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Search Results: 1 - 10 of 142 matches for " Jelle Vlaanderen "
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The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerability
Paolo Vineis, Aneire E Khan, Jelle Vlaanderen, Roel Vermeulen
Environmental Health , 2009, DOI: 10.1186/1476-069x-8-54
Abstract: We are still far from completely understanding the etiology and causal patterns for many common diseases, such as breast and colon cancer, or neurodegenerative diseases. In spite of decades of epidemiological research, the etiology of many such conditions is still largely unknown.For a long time it has been hypothesized that most chronic diseases have an environmental origin (using the term "environment" in a broad sense, to indicate essentially what is not due to genetic predisposition). This claim was based on descriptive data showing the broad range of incidence rates in different parts of the world, the rapid temporal changes - such as those currently occurring in China and India - and the crucial observation of incidence rates in migrant populations. The latter unequivocally showed that migrants rapidly acquire - sometimes already in the first generation after migration - the risk of disease that is typical of the population where they move.However, "environmental" risks have been largely elusive in epidemiological research, and there is still much debate on the real impact of the environment, whose role tends to be overshadowed in recent times by the successes of genetics, in particular Genome-wide association studies (GWAS). Clearly, we need a disease model that allows us to encompass both the mass of genetic data coming from GWAS and the still elusive role of many environmental exposures.The technological revolution in genetics, which in 2007-2009 led to the identification of a number of novel genes for several common diseases, is inspiring but at the same time a little disappointing. Most highly-penetrant genes had already been uncovered by linkage studies, so that "genome-wide scans" could mainly identify low-penetrant genes. It is a fact that - with a few exceptions - what has been found is genetic variants weakly associated with chronic diseases, with relative risks of 1.15-1.5. These risks are much lower than some known environmental exposures, and of t
A Case-Control Study of the Protective Effect of Alcohol, Coffee, and Cigarette Consumption on Parkinson Disease Risk: Time-Since-Cessation Modifies the Effect of Tobacco Smoking
Marianne van der Mark, Peter C. G. Nijssen, Jelle Vlaanderen, Anke Huss, Wim M. Mulleners, Antonetta M. G. Sas, Teus van Laar, Hans Kromhout, Roel Vermeulen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095297
Abstract: The aim of this study was to investigate the possible reduced risk of Parkinson Disease (PD) due to coffee, alcohol, and/or cigarette consumption. In addition, we explored the potential effect modification by intensity, duration and time-since-cessation of smoking on the association between cumulative pack-years of cigarette smoking (total smoking) and PD risk. Data of a hospital based case-control study was used including 444 PD patients, diagnosed between 2006 and 2011, and 876 matched controls from 5 hospitals in the Netherlands. A novel modeling method was applied to derive unbiased estimates of the potential modifying effects of smoking intensity, duration, and time-since-cessation by conditioning on total exposure. We observed no reduced risk of PD by alcohol consumption and only a weak inverse association between coffee consumption and PD risk. However, a strong inverse association of total smoking with PD risk was observed (OR = 0.27 (95%CI: 0.18–0.42) for never smokers versus highest quartile of tobacco use). The observed protective effect of total smoking was significantly modified by time-since-cessation with a diminishing protective effect after cessation of smoking. No effect modification by intensity or duration of smoking was observed indicating that both intensity and duration have an equal contribution to the reduced PD risk. Understanding the dynamics of the protective effect of smoking on PD risk aids in understanding PD etiology and may contribute to strategies for prevention and treatment.
Reviewing the Learning Process through Creative Puzzle Solving  [PDF]
Bj?rn Petter Jelle
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.813137
Abstract: Human beings are at a continuous learning process at various levels and with different motivations during their whole lifetime. Puzzle solving may beneficially be applied to increase the motivation, enhance the mastering apprehension, promote the creative processes, expand the ability to engage and solve miscellaneous challenges from various viewpoints, and hence lead to an improved learning process and problem solving capability. That is, the application of puzzles may lead to better learning and increased knowledge in general, stimulating the reasoning process and the apprehension of the need for both creativity and hard work. Thus, teachers of both students and teachers may find it beneficial to utilize the art of puzzle solving. Typically, the puzzles are very suitable for and mostly used in mathematics and natural science classes. Nevertheless, the puzzles are in general also applicable for any type of class. The aim of this study is to examine and discuss the learning process through applying creative puzzle solving as a teaching tool. These aspects are illustrated through a review of several selected puzzle examples.
Anthropology, demography and history; Shortage of women, inter-tribal marriage relations, and slave trading in de Bird’s Head of New Guinea
Jelle Miedema
Bijdragen tot de Taal-, Land- en Volkenkunde , 1988,
The water demon and related mythic figures; The Bird’s Head peninsula of Irian Jaya / Papua in comparative perspective
Jelle Miedema
Bijdragen tot de Taal-, Land- en Volkenkunde , 2000,
Opstand adelt? De rechtvaardiging van het politieke verzet van de adel in de Vlaamse Opstand (1482-1492)
Jelle Haemers
BMGN : Low Countries Historical Review , 2008,
Abstract: Can a Revolt be Ennobling? Justification of the Political Opposition of the Nobility during the Flemish Revolt (1482-1492) This article analyses the political ideas of the late mediaeval nobility. In 1491, Archduke Maximilian of Austria accused three noblemen, Louis of Bruges, Adolf of Cleves and his son Philip, of lese majesty. The pleas made by the above-mentioned noblemen in this particular case are used to reconstruct their political ideology. The three noblemen maintained that service to the sovereign was one the most noble virtues of a nobleman, but they also considered that this political service had to be reciprocal. Using customary law, judicial treatises and political practices, they argued that the sovereign was the keystone of the political order, as long as he obtained advice from the noblemen when setting out his policies. He was also not allowed to violate any laws, traditions or privileges. These ideas had a long history in mediaeval political thought, and they would continue to dominate sixteenth-century society.
P. Cockshaw, Prosopographie des secrétaires de la cour de Bourgogne (1384-1477)
Jelle Haemers
BMGN : Low Countries Historical Review , 2008,
Journal of Special Education and Rehabilitation , 2006,
Joost C.M. Cox, ‘Hebbende privilege van stede’. De verlening van stadsrechtprivileges in Holland en Zeeland (13de-15de eeuw)
Jelle Haemers
BMGN : Low Countries Historical Review , 2012,
On the large-scale structure of the inflationary universe
Jelle Boersma
Physics , 1998,
Abstract: We study the evolution of quantum fluctuations of a scalar field which is coupled to the geometry, in an exponentially expanding universe. We derive an expression for the spectrum of intrinsic perturbations, and it is shown that the intrinsic degrees of freedom are well behaved in the infra-red part of the spectrum. We conclude that quantum fluctuations do not change the dynamics of the spacetime in a way which makes its evolution non-perturbative and stochastic. This result contradicts previous derivations which are based on the study of a quantum field on a fixed geometry.
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