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Search Results: 1 - 10 of 99053 matches for " Jennifer Y. Wu "
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Anaphylaxis and Undiagnosed Aspirin Exacerbated Respiratory Disease in the Ambulatory Surgery Center: A Case Report  [PDF]
Jennifer Wu
Open Journal of Anesthesiology (OJAnes) , 2015, DOI: 10.4236/ojanes.2015.512043
Abstract: Severe bronchospasm and anaphylaxis are unanticipated emergencies that may occur in the ambulatory surgery setting. I present a case in which an asthmatic male with nasal congestion has anaphylaxis after induction, with severe bronchospasm as the primary manifestation. During the course of hospitalization, he was exposed to aspirin and a second episode of severe bronchospasm occurred. He was diagnosed with both anaphylaxis to an anesthetic medication and Aspirin Exacerbated Respiratory Disease, or Samter’s Triad.
Dietary n-3 Polyunsaturated Fatty Acids (PUFA) Decrease Obesity-Associated Th17 Cell-Mediated Inflammation during Colitis
Jennifer M. Monk, Tim Y. Hou, Harmony F. Turk, Brad Weeks, Chaodong Wu, David N. McMurray, Robert S. Chapkin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049739
Abstract: Clinical and experimental evidence suggests that obesity-associated inflammation increases disease activity during colitis, attributed in part to the effects of Th17 cells. Using a model of concurrent obesity and colitis, we monitored changes in critical immune cell subsets and inflammatory biomarker expression in three key tissues: visceral adipose tissue, colon (local inflammatory site) and spleen (systemic inflammatory site), and we hypothesized that n-3 PUFA would reduce the percentage of inflammatory immune cell subsets and suppress inflammatory gene expression, thereby improving the disease phenotype. Obesity was induced in C57BL/6 mice by feeding a high fat (HF) diet (59.2% kcal) alone or an isocaloric HF diet supplemented with fish oil (HF-FO) for 12 weeks. Colitis was induced via a 2.5% trinitrobenzene sulfonic acid (TNBS) enema. The HF-FO diet improved the obese phenotype by reducing i) serum hormone concentrations (leptin and resistin), ii) adipose tissue mRNA expression of inflammatory cytokines (MCP-1, IFNγ, IL-6, IL17F and IL-21) and iii) total (F4/80+ CD11b+) and inflammatory adipose tissue M1 (F4/80+ CD11c+) macrophage content compared to HF (P<0.05). In addition, the HF-FO diet reduced both colitis-associated disease severity and colonic mRNA expression of the Th17 cell master transcription factor (RORγτ) and critical cytokines (IL-6, IL-17A, IL-17F, IL-21, IL-23 and IFNγ) versus HF (P<0.05). Compared to HF, the percentage of both splenic Th17 and Th1 cells were reduced by the HF-FO group (P<0.05). Under ex vivo polarizing conditions, the percentage of HF-FO derived CD4+ T cells that reached Th17 cell effector status was suppressed (P = 0.05). Collectively, these results indicate that n-3 PUFA suppress Th1/Th17 cells and inflammatory macrophage subsets and reconfigure the inflammatory gene expression profile in diverse tissue sites in obese mice following the induction of colitis.
The incidence of experimental smoking in school children: an 8-year follow-up of the child and adolescent behaviors in long-term evolution (CABLE) study
Hsing-Yi Chang, Wen-Chi Wu, Chi-Chen Wu, Jennifer Y Cheng, Baai-Shyun Hurng, Lee-Lan Yen
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-844
Abstract: We used cohort data collected as part of the Child and Adolescent Behaviors in Long-term Evolution (CABLE) study, which selected nine elementary schools each from an urban area (Taipei City) and a rural area (Hsingchu county) in northern Taiwan. From 2002 to 2008, children were asked annually whether they had smoked in the previous year. An accelerated lifetime model with Weibull distribution was used to examine the factors associated with experimental smoking.In 2001, 2686 4th-graders participated in the study. For each year from 2002 to 2008, their incidences of trial smoking were 3.1%, 4.0%, 2.8%, 6.0%, 5.3%, 5.0% and 6.0%, respectively. There was an increase from 7th to 8th grade (6.0%). Children who were males, lived in rural areas, came from single-parent families, had parents who smoked, and had peers who smoked were more likely to try smoking earlier. The influence of parents and peers on experimental smoking demonstrated gradient effects.This study used a cohort to examine incidence and multiple influences, including individual factors, familial factors, and community factors, on experimental smoking in adolescents. The findings fit the social ecological model, highlighting the influences of family and friends. School and community attachment were associated with experimental smoking in teenagers.Smoking is one of the most popular forms of drug use and is a major risk factor for lung cancer and cardiovascular disease [1]. In a systematic review of 17 studies, smoking was found to be associated with peripheral arterial disease not only among current smokers but also among former smokers [2]. Due to its public accessibility, smoking has become one of the world's most prominent public health issues and is a leading cause of premature death worldwide [3,4]. A high prevalence of smoking has been observed in Chinese societies [5]. Several studies have established that most regular adult smokers become addicted to nicotine in their adolescent years [6-8]. Public h
Burnout: Drudgery, Repetition, Creativity  [PDF]
John Y. Wu, Kuangming Wu
Open Journal of Philosophy (OJPP) , 2016, DOI: 10.4236/ojpp.2016.62020
Abstract: Identical repetition composes drudgery that results in burnout. But besides identical, there can be repetition of daily routine, and also can be continuing creative novelty. We must dissolve burnout by turning identical repetition into regular routines of creative novelty. This essay is thus composed of three sections, drudgery, repetition, and creativity.
Hand-Washing Global  [PDF]
John Y. Wu
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.43044
Abstract:

By the practical nature of the case, here is no theoretical argument but pragmatic reasoning for washing hands, with scientific evidence of hand-washing flushing out diseases into a sanitary condition globally. All facts found show some people surviving long without hand-washing, not denying healthful hand-washing, spreading health. Hand-washing remains a medium simplest most efficacious for global health. Thus this essay delivers an important message of global health by routine hand-washing, in four sections. 1) It describes what is hand washing (Section 2). 2) How to wash hands is concretely specified (Section 3). 3) Exceptions are responded to (Section 4). 4) How pivotal such an easy practice of hand washing is to global health is elucidated, to clinch the whole crucial issue at stake worldwide (Section 5).

Everyone Vegetarian, World Enriching  [PDF]
John Y. Wu
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.42023
Abstract:

This essay advocates global vegetarian diet. Firstly, seven personal health benefits and four global benefits of vegetarian dinners are specified to enrich the entire globe, and then, secondly, I explore concretely how to overcome internal hurdle and external hurdle, so as to effectively propagate vegetarian dinners throughout the world. Everyone wins, including animals!

Statistics: Its Utility, Its Risks  [PDF]
John Y. Wu
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.44049
Abstract: Since natural science is our most precise and careful method of investigation of reality, based on our most precise thinking, mathematics, statistics as the mathematical point of contact with reality is the spearhead of scientific investigations-points of reality-contact-such as physics and engineering. This essay briefs technical calculations of statistics, as it focuses on the vast significance of statistics by One, citing two concrete examples to show its utilitarian power penetrating the concrete situations, and then Two, our cautions on its use, some quite serious.
Four-ball genus bounds and a refinement of the Ozsvath-Szabo tau-invariant
Jennifer Hom,Zhongtao Wu
Mathematics , 2014,
Abstract: Based on work of Rasmussen, we construct a concordance invariant associated to the knot Floer complex, and exhibit examples in which this invariant gives arbitrarily better bounds on the 4-ball genus than the Ozsvath-Szabo tau invariant.
Can public report cards affect consumer’s private learning of quality? An evaluation of the impact of Florida hospital report cards on acute myocardial infarction patient admission patterns  [PDF]
Vivian Y. Wu, Pai Liu
Health (Health) , 2013, DOI: 10.4236/health.2013.512297
Abstract:

The empirical literature on hospital report cards typically assumes that report card cannot interact with consumer’s private learning. This study examines the impact of the implementation of FL hospital quality reporting system in late 2004 on hospital admission patterns using a pre-post difference-in-difference design. The estimation model allows for the possibility that report-card learning may interact with non-report-card learning. The study sample is comprised of all patients admitted to any FL hospital between 2000 and 2008 with a principal diagnosis of acute myocardial infarction (AMI). We find that hospital admission patterns for AMI patients did not respond to report card information. However, we find evidence consistent with the possibility that the implementation of a report card system may stimulate consumers (either patients or physicians) to seek higher quality hospitals through private information channels.

 

Targeting insulin-like growth factor axis in hepatocellular carcinoma
Jennifer Wu, Andrew X Zhu
Journal of Hematology & Oncology , 2011, DOI: 10.1186/1756-8722-4-30
Abstract: Hepatocellular carcinoma (HCC) is the 5th most common neoplasm worldwide with more than 600,000 cases per year and the 3rd leading cause of cancer-related death [1,2]. For the past 3 decades, the incidence of HCC in the US has tripled, yet the 1 year survival rate of HCC remains less than 50% [3]. Currently sorafenib is the only medication that shows overall survival advantage compared to placebo in patients with advanced HCC [4,5]. However, the benefits with sorafenib are moderate and its toxicities can be challenging to manage. For patients who fail or cannot tolerate sorafenib, there are currently no standard treatments. Therefore, there is an urgent need to search for novel effective therapies in advanced HCC. Recently, the insulin-like growth factor (IGF) axis has emerged as an important pathway in the development and progression of HCC and as a potential therapeutic target.Here we review the complexity of IGF axis, the supporting preclinical and clinical data highlighting the significance of this pathway in HCC, and the early clinical trials of targeting this axis in advanced HCC.The insulin-like growth factor (IGF) pathway has highly conserved function in mammals and plays a critical role in energy metabolism and cell renewal in response to nutrients [6-11]. IGF pathway is not only involved in cell growth in tissue culture [12,13], but it also promotes cell proliferation, migration and transformation into malignant clone [12,14]. The IGF-1 pathway revolves around 4 essential components.The first component contains the IGF ligands, which include both insulin-like growth factor 1 (IGF-1) and IGF-2. Their names are based on the observation that both IGF-1 and IGF-2 are peptides, similar to insulin, and they share 40% homology with proinsulin [15,16]. They are, however, slightly different from insulin structurally by containing an additional domain, which could account for their dramatically different role in neoplasms in comparison with insulin [16].The IGF liga
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