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Search Results: 1 - 10 of 427511 matches for " Jean Pierre M. Ilunga "
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Diagnostic Accuracy of PCR in gambiense Sleeping Sickness Diagnosis, Staging and Post-Treatment Follow-Up: A 2-year Longitudinal Study
Stijn Deborggraeve equal contributor,Veerle Lejon equal contributor ,Rosine Ali Ekangu,Dieudonné Mumba Ngoyi,Patient Pati Pyana,Médard Ilunga,Jean Pierre Mulunda,Philippe Büscher
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0000972
Abstract: Background The polymerase chain reaction (PCR) has been proposed for diagnosis, staging and post-treatment follow-up of sleeping sickness but no large-scale clinical evaluations of its diagnostic accuracy have taken place yet. Methodology/Principal Findings An 18S ribosomal RNA gene targeting PCR was performed on blood and cerebrospinal fluid (CSF) of 360 T. brucei gambiense sleeping sickness patients and on blood of 129 endemic controls from the Democratic Republic of Congo. Sensitivity and specificity (with 95% confidence intervals) of PCR for diagnosis, disease staging and treatment failure over 2 years follow-up post-treatment were determined. Reference standard tests were trypanosome detection for diagnosis and trypanosome detection and/or increased white blood cell concentration in CSF for staging and detection of treatment failure. PCR on blood showed a sensitivity of 88.4% (84.4–92.5%) and a specificity of 99.2% (97.7–100%) for diagnosis, while for disease staging the sensitivity and specificity of PCR on cerebrospinal fluid were 88.4% (84.8–91.9%) and 82.9% (71.2–94.6%), respectively. During follow-up after treatment, PCR on blood had low sensitivity to detect treatment failure. In cerebrospinal fluid, PCR positivity vanished slowly and was observed until the end of the 2 year follow-up in around 20% of successfully treated patients. Conclusions/Significance For T.b. gambiense sleeping sickness diagnosis and staging, PCR performed better than, or similar to, the current parasite detection techniques but it cannot be used for post-treatment follow-up. Continued PCR positivity in one out of five cured patients points to persistence of living or dead parasites or their DNA after successful treatment and may necessitate the revision of some paradigms about the pathophysiology of sleeping sickness.
Prognostic Signification of Admission Hyperglycemia among Acute Stroke Patients in Intensive Care Units in Kinshasa, the Democratic Republic of the Congo  [PDF]
Josée K. Tshituta, Fran?ois B. Lepira, Fran?ois P. Kajingulu, Jean Robert R. Makulo, Ernest K. Sumaili, Pierre Z. Akilimali, Aliocha N. Nkodila, Freddy M. Mbuyi, Angèle I. Masewu, Stéphane Mutombo, Eric B. Amisi, Jean Pierre M. Ilunga, Wilfrid B. Mbombo, Patrick M. Mukuna, Adolphe M. Kilembe
World Journal of Cardiovascular Diseases (WJCD) , 2019, DOI: 10.4236/wjcd.2019.99060
Abstract:
BACKGROUND AND AIM: Although admission hyperglycemia has been reported to be associated with unfavorable outcomes in acute stroke, little is known about this association in sub-Saharan Africa. Therefore, the aim of the present study was to assess the prognostic significance of admission hyperglycemia in the acute phase of stroke in Congolese patients. METHODS: In a multicenter prospective cohort study, consecutive patients with acute stroke were examined in 5 Emergency Rooms or Intensive Care Units of Kinshasa between July 15th, 2017 and March 15th, 2018. The severity of stroke was assessed at admission using the Glasgow Coma Scale. Stress hyperglycemia was defined as random blood glucose levels at admission > 140 mg/dL in patients without known type 2 diabetes mellitus (T2DM). The endpoint was 10-day all-cause in-hospital mortality. Survival (time-to-death) curves were built using the Kaplan Meier methods. Cox proportional analysis was used to identify predictors of 10-day all-cause in-hospital mortality. The predictive performance of blood glucose level
Preliminary Study on Counterfeiting of Artemether and Artesunate Marketed in Lubumbashi  [PDF]
Pierrot Mwamba Tshilumba, Elie Rongorongo Kagoha, Valentin Bashige Chiribagula, Glauber Mbayo Kalubandika, Vianney Ntabaza Ndage, Trésor Sumbu Nzuzi, Evodie Numbi Wa Ilunga, Pierre Duez, Jean Baptiste Kalonji Ndoumba
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.75024
Abstract: Pharmaceutical counterfeiting is a health scourge responsible for several cases of morbidity and mortality. Counterfeit medicines cause therapeutic failure, emergence of resistance in the treatment of infections. This study was conducted in order to identify counterfeit and authentic medicines in circulation in Lubumbashi. The study included artemether and artesunate for oral administration. A careful visual inspection of medicine, investigation of authenticity of pharmaceutical products from manufacturers and pharmaceutical regulatory authorities and determination of content were used as study parameters. 52 samples: 37 artemether and 15 of artésunate were collected. 7 samples (13%) have proven to be counterfeit. Artemether was the most counterfeit (71%) and 29% for artesunate. 6 (12%) samples were substandard according to the international pharmacopoeia in terms of content of active ingredient. Sixty-seven percent of non-compliance concerned counterfeit medicines. The proportion of non-compliance is highest among counterfeit medicines (71.43% vs 2.22%; p = 0.000004). It is obvious that strengthening the capacity of the drug regulatory authority of the DRC reduces the influx of counterfeit drug and substandard.
Infilling annual rainfall data using feedforward back-propagation Artificial Neural Networks (ANN): application of the standard and generalised back-propagation techniques
M Ilunga
Journal of the South African Institution of Civil Engineering , 2010,
Abstract: Water resource planning and management require long time series of hydrological data (e.g. rainfall, river flow). However, sometimes hydrological time series have missing values or are incomplete. This paper describes feedforward artificial neural network (ANN) techniques used to infill rainfall data, specifically annual total rainfall data. The standard back-propagation (BP) technique and the generalised BP technique were both used and evaluated. The root mean square error of predictions (RMSEp) was used to evaluate the performance of these techniques. A preliminary case study in South Africa was done using the Bleskop rainfall station as the control and the Luckhoff-Pol rainfall station as the target. It was shown that the generalised BP technique generally performed slightly better than the standard BP technique when applied to annual total rainfall data. It was also observed that the RMSEp increased with the proportion of missing values in both techniques. The results were similar when other rainfall stations were used. It is recommended for further study that these techniques be applied to other rainfall data (e.g. annual maximum series, etc) and to rainfall data from other climatic regions.
Vertical Transmission Rate of HIV from Seropositive Mothers Followed in the Different Care Centers in Kinshasa from 2010 to 2015  [PDF]
Divine Chuga, Ben Ilunga Bulanda, Jean Yves Debels Kabasele, Médard Omakoy Okonda, Berry Ikolango Bongenya, Erick Ntambwe Kamangu
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104769
Abstract:
Background: In the Democratic Republic of Congo, the use of Prevention of Transmission of Human Immunodeficiency Virus infection from mother to child is still very low. Objective: The objective of this study was to estimate the prevalence of infants born from HIV-positive mother in different centers in Kinshasa. Methods: This study is a retrospective cohort of at least 2 years on the records of mother-child couple followed in 8 centers of Kinshasa. Based on a sample survey form with specific criteria, some files were selected. Results: The record keeping of all centers was estimated at 70% on average; the most represented age group was from 26 to 35 years with 102 women (54%) out of 190. Forty-five percent (45%) of pregnant women started pre-natal consultation (CPN) in the 2nd trimester of pregnancy. All mothers had been diagnosed with 3 Rapid Diagnostic Tests (RDT). The majority of women were under: AZT 3TC NVP and CTX and 139 (73%) women were diagnosed at stage 1 of HIV infection according to WHO’s standard. One hundred new born were male. Seventy-eight newborns weighed between 2.01 and 3.00 kg at birth. Ninety seven percent of newborns were treated at birth. Ninety-one children who were on Nevirapine syrup; six of them were not put on treatment. Ninety five percent of newborns were diagnosed HIV-negative 9 months after birth by PCR; 2% of children were undiagnosed as a result of refusal and 3% of children had undetermined serology. This gives a mother-to-child transmission rate of 2% at 9 months of birth for the centers of Kinshasa. Conclusion: Despite the insufficient coverage of the PMTCT service in our community, the centers in Kinshasa respond to the PMTCT approach and the transmission rate in the 8 centers of 4 districts of Kinshasa is 2%.
Post-Traumatic Stress Disorder and Health-Related Quality of Life in Patients and Their Significant Others Facing Lung Cancer Diagnosis: Intrusive Thoughts as Key Factors  [PDF]
Jean-Louis Pujol, Carine Plassot, Jean-Pierre Mérel, Elodie Arnaud, Michel Launay, Jean-Pierre Daurès, Isabelle Boulze
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.46A1001
Abstract:

Purpose: 1) to determine the level of post-traumatic stress disorder (PTSD) by means of impact of event scale (IES) in patients for whom lung cancer has been diagnosed for the first time and compare this level in patients having learnt that they affected by chronic obstructive pulmonary disease (COPD); 2) to compare PTSD in patients and their significant others facing a diagnosis of lung cancer; 3) to determine whether or not IES and General Health Questionnaire 28 (GHQ-28) correlate. Methods: This prospective survey-study included 41 consecutive patients who learnt that they were afflicted by primary lung cancer. IES and GHQ-28 were answered once between four and five weeks following medical appointment. The significant others (n = 16) who were present during the lung cancer diagnostic appointment were also invited to complete similar questionnaires. Control group consisted of 19 patients with chronic asthma or COPD. Results: Following a lung cancer diagnosis, patients and their significant others are indistinctly affected by a high level of PTSD. These two groups had a higher frequency of high IES total score when compared with COPD patients. The IES intrusion subscale score significantly differed among groups: median [IR] values: 20 [12 - 26]; 15 [9 - 22]; 7 [5 - 15] for significant others, cancer patients and COPD patients respectively; P = 0.02). IES and GHQ-28 inversely correlated. Conclusion: Patients and

Knowledge and Rates of Use of Preschool Consultation by the Mothers in the Area of Health Tshitenge/Democratic Republic of Congo  [PDF]
Jean Christophe Bukasa Tshilonda, Augustin Kadiata Bukasa, Zelda Nkongolo Kitenge, Isaac Kalenda Ilunga, Cedrick Ilunga Bimpa, Jean Pierre Kufua Katukumbanyi, Dominique Kapitena Mangola, Astrid Kabanga, Benedicte Bileo, Axel Ngoyi, Therese Kapenga Mitanta, Olivier Ejiba Nyongonyi, Paulin Kabamba Lupueka, Alain Ngoyi Kibambe, Jean Felix Kabangu, Geremie Kazadi, Alexis Ntambwe Mayombo, Andre Kazadi Mukendi
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105064
Abstract:
Introduction: The postponement of the preventive activities of the Provincial Division of Health of East Kasai 2016 revealed que le level of attendance of the preschool consultation is decreasing less and less in the Health Area Tshitenge. Thus, this study set the goal of determining the knowledge and use of maternal pre-school counseling in the Health Area Tshitenge. Methods: The survey method was used by means of a questionnary administered to mothers in this region, but more specifically, we collected data from 422 mothers responsible for randomly selected children aged 0 to 5 in the four health. Results: After analysis and analysis of the data with the computer tool, we obtained the following results: the rate of use of the preschool consultation service is 60.7%; the level of education, occupation and the number of children under 5 years of age have a strong influence on the use of preschool counseling; lack of knowledge about the most important activity of preschool counseling has a negative influence on its use. There is a link between the use of the preschool consultation and the most important activity of the preschool consultation for the respondent; there is also a link between this and an appointment on the map; and finally, the cost judgment of SPC strongly influences its use. Conclusion: In order to raise this activity, the revitalization of preschool consultation activities in the Tshitenge health area, the reinforcement of the parents’ awareness on the use of preschool counseling from 0 to 59 months, and the revival of visits to homes for children whose mothers drop out of preschool counseling sufficient are a basis.
Infilling streamflow data using feed-forward back-propagation (BP) artificial neural networks: Application of standard BP and pseudo Mac Laurin power series BP techniques
M Ilunga, D Stephenson
Water SA , 2005,
Abstract: Hydrological data (e.g. rainfall, river flow data) are used in water resource planning and management. Sometimes hydrological time series have gaps or are incomplete, or are not of good quality or are not of sufficient length. This problem seems to be more prevalent in developing countries than in developed countries. In this paper, feed-forward artificial neural networks (ANNs) techniques are used for streamflow data infilling. The standard back-propagation (BP) technique with a sigmoid activation function is used. Besides this technique, the BP technique with an approximation of the sigmoid function by pseudo Mac Laurin power series Order 1 and Order 2 derivatives, as introduced in this paper, is also used. Empirical comparisons of the predictive accuracy, in terms of root mean square error of predictions (RMSEp), are then made. A preliminary case study in South Africa (i.e. using the Diepkloof (control) gauge on the Wonderboomspruit River and the Molteno (target) gauge on Stormbergspruit River in the River summer rainfall catchment) was then done. Generally, this demonstrated that the standard BP technique performed just slightly better than the pseudo BP Mac Laurin Orders 1 and 2 techniques when using mean values of seasonal data. However, the pseudo Mac Laurin approximation power series of the sigmoid function did not show any substantial impact on the accuracy of the estimated missing values at the Molteno gauge. Thus, all three the standard BP and pseudo BP Mac Laurin orders 1 and 2 techniques could be used to fill in the missing values at the Molteno gauge. It was also observed that a linear regression could describe a strong relationship between the gap size (0 to 30 %) and the expected RMSEp (thus accuracy) for the three techniques used here. Recommendations for further work on these techniques include their application to other flow regimes (e.g. 4-month seasons, mean annual extreme, etc) and to streamflow series of a winter rainfall region. Water SA Vol. 31 (2) 2005: pp.171-176
Frequency and Causes of Vaginal Hemorrhage outside Pregnancy in Women of Reproductive Age at Bonzola Hospital, Mbuji-Mayi, DRC  [PDF]
Kaya Tompa Brigitte, Ciamala Mukendi Paul, Nzembu Kabwasa Peter, Kanyiki Katala Moses, Ntumba Mukendi Kennedy, Jean Mukendi Mukendi Rene, Kolela Kolela Alain, Ilunga Bimpa Cedric, Cibangu Muana Wamuenyi Franck, Kaseka Ciswaka Jeanne, Amuli Jiwe Jean-Pierre
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104940
Abstract:
Vaginal haemorrhages outside pregnancy in women of childbearing age are a major public health problem in both developed and developing countries. The purpose of this study was to determine the frequency and causes of vaginal haemorrhage outside pregnancy. This is a descriptive study conducted in the city of Mbuji-Mayi at Bonzola General Hospital, registered from 01 to 31 December 2017; the data were collected transversally. The following observations were made during the study period; 174 women of childbearing age were registered. After analyzing the data, the incidence of vaginal haemorrhage in women of childbearing age was 15.8% and the main causes were: cervical cancer: 32.7% and uterine myoma 22.5%.
Infection with Hepatitis B and C Virus in the Democratic Republic of Congo: A Public Health Problem  [PDF]
Ben Ilunga Bulanda, Berry Ikolango Bongenya, Jean-Yves Debels Kabasele, Médard Omakoy Okonda, Divine Chuga, Christian Tshisumbu, Elvis Tshunza Kateba, Erick Ntambwe Kamangu
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104760
Abstract:
Background: Viral hepatitis represents a major public health burden with more than 375 million people with chronic hepatitis B infection and 130 to 150 million with hepatitis C for 2016. Sub-Saharan Africa has the heaviest burden of the epidemic. Objective: The objective of this review is to present the characteristics of hepatitis B and C infections (HBV and HCV), present the synthesis and estimate its magnitude in the Democratic Republic of Congo for the last 20 years. Methods: This work consisted in cataloging the various published articles and abstracts presented in scientific conferences having as subject of interest the infection with viral hepatitis B and C in the DRC. The search for these published works on different infections was done on the internet from different search engines. The research was limited to published works and abstracts presented over the last 20 years. Pediatric studies, studies in patients with renal or hepatic infections or without original data were not included in this review. Results: According to the various works published and presented in conference since 1997, the populations targeted for the investigations on the hepatitis B and C infections are the poly-transfused, the blood donors and the People Living with HIV. Seven (7) works have been documented for the DRC meeting the various selection criteria. In 1999, the carriage of HBV infection was 9.2% in Kinshasa. In 2000, the carriage of HBV was 5.9% while that of HCV was 4.8% in Kinshasa. In 2001, the portage of HCV was 5.0% in Kinshasa. In 2004, the prevalence of HBs antigen was 5.4% in Kisangani. In 2008, the prevalence of HBV and HCV was 8% and 4% respectively in Bukavu. In 2008, seroprevalences of HBV and HCV were respectively 4.2% and 3.8% in Bukavu. In 2012 and 2013, prevalence of HCV was 5.8% and 5.2% respectively in Kinshasa. Conclusions: Although often asymptomatic, viral hepatitis B and C are a public health problem for the Democratic Republic of Congo. The prevalence of these viral infections is far superior to that of HIV infection in Blood Transfusion Centers across the country.
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