmentation. Product properties were analyzed by using a Mineral Liberation Analyser (MLA) and the obtained mineralogical and mineral processing relevant parameters were carefully evaluated with special focus on the characteristics of zinnwaldite. The results illustrate that both samples contain a significant quantity of very fine particles that are products of comminution. The modal mineralogy in the different sieve fractions is characterized by the accumulation of minerals of low hardness in the finest fraction and the enrichment of topaz, having a high hardness, in the somewhat larger fractions. Based on the results of mineral association data for zinnwaldite, a displacement of the muscovite-quartz ratio, in comparison to the results of modal mineralogy, was observed by indicating good quartz-zinnwaldite boundary breakage and weak muscovite-zinnwaldite breakage. Liberation as well as mineral grade recovery curves indicate that fraction 1000 to +500 μm is most suitable for beneficiation. The results of this study demonstrate that SEM-based image analysis, such as MLA, can effectively be used to investigate and evaluate phyllosilicate minerals in a fast and precise way. It is shown that the results of MLA investigations, such as modal mineralogy, are in good agreement with other analytical methods such as quantitative X-ray powder diffraction.
Outcome of Early Neurological Rehabilitation Patients Colonized with Extended-Spectrum Beta-Lactamase (ESBL) Producing Bacteria  [PDF]
Jens D. Rollnik
Open Journal of Therapy and Rehabilitation (OJTR) , 2015, DOI: 10.4236/ojtr.2015.31001
Abstract: Colonization with multidrug-resistant germs, in particular methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum betalactamase producing bacteria (ESBL), is an emerging threat in early neurological rehabilitation. This study examined whether colonization with ESBL bacteria had deteriorating effects on neurological rehabilitation patients because of contact precautions (CP). Medical records have been carefully reviewed with respect to colonization with ESBL, outcome variables (functional independence), morbidity, and length of stay (LOS). 148/643 (23.0%) patients were ESBL positive on admission. ESBL carriers had a significantly longer LOS in early neurological rehabilitation (67.5 (42.0) vs. 25.8 (24.5), p < 0.001), worse functional status on admission (Barthel Index (BI) 13.0 (5.8) vs. 25.6 (24.1), p < 0.001), worse Glasgow Coma Scale (9.7 (3.8) vs. 12.0 (3.3), p < 0.001), worse Coma Remission Scale (9.5 (6.4) vs. 14.0 (6.8), p = 0.001), more codiagnoses (18.8 (5.1) vs. 13.3 (5.5), p < 0.001), and higher Patient Clinical Complexity Levels (PCCL). The outcome was significantly worse among ESBL positive patients (BI 28.2 (21.7) vs. 47.4 (31.0), p < 0.001; Early Rehabilitation Index -43.0 (51.7) vs. -26.0 (35.4), p < 0.001). ESBL patients had the same amount of therapy per day (136.2 (20.2) vs. 140.2 (18.7) min/day, n.s.), but the overall sum was significantly larger in the ESBL group due to longer LOS (p < 0.001). Mortality of both groups was comparable (3.8% vs. 4.1%). 54.3% of ESBL negative patients were discharged to home, but only 34.5% of ESBL colonized. 48% of ESBL positive patients were discharged to a nursing home, but only 25.1% of the ESBL free patients. Functional recovery of ESBL carriers undergoing neurological early rehabilitation is worse than that of patients without multidrug-resistant germs. Poorer outcome is not resulting from less therapy due to CP, but from functional status and higher morbidity on admission.
The Bistability Theorem in a Model of Metastatic Cancer  [PDF]
Jens Christian Larsen
Applied Mathematics (AM) , 2016, DOI: 10.4236/am.2016.710105
Abstract: The main theorem of the present paper is the bistability theorem for a four dimensional cancer model, in the variables?\"\"?representing primary cancer C, metastatic cancer \"\"?, growth factor GF and growth inhibitor GI, respectively. It says that for some values of the para- meters this system is bistable, in the sense that there are exactly two positive singular points of this vector field. And one is stable and the other unstable. We also find an expression for?\"\" for the discrete model T of the introduction, with variables \"\" , where C is cancer, are growth factors and growth inhibitors respectively. We find an affine vector field Y whose time one map is T2 and then compute \"\"?, where \"\"?is an integral curve of Y through \"\"?. We also find a formula for the first escape time for the vector field associated to T, see section four.
A Study on Multipeutics  [PDF]
Jens Christian Larsen
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.85059
Abstract: Multipeutics is the simultaneous application of m ≥ 4 cancer treatments. m = 4 is quadrapeutics, which was invented by researchers at Rice University, Northeastern University, MD Anderson Cancer Centre and China Medical University, see [1]. Multipeutics is our idea. From section 6 Summary, it follows that multipeutics can be more potent than quadrapeutics by comparing these two mathematical models. The first two treatments in quadrapeutics are systemically administered nano gold particles G and lysosomal chemo therapeutic drug D. They form mixed clusters M primarily in cancer cells and can be excited by a laser pulse, the third treatment, to form plasmonic nanobubbles N. These nanobubbles can kill the cancer cells by mechanical impact. If they do not the chemo therapeutic drug can be released into the cytoplasm, which might be lethal to the cancer cell. The fourth treatment is x rays X and the cancer cells have been sensitized to x rays by the treatment. We present an ODE (ordinary differential equations) model of quadrapeutics and of multipeutics, which is quadrapeutics and n ≥ 1 immune or chemo therapies. In the present paper we have found a polynomial p of degree at most 2(n + 3), such that a singular point (C, D, G, M, N, I1, …, In) will have p(M) = 0 Here I1, …, In are immune or chemo therapies. So this gives us candidates for singular points. Quadrapeutics is treated extensively. We find in theorem 3 a polynomium s of degree at most six in M such that a positive singular point (C, D, G, M, N) of the quadrapeutics system will have s(M) = 0. The main theorem of the present paper is the multipeutics theorem, saying that the more treatments we apply the lower the cancer burden, even if we take the doses of each treatment smaller. From the proof of this theorem, we can say, that quadrapeutics can outperform chemo radiation if the nanobubble kill rate k21 is sufficiently big. See also Figure 1 and Figure 2 and the text explaining them.
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