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Search Results: 1 - 10 of 401532 matches for " Jeanine M Walenga "
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Why differentiate low molecular weight heparins for venous thromboembolism?
Jawed Fareed, Jeanine M Walenga
Thrombosis Journal , 2007, DOI: 10.1186/1477-9560-5-8
Abstract: 1. Differentiation of low molecular weight heparins from unfractionated heparins2. Differentiation of commercially available low molecular weight heparins, which are produced by different methods.3. Differentiation of the branded low molecular weight heparins from the generic versions of these drugs.4. Differentiation of low molecular weight heparins from synthetic heparin derived oligosaccharides such as the pentasaccharides such as Arixtra and Idraparinux.5. Differentiation of low molecular weight heparins from heparinoids and GAG mixtures such as the danaparoid, dermatan and heparans.6. Differentiation of low molecular weight heparins from synthetic anti-Xa agents.7. Differentiation of low molecular weight heparins from synthetic anti-IIa agents8. Differentiation of low molecular weight heparins from oral anticoagulant drugs such as warfarin.It is now clear that the clinical spectrum of the LMWHs is relatively broader from the different anticoagulant/antithrombotic drugs. Moreover, these agents have multiple interactions with plasmatic and cellular components and produce polytherapeutic effects. The synthetic monotherapeutic agents therefore will not have the same broad clinical profile as the LMWHs. It is important to differentiate the therapeutic effects of individual LMWH as each of these products is approved for specific indications. More recently dalteparin is approved for the treatment of cancer-associated thrombosis, an indication, which is solely approved for this product for this time. Therefore, it is important to differentiate these drugs and caution should be exercised for therapeutic and generic interchange.Of all anticoagulants developed during the past 25 years, LMWHs have become the standard of care for the management of venous thromboembolism. Unlike unfractionated heparin (UFH), different brands of LMWHs can be differentiated biologically and clinically. Based on their different pharmacological and therapeutic profiles, LMWHs are largely conside
Heparan sulphate inhibition of cell proliferation induced by TGFβ and PDGF
lan E. Silber,Jeanine M. Walenga,Jawed Fareed,Elizabeth J. Kovacs
Mediators of Inflammation , 1993, DOI: 10.1155/s0962935193000419
The revelation(s) of Asher Levi: An iconographic literacy event as a tool for the exploration of fragmented selves in new literacies studies after 9/11
Jeanine M. Staples
Qualitative Studies , 2011,
Abstract: This article considers the dynamics of an iconographic literacy event that functions as a tool for explorations of literacy practices and fragmented selves, particularly in relationship to the literate lives of marginalized individuals in the post 9/11 era. The author examines what happened when a group of 10 African American women in an urban area employed new literacies in the teaching/learning spaces of their personal lives (i.e. individual homes, familiar eateries, communicative digital technologies) to explore and respond to stories in post 9/11 popular culture narratives. The study employed ethnographic methods (interviews, journaling, email and instant message writing and critical observations) with members of the inquiry over the course of two years. The author investigated critically the meeting of biography, fiction and autoethnography as a literacy event used to couch the literacies and fragmented selves of these women in the post 9/11 era. Findings regarding the nature of their post 9/11 literacies, as expressed through fragmented selves, are shared, along with implications for new literacies research and teaching. Findings show that the women’s post 9/11 literacies include a range and variation of critical sensibilities that include, but are not limited to, multiple levels of sociolinguistic integration, sociocultural criticality and heightened awarenesses.
Global Analysis of mRNA Half-Lives and de novo Transcription in a Dinoflagellate, Karenia brevis
Jeanine S. Morey, Frances M. Van Dolah
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066347
Abstract: Dinoflagellates possess many physiological processes that appear to be under post-transcriptional control. However, the extent to which their genes are regulated post-transcriptionally remains unresolved. To gain insight into the roles of differential mRNA stability and de novo transcription in dinoflagellates, we biosynthetically labeled RNA with 4-thiouracil to isolate newly transcribed and pre-existing RNA pools in Karenia brevis. These isolated fractions were then used for analysis of global mRNA stability and de novo transcription by hybridization to a K. brevis microarray. Global K. brevis mRNA half-lives were calculated from the ratio of newly transcribed to pre-existing RNA for 7086 array features using the online software HALO (Half-life Organizer). Overall, mRNA half-lives were substantially longer than reported in other organisms studied at the global level, ranging from 42 minutes to greater than 144 h, with a median of 33 hours. Consistent with well-documented trends observed in other organisms, housekeeping processes, including energy metabolism and transport, were significantly enriched in the most highly stable messages. Shorter-lived transcripts included a higher proportion of transcriptional regulation, stress response, and other response/regulatory processes. One such family of proteins involved in post-transcriptional regulation in chloroplasts and mitochondria, the pentatricopeptide repeat (PPR) proteins, had dramatically shorter half-lives when compared to the arrayed transcriptome. As transcript abundances for PPR proteins were previously observed to rapidly increase in response to nutrient addition, we queried the newly synthesized RNA pools at 1 and 4 h following nitrate addition to N-depleted cultures. Transcriptome-wide there was little evidence of increases in the rate of de novo transcription during the first 4 h, relative to that in N-depleted cells, and no evidence for increased PPR protein transcription. These results lend support to the growing consensus of post-transcriptional control of gene expression in dinoflagellates.
Second hand smoke and COPD: lessons from animal studies
Monica P. Goldklang,Sarah M. Marks,Jeanine M. D'Armiento
Frontiers in Physiology , 2013, DOI: 10.3389/fphys.2013.00030
Abstract: Exposure to second hand smoke is a major cause of chronic obstructive pulmonary disease (COPD) in the non-smoker. In this review we explore the use of animal smoke exposure models and their insight into disease pathogenesis. The methods of smoke exposure, including exposure delivery systems, are described. Key findings from the acute and chronic smoke exposure models are outlined, including descriptions of the inflammation processes, proteases involved, oxidative stress, and apoptosis. Finally, alternatives to rodent models of lung disease are presented.
Meat Consumption and Cancer Risk
Jeanine M Genkinger equal contributor,Anita Koushik equal contributor
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040345
Barradas Maria Mércia,Fagg Jeanine Maria Felfili
Acta Botanica Brasilica , 2002,
Reyes, Esperanza. En nombre del Estado. Servidores públicos en una microrred de salud en la costa rural del Perú. Lima: Universidad Peruana Cayetano Heredia / Instituto de Estudios Peruanos / Salud Global, 2007, 286 pp.
Jeanine Anderson
Anthropologica , 2008,
Abstract: "La rese a no presenta resumen"
Rese a de "El eclipse del sue o americano"
Jeanine Wuest
Argumentos (México, D.F.) , 2005,
Rese a de "El ataque contra la razón. Cómo la política del miedo, el secretismo y la fe ciega erosionan la democracia y ponen en peligro a Estados Unidos y al mundo" de Al Gore
Jeanine Wuest
El Cotidiano , 2009,
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