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Search Results: 1 - 10 of 14506 matches for " Jee Young Park "
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Expression of CYLD and NF- B in Human Cholesteatoma Epithelium
Jae Yong Byun,Tae Young Yune,Jee Youn Lee,Seung Geun Yeo,Moon Suh Park
Mediators of Inflammation , 2010, DOI: 10.1155/2010/796315
Abstract: The tumor suppressor CYLD is a deubiquitinating enzyme that inhibits activation of the NF-B, which has key roles in inflammation and apoptosis. We hypothesized that CYLD may regulate the NF-B signaling pathway in cholesteatoma. We conducted immunohistochemistry to examine the expression of CYLD and NF-B in 16 cases of cholesteatoma and paired cases of retroauricular (RA) skin. In cholesteatoma epithelium, activated NF- B expression was significantly higher than in RA skin, whereas CYLD expression was significantly lower in cholesteatoma epithelium than in RA skin (<.05). Furthermore, a significant inverse correlation was detected between CYLD and activated NF-B expression in cholesteatoma epithelium (=?0.630). We found that CYLD reduced and activated increased NF-B in cholesteatoma epithelium in comparison to RA skin. The inverse correlation between CYLD and activated NF-B in cholesteatoma may be involved in cholesteatoma epithelial hyperplasia.
A Second-order bias model for the Logarithmic Halo Mass Density
Inh Jee,Changbom Park,Juhan Kim,Yun-Young Choi,Sungsoo S. Kim
Physics , 2012, DOI: 10.1088/0004-637X/753/1/11
Abstract: We present an analytic model for the local bias of dark matter halos in a LCDM universe. The model uses the halo mass density instead of the halo number density and is searched for various halo mass cuts, smoothing lengths, and redshift epoches. We find that, when the logarithmic density is used, the second-order polynomial can fit the numerical relation between the halo mass distribution and the underlying matter distribution extremely well. In this model the logarithm of the dark matter density is expanded in terms of log halo mass density to the second order. The model remains excellent for all halo mass cuts (from M_{cut}=3\times10^{11}$ to $3\times10^{12}h^{-1}M_{\odot}$), smoothing scales (from $R=5h^{-1}$Mpc to $50h^{-1}$Mpc), and redshift ranges (from z=0 to 1.0) considered in this study. The stochastic term in the relation is found not entirely random, but a part of the term can be determined by the magnitude of the shear tensor.
A Study on Water Repellent Effectiveness of Natural Oil-Applied Soil as a Building Material  [PDF]
Jong-Kook Lee, Jee-Eun Lee, Seong-Cheol Park, Hee-Dong Cho, Hye-Woong Yoo, Young-Sang Kim, Seong-Ryong Ryu, Woo-Suk Kim, Dong-Joon Ahn
Open Journal of Civil Engineering (OJCE) , 2015, DOI: 10.4236/ojce.2015.51014
Abstract: This study was performed to investigate the water repellent effectiveness of natural oil-applied soil when it is used as a building material. Natural oil types such as olive oil, bean oil, perilla oil and linseed oil, which are being used for producing water repellent timber, are selected for the experiments. It is expected that perilla oil and in seed oil, which are drying oil types will have better water repellent effectiveness than the other types. For the evaluation of water repellence of natural oil-applied soil, a contact angle test was performed. A contact angle of water drop on various surface conditions were tested, and large differences were seen between the natural oil-applied soil and untreated soil. As a result, it is showed that all natural oil types have water repellent effectiveness. However, linseed oil, which is a drying oil type, shows an outstanding water repellent effectiveness value, while perila oil, which is also a drying oil type, shows the lowest value. Additionally, results show that there is no link between water repellent effectiveness and the number of applications of natural oil. Nevertheless, existing commercial water repellents show better performance than natural oil, and it is anticipated that the results of this study will provide essential information for further research to enhance the water repellent effectiveness of soil as a building material.
Factors Associated With the Time to Next Attack in Neuromyelitis Optica: Accelerated Failure Time Models With Random Effects
Sung-Min Kim, Junwoo Park, Sun Hee Kim, Su-Yeon Park, Jee Young Kim, Jung-Joon Sung, Kyung Seok Park, Kwang-Woo Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082325
Abstract: Background and Objective Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder of the central nervous system with a relapsing and remitting course. We aimed to identify factors associated with the time to next attack, including the effect of the natural disease course and the diverse treatment regimens, by applying a longitudinal statistical analysis to the individual attacks of each patient. Methods In total, 184 acute attacks among 58 patients with either NMO or NMO spectrum disorder with anti-aquaporin-4 antibody were assessed retrospectively. Patient demographics, clinical characteristics at each attack, and type of treatment during inter-attack periods were assessed. The dependent variable was defined as the time from each attack to the next attack (inter-attack interval). An exponential accelerated failure time model with shared gamma frailty was adapted for statistical analysis. Results A multivariable analysis revealed that the time from each attack to the next attack in NMO increased independently by 1.31 times (95% confidence interval (CI), 1.02–1.67; p = 0.035) with each additional cumulative attack experienced, by 5.34 times (95% CI, 1.57–18.13; p = 0.007) with combined azathioprine treatment and continued oral prednisolone, and by 4.26 times (95% CI, 1.09–16.61; p = 0.037) with rituximab treatment. Conclusion The time to next attack in NMO can increase naturally in the later stages of the disease as the number of cumulative attacks increases. Nevertheless, both combined azathioprine treatment with continued oral prednisolone and rituximab treatment were also associated with a longer time to next attack, independently of the natural disease course of NMO.
Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw264.7 Cells
Seung-Chul Chun,Seon Young Jee,Sang Gon Lee,Sook Jahr Park,Jong Rok Lee,Sang Chan Kim
Evidence-Based Complementary and Alternative Medicine , 2007, DOI: 10.1093/ecam/nel093
Abstract: Moutan Cortex (MCE) has been used in traditional medicine to remove heat from the blood, promote blood circulation and alleviate blood stasis. This study was conducted to evaluate the effects of MCE on regulatory mechanisms of cytokines and nitric oxide (NO) involved in immunological activity of Raw264.7 cells. Cells were pretreated with methanolic extracts of MCE, and further cultured for an appropriate time after lipopolyssacharide (LPS) addition. During the entire experimental period, 0.1 and 0.3 mg ml−1 of MCE had no cytotoxicity. In these concentrations, MCE inhibited the production of NO and prostaglandin E2 (PGE2), the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and phosphorylated inhibitor of κBα (p-IκBα), and the activation of nuclear factor κB (NF-κB). MCE also reduced the concentration of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the Raw264.7 cells that were activated by LPS. These results demonstrate that MCE has anti-inflammatory effects through the inhibition of iNOS and COX-2 expression by suppressing the phosphorylation of I-κBα and the activation of NF-κB.
Ell3 Enhances Differentiation of Mouse Embryonic Stem Cells by Regulating Epithelial-Mesenchymal Transition and Apoptosis
Hee-Jin Ahn, Young Cha, Seok-Ho Moon, Jee-Eun Jung, Kyung-Soon Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040293
Abstract: Ell3 is a testis-specific RNA polymerase II elongation factor whose cellular function is not clear. The present study shows that Ell3 is activated during the differentiation of mouse embryonic stem cells (mESCs). Furthermore, Ell3 plays a critical role in stimulating lineage differentiation of mESCs by promoting epithelial-mesenchymal transition (EMT) and suppressing apoptosis. Mouse ESCs engineered to stably express Ell3 were rapidly differentiated compared with control cells either under spontaneous differentiation or neural lineage-specific differentiation conditions. Gene expression profile and quantitative RT-PCR analysis showed that the expression of EMT markers, such as Zeb1 and Zeb2, two major genes that regulate EMT, was upregulated in Ell3-overexpressing mESCs. Remarkably, knockdown of Zeb1 attenuated the enhanced differentiation capacity of Ell3-overexpressing mESCs, which indicates that Ell3 plays a role in the induction of mESC differentiation by inducing EMT. In contrast to Ell3-overexpressing mESCs, Ell3-knock down mESCs could not differentiate under differentiation conditions and, instead, underwent caspase-dependent apoptosis. In addition, apoptosis of differentiating Ell3-knock out mESCs was associated with enhanced expression of p53. The present results suggest that Ell3 promotes the differentiation of mESCs by activating the expression of EMT-related genes and by suppressing p53 expression.
Prevalence of Korean cats with natural feline coronavirus infections
Dong-Jun An, Hye-Young Jeoung, WooSeog Jeong, Jee-Yong Park, Myoung-Heon Lee, Bong-Kyun Park
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-455
Abstract: Fourteen cats were FCoV-positive, including infections with type I FCoV (n = 8), type II FCoV (n = 4), and types I and II co-infection (n = 2). Low seroprevalences (13.7%, 29/212) of FCoV were identified in chronically ill cats (19.3%, 16/83) and healthy cats (10.1%, 13/129).Although the prevalence of FCoV infection was not high in comparison to other countries, there was a higher prevalence of type I FCoV in Korean felines. The prevalence of FCoV antigen and antibody in Korean cats are expected to gradually increase due to the rising numbers of stray and companion cats.Feline coronavirus (FCoV) is an enveloped, positive-sense, single-stranded RNA virus of the family Coronavirideae within the order Nidovirales. FCoVs are comprised of two pathogenic biotypes [1] consisting of feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV), which are both divided into two serotypes (Type I and II). The serotypes differ in their growth characteristics in cell culture and antigenicity, relative to canine coronaviruses (CCoVs) [2].The prevalence of type I and II FCoV have been surveyed in many countries, including Japan [3], United States [4], United Kingdom [5], Austria [6], Switzerland [7], and Taiwan [8]. The majority of field isolates in these countries are of type I, regardless of the assay method [4].FCoVs are associated with mild or subclinical enteric infections [9]. However, in a small proportion of cats, FCoV infection leads to the development of a lethal, immune-mediated condition known as feline infectious peritonitis (FIP) [10,11]. FIP is a complex immune disease involving virus or viral antigen, antiviral antibodies, and complement. Cats that do not develop anti-FCoV antibodies do not develop FIP.Serological surveys of FCoV infection have involved detection of antibody by indirect fluorescent antibody assay (IFA) or enzyme-linked immunosorbent assay (ELISA) [12-15]. A plaque-reduction neutralization test (PRNT) was developed to serologicall
Hepatoprotective Activity of Licorice Water Extract against Cadmium-Induced Toxicity in Rats
Jong Rok Lee,Sook Jahr Park,Hyeung-Sik Lee,Seon Young Jee,Jungcheol Seo,Young Kyu Kwon,Taeg Kyu Kwon,Sang Chan Kim
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nem078
Abstract: Licorice is commonly used as a cure for digestive disorders and as a detoxification agent in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl2, Cd)-induced liver toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously (i.v.) injected into rats. The rats then received either a vehicle or licorice water extract (50, 100 mg/kg/day) for 3 days, and were subsequently exposed to a single injection of Cd 24 h after the last licorice/vehicle treatment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with licorice reduced ALT, AST and LDH. In histopathological analysis, licorice decreased the central necrosis around central veins, the peripheral hemorrhage around portal triads, the percentage of degenerative hepatic regions (%/mm2 hepatic parenchyma) and the number of degenerative hepatic cells (N/100 hepatic cells). Licorice also inhibited the increment of Bad (a BH3 domain-containing protein) translocation by Cd in liver cells. These results demonstrate that licorice could have a hepatoprotective effect by inhibiting the translocation of Bad to the mitochondria in Cd-intoxificated rats.
Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO2 Reactivity in Normal Subjects
Woo-Sang Jung,Joo-Young Park,Hyung-Sik Byeon,Young-Jee Kim,Jung-Mi Park,Seong-Uk Park,Seung-Yeon Cho,Sang-Kwan Moon
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/725241
Abstract: Aim. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO2 reactivity (CVR) in healthy male subjects. Materials and Methods. We examined erythrocyte deformability in an HCEt group (=14) and a control group (=10). CVR was measured using hyperventilation-induced CO2 reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group (=11). A historical control group (=10) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration. Results. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (2.9±1.1% versus ?0.6±1.0%, =0.034). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1±4.0% versus ?8.1±4.1%, =0.007). The mean blood pressure and pulse rate did not vary from baseline values in either group. Conclusions. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt’s effect on cerebral microcirculation.
Relationship between Blood Stasis Syndrome Score and Cardioankle Vascular Index in Stroke Patients
Ki-Ho Cho,Kyoo-Pil Kim,Byung-Cheol Woo,Young-Jee Kim,Joo-Young Park,Seung-Yeon Cho,Seong-Uk Park,Woo-Sang Jung,Jung-Mi Park,Sang-Kwan Moon
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/696983
Abstract: Blood stasis syndrome (BSS) in traditional Asian medicine has been considered to correlate with the extent of atherosclerosis, which can be estimated using the cardioankle vascular index (CAVI). Here, the diagnostic utility of CAVI in predicting BSS was examined. The BSS scores and CAVI were measured in 140 stroke patients and evaluated with respect to stroke risk factors. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic accuracy of CAVI for the diagnosis of BSS. The BSS scores correlated significantly with CAVI, age, and systolic blood pressure (SBP). Multiple logistic regression analysis showed that CAVI was a significant associate factor for BSS (OR 1.55, =0.032) after adjusting for the age and SBP. The ROC curve showed that CAVI and age provided moderate diagnostic accuracy for BSS (area under the ROC curve (AUC) for CAVI, 0.703, <0.001; AUC for age, 0.692, =0.001). The AUC of the “CAVI
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