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Search Results: 1 - 10 of 146552 matches for " Jeng-Yi Li "
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Massive Lower Gastrointestinal Bleeding from an External Iliac Artery Fistula in a Patient with Bladder Cancer
Chih-Chien Chin,Chien-Yuh Yeh,Yi-Hung Kuo,Jeng-Yi Wang
Chang Gung Medical Journal , 2008,
Abstract: Arterioenteric fistula is a rare cause of lower gastrointestinal bleeding, yet it can potentiallycause massive, life-threatening bleeding. Patients with an advanced pelvic malignancycan develop hemorrhage from an arterioenteric fistula. Selective mesenteric angiography isunable to demonstrate the source of bleeding in these patients, so evaluation of the iliacarteries is essential. We present a 67-year old man with advanced bladder cancer presentingas massive, life-threatening lower gastrointestinal bleeding from an external iliac arterial fistulato the cecum.
Functional characterization of cellulases identified from the cow rumen fungus Neocallimastix patriciarum W5 by transcriptomic and secretomic analyses
Tzi-Yuan Wang, Hsin-Liang Chen, Mei-Yeh J Lu, Yo-Chia Chen, Huang-Mo Sung, Chi-Tang Mao, Hsing-Yi Cho, Huei-Mien Ke, Teh-Yang Hwa, Sz-Kai Ruan, Kuo-Yen Hung, Chih-Kuan Chen, Jeng-Yi Li, Yueh-Chin Wu, Yu-Hsiang Chen, Shao-Pei Chou, Ya-Wen Tsai, Te-Chin Chu, Chun-Chieh A Shih, Wen-Hsiung Li, Ming-Che Shih
Biotechnology for Biofuels , 2011, DOI: 10.1186/1754-6834-4-24
Abstract: We have developed an efficient platform that uses a combination of transcriptomic and proteomic approaches to N. patriciarum to accelerate gene identification, enzyme classification and application in rice straw degradation. By conducting complementary studies of transcriptome (Roche 454 GS and Illumina GA IIx) and secretome (ESI-Trap LC-MS/MS), we identified 219 putative GH contigs and classified them into 25 GH families. The secretome analysis identified four major enzymes involved in rice straw degradation: β-glucosidase, endo-1,4-β-xylanase, xylanase B and Cel48A exoglucanase. From the sequences of assembled contigs, we cloned 19 putative cellulase genes, including the GH1, GH3, GH5, GH6, GH9, GH18, GH43 and GH48 gene families, which were highly expressed in N. patriciarum cultures grown on different feedstocks.These GH genes were expressed in Pichia pastoris and/or Saccharomyces cerevisiae for functional characterization. At least five novel cellulases displayed cellulytic activity for glucose production. One β-glucosidase (W5-16143) and one exocellulase (W5-CAT26) showed strong activities and could potentially be developed into commercial enzymes.Cellulosic ethanol produced by microbial fermentation from feedstocks has been proposed to replace fossil fuels in transportation. A key step in cellulosic ethanol production is to break down cellulose into glucose and hemicellulose into xylose, which can subsequently be converted into ethanol by fermentative microbes. Therefore, finding efficient cellulases is important to bioethanol production, as well as for hydrolyzing feedstocks into sugars in general. Neocallimastix species is one of the major anaerobic fungi in the rumen of water buffalo capable of efficiently digesting cellulosic biomass [1-4]. Such anaerobic fungi are potential sources for highly active cellulolytic enzymes that are useful for cellulose hydrolysis [5-7]. Plant cell wall degrading enzymes from rumen fungi such as Neocallimastix patriciarum may
Outcomes of resection for colorectal cancer hepatic metastases stratified by evolving eras of treatment
Kun-Ming Chan, Jy-Ming Chiang, Chen-Fang Lee, Ming-Chin Yu, Wei-Chen Lee, Jinn-Shiun Chen, Jeng-Yi Wang
World Journal of Surgical Oncology , 2011, DOI: 10.1186/1477-7819-9-174
Abstract: We conducted a retrospective review of 279 patients who underwent liver resection (LR) for CRC hepatic metastases. The prognoses of patients treated pre-2003 (era 1) and post-2003 (era 2) were examined.Of the patients included in the study, 210 (75.3%) had CRC recurrence after LR. There was a significant difference in the ratio of CRC recurrence between the 2 eras (82.0% in era 1 vs. 69.5% in era 2; p = 0.008). Analysis of recurrence-free and overall survival rates also showed that the patient outcome was significantly better in the post-2003 era than in the pre-2003 era. Further analysis showed that a significantly higher percentage of patients in era 2 had received modern chemotherapeutic regimens including irinotecan and oxaliplatin, while patients in era 1 were mainly administered fluorouracil and leucovorin for adjuvant chemotherapy. Among patients with CRC recurrence, a significant ratio of those in era 2 underwent surgical resection for recurrent lesions, and these patients had a better survival curve than did patients without resection (34.1% vs. 2.2% for 5-year survival; p < 0.0001).The incidence of CRC recurrence after LR for hepatic metastasis remains very high. However, the management and outcomes of patients with CRC hepatic metastasis have greatly improved with time, suggesting that the current use of aggressive multimodality treatments including surgical resection combined with modern chemotherapeutic regimens effectively prolongs the life expectancy of these patients.Hepatic metastasis is the most common form of distant spread of primary colorectal cancer (CRC) and occurs in over 50% of patients with metastases. Aggressive liver resection (LR), which provides the only curative treatment, is believed to have improved the long-term outcome of these patients [1-3]. Recently published studies have shown that these patients have variable 5-year survival rates ranging from 36% to 58% [4-8]. However, despite the excellent results of aggressive treatment for
Bacteremic community-acquired pneumonia due to Klebsiella pneumoniae: Clinical and microbiological characteristics in Taiwan, 2001-2008
Yi-Tsung Lin, Yuan-Yu Jeng, Te-Li Chen, Chang-Phone Fung
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-307
Abstract: The clinical characteristics of bacteremic community-acquired pneumonia (CAP) in adults due to K. pneumoniae were compared to those of adults with bacteremic CAP due to Streptococcus pneumoniae at a tertiary medical center in Taiwan from 2001-2008. Risk factors for mortality of bacteremic CAP due to K. pneumoniae were analyzed. All clinical isolates of K. pneumoniae were examined for capsular serotypes, hypermucoviscosity phenotype, aerobactin and rmpA gene.K. pneumoniae was the dominant cause of bacteremic CAP and was associated with a more fulminant course and a worse prognosis than bacteremic CAP due to Streptococcus pneumoniae. Initial presentation with septic shock and respiratory failure were independent risk factors for both early and total mortality. Serotype K1 and K2 comprised around half of all isolates. There were no significant differences in the clinical characteristics of patients with bacteremic CAP due to K1/K2 and non-K1/K2 isolates. Hypermucoviscosity phenotype as well as the aerobactin and rmpA genes were highly prevalent in the K. pneumoniae isolates.K. pneumoniae continued to be the dominant cause of bacteremic CAP in Taiwanese adults during 2001-2008. Initial presentation with septic shock and respiratory failure were independent risk factors for both early and total mortality from K. pneumoniae bacteremic CAP. Serotypes K1/K2 comprised around half of all isolates, but did not predispose patients to a poor clinical outcome. Physicians should be aware of the poor prognosis of any patient with bacteremic K. pneumoniae CAP and monitor these patients more closely.Klebsiella pneumoniae is the major cause of liver abscess, Gram-negative bacillary meningitis, brain abscess, lung abscess, thoracic empyema, prostatic abscess, deep neck infection and complicated skin and soft tissue infections in Taiwan [1], and comprised 4.8% of the common causative pathogens of community-acquired pneumonia (CAP) in a multi-center survey [2]. Although K. pneumoniae is
A Compact Wideband Matching 0.18-μM Cmos UWB Low-Noise Amplifier Using Active Feedback Technique
Jian-Yi Li;Wen-Jeng Lin;Mau-Phon Houng;Lih-Shan Chen
PIER C , 2010, DOI: 10.2528/PIERC10090201
Abstract: This work presents an ultra-wideband (UWB) low noise amplifier (LNA) with active shunt-feedback technique for wideband and flat gain by using standard 0.18 μm CMOS processes. Different from past resistive shunt-feedback technique, the capacitor supersedes by a transistor in active shunt-feedback technique. The active shunt-feedback provides input matching generating a 50 Ω real part with proper design and achieves flat gain from 2.5 GHz to 12 GHz. The UWB LNA achieved 11.4±0.2 dB gains, 4.5~5.2 dB noise figure (NF), 13.5 mW power consumption at frequency 3.1 GHz to 10.6 GHz, -15 dBm of 1-dB compression point (P1dB), and -3 dBm of input third intercept point (IIP3) at 6 GHz. The chip size including pads is only 0.6×0.5 mm.
A Miniaturized Bandpass Filter with Controllable Harmonic by Using Split Impedance Resonators
Jian-Yi Li;Wen-Jeng Lin;Ding-Bing Lin;Lih-Shan Chen;Mau-Phon Houng
PIER C , 2010, DOI: 10.2528/PIERC10052306
Abstract: In this paper, a miniaturized bandpass filter with controllable harmonic by using split impedance resonators is proposed. The proposed split impedance resonator is based on the theories of the basic parallel impedance formula and stepped impedance resonators (SIRs). In this way, the split impedance resonator can be effectively designed to obtain good coupling for reducing the insertion loss. Furthermore, a miniaturized bandpass filter with controllable spurious frequency is proposed. The proposed bandpass filter not only has good passband characteristics but also obtains miniaturization around 21.87% versus the traditional SIR bandpass filters.
Significantly Increased Risk of Cardiovascular Disease among Patients with Gallstone Disease: A Population-Based Cohort Study
Muideen Tunbosun Olaiya, Hung-Yi Chiou, Jiann-Shing Jeng, Li-Ming Lien, Fang-I Hsieh
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076448
Abstract: Objective To investigate whether gallstone disease (GD) increases the risk of developing cardiovascular disease (CVD) in a large population-based cohort. Methods A study population including 6,981 patients with GD was identified from The Taiwan National Health Insurance Research Database between 2004 and 2005. GD patients were defined as patients with principal discharge diagnoses of cholelithiasis using the ICD-9-CM code 574. 27,924 patients without GD were randomly selected and matched for age and gender. All patients were followed for 6 years or until diagnosis for CVD. Cox proportional hazards regression model was used to assess the risk of developing CVD with adjustment for age, gender and co-morbid conditions. Results During the six years follow-up period, 935 patients with GD and 2,758 patients without GD developed CVD. Patients with GD had an elevated risk of CVD (HR, 1.32; 95% CI, 1.22-1.43) when compared with those without GD. Similar relationship was observed when CVD was categorized i.e. stroke (HR, 1.15; 95% CI, 1.01-1.32), coronary heart disease (HR, 1.42; 95% CI, 1.28-1.58) and heart failure (HR, 1.31; 95% CI, 1.00-1.73). When GD was classified according to the level of severity, using patients without GD as reference, the risks of CVD were elevated in patients with non-severe GD (HR, 1.34; 95% CI, 1.24-1.46) as well as those with severe GD (HR, 1.20, 95% CI, 1.02-1.40), after adjusting for age, gender and comorbidities. In age-stratified analysis, patients aged 18-40 years with GD were at higher risk of developing CVD (HR, 1.42; 95% CI, 1.09-1.84) than older GD patients. Conclusion This study found an increased risk of CVD in patients diagnosed with GD. The excess risk was particularly high in younger GD patients. Prevention of GD could help reduce the risk of developing CVD, and the better effect could be achieved for the younger age groups.
Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9
Yi-Ting Yeh, Sung Sik Hur, Joann Chang, Kuei-Chun Wang, Jeng-Jiann Chiu, Yi-Shuan Li, Shu Chien
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046889
Abstract: Endothelial proliferation, which is an important process in vascular homeostasis, can be regulated by the extracellular microenvironment. In this study we demonstrated that proliferation of endothelial cells (ECs) was enhanced on hydrogels with high stiffness (HSG, 21.5 kPa) in comparison to those with low stiffness (LSG, 1.72 kPa). ECs on HSG showed markedly prominent stress fibers and a higher RhoA activity than ECs on LSG. Blockade of RhoA attenuated stress fiber formation and proliferation of ECs on HSG, but had little effect on ECs on LSG; enhancement of RhoA had opposite effects. The phosphorylations of Src and Vav2, which are positive RhoA upstream effectors, were higher in ECs on HSG. The inhibition of Src/Vav2 attenuated the HSG-mediated RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG. Septin 9 (SEPT9), the negative upstream effector for RhoA, was significantly higher in ECs on LSG. The inhibition of SEPT9 increased RhoA activation, Src/Vav2 phosphorylations, and EC proliferation on LSG, but showed minor effects on ECs on HSG. We further demonstrated that the inactivation of integrin αvβ3 caused an increase of SEPT9 expression in ECs on HSG to attenuate Src/Vav2 phosphorylations and inhibit RhoA-dependent EC proliferation. These results demonstrate that the SEPT9/Src/Vav2/RhoA pathway constitutes an important molecular mechanism for the mechanical regulation of EC proliferation.
Determinants of Long-Term Care Services among the Elderly: A Population-Based Study in Taiwan
Chen-Yi Wu, Hsiao-Yun Hu, Nicole Huang, Yi-Ting Fang, Yiing-Jeng Chou, Chung-Pin Li
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089213
Abstract: Objectives The aim of the study was to investigate determinants of long-term care use and to clarify the differing characteristics of home/community-based and institution-based services users. Design Cross-sectional, population-based study. Setting Utilizing data from the 2005 National Health Interview Survey conducted in Taiwan. Participants A national sample of 2,608 people (1,312 men, 1,296 women) aged 65 and older. Measurements The utilization of long-term care services (both home/community- and institution-based services) was measured. A χ2 analysis tested differences in baseline characteristics between home/community-based and institution-based long-term care users. The multiple-logistic model was adopted with a hierarchical approach adding the Andersen model’s predisposing, enabling, and need factors sequentially. Multiple logistic models further stratified data by gender and age. Results Compared with users of home/community-based care, those using institution-based care had less education (p = 0.019), greater likelihood of being single (p = 0.001), fewer family members (p = 0.002), higher prevalence of stool incontinence (p = 0.011) and dementia (P = .025), and greater disability (p = 0.016). After adjustment, age (compared with 65–69 years; 75–79 years, odds ratio [OR] = 2.08, p = 0.044; age ≥80, OR = 3.30, p = 0.002), being single (OR = 2.16, p = 0.006), urban living (OR = 1.68, p = 0.037), stroke (OR = 2.08, p = 0.015), dementia (OR = 2.32, p = 0.007), 1–3 items of activities of daily living (ADL) disability (OR = 5.56, p<0.001), and 4–6 items of ADL disability (OR = 21.57, p<0.001) were significantly associated with long-term care use. Conclusion Age, single marital status, stroke, dementia, and ADL disability are predictive factors for long-term care use. The utilization was directly proportional to the level of disability.
Improved Compact Broadband Bandpass Filter Using Branch Stubs Co-via Structure with Wide Stopband Characteristic
Wen-Jeng Lin;Chin-Sheng Chang;Jian-Yi Li;Ding-Bing Lin;Lih-Shan Chen;Mau-Phon Houng
PIER C , 2008,
Abstract: In this paper, a broadband bandpass filter (BPF) with superior spurious suppression over a wide frequency range at least up to 20 GHz at 20 dB has been designed. The proposed broadband bandpass filter has designed using quarter-wavelength short stubs alternating with branch stubs co-via structure, and inserting the bandstop filters to substitute for redundant connecting lines. Compare with some traditional co-via structure, this work by using the branch stubs to construct the co-via structure, not only reduce the size around 70% but also decrease the radiation loss due to some complex meander configurations occurring in the connecting lines. For the prototype broadband filter, center frequencies around 4 GHz were selected. The bandwidth of passband was between 1.95 GHz and 6.25 GHz, in which the insertion-loss amounts to around 1.5 dB. The suppression range of stopbandis between 8.2-20.3 GHz, in which the insertion-loss amounts to around 20 dB.
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