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Search Results: 1 - 10 of 38580 matches for " Jeffery Lin "
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A transient solution for droplet deformation under electric fields
Jia Zhang,Jeffery D. Zahn,Hao Lin
Physics , 2012, DOI: 10.1103/PhysRevE.87.043008
Abstract: A transient analysis to quantify droplet deformation under DC electric fields is presented. The full Taylor-Melcher leaky dielectric model is employed where the charge relaxation time is considered to be finite. The droplet is assumed to be spheroidal in shape for all times. The main result is an ODE governing the evolution of the droplet aspect ratio. The model is validated by extensively comparing predicted deformation with both previous theoretical and numerical studies, and with experimental data. Furthermore, the effects of parameters and stresses on deformation characteristics are systematically analyzed taking advantage of the explicit formulae on their contributions. The theoretical framework can be extended to study similar problems, e.g., vesicle electrodeformation and relaxation.
Ropinirole Implants Reverse MPTP-Induced Parkinsonism in Rhesus Monkeys  [PDF]
Steven J. Siegel, Lauren Nagy, Torben Skarsfeldt, Mark Pierce, Carol O’ Neill, Robert Lin, Lori Langhamer, Jeffery H. Kordower
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43A001
Abstract:

Purpose: We compared efficacy and side effects of ropinirole implants with oral ropinirole in parkinsonian monkeys. Methods: Twenty monkeys received injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloride (MPTP) to render them parkinsonian. Monkeys were then placed into 3 groups based upon clinical rating scores (CRS). Group 1 received oral ropinirole and placebo implants. Group 2 receivedropinirole implants that released 1/9th of the animals’ optimal daily oral dose and oral placebo. Group 3 received placebo implants and oral placebo. Monkeys were assessed for pharmacokinetic data, CRS, Global Dyskinesia Rating Scale, and skin irritation. Results: For the ropinirole implant group, the activity pattern was similar to that seen pre-MPTP; which extended through the weekends and was greater than control treated parkinsonian monkeys. Oral ropinirole yielded a high degree of variability for activity, with values following oral dosing being higher than the pre-MPTP periodbut levels similar to placebo treated parkinsonian animals during weekends, which were excluded from oral dosing. Implants and oral treatment achieved significant improvement in CRS between 11 - 60 days and 4 - 60 days respectively. Conclusion: Low dose ropinirole implants have the potential to provide continuous clinical improvement in bradykinesia with fewer “off periods” and lower risk for medication-induced psychosis than oral medication.

Medical Image Registration Using the Fourier Transform  [PDF]
Jason Luce, James Gray, Mark A. Hoggarth, Jeffery Lin, Elizabeth Loo, Maria I. Campana, John C. Roeske
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2014, DOI: 10.4236/ijmpcero.2014.31008
Abstract:

A Fourier Transform (FT) based pattern-matching algorithm was adapted for use in medical image registration. This algorithm obtained the FT of two images, determined the normalized cross-power spectrum of the transformed images, and then applied an inverse FT. The result was a delta function with a maximum value at the location corresponding to the distance between the two images; a similar method was used to recover rotations. This algorithm was first tested using a simple two-dimensional image, with induced shifts of ±20 pixels and ±10 degrees. All translations were recovered with no error and all rotations were recovered within 0.18 degrees. Subsequently, this algorithm was tested on eight clinical kV images drawn from four different body sites. Twenty-five random shifts and rotations were applied to each image. The average mean error of the registration solution was -0.002 ± 0.077 mm in the x direction, 0.002 ± 0.075 mm in the y direction, and -0.012 ± 0.099 degrees. These initial results suggest that a FT algorithm has a high degree of accuracy when registering clinical kV images.

A transient solution for vesicle electrodeformation and relaxation
Jia Zhang,Jeffery D. Zahn,Wenchang Tan,Hao Lin
Physics , 2012, DOI: 10.1063/1.4812662
Abstract: A transient analysis for vesicle deformation under DC electric fields is developed. The theory extends from a droplet model, with the additional consideration of a lipid membrane separating two fluids of arbitrary properties. For the latter, both a membrane-charging and a membrane-mechanical model are supplied. The vesicle is assumed to remain spheroidal in shape for all times. The main result is an ODE governing the evolution of the vesicle aspect ratio. The effects of initial membrane tension and pulse length are examined. The model prediction is extensively compared with experimental data, and is shown to accurately capture the system behavior in the regime of no or weak electroporation. More importantly, the comparison reveals that vesicle relaxation obeys a universal behavior regardless of the means of deformation. The process is governed by a single timescale that is a function of the vesicle initial radius, the fluid viscosity, and the initial membrane tension. This universal scaling law can be used to calculate membrane properties from experimental data.
Health Impact of Community-Based Water Treatment Systems in Honduras
Jeffery Deal
Journal of Anthropology , 2011, DOI: 10.1155/2011/929860
Abstract: This paper provides a followup on a previous report in this journal on the health impact of providing access to water treatment and flush toilets to region of Honduras. Significant reductions were found in the one-year incidence of positive test results for the three protozoan species tested. This finding combined with the previously reported ethnographic and medical chart review data provides compelling evidence that such interventions significantly reduce the disease load from waterborne pathogens within this population. Furthermore, the finding that initial results are significantly different, even in the initial round of testing, if individuals who are not followed up are eliminated from the analysis has profound methodological implications which warrant further investigation and demonstrates the need for precise definitions of community in future studies.
Letter: Blueprint for Improvements
Kate Jeffery
Opticon1826 , 2008, DOI: 10.5334/opt.040816
Abstract: Ambily Banerjee's letter was very thought-provoking and expressed the frustration that I think many of us academic mothers feel, in being expected to participate in the academic equivalent of running a marathon with a concrete breeze block strapped to one leg. It's hardly surprising that even the most academically athletic mothers do not make it to the finish line, or, if they do, they find themselves pulling up at the rear. It's also not surprising that many ambitious women with a dislike of failure choose to avoid altogether a competition that is so stacked against them. Indeed, it is a testament to the power of human curiosity (and optimism) that so many even decide to try.
Taxonomic synopsis of invasive and native Spartina (Poaceae, Chloridoideae) in the Pacific Northwest (British Columbia, Washington and Oregon), including the first report of Spartina ×townsendii for British Columbia, Canada
Jeffery Saarela
PhytoKeys , 2012, DOI: 10.3897/phytokeys.10.2734
Abstract: Five species of the grass genus Spartina are invading salt marshes along the Pacific coast of North America, of which three have been documented in British Columbia, Canada, in only the last decade. A taxonomic synopsis of the two native (S. gracilis, S. pectinata) and five introduced Spartina taxa (S. anglica, S. alterniflora, S. densiflora, S. patens, S. ×townsendii) in the Pacific Northwest is presented to facilitate their identification, including nomenclature, a new taxonomic key, new descriptions for a subset of taxa, and representative specimens. Spartina ×townsendii is newly reported for the flora of British Columbia. The non-coastal species S. pectinata is reported from an urban site in British Columbia, the first confirmed report of the taxon for the province. Lectotypes are newly designated for S. anglica C.E. Hubb., S. maritimasubvar.fallax St.-Yves, and S. cynosuroides f. major St.-Yves.
The Internet of Things: The Death of a Traditional Database?
Jeffery Keith
IETE Technical Review , 2009,
Abstract: Traditional database research has developed technology to ensure that the database - even when -distributed - represents the world of interest with integrity and a consistent state. Important concepts have been developed and proven. However, the internet of things challenges all this. Very large numbers of nodes handle volumes that are vast, the speed is fast and the data/information space is global - indeed with space data - universal. This poses challenges. What does the concept of a state mean when the -information map of the real world of interest is represented across millions of nodes, many of which are updating in real-time? What does a transaction look like when the data being updated is spread across -hundreds or thousands of nodes with differing update policies? Worse, how does one roll back or -compensate a -transaction? We have -already seen database research applied to semi-structured data, to streamed data, and real-time -applications. Is it possible for these techniques to be applied to the internet of things? The internet of things opens up more opportunities for security compromises. How do we develop trust band security techniques across multiple policies? How do we prevent the unauthorized use of private information yet permit -authorized use? We need dynamic trust, security, and privacy management. Do we need a new theoretical framework?
Workshop attendees suggest methods to improve the number and advancement of women scientists in NanoScience/NanoTechnology
Constance Jeffery
Nano Reviews , 2012, DOI: 10.3402/nano.v3i0.15895
Abstract:
Health Impact of Community-Based Water Treatment Systems in Honduras
Jeffery Deal
Journal of Anthropology , 2011, DOI: 10.1155/2011/929860
Abstract: This paper provides a followup on a previous report in this journal on the health impact of providing access to water treatment and flush toilets to region of Honduras. Significant reductions were found in the one-year incidence of positive test results for the three protozoan species tested. This finding combined with the previously reported ethnographic and medical chart review data provides compelling evidence that such interventions significantly reduce the disease load from waterborne pathogens within this population. Furthermore, the finding that initial results are significantly different, even in the initial round of testing, if individuals who are not followed up are eliminated from the analysis has profound methodological implications which warrant further investigation and demonstrates the need for precise definitions of community in future studies. 1. Introduction A key component of the United Nations Millennium Development Goal Number 7 states “halve, by 2015 the proportion of the population (global) without sustainable access to safe drinking water and basic sanitation.” Most waterborne diseases result in diarrhea which continues to be a leading cause of morbidity and mortality worldwide. According to World Health Organization data, using existing technologies approximately ten percent of the worldwide burden of disease would be removed by the water supply, sanitation, hygiene, and management of water resources, making water-related diseases arguably the most manageable set of health problems affecting humans [1]. A great deal of work has been done attempting to measure the impact of interventions to provide improved water sources at the household level, and less frequently at the community level. The overwhelming majority of these studies have also used either key informant or self-reporting of diarrhea (defined as three or more loose stools per day) as the measure of disease burden [2–4]. Reliance upon such nonobjective measures introduces a host of potentially confounding variables [2, 5, 6] and yet appears to have been used in all of the 2,120 published studies reviewed in a far reaching meta-analysis produced for the World Bank on diarrhea and water interventions [7]. While some of these deficiencies may be reduced by shortening recall time to seventy-two hours or less, potentially profound observer effects remain. Estimates of disease load changes are further impeded by researchers’ concentration on known users of water systems rather than measurements on community disease levels of disease changes regardless of compliance, thus
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