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Search Results: 1 - 10 of 7067 matches for " Jeffrey Rice "
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Is the “Almost Perfect Scale” Almost Perfect? The Psychometric Properties of the Arabic Version of APS-R and Its Short Form  [PDF]
Ibrahim Kira, Hanaa Shuwiekh, Kenneth Rice, Jeffrey Ashby
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.97109
Abstract: The goal was to evaluate the construct and predictive validity of the Arabic version of APS-R and check its invariance across genders and the English version supplied by one of the measure authors. We used its translated Arabic version, and measures of PTSD, complex PTSD (CTD), depression, and existential annihilation anxiety (AA), in a sample of 620 students from two Egyptian Universities. We conducted exploratory and confirmatory factor analysis (CFA) to test the APS-R’s construct validity and zero-order correlation, curve estimation regression to test its predictive validity, and Multigroup invariance analysis to check its invariance between languages and genders. The three-factor model did not fit well which made its structural validity questionable. However, the model fitted well for each dimension separately. The results indicated that striving for standards and order, and self-discrepancy are distinct measures, and each has good construct and predictive validity. Order and standards predicted linearly and non-linearly lower PTSD, CTD (post-cumulative trauma disorders), depression, and AA. Self-discrepancy predicted linearly and non-linearly higher depression, PTSD, CTD, and AA. The non-linear models accounted for more variance than the linear models. While the measures were strongly invariant across genders, they were partially invariant across the English and Arabic samples.
An exceptional horizontal gene transfer in plastids: gene replacement by a distant bacterial paralog and evidence that haptophyte and cryptophyte plastids are sisters
Danny W Rice, Jeffrey D Palmer
BMC Biology , 2006, DOI: 10.1186/1741-7007-4-31
Abstract: Although several genes gave strongly supported conflicting trees under certain conditions, we are confident of HGT in only a single case beyond the rubisco HGT already reported. Most of the conflicts involved near neighbors connected by long branches (e.g. red algae and their secondary hosts), where phylogenetic methods are prone to mislead. However, three genes – clpP, ycf2, and rpl36 – provided strong support for taxa moving far from their organismal position. Further taxon sampling of clpP and ycf2 resulted in rejection of HGT due to long-branch attraction and a serious error in the published plastid genome sequence of Oenothera elata, respectively. A single new case, a bacterial rpl36 gene transferred into the ancestor of the cryptophyte and haptophyte plastids, appears to be a true HGT event. Interestingly, this rpl36 gene is a distantly related paralog of the rpl36 type found in other plastids and most eubacteria. Moreover, the transferred gene has physically replaced the native rpl36 gene, yet flanking genes and intergenic regions show no sign of HGT. This suggests that gene replacement somehow occurred by recombination at the very ends of rpl36, without the level and length of similarity normally expected to support recombination.The rpl36 HGT discovered in this study is of considerable interest in terms of both molecular mechanism and phylogeny. The plastid acquisition of a bacterial rpl36 gene via HGT provides the first strong evidence for a sister-group relationship between haptophyte and cryptophyte plastids to the exclusion of heterokont and alveolate plastids. Moreover, the bacterial gene has replaced the native plastid rpl36 gene by an uncertain mechanism that appears inconsistent with existing models for the recombinational basis of gene conversion.Unlike the dynamic mitochondrial genome of flowering plants, which frequently incorporates plastid and nuclear sequences via intracellular gene transfer [1-3], the plastid genome is highly resistant to the
Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells  [PDF]
Edward C. Lisic, Victoria G. Rand, Lana Ngo, Patrick Kent, Jeffrey Rice, Deidra Gerlach, Elizabeth T. Papish, Xiaohua Jiang
Open Journal of Medicinal Chemistry (OJMC) , 2018, DOI: 10.4236/ojmc.2018.82004
Abstract: Two new thiosemicarbazone ligands, 2-propionylthiazole ethylthiosemicarbazone (PTZ-ETSC), and 2-propionylthiazole tert-butylthiosemicarbazone (PTZ-tBTSC), along with their two copper(II) complexes, [Cu(PTZ-ETSC)Cl] and [Cu(PTZ-tBTSC)Cl], are reported here for the first time. Once characterized by NMR and MS, these mono-anionic tridentate ligands were reacted with Cu2+ to form the square planar metal complexes [Cu(PTZ-ETSC)Cl] and [Cu(PTZ-tBTSC)Cl]. The x-ray crystal structure of the [Cu(PTZ-tBTSC)Cl] complex shows that the complex adopts a square planar arrangement around the copper(II) ion, but forms a sulfur-bridged dimer in the solid state. Both of the copper complexes displayed strong inhibition of human topoisomerase IIα at activities between 2-4 μM for [Cu(PTZ-ETSC)Cl], and between 8-10 μM for the [Cu(PTZ-tBTSC)Cl] complex. The EC50 values for the MDA-MB-231 breast cancer cell line were 82.6 μM for (PTZ-ETSC), 17.9 μM for [Cu(PTZ- ETSC)Cl], 97.8 μM for (PTZ-tBTSC), and 1.41 μM for [Cu(PTZ-tBTSC)Cl]. The EC50 values for the MCF7 breast cancer cell lines were 9.36 μM for (PTZ-ETSC), 0.13 μM for [Cu(PTZ-ETSC)Cl], 0.333 μM for (PTZ-tBTSC), and 0.093 μM for [Cu(PTZ-tBTSC)Cl].
Long branch attraction, taxon sampling, and the earliest angiosperms: Amborella or monocots?
Sa?a Stefanovi?, Danny W Rice, Jeffrey D Palmer
BMC Evolutionary Biology , 2004, DOI: 10.1186/1471-2148-4-35
Abstract: We used two main approaches to test this hypothesis. First, we sequenced a large number of chloroplast genes from the monocot Acorus and added these plus previously sequenced Acorus genes to the Goremykin et al. (2003) dataset in order to explore the effects of altered monocot sampling under the same analytical conditions used in their study. With Acorus alone representing monocots, strongly supported Amborella-sister trees were obtained in all maximum likelihood and parsimony analyses, and in some distance-based analyses. Trees with both Acorus and grasses gave either a well-supported Amborella-sister topology or else a highly unlikely topology with 100% support for grasses-sister and paraphyly of monocots (i.e., Acorus sister to "dicots" rather than to grasses). Second, we reanalyzed the Goremykin et al. (2003) dataset focusing on methods designed to account for rate heterogeneity. These analyses supported an Amborella-sister hypothesis, with bootstrap support values often conflicting strongly with cognate analyses performed without allowing for rate heterogeneity. In addition, we carried out a limited set of analyses that included the chloroplast genome of Nymphaea, whose position as a basal angiosperm was also, and very recently, challenged.These analyses show that Amborella (or Amborella plus Nymphaea), but not monocots, is the sister group of all other angiosperms among this limited set of taxa and that the grasses-sister topology is a long-branch-attraction artifact leading to incorrect rooting of angiosperms. These results highlight the danger of having lots of characters but too few and, especially, molecularly divergent taxa, a situation long recognized as potentially producing strongly misleading molecular trees. They also emphasize the importance in phylogenetic analysis of using appropriate evolutionary models.A correct understanding of relationships among the "earliest" lineages of angiosperms is important if we wish to elucidate the causes and consequ
Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain
Laura De Laporte, Jeffrey J. Rice, Federico Tortelli, Jeffrey A. Hubbell
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062076
Abstract: Tenascin C (TNC) is an extracellular matrix protein that is upregulated during development as well as tissue remodeling. TNC is comprised of multiple independent folding domains, including 15 fibronectin type III-like (TNCIII) domains. The fifth TNCIII domain (TNCIII5) has previously been shown to bind heparin. Our group has shown that the heparin-binding fibronectin type III domains of fibronectin (FNIII), specifically FNIII12–14, possess affinity towards a large number of growth factors. Here, we show that TNCIII5 binds growth factors promiscuously and with high affinity. We produced recombinant fragments of TNC representing the first five TNCIII repeats (TNCIII1–5), as well as subdomains, including TNCIII5, to study interactions with various growth factors. Multiple growth factors of the platelet-derived growth factor (PDGF) family, the fibroblast growth factor (FGF) family, the transforming growth factor beta (TGF-β) superfamily, the insulin-like growth factor binding proteins (IGF-BPs), and neurotrophins were found to bind with high affinity to this region of TNC, specifically to TNCIII5. Surface plasmon resonance was performed to analyze the kinetics of binding of TNCIII1–5 with TGF-β1, PDGF-BB, NT-3, and FGF-2. The promiscuous yet high affinity of TNC for a wide array of growth factors, mediated mainly by TNCIII5, may play a role in multiple physiological and pathological processes involving TNC.
The Mitochondrial Genome of the Legume Vigna radiata and the Analysis of Recombination across Short Mitochondrial Repeats
Andrew J. Alverson,Shi Zhuo,Danny W. Rice,Daniel B. Sloan,Jeffrey D. Palmer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016404
Abstract: The mitochondrial genomes of seed plants are exceptionally fluid in size, structure, and sequence content, with the accumulation and activity of repetitive sequences underlying much of this variation. We report the first fully sequenced mitochondrial genome of a legume, Vigna radiata (mung bean), and show that despite its unexceptional size (401,262 nt), the genome is unusually depauperate in repetitive DNA and "promiscuous" sequences from the chloroplast and nuclear genomes. Although Vigna lacks the large, recombinationally active repeats typical of most other seed plants, a PCR survey of its modest repertoire of short (38–297 nt) repeats nevertheless revealed evidence for recombination across all of them. A set of novel control assays showed, however, that these results could instead reflect, in part or entirely, artifacts of PCR-mediated recombination. Consequently, we recommend that other methods, especially high-depth genome sequencing, be used instead of PCR to infer patterns of plant mitochondrial recombination. The average-sized but repeat- and feature-poor mitochondrial genome of Vigna makes it ever more difficult to generalize about the factors shaping the size and sequence content of plant mitochondrial genomes.
Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research
Frances Rice
Genome Medicine , 2010, DOI: 10.1186/gm189
Abstract: Major depressive disorder (MDD) during childhood is relatively uncommon and the 12-month prevalence ranges from 0.5% to 3% [1,2], with an equal proportion of girls and boys affected or a slight preponderance of boys. Adolescence is a period of vulnerability for depressive disorder with first onsets often occurring during this period and subthreshold symptoms increasing markedly [3-5]. Estimates of the 12-month prevalence of depressive disorder in adolescence range from 2% to 8%, and the figure for lifetime adolescent depression is 20% [1,2,6]. In adolescence, the ratio of affected females to males is 2:1, which mirrors the pattern seen in adult life [2,6]. Adolescent subthreshold symptoms are not benign, and high levels of depressive symptoms that fall below the diagnostic threshold are associated with functional impairment [7]. Depression interferes with the ability of young people to meet their academic, economic and social potential, and is associated with a greatly increased risk of suicide and suicidal behaviour [1]. A significant proportion of depressed adolescents continue to have mental health problems and poor social outcomes in adult life [8].The criteria used to diagnose depression in children and adolescents are the same as those used in adults, with the only exception being that the Diagnostic and Statistical Manual of Mental Disorders criteria allow irritable mood instead of depressed mood as a core symptom for children and adolescents [9]. The fact that the same criteria are used to diagnose depression in childhood/adolescence and adulthood implicitly assumes similarity in the presentation of depression across developmental stages. Although very few studies have compared the phenomenology or symptom profiles of childhood/adolescent depression with that of adult depression, evidence suggests that there may be heterogeneity between childhood/adolescent and adult depression, and also between depression in childhood and adolescence. This evidence comes fr
Treatment of immune thrombocytopenic purpura: focus on eltrombopag
Lawrence Rice
Biologics: Targets and Therapy , 2009, DOI: http://dx.doi.org/10.2147/BTT.S3130
Abstract: eatment of immune thrombocytopenic purpura: focus on eltrombopag Review (5470) Total Article Views Authors: Lawrence Rice Published Date March 2009 Volume 2009:3 Pages 151 - 157 DOI: http://dx.doi.org/10.2147/BTT.S3130 Lawrence Rice Weill Cornell Medical College, The Methodist Hospital, Houston, Texas, USA Abstract: Immune thrombocytopenic purpura (ITP) is a relatively common autoimmune disorder in which antibodies are produced to circulating platelets. Symptoms can be mild, but for most patients the risk of severe bleeding is unacceptable and treatment is required. Glucocorticoids followed by splenectomy had been the mainstays of therapy. High dose intravenous immunoglobulin and anti-RhD therapy are available for patients with severe illness, but produce only temporary benefit. Rituximab may provide more durable responses, danazol may be underutilized, and immunosuppressants and cytotoxic agents are less often required. Recently the pathophysiology of ITP has been more clearly elucidated, particularly the importance of decreased production of platelets in most patients and the very blunted rise that occurs in serum thrombopoietin (TPO). The isolation of TPO and better understanding of its role in thrombopoiesis has led to the development of new highly effective treatments. TPO analogs had some successes in treating highly refractory ITP patients but were taken out of development due to TPO-antibody induction. Two second-generation TPO-mimetics, romiplostim and the orally available eltrombopag, have recently been licensed in some territories for the treatment of ITP. Approval of eltrombopag was based on results from Phase II and III placebo-controlled clinical trials and a long-term extension study. About 80% of patients achieve significant increases in platelet count (11% of placebo patients), with reduced bleeding and reduced use of concomitant medications; responses are often durable with no tachyphylaxis. The side effects of eltrombopag are generally mild and not worse than placebo, although there are concerns about hepatic dysfunction, and the potentials for thromboses, marrow reticulin fibrosis, rebound thrombocytopenia and cataracts. This is an important new option for highly refractory patients, and its niche in earlier treatment (and for other thrombocytopenic disorders) is yet to be defined.
Treatment of immune thrombocytopenic purpura: focus on eltrombopag
Lawrence Rice
Biologics: Targets and Therapy , 2009,
Abstract: Lawrence RiceWeill Cornell Medical College, The Methodist Hospital, Houston, Texas, USAAbstract: Immune thrombocytopenic purpura (ITP) is a relatively common autoimmune disorder in which antibodies are produced to circulating platelets. Symptoms can be mild, but for most patients the risk of severe bleeding is unacceptable and treatment is required. Glucocorticoids followed by splenectomy had been the mainstays of therapy. High dose intravenous immunoglobulin and anti-RhD therapy are available for patients with severe illness, but produce only temporary benefit. Rituximab may provide more durable responses, danazol may be underutilized, and immunosuppressants and cytotoxic agents are less often required. Recently the pathophysiology of ITP has been more clearly elucidated, particularly the importance of decreased production of platelets in most patients and the very blunted rise that occurs in serum thrombopoietin (TPO). The isolation of TPO and better understanding of its role in thrombopoiesis has led to the development of new highly effective treatments. TPO analogs had some successes in treating highly refractory ITP patients but were taken out of development due to TPO-antibody induction. Two second-generation TPO-mimetics, romiplostim and the orally available eltrombopag, have recently been licensed in some territories for the treatment of ITP. Approval of eltrombopag was based on results from Phase II and III placebo-controlled clinical trials and a long-term extension study. About 80% of patients achieve significant increases in platelet count (11% of placebo patients), with reduced bleeding and reduced use of concomitant medications; responses are often durable with no tachyphylaxis. The side effects of eltrombopag are generally mild and not worse than placebo, although there are concerns about hepatic dysfunction, and the potentials for thromboses, marrow reticulin fibrosis, rebound thrombocytopenia and cataracts. This is an important new option for highly refractory patients, and its niche in earlier treatment (and for other thrombocytopenic disorders) is yet to be defined.Keywords: eltrombopag, immune thrombocytopenic purpura, autoimmune disorder, serum thrombopoietin
Intramedullary Spinal Neurocysticercosis Presenting as Brown- Sequard Syndrome
Brian Rice
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2012,
Abstract: Cysticercosis is an emerging disease in the United States. Neurocysticercosis may rarely cause disease within the spinal cord, but the occurrence of such pathology can produce debilitating symptoms for patients. We present the second report in the literature of intramedullary spinal neurocysticercosis presenting with a Brown-Sequard syndrome.
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