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Search Results: 1 - 10 of 6498 matches for " Jeffrey Mangel "
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2-Octyl Cyanoacrylate Skin Adhesive for Topical Skin Incision Closure in Female Pelvic Surgery  [PDF]
Rebecca L. James, Marilyn Alejandro-Rodriquez, Elba Adriana Perez, Jeffrey Mangel
Open Journal of Obstetrics and Gynecology (OJOG) , 2015, DOI: 10.4236/ojog.2015.55041
Abstract: Background: 2-octyl cyanoacrylate (2OCA) high viscosity tissue adhesive (Medline Industries, Inc., Mundelein, IL) is a liquid topical skin adhesive. 2OCA offers the same design features and clinical utility in terms of flexibility, strength, and low complication rate as the commercially available 2OCA tissue adhesives. Additionally, 2OCA features high viscosity allowing for better control during the application process, polymerization without the use of an external activator, and a distinctive violet color for ease of application visualization. Objective: The aim of this prospective case series is to descriptively report clinical data with the application of 2OCA as a topical incision closure system in female pelvic surgery. The primary outcomes included: incisional pain, incisional dehiscence, and post-operative bleeding. The secondary outcome included drying times of the adhesive with regard to incision length. Methods: A prospective open-label observational case series study was conducted to evaluate the use of 2OCA in surgical wound closure of the topical skin in adult patients undergoing gynecologic surgical procedures. A total of 50 adult women undergoing gynecologic surgery were enrolled. 2OCA was applied only by surgeons who had undergone product training to the incisions in a standardized, protocol-defined fashion. Drying times for the adhesive and photography were recorded intraoperatively. Post treatment follow-up was conducted with queries of pain level, incisional dehiscence, and incisional bleeding immediately post-operatively, 48 hours, 5 - 10 days and 14 days post-treatment. Adverse events were documented. Results: 2OCA was applied to a total of 154 incisions from the 50 patients enrolled to the study. The procedures included: 16 laparoscopic total hysterectomies, 4 diagnostic laparoscopies, 2 laparoscopic myomectomies, 2 laparoscopic bilateral or unilateral salpingo-oophorectomies, 5 total robotic-assisted laparoscopic surgeries (2 total hysterectomies, 1 supracervical hysterectomy, 1 sacrocolpopexy, and one excision of endometriosis), 7 sacral neuromodulation procedures, and 18 midurethral slings. The overall rate of incisional dehiscence was 3% (4/154). The rate of reported incisional bleeding was 3% (4/154). There was 1 incisional infection. The pain reports based on a 10-point scale had a mean of 4.96 immediately post-operatively, which decreased to a mean score < 1 (0.2) by post-op day (POD) 14. The mean drying times for the various lengths of incisions included the following: 1.28 minutes for incisions ≤ 5 mm, 1.53 minutes for
NUEVO REGISTRO DE LA NUTRIA MARINA Lontra felina (MOLINA, 1782) AL NORTE DE SU DISTRIBUCIóN ACTUAL
Joanna Alfaro-Shigueto,Juan Valqui,Jeffrey C. Mangel
Ecología Aplicada , 2011,
Abstract: La nutria marina Lontra felina es una especie en peligro de extinción cuyo rango de distribución es controversial, siendo considerada el área de Chimbote (9°10'S) como el límite norte de su distribución actual. Aquí se documenta por primera vez su presencia a 115 km al norte de Chimbote, en el puerto artesanal de Huanchaco (08°04'S). La discusión de esta nota científica busca promover la generación de investigaciones que esclarezcan tanto los factores que determinan la presencia de la nutria marina en un determinado lugar, así como su rango de distribución límite norte. Se sugieren medidas de conservación a favor de la nutria marina y del hábitat costero a nivel local (puertos y ciudades) y regional (departamentos y países), aprovechando el carácter de especie bandera de L. felina.
Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review
Mangel AW, Hicks GA
Clinical and Experimental Gastroenterology , 2012, DOI: http://dx.doi.org/10.2147/CEG.S23274
Abstract: simadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review Review (3596) Total Article Views Authors: Mangel AW, Hicks GA Published Date January 2012 Volume 2012:5 Pages 1 - 10 DOI: http://dx.doi.org/10.2147/CEG.S23274 Received: 11 October 2011 Accepted: 08 December 2011 Published: 12 January 2012 Allen W Mangel1, Gareth A Hicks2 1RTI Health Solutions, Research Triangle Park, NC, 2Tioga Pharmaceuticals Inc, San Diego, CA, USA Abstract: Irritable bowel syndrome (IBS) is a multifactorial condition with principal symptoms of pain and altered bowel function. The kappa-opioid agonist asimadoline is being evaluated in Phase III as a potential treatment for IBS. Asimadoline, to date, has shown a good safety profile and the target Phase III population – diarrhea-predominant IBS patients with at least moderate pain – was iteratively determined in a prospective manner from a Phase II dose-ranging study. The clinical data in support of this population are reviewed in this article. Furthermore, the scientific rationale for the use of asimadoline in the treatment of IBS is reviewed. Considering the high patient and societal burdens of IBS, new treatments for IBS represent therapeutic advances.
Nefroprotección en Diabetes Mellitus tipo 2
Fernando Mangel Morales
Acta Médica Costarricense , 2003,
Abstract:
Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review
Mangel AW,Hicks GA
Clinical and Experimental Gastroenterology , 2012,
Abstract: Allen W Mangel1, Gareth A Hicks21RTI Health Solutions, Research Triangle Park, NC, 2Tioga Pharmaceuticals Inc, San Diego, CA, USAAbstract: Irritable bowel syndrome (IBS) is a multifactorial condition with principal symptoms of pain and altered bowel function. The kappa-opioid agonist asimadoline is being evaluated in Phase III as a potential treatment for IBS. Asimadoline, to date, has shown a good safety profile and the target Phase III population – diarrhea-predominant IBS patients with at least moderate pain – was iteratively determined in a prospective manner from a Phase II dose-ranging study. The clinical data in support of this population are reviewed in this article. Furthermore, the scientific rationale for the use of asimadoline in the treatment of IBS is reviewed. Considering the high patient and societal burdens of IBS, new treatments for IBS represent therapeutic advances.Keywords: irritable bowel syndrome, kappa-opioid agonist, asimadoline, visceral pain, visceral hypersensitivity
Phenotypic Evolutionary Models in Stem Cell Biology: Replacement, Quiescence, and Variability
Marc Mangel, Michael B. Bonsall
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001591
Abstract: Phenotypic evolutionary models have been used with great success in many areas of biology, but thus far have not been applied to the study of stem cells except for investigations of cancer. We develop a framework that allows such modeling techniques to be applied to stem cells more generally. The fundamental modeling structure is the stochastic kinetics of stem cells in their niche and of transit amplifying and fully differentiated cells elsewhere in the organism, with positive and negative feedback. This formulation allows graded signals to be turned into all or nothing responses, and shows the importance of looking beyond the niche for understanding how stem cells behave. Using the deterministic version of this framework, we show how competition between different stem cell lines can be analyzed, and under what circumstances stem cells in a niche will be replaced by other stem cells with different phenotypic characteristics. Using the stochastic version of our framework and state dependent life history theory, we show that the optimal behavior of a focal stem cell will involve long periods of quiescence and that a population of identical stem cells will show great variability in the times at which activity occurs; we compare our results with classic ones on quiescence and variability in the hematopoietic system.
Identification of a Circadian Clock-Controlled Neural Pathway in the Rabbit Retina
Christophe Ribelayga,Stuart C. Mangel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011020
Abstract: Although the circadian clock in the mammalian retina regulates many physiological processes in the retina, it is not known whether and how the clock controls the neuronal pathways involved in visual processing.
Implications of Aging in Bacteria
Leah R. Johnson,Marc Mangel
Quantitative Biology , 2005, DOI: 10.1016/j.mad.2006.07.004
Abstract: Motivated by recent research of aging in E. coli, we explore the effects of aging on bacterial fitness. The disposable soma theory of aging was developed to explain how differences in lifespans and aging rates could be linked to life history trade-offs. Although generally applied for multicellular organisms, it is also useful for exploring life history strategies of single celled organisms such as bacteria. Starting from the Euler-Lotka equation, we propose a mathematical model to explore how a finite lifespan effects fitness of bacteria. We find that that there is surprisingly little loss of fitness when the bacterium has limited opportunities to reproduce. Instead, the fitness gained each time the bacteria reproduces decreases rapidly, and investing resources to survive to reproduce the first few times is likely more advantageous than investing additional resources to try to maintain cell integrity longer.
Compensatory dynamics of fish recruitment illuminated by functional elasticities
Justin D. Yeakel,Marc Mangel
Quantitative Biology , 2013,
Abstract: Models of Stock Recruitment Relationships (SRRs) are often used to predict fish population dynamics. Commonly used SRRs include the Ricker, Beverton-Holt, and Cushing functional forms, which differ primarily by the degree of density dependent effects (compensation). The degree of compensation determines whether recruitment respectively decreases, saturates, or increases at high levels of spawning stock biomass. In 1982 J.G. Shepherd united these dynamics into a single model, where the degree of compensation is determined by a single parameter, however the difficulty in relating this parameter to biological data has limited its usefulness. Here we use a generalized modeling framework to show that the degree of compensation can be related directly to the functional elasticity of growth, which is a general quantity that measures the change in recruitment relative to a change in biomass, irrespective of the specific SRR. We show that the elasticity of growth can be calculated from short-term fluctuations in fish biomass, is robust to observation error, and can be used to determine general attributes of the SRR in both continuous time production models, as well as discrete time age-structured models. This framework may be particularly useful if fisheries time-series data are limited, and not conducive to determining functional relationships using traditional methods of statistical best-fit.
Depolarization-Stimulated Contractility of Gastrointestinal Smooth Muscle in Calcium-Free Solution: A Review
Emily D. Evans,Allen W. Mangel
ISRN Gastroenterology , 2011, DOI: 10.5402/2011/692528
Abstract:
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