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Search Results: 1 - 10 of 147838 matches for " Jeffrey K Tobias "
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Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia
Lynn R Webster, Marvin Tark, Richard Rauck, Jeffrey K Tobias, Geertrui F Vanhove
BMC Neurology , 2010, DOI: 10.1186/1471-2377-10-92
Abstract: This multicenter, double-blind, controlled study randomized 155 patients 2:1 to receive either NGX-4010 or a 0.04% capsaicin control patch. Patients were at least 18 years old with PHN for at least 3 months, and an average Numeric Pain Rating Scale (NPRS) score of 3 to 9. The primary efficacy endpoint was the percentage change in NPRS score from baseline to weeks 2-8.The mean percent reduction in "average pain for the past 24 hours" NPRS scores from baseline to weeks 2-8 was greater in the NGX-4010 group (36.5%) compared with control (29.9%) although the difference was not significant (p = 0.296). PGIC analysis demonstrated that more NGX-4010 recipients considered themselves improved (much, or very much) compared with control at weeks 8 and 12, but the differences did not reach statistical significance. Post hoc analyses of patients with PHN for at least 6 months showed significantly greater reductions in "average pain for the past 24 hours" NPRS scores from baseline to weeks 2-8 in NGX-4010 patients compared to controls (37.6% versus 23.4%; p = 0.0291). PGIC analysis in this subgroup demonstrated that significantly more NGX-4010 recipients considered themselves much or very much improved compared with control at week 12 (40% versus 20%; p = 0.0403;).Although treatment appeared to be safe and well tolerated, a single 60-minute application of NGX-4010 failed to show efficacy in this study which included patients with PHN for less than 6 months. Large reductions in pain observed among control patients with pain for less than 6 months may have been due to spontaneous resolution of PHN, may have confounded the results of the prespecified analyses, and should be taken into account when designing PHN studies.NCT00068081Postherpetic neuralgia (PHN) is a painful complication of acute herpes zoster (shingles) that is caused by reactivation of the varicella zoster virus usually contracted in childhood. Acute herpes zoster is often very painful. Usually this pain subsides, but
Tolerability of NGX-4010, a capsaicin 8% dermal patch, following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with post-herpetic neuralgia
Lynn R Webster, Margarita Nunez, Marvin D Tark, Edwin D Dunteman, Biao Lu, Jeffrey K Tobias, Geertrui F Vanhove
BMC Anesthesiology , 2011, DOI: 10.1186/1471-2253-11-25
Abstract: Twenty-four patients with PHN were pretreated with lidocaine 2.5%/prilocaine 2.5% cream for 60 minutes before receiving a single 60-minute application of NGX-4010. Tolerability was assessed by measuring patch application duration, the proportion of patients completing over 90% of the intended treatment duration, application site-related pain using the Numeric Pain Rating Scale (NPRS), and analgesic medication use to relieve such pain. Safety was assessed by monitoring adverse events (AEs) and dermal irritation using dermal assessment scores.The mean treatment duration of NGX-4010 was 60.2 minutes and all patients completed over 90% of the intended patch application duration. Pain during application was transient. A maximum mean change in NPRS score of +3.0 was observed at 55 minutes post-patch application; pain scores gradually declined to near pre-anesthetic levels (+0.71) within 85 minutes of patch removal. Half of the patients received analgesic medication on the day of treatment; by Day 7, no patients required medication. The most common AEs were application site-related pain, erythema, edema, and pruritus. All patients experienced mild dermal irritation 5 minutes after patch removal, which subsequently decreased; at Day 7, no irritation was evident. The maximum recorded dermal assessment score was 2.NGX-4010 was well tolerated following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with PHN. The tolerability of the patch application appeared comparable with that seen in other studies that used 4% lidocaine cream as the pretreatment anesthetic. This study is registered at http://www.clinicaltrials.gov webcite as number NCT00916942.Neuropathic pain is pain arising as a direct consequence of a lesion or disease affecting the somatosensory system [1]. Post-herpetic neuralgia (PHN) is a common type of neuropathic pain occurring as a complication of reactivation of the varicella zoster virus (shingles). PHN is caused by damage to the small-diamet
A Cognitive Radio Receiver Supporting Wide-Band Sensing  [PDF]
Volker BLASCHKE, Tobias RENK, Friedrich K. JONDRAL
Wireless Sensor Network (WSN) , 2009, DOI: 10.4236/wsn.2009.13018
Abstract: The specification of IEEE 802.22 defines the world-wide first cognitive radio (CR) standard. Within a range of 40 MHz to 910 MHz CR systems are allowed to allocate spectrum besides the currently established radio services like radio and TV broadcasting. In order to fulfill the regulative guidelines of interference limita-tions, a capable spectral sensing and user detection has to be provided. Due to the wide frequency range specified in IEEE 802.22 and the high dynamic range of signals allocated in this band there are high de-mands on the CR receiver’s front-end. Especially the performance requirements on analog-to-digital con-verters increase significantly compared to current wireless systems. Based on measurements taken in this frequency range requirements to CR’s ADCs are figured out. Furthermore, the measurement results are ana-lyzed regarding expectable allocation scenarios and their impacts to spectral sensing. Derived from this re-sults and a comparison of general spectral sensing mechanisms an approach for a CR receiver supporting wide-band sensing is presented. Considering the apriori information resulting from scenario analysis and including adapted information processing in the terminal the ADC’s performance requirements can be re-duced.
Incisional Negative Pressure Wound Therapy in the Prevention of Surgical Site Infection after Vascular Surgery with Inguinal Incisions: Rationale and Design of a Randomized Controlled Trial (INVIPS-Trial)  [PDF]
Julien Hasselmann, Tobias Kühme, Jonas Bj?rk, Stefan Acosta
Surgical Science (SS) , 2015, DOI: 10.4236/ss.2015.612080
Abstract: Background/Aims: Inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surgery to prevent SSI and other wound complications. Methods: This randomized controlled trial (RCT) registered at ClinicalTrials.gov (Identifier: NCT01913132) compares the effects of a NPWT dressing (PICO, Smith & Nephew, UK) and the center’s standard wound dressing (Vitri Pad, ViTri Medical, Sweden) on postoperative wound complications, especially SSI. The study includes two distinct vascular procedures with different SSI risk profiles: endovascular aortic repair (EVAR) and open surgical approaches involving the common femoral artery (OPEN). Results: Four hundred ninety-five groin incisions in both treatment arms are anticipated to be included in the EVAR group and 147 inguinal incisions in both treatment arms in the OPEN group. Since a large percentage of inguinal vascular procedures in both groups but especially in the EVAR group are performed bilaterally, many patients can serve as their own control by randomly receiving NPWT on one and the standard dressing on the contralateral inguinal incision. Conclusions: This ongoing RCT attempts to elucidate the potential benefit of NPWT on closed inguinal incisions after
Review: Richard A. Krueger & Mary Anne Casey (2000). Focus Groups. A Practical Guide for Applied Research (3. Auflage) Review: Richard A. Krueger & Mary Anne Casey (2000). Focus Groups. A Practical Guide for Applied Research (3rd edition) Rese a: Richard A. Krueger & Mary Anne Casey (2000). Focus Groups. A Practical Guide for Applied Research (tercera edición)
Jeffrey K. Lange
Forum : Qualitative Social Research , 2002,
Abstract: KRUEGER und CASEY haben ein Handbuch für die Planung, Vorbereitung und Durchführung von Fokusgruppen-Untersuchungen vorgelegt. Da die Autor(inn)en sich offensichtlich vor allem an Noviz(inn)en richten, mangelt es dem Buch an einer soliden theoretisch-methodologischen Grundlegung, und sie leisten damit teilweise dem Misstand Vorschub, dass anstelle gebr uchlicherer Termini idiosynkratische Ausdrucksweisen verwendet werden. Untersch tzt werden in dem Handbuch auch m gliche Vorteile von Fokusgruppen zum strukturierten Hervorrufen von "überraschung" und für das Aufdecken linguistischer Konstruktionen in den (Ziel-) Gruppen. URN: urn:nbn:de:0114-fqs0204280 KRUEGER and CASEY have prepared a handbook for planning, preparing for, and carrying out focus group studies. A work apparently aimed at an audience of novices, Focus Groups lacks solid theoretical grounding, promotes substituting idiosyncratic phrasing for technical terms more commonly used in the field, and overlooks or minimizes focus group advantages for evoking structured surprise and revealing target-audiences' linguistic constructions. URN: urn:nbn:de:0114-fqs0204280 KRUEGER y CASEY han presentado un manual para la planificación, preparación y realización de investigaciones sobre grupos focales. El libro carece de sólidos fundamentos teóricos metodológicos debido a que los autores se dirigen evidentemente ante todo a principiantes, y así favorecen en parte al inconveniente de utilizar expresiones idiosincráticas en vez de términos técnicos. En el manual se desestiman también las ventajas que pueden tener los grupos focales para evocaciones estructuradas de "sorpresa" y para develar construcciones linguísticas en el grupo de objetivos. URN: urn:nbn:de:0114-fqs0204280
Recently Recognized Types of Some Homoptera Described by Dr. Asa Fitch
Jeffrey K. Barnes
Psyche , 1984, DOI: 10.1155/1984/10837
Case variation in coordination: Danish vs. Faroese
Jeffrey K. Parrott
Nordlyd : Troms? University Working Papers on Language & Linguistics / Institutt for Spr?k og Litteratur, Universitetet i Troms? , 2009,
Abstract: This paper is primarily concerned with inter- and intra-individually variable case-form mismatches inside coordinate determiner phrases (CoDPs). For English, the phenomenon is both socially salient (e.g., O'Conner & Kellerman 2009, among many others) and well studied (Angermeyer & Singler 2003, Quinn 2005, Grano 2006, Parrott 2007: Ch. 6). The most prominent theory of (default) case (Schütze 2001, incorporating Johannessen 1998) explains English variation in CoDPs mostly with parameterized syntactic mechanisms. The parametric theory does not make clear cross-linguistic predictions, and accordingly there has been little cross-linguistic investigation of case variation in CoDPs. This paper therefore has two main purposes. The first is to argue for a theory of (default) case (Parrott 2007, 2009a, following Emonds 1986, and incorporating McFadden 2004, 2007) within the Distributed Morphology (DM) framework (Halle & Marantz 1993, Embick & Noyer 2007). In contrast with the parametric theory, the DM theory makes testable cross-linguistic predictions that, inter alia, connect the (non) attestation of case mismatches in CoDPs with Germanic case typology. Thus, the paper’s second purpose is to present some results from investigations, utilizing diverse empirical methods, into case variation in CoDPs for Danish and Faroese. These results are consistent with predictions made by the DM theory.
Spelling is just a click away – a user-centered brain-computer interface including auto-calibration and predictive text entry
Tobias Kaufmann,Andrea Kübler
Frontiers in Neuroscience , 2012, DOI: 10.3389/fnins.2012.00072
Abstract: Brain–computer interfaces (BCI) based on event-related potentials (ERP) allow for selection of characters from a visually presented character-matrix and thus provide a communication channel for users with neurodegenerative disease. Although they have been topic of research for more than 20 years and were multiply proven to be a reliable communication method, BCIs are almost exclusively used in experimental settings, handled by qualified experts. This study investigates if ERP–BCIs can be handled independently by laymen without expert support, which is inevitable for establishing BCIs in end-user’s daily life situations. Furthermore we compared the classic character-by-character text entry against a predictive text entry (PTE) that directly incorporates predictive text into the character-matrix. N = 19 BCI novices handled a user-centered ERP–BCI application on their own without expert support. The software individually adjusted classifier weights and control parameters in the background, invisible to the user (auto-calibration). All participants were able to operate the software on their own and to twice correctly spell a sentence with the auto-calibrated classifier (once with PTE, once without). Our PTE increased spelling speed and, importantly, did not reduce accuracy. In sum, this study demonstrates feasibility of auto-calibrating ERP–BCI use, independently by laymen and the strong benefit of integrating predictive text directly into the character-matrix.
Comparison of tactile, auditory, and visual modality for brain-computer interface use: a case study with a patient in the locked-in state
Tobias Kaufmann,Andrea Kübler
Frontiers in Neuroscience , 2013, DOI: 10.3389/fnins.2013.00129
Abstract: This paper describes a case study with a patient in the classic locked-in state, who currently has no means of independent communication. Following a user-centered approach, we investigated event-related potentials (ERP) elicited in different modalities for use in brain-computer interface (BCI) systems. Such systems could provide her with an alternative communication channel. To investigate the most viable modality for achieving BCI based communication, classic oddball paradigms (1 rare and 1 frequent stimulus, ratio 1:5) in the visual, auditory and tactile modality were conducted (2 runs per modality). Classifiers were built on one run and tested offline on another run (and vice versa). In these paradigms, the tactile modality was clearly superior to other modalities, displaying high offline accuracy even when classification was performed on single trials only. Consequently, we tested the tactile paradigm online and the patient successfully selected targets without any error. Furthermore, we investigated use of the visual or tactile modality for different BCI systems with more than two selection options. In the visual modality, several BCI paradigms were tested offline. Neither matrix-based nor so-called gaze-independent paradigms constituted a means of control. These results may thus question the gaze-independence of current gaze-independent approaches to BCI. A tactile four-choice BCI resulted in high offline classification accuracies. Yet, online use raised various issues. Although performance was clearly above chance, practical daily life use appeared unlikely when compared to other communication approaches (e.g., partner scanning). Our results emphasize the need for user-centered design in BCI development including identification of the best stimulus modality for a particular user. Finally, the paper discusses feasibility of EEG-based BCI systems for patients in classic locked-in state and compares BCI to other AT solutions that we also tested during the study.
The proper motion of Palomar 5
Tobias K. Fritz,Nitya Kallivayalil
Physics , 2015, DOI: 10.1088/0004-637X/811/2/123
Abstract: Palomar 5 (Pal 5) is a faint halo globular cluster associated with narrow tidal tails. It is a useful system to understand the process of tidal dissolution, as well as to constrain the potential of the Milky Way. A well-determined orbit for Pal 5 would enable detailed study of these open questions. We present here the first CCD-based proper motion measurement of Pal 5 obtained using SDSS as a first epoch and new LBT/LBC images as a second, giving a baseline of 15 years. We perform relative astrometry, using SDSS as a distortion-free reference, and images of the cluster and also of the Pal 5 stream for the derivation of the distortion correction for LBC. The reference frame is made up of background galaxies. We correct for differential chromatic refraction using relations obtained from SDSS colors as well as from flux-calibrated spectra, finding that the correction relations for stars and for galaxies are different. We obtain mu_alpha=-2.296+/-0.186 mas/yr and mu_delta=-2.257+/-0.181 mas/yr for the proper motion of Pal 5. We use this motion, and the publicly available code galpy, to model the disruption of Pal 5 in different Milky Way models consisting of a bulge, a disk and a spherical dark matter halo. Our fits to the observed stream properties (streak and radial velocity gradient) result in a preference for a relatively large Pal 5 distance of around 24 kpc. A slightly larger absolute proper motion than what we measure also results in better matches but the best solutions need a change in distance. We find that a spherical Milky Way model, with V_0=220 km/s and V_(20 kpc), i.e., approximately at the apocenter of Pal 5, of 218 km/s, can match the data well, at least for our choice of disk and bulge parametrization.
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