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Search Results: 1 - 10 of 466132 matches for " Jennifer A. DeSimone "
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Low Dose Total Skin Electron Beam Radiation in Cutaneous T-Cell Lymphoma: Review  [PDF]
Misty Gamble, Elizabeth Tocci, Jennifer A. DeSimone
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.514138
Abstract: The treatment of advanced stage MF is especially challenging as single agent overall response rates are in the 35% range and chronic recurrence is the rule. The treatment of CTCL across all stages of disease is aimed at the goal of achieving and sustaining remission. Increasingly, low dose total skin electron beam therapy (TSEBT) is being utilized as a skin directed component in combination therapy for advanced stage CTCL. Researchers are seeking to better define the utility of low dose TSEBT as a method of debulking skin disease while simultaneously treating other disease compartments and in combination with sustained maintenance therapies of both the skin directed and systemic varieties. Data exists showing the efficacy of low dose TSEBT in early and advanced disease. There is also data documenting prolonged treatment responses with TSEBT plus adjuvant skin directed therapies such as PUVA and topical nitrogen mustard. Emerging data examining the role of low dose TSEBT in the prestem cell transplant preparation is also promising. This brief review summarizes the utility of low dose TSEBT in multiagent treatment regimens in CTCL.
Spontaneous division and motility in active nematic droplets
L. Giomi,A. DeSimone
Physics , 2013, DOI: 10.1103/PhysRevLett.112.147802
Abstract: We investigate the mechanics of an active droplet endowed with internal nematic order and surrounded by an isotropic Newtonian fluid. Using numerical simulations we demonstrate that, due to the interplay between the active stresses and the defective geometry of the nematic director, this system exhibits two of the fundamental functions of living cells: spontaneous division and motility, by means of self-generated hydrodynamics flows. These behaviors can be selectively activated by controlling a single physical parameter, namely, an active variant of the capillary number.
Attainment results for nematic elastomers
V. Agostiniani,G. Dal Maso,A. DeSimone
Mathematics , 2013,
Abstract: We consider a class of non-quasiconvex frame indifferent energy densities which includes Ogden-type energy densities for nematic elastomers. For the corresponding geometrically linear problem we provide an explicit minimizer of the energy functional satisfying a nontrivial boundary condition. Other attainment results, both for the nonlinear and the linearized model, are obtained by using the theory of convex integration introduced by M\"uller and Sver\'ak in the context of crystalline solids.
Time-dependent systems of generalized Young measures
G. Dal Maso,A. DeSimone,M. G. Mora,M. Morini
Mathematics , 2005,
Abstract: In this paper some new tools for the study of evolution problems in the framework of Young measures are introduced. A suitable notion of time-dependent system of generalized Young measures is defined, which allows to extend the classical notions of total variation and absolute continuity with respect to time, as well as the notion of time derivative. The main results are a Helly type theorem for sequences of systems of generalized Young measures and a theorem about the existence of the time derivative for systems with bounded variation with respect to time.
Evaluation of Nutrition and Physical Activity Knowledge, Attitudes, Self Efficacy and Behaviors in Teachers and Children after Implementation of the “Healthy Active Kids” Online Program in Australian Elementary Schools  [PDF]
Jennifer A. O’Dea
Health (Health) , 2016, DOI: 10.4236/health.2016.84031
Abstract: The aims were to examine change in nutrition and physical activity knowledge, self efficacy and attitudes in a cohort of 23 teachers and 304 year 5 and 6 children after the “Healthy Active Kids” online program and to assess any behavioral change in children’s self reported nutrition and physical activity behaviors and investigate the predictors of nutrition knowledge gain in teachers and children. Results found significant (p < 0.0001) increases in teacher and student knowledge of the five food groups; key nutrients provided by each food group, The Australian Guide to Healthy Eating; food labelling laws, identification of common names for fats, sugars and salts on food labels, food proportions on the Healthy Food Plate and the level and percentage of water in the human body and human brain. Teacher attitudes towards the importance of nutrition and diet and self efficacy related to teaching nutrition in class improved (p < 0.01). The final regression model for predictors of the dependent variable, knowledge gain in students was R = 0.53, Adjusted R square = 0.28 (F = 4.76, p < 0.01) indicating that 28% of the variation in knowledge gain was predicted by the negative (low) Time 1 knowledge. Changes to eating habits reported by children were “drinking more water each day” (89.1%) and “eating foods from the five food groups each day” (76.2%); “sharing information about food labels with your family” (52.4%); “reading food labels when you go shopping” (50.0%); “changing what is on your dinner plate each night” (44.2%); “vegetables that you eat now that you didn’t eat before” (42.1%) and “fruits that you eat now” (39%). Results suggest that the development of basic nutrition knowledge is still very important for both teachers and students, but that other factors such as self efficacy, empowerment and skill development also contribute to nutrition behavior change in children.
Optimal Design of a Multibody Self-Referencing Attenuator  [PDF]
Dongmei Zhou, Jennifer A. Eden
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.39005
Abstract: The purpose of this paper is to determine the optimal size and number of tubes for a generic attenuator that is similar to Pelamis P2, the wave energy converter. Simulations using ANSYS Workbench, Design Modeler, and AQWA are performed to study the energy absorption at the nodes between the tubes. The analysis is limited to linearized hydrodynamic fluid waves loading on floating bodies by employing three-dimensional radiation/diffraction theory in regular waves in the frequency domain. Three sets of tests are conducted by varying total tube number, each tube length and the order of tubes with different lengths. After a systematic study in the frequency domain, the optimal size and number of the genetic attenuator is recommended.
Cortical connections of area V4 in the macaque
UNGERLEIDER LESLIE G.,MONTEIRO RENATA A. P.,GATTASS RICARDO,DESIMONE ROBERT
Anais da Academia Brasileira de Ciências , 2000,
Abstract:
Cost-Effective Control of Plant Disease When Epidemiological Knowledge Is Incomplete: Modelling Bahia Bark Scaling of Citrus
Nik J. Cunniffe ,Francisco F. Laranjeira ,Franco M. Neri,R. Erik DeSimone,Christopher A. Gilligan
PLOS Computational Biology , 2014, DOI: doi/10.1371/journal.pcbi.1003753
Abstract: A spatially-explicit, stochastic model is developed for Bahia bark scaling, a threat to citrus production in north-eastern Brazil, and is used to assess epidemiological principles underlying the cost-effectiveness of disease control strategies. The model is fitted via Markov chain Monte Carlo with data augmentation to snapshots of disease spread derived from a previously-reported multi-year experiment. Goodness-of-fit tests strongly supported the fit of the model, even though the detailed etiology of the disease is unknown and was not explicitly included in the model. Key epidemiological parameters including the infection rate, incubation period and scale of dispersal are estimated from the spread data. This allows us to scale-up the experimental results to predict the effect of the level of initial inoculum on disease progression in a typically-sized citrus grove. The efficacies of two cultural control measures are assessed: altering the spacing of host plants, and roguing symptomatic trees. Reducing planting density can slow disease spread significantly if the distance between hosts is sufficiently large. However, low density groves have fewer plants per hectare. The optimum density of productive plants is therefore recovered at an intermediate host spacing. Roguing, even when detection of symptomatic plants is imperfect, can lead to very effective control. However, scouting for disease symptoms incurs a cost. We use the model to balance the cost of scouting against the number of plants lost to disease, and show how to determine a roguing schedule that optimises profit. The trade-offs underlying the two optima we identify—the optimal host spacing and the optimal roguing schedule—are applicable to many pathosystems. Our work demonstrates how a carefully parameterised mathematical model can be used to find these optima. It also illustrates how mathematical models can be used in even this most challenging of situations in which the underlying epidemiology is ill-understood.
The Development of LISTEN: A Novel Intervention for Loneliness  [PDF]
Laurie A. Theeke, Jennifer A. Mallow
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.52016
Abstract: Purpose: The purpose of this paper is to present the development of LISTEN (Loneliness Intervention using Story Theory to Enhance Nursing-sensitive outcomes), a new intervention for loneliness. Methods: LISTEN was developed using the Medical Research Council (MRC) framework for intervention development. Extensive literature review revealed that belonging, relating, placing in community, challenges, and meanings of coping were concepts significant to loneliness. Past interventions were limited but it was determined from a recent meta-analysis that enhanced effectiveness might result from interventions that targeted the poorly adapted cognitive processes of loneliness. These processes include social undesirability, stigma, and negative thoughts about self in relation to others. LISTEN is designed to be delivered in a determined logical sequence of 5 sessions, each focusing on the concepts relevant to loneliness as derived from the literature. For each session, intervention delivery is guided by the concepts from story theory (including intentional dialogue, nurse as listener, examination of self in relation to others and community, synthesizing concerns and patterns, and identifying messages) and the principles of cognitive restructuring (self-assessment of maladaptive cognitions, emotions, and behaviors, identifying challenges of changing, reconceptualization of self, new skill acquisition through group interaction, and identifying patterns of meaning in loneliness). Results: LISTEN is developed and the first randomized trial is complete with a sample of 27 lonely, chronically ill, community dwelling, and older adults. LISTEN was evaluated as feasible to deliver by the study team and acceptable for significantly diminishing loneliness by participants of the LISTEN groups who were compared to attention control groups (p < 0.5). Conclusions: LISTEN has the potential to enhance health by diminishing loneliness which could result in improving the long-term negative known sequelae of loneliness. Future longitudinal randomized trials are needed in varied populations to assess long term health and healthcare system benefit of using LISTEN to treat loneliness.
Motility of a Model Bristle-Bot: a Theoretical Analysis
Giancarlo Cicconofri,Antonio DeSimone
Physics , 2014, DOI: 10.1016/j.ijnonlinmec.2014.12.010
Abstract: Bristle-bots are legged robots that can be easily made out of a toothbrush head and a small vibrating engine. Despite their simple appearance, the mechanism enabling them to propel themselves by exploiting friction with the substrate is far from trivial. Numerical experiments on a model bristle-bot have been able to reproduce such a mechanism revealing, in addition, the ability to switch direction of motion by varying the vibration frequency. This paper provides a detailed account of these phenomena through a fully analytical treatment of the model. The equations of motion are solved through an expansion in terms of a properly chosen small parameter. The convergence of the expansion is rigorously proven. In addition, the analysis delivers formulas for the average velocity of the robot and for the frequency at which the direction switch takes place. A quantitative description of the mechanism for the friction modulation underlying the motility of the bristle-bot is also provided.
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