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Search Results: 1 - 10 of 466183 matches for " Jennifer A. Eden "
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Optimal Design of a Multibody Self-Referencing Attenuator  [PDF]
Dongmei Zhou, Jennifer A. Eden
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.39005
Abstract: The purpose of this paper is to determine the optimal size and number of tubes for a generic attenuator that is similar to Pelamis P2, the wave energy converter. Simulations using ANSYS Workbench, Design Modeler, and AQWA are performed to study the energy absorption at the nodes between the tubes. The analysis is limited to linearized hydrodynamic fluid waves loading on floating bodies by employing three-dimensional radiation/diffraction theory in regular waves in the frequency domain. Three sets of tests are conducted by varying total tube number, each tube length and the order of tubes with different lengths. After a systematic study in the frequency domain, the optimal size and number of the genetic attenuator is recommended.
Cohesinopathies of a Feather Flock Together
Robert V. Skibbens ,Jennifer M. Colquhoun,Megan J. Green,Cody A. Molnar,Danielle N. Sin,Brian J. Sullivan,Eden E. Tanzosh
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1004036
Abstract: Roberts Syndrome (RBS) and Cornelia de Lange Syndrome (CdLS) are severe developmental maladies that present with nearly an identical suite of multi-spectrum birth defects. Not surprisingly, RBS and CdLS arise from mutations within a single pathway—here involving cohesion. Sister chromatid tethering reactions that comprise cohesion are required for high fidelity chromosome segregation, but cohesin tethers also regulate gene transcription, promote DNA repair, and impact DNA replication. Currently, RBS is thought to arise from elevated levels of apoptosis, mitotic failure, and limited progenitor cell proliferation, while CdLS is thought to arise, instead, from transcription dysregulation. Here, we review new information that implicates RBS gene mutations in altered transcription profiles. We propose that cohesin-dependent transcription dysregulation may extend to other developmental maladies; the diagnoses of which are complicated through multi-functional proteins that manifest a sliding scale of diverse and severe phenotypes. We further review evidence that cohesinopathies are more common than currently posited.
Evaluation of Nutrition and Physical Activity Knowledge, Attitudes, Self Efficacy and Behaviors in Teachers and Children after Implementation of the “Healthy Active Kids” Online Program in Australian Elementary Schools  [PDF]
Jennifer A. O’Dea
Health (Health) , 2016, DOI: 10.4236/health.2016.84031
Abstract: The aims were to examine change in nutrition and physical activity knowledge, self efficacy and attitudes in a cohort of 23 teachers and 304 year 5 and 6 children after the “Healthy Active Kids” online program and to assess any behavioral change in children’s self reported nutrition and physical activity behaviors and investigate the predictors of nutrition knowledge gain in teachers and children. Results found significant (p < 0.0001) increases in teacher and student knowledge of the five food groups; key nutrients provided by each food group, The Australian Guide to Healthy Eating; food labelling laws, identification of common names for fats, sugars and salts on food labels, food proportions on the Healthy Food Plate and the level and percentage of water in the human body and human brain. Teacher attitudes towards the importance of nutrition and diet and self efficacy related to teaching nutrition in class improved (p < 0.01). The final regression model for predictors of the dependent variable, knowledge gain in students was R = 0.53, Adjusted R square = 0.28 (F = 4.76, p < 0.01) indicating that 28% of the variation in knowledge gain was predicted by the negative (low) Time 1 knowledge. Changes to eating habits reported by children were “drinking more water each day” (89.1%) and “eating foods from the five food groups each day” (76.2%); “sharing information about food labels with your family” (52.4%); “reading food labels when you go shopping” (50.0%); “changing what is on your dinner plate each night” (44.2%); “vegetables that you eat now that you didn’t eat before” (42.1%) and “fruits that you eat now” (39%). Results suggest that the development of basic nutrition knowledge is still very important for both teachers and students, but that other factors such as self efficacy, empowerment and skill development also contribute to nutrition behavior change in children.
Does The 3N-Force Have A Hard Core?
J. A. Eden,M. F. Gari
Physics , 1996, DOI: 10.1103/PhysRevC.53.1510
Abstract: The meson-nucleon dynamics that generates the hard core of the RuhrPot two-nucleon interaction is shown to vanish in the irreducible 3N force. This result indicates a small 3N force dominated by conventional light meson-exchange dynamics and holds for an arbitrary meson-theoretic Lagrangian. The resulting RuhrPot 3N force is defined in the appendix. A completely different result is expected when the Tamm-Dancoff/Bloch-Horowitz procedure is used to define the NN and 3N potentials. In that approach, (e.g. full Bonn potential) both the NN {\it and} 3N potentials contain non-vanishing contributions from the coherent sum of meson-recoil dynamics and the possibility of a large hard core requiring explicit calculation cannot be ruled out.
On Particle Multiplicities in Three-jet Events
P. Eden,G. Gustafson,V. A. Khoze
Physics , 1999, DOI: 10.1007/s100520050639
Abstract: A thorough verification of the distinct differences in the properties of quark and gluon jets is considered as one of the most instructive tests of the basic ideas of QCD. In the real life experiments such a comparison appears to be quite a delicate task and various subtle issues require further theoretical efforts. In this paper we discuss in detail the possibility to extract the theoretically adequate information from the particle multiplicity patterns in three-jet events in e+e- annihilation.
Sensitivity of pp-Bremsstrahlung to Meson-Exchange Currents
J. A. Eden,M. F. Gari
Physics , 1995, DOI: 10.1016/0370-2693(95)00086-Z
Abstract: We present pp-bremsstrahlung cross section calculations at the $\pi$-production threshold to search for kinematics that best differentiate model-dependent descriptions of the NN $t$-matrix and accentuate the contributions of isoscalar meson-exchange currents. Existing optimization procedures are shown to be completely unreliable due to the neglect of meson-exchange currents and phase space variations. We show that phase-space hides the most important differences in model $t$-matrices, but that improved data will be critical to further investigations of exchange currents.
Meson-Exchange Currents in pp-Bremsstrahlung
J. A. Eden,M. F. Gari
Physics , 1995,
Abstract: The long-standing discrepancy between pp-bremsstrahlung data and calculations based on the relativistic impulse approximation current is substantially reduced by the inclusion of the PV$\gamma$ and intermediate-state $\Delta$-resonance iso-scalar meson-exchange currents. The success of the standard procedures adopted here shows that pp-bremsstrahlung provides a powerful tool for the further study of $T$=1 isoscalar exchange currents. The need for addition high-precision data is stressed.
A Consistent Meson-Field-Theoretical Description of PP-Bremsstrahlung
J. A. Eden,M. F. Gari
Physics , 1995, DOI: 10.1103/PhysRevC.53.1102
Abstract: A parameter-free and relativistic extension of the RuhrPot meson-baryon model is used to define the dominant isoscalar meson-exchange currents. We compute pp-bremsstrahlung observables below the $\pi-$production threshold using a relativistic hadronic current density that includes impulse, wave function re-orthonormalization, meson-recoil, $\bar{{\rm N}}$N creation and annihilation, $\rho\pi\gamma$ + $\omega\pi\gamma$ + $\rho\eta\gamma$ + $\omega\eta\gamma$ vector-meson decay and N$\Delta\gamma(\pi,\rho)$ exchange currents. We obtain a good description of the available data. The N$\Delta\gamma(\pi)$ current is shown to dominate the large two-body contributions and closed-form expressions for various non-relativistic approximations are analyzed. An experimental sensitivity to the admixture of pseudo-scalar and pseudo-vector admixture of the NN$\pi$ interaction is demonstrated. We examine the Lorentz invariance of the NN$\rightleftharpoons$NN $t$-matrices and show a dominantly pseudo-vector NN$\pi$ coupling renders impulse approximation calculations without boost operators to be essentially exact. Conversely, a similar analysis of the $\Delta{\rm N}\rightleftharpoons$NN transitions shows that boost operators and the two-body $N\Delta\gamma$ wave function re-orthonormalization meson-recoil currents are required in NN, $\Delta$N and $\Delta\Delta$ coupled channel $t$-matrix applications. The need for additional data is stressed.
The Development of LISTEN: A Novel Intervention for Loneliness  [PDF]
Laurie A. Theeke, Jennifer A. Mallow
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.52016
Abstract: Purpose: The purpose of this paper is to present the development of LISTEN (Loneliness Intervention using Story Theory to Enhance Nursing-sensitive outcomes), a new intervention for loneliness. Methods: LISTEN was developed using the Medical Research Council (MRC) framework for intervention development. Extensive literature review revealed that belonging, relating, placing in community, challenges, and meanings of coping were concepts significant to loneliness. Past interventions were limited but it was determined from a recent meta-analysis that enhanced effectiveness might result from interventions that targeted the poorly adapted cognitive processes of loneliness. These processes include social undesirability, stigma, and negative thoughts about self in relation to others. LISTEN is designed to be delivered in a determined logical sequence of 5 sessions, each focusing on the concepts relevant to loneliness as derived from the literature. For each session, intervention delivery is guided by the concepts from story theory (including intentional dialogue, nurse as listener, examination of self in relation to others and community, synthesizing concerns and patterns, and identifying messages) and the principles of cognitive restructuring (self-assessment of maladaptive cognitions, emotions, and behaviors, identifying challenges of changing, reconceptualization of self, new skill acquisition through group interaction, and identifying patterns of meaning in loneliness). Results: LISTEN is developed and the first randomized trial is complete with a sample of 27 lonely, chronically ill, community dwelling, and older adults. LISTEN was evaluated as feasible to deliver by the study team and acceptable for significantly diminishing loneliness by participants of the LISTEN groups who were compared to attention control groups (p < 0.5). Conclusions: LISTEN has the potential to enhance health by diminishing loneliness which could result in improving the long-term negative known sequelae of loneliness. Future longitudinal randomized trials are needed in varied populations to assess long term health and healthcare system benefit of using LISTEN to treat loneliness.
CAPL: an efficient association software package using family and case-control data and accounting for population stratification
Ren-Hua Chung, Michael A Schmidt, Eden R Martin
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-201
Abstract: We used a hybrid of open message passing interface (open MPI) and POSIX threads to parallelize CAPL, which enable the program to operate in a cluster environment. We used simulations to demonstrate that the parallel implementation of CAPL can analyze a large GWAS dataset in a reasonable time frame when a parallel computing resource is available.As many GWAS datasets based on both family and case-control designs are available, a flexible and efficient tool such as CAPL will be very helpful to combine the datasets to greatly increase statistical power and finish the analysis in a reasonable time frame.Family-based and case-control association designs have been used in many genome-wide association studies (GWAS). For GWAS where ~1 million markers are tested, the major challenge is sorting out true positives from the many false positives. Many GWAS datasets have been deposited into public databases such as the database of Genotypes and Phenotypes (dbGaP). Also the Welcome Trust Case Control Consortium (WTCCC) provides a large number of case-control samples for public analysis [1]. These resources provide the crucial opportunity to increase power by combining datasets. However, this requires flexible analytic methods that can accommodate diverse study designs (e.g., family and case-control).Current available software for combining case-control and family data all have restrictions. Most of them such as SCOUT [2], CHRR [3] and UNPHASED [4] require sampling a homogeneous population, which may not be a reasonable assumption for data from a large consortium. FamCC [5] can account for population stratification and uses nuclear families with arbitrary number of siblings but requires parental genotype data, which are often unavailable for late-onset diseases. To overcome these restrictions, we have developed the Combined APL test (CAPL) [6], which is a novel and powerful statistical test that can accommodate family and case-control datasets and can account for population strati
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