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Search Results: 1 - 10 of 27399 matches for " Jean Michel Vignaud "
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Polymorphisms of GSTs in Lung Adenocarcinoma Patients Followed in the Context of a Biobank  [PDF]
Fotis Vlastos, Georgios Hillas, Nektarios Anagnostopoulos, Jean Michel Vignaud, Nadine Martinet, Nikolaos G. Koulouris
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A004

Background: Lung Adenocarcinoma (ADC) has been recently associated with distinct molecular changes, leading to the development of molecular-based targeted therapy. The Nancy’s Centre of Biological Resources (“Centre des Ressources Biologiques”, CRB) is an ISO 9001-2000 certified biobank with biological material and follow-up data from lung cancer patients, which collected during the last 20 years. Objective: To estimate and compare the frequency of Glutathionne S-Transferase (GST) polymorphisms in a French population of ADC patients. Methods: A retrospective study was conducted by the CRB between 1988 and 2007: 296 consecutive patients operated upon for ADC and 447 healthy subjects were evaluated. Genomic DNA was obtained from peripheral blood samples collected in EDTA tubes. The DNA was extracted using proteinase K digestion and phenol: chloroform purification. The GST polymorphisms were studied with duplex SYBR Green q PCR using specific primers and results being read on melt curves. Results: Two GST classes were monitored during this research. The Mu class GST (GSTM) and the Theta class GST (GSTT) members. We studied the incidence of each genotype, as well as the GSTMT (combined Mu and Theta class) and null genotype in ADC and control patients. ADC patients had a higher incidence of

Refeeding syndrome influences outcome of anorexia nervosa patients in intensive care unit: an observational study
Marie Vignaud, Jean-Michel Constantin, Marc Ruivard, Michele Villemeyre-Plane, Emmanuel Futier, Jean-Etienne Bazin, Djillali Annane, AZUREA group (AnorexieRea Study Group)
Critical Care , 2010, DOI: 10.1186/cc9274
Abstract: We randomly selected 30 ICUs throughout France. Thereafter, we retrospectively analyzed all patients with AN admitted to any of these 30 ICUs between May 2006 and May 2008. We considered demographic data, diagnosis at admission and complications occurring during the stay, focusing on refeeding syndrome and management of refeeding.Eleven of the 30 ICUs participated in the retrospective study, featuring 68 patients, including 62 women. Average body mass index at the admission was 12 ± 3 kg/m2. Twenty one were mechanically ventilated, mainly for neurological reasons. The reported average calorie intake was 22.3 ± 13 kcal/kg/24 h. Major diagnoses at admission were metabolic problems, refeeding survey and voluntary drug intoxication and infection. The most common complications were metabolic, hematological, hepatic, and infectious events, of which 10% occurred during refeeding. Seven patients developed refeeding syndrome. At day one, the average calorie intake was higher for patients who developed refeeding syndrome (23.2 ± 5 Kcal/kg/j; n = 7) versus patients without refeeding syndrome (14.1 ± 3 Kcal/kg/j; n = 61) P = 0.02. Seven patients died, two from acute respiratory distress syndrome and five from multiorgan-failure associated with major hydroelectrolytic problems.The frequency of AN in ICU patients is very low and the crude mortality in this group is about 10%. Prevention and early-detection of refeeding syndrome is the key point.The American Psychiatric Association definition of anorexia nervosa (AN) includes refusal to maintain body weight at or above a minimum normal weight for age and size, an intense fear of gaining weight or becoming large when weight is below normal, alteration of perception of body weight or shape, and amenorrhea in postpubertal women. The disease affects 0.5% of the population and 90% of patients are women. AN has the highest mortality of any psychiatric disorder [1]. There are two types of AN. The pure restrictive form, with physical hype
Signalling with retinoids in the human lung: validation of new tools for the expression study of retinoid receptors
Stéphane Poulain, Stéphanie Lacomme, Shyue-Fang Battaglia-Hsu, Stanislas du Manoir, Lydia Brochin, Jean-Michel Vignaud, Nadine Martinet
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-423
Abstract: Biocomputing was used to assess the genomic organization of RAR beta. Its putative RAR-beta1' promoter features were investigated experimentally. Specific measures realized, with qRT-PCR Syber Green assays and a triplex of Taqman probes, were extensively validated to establish Retinoid Receptors mRNAs reference values for in vivo normal human bronchial cells, lung tumors and cell lines. Finally, a pan-RAR-beta antibody was generated and extensively validated by western-blot and immunoprecipitation.No promoter-like activity was found for RAR-beta1'. RAR-beta2 mRNAs increase signs the normal differentiation of the human bronchial epithelium while a decrease is observed in most lung cancer cell lines. Accordingly, it is also, along with RXR beta, down-regulated in lung tumors. When using nuclear extracts of BEAS-2B and normal lung cells, only the RAR-beta2 long protein isoform was recognized by our antibody.Rigorous samples processing and extensive biocomputing, were the key factors for this study. mRNA reference values and validated tools can now be used to advance researches on retinoid signalling in the lung.Vitamin A and its active derivatives referred to as retinoids are non-steroid hormones which play a critical role in the development and homeostasis of vertebrate tissues [1-3]. They exert their actions by regulating the expression of target genes, influencing likewise: cell proliferation, differentiation and apoptosis through nuclear Retinoid Receptors (RRs) binding [4]. Six different RRs are encoded by separate genes (Retinoic Acid Receptors (RAR) α, β, γ and Retinoid X Receptors (RXR) α, β, γ) with at least two isoforms for each, depending upon promoter usage and alternative splicing [5]. RAR/RXR heterodimers are the functional units transducing the retinoid signal when binding Retinoic Acid (RA), co-activators and DNA response elements (RAREs) of target genes [6,7]. RXRs form homodimers and/or heterodimers with RARs and most other nuclear receptors for exten
Determination of Angptl4 mRNA as a Diagnostic Marker of Primary and Metastatic Clear Cell Renal-Cell Carcinoma
Jér?me Verine,Jacqueline Lehmann-Che,Hany Soliman,Jean-Paul Feugeas,Jean-Sébastien Vidal,Pierre Mongiat-Artus,Stéphanie Belhadj,Josette Philippe,Matthieu Lesage,Evelyne Wittmer,Stéphane Chanel,Anne Couvelard,Sophie Ferlicot,Nathalie Rioux-Leclercq,Jean-Michel Vignaud,Anne Janin,Stéphane Germain
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010421
Abstract: We have previously shown that angiopoietin-like 4 (angptl4) mRNA, a hypoxia-inducible gene, is highly expressed in clear cell renal-cell carcinoma (ccRCC), the most common subtype of RCC for which no specific marker is available. We here investigated whether angptl4 mRNA 1) could be a useful diagnostic and/or prognostic marker of ccRCC in a large and comprehensive retrospective series, 2) induction is dependent on the VHL status of tumors.
Direito de autor, direito de cópia e direito à informa??o: o ponto de vista e a a??o das associa??es de profissionais da informa??o e da documenta??o
Michel, Jean;
Ciência da Informa??o , 1997, DOI: 10.1590/S0100-19651997000200005
Abstract: new technologies of production, processing, dissemination and exploration of digital information have deeply changed the traditional practices on the use and industry of information, electronic networks, tools and multimedia products. the president of association de professionnels de l'information et de la documentation (adbs) presents the current position, before this new context, of his company as well as of other national and international partners. in addition to the author's and editor's rights, the user or consumer right (right to information, to knowledge, access to legal texts, etc.) must be taken into consideration. a distinction should be made between the author and the information works. the new sui generis right protects information products and services (e.g., databses) and seeks to set up a right which can protect economic investment without supporting the author's right. the legal use (fair use) of protected works must be preserved, as well as the private copyright use, in the new electronic context, and shall also play an important role in the future to assure democracy and knowlege development. before the fast changes of technologies of information production, publishing and circulation, an equilibrium should be sought between the rights of information actors and spectators for knowledge and democracy development.
"Case-free" derivation for Weyl groups of the number of reflection factorisations of a Coxeter element
Jean Michel
Mathematics , 2014,
Abstract: Chapuy and Stump have given a nice generating series for the number of factorisations of a Coxeter element as a product of reflections. Their method is to evaluate case by case a character-theoretic expression. The goal of this note is to give a uniform evaluation of their character-theoretic expression in the case of Weyl groups, by using combinatorial properties of Deligne-Lusztig representations.
Hurwitz action on tuples of Euclidean reflections
Jean Michel
Mathematics , 2004,
Abstract: We show that if a tuple of Euclidean reflections has a finite orbit under the Hurwitz action of the Artin braid group, then the group generated by these reflections is finite. Humphries has published a similar statement but his proof is irremediably flawed. At the same time as correcting his proof, our proof is much simpler that Dubrovin and Mazocco's proof for triples of reflections.
The development version of the CHEVIE package of GAP3
Jean Michel
Mathematics , 2013,
Abstract: I describe the current state of the development version of the CHEVIE package, which deals with Coxeter groups, reductive algebraic groups, complex reflection groups, Hecke algebras, braid monoids, etc... Examples are given, showing the code to check some results of Lusztig.
Rural Wireless Mesh Network: A Design Methodology  [PDF]
Jean Louis Ebongue Kedieng Fendji, Jean Michel Nlong
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2015, DOI: 10.4236/ijcns.2015.81001
Abstract: Wireless Mesh Network is presented as an appealing solution for bridging the digital divide between developed and under-developed regions. But the planning and deployment of these networks are not just a technical matter, since the success depends on many other factors tied to the related region. Although we observe some deployments, to ensure usefulness and sustainability, there is still a need of concrete design process model and proper network planning approach for rural regions, especially in Sub-Saharan Africa. This paper presents a design methodology to provide network connectivity from a landline node in a rural region at very low cost. We propose a methodology composed of ten steps, starting by a deep analysis of the region in order to identify relevant constraints and useful applications to sustain local activities and communication. Approach for planning the physical architecture of the network is based on an indoor-outdoor deployment for reducing the overall cost of the network.
Viruses take center stage in cellular evolution
Jean-Michel Claverie
Genome Biology , 2006, DOI: 10.1186/gb-2006-7-6-110
Abstract: The reputedly intractable problem of the origin of viruses has long been neglected. In the modern literature, 'virus evolution' has come to refer to studies more akin to population genetics, such as the worldwide scrutiny of new polymorphisms appearing daily in the H5N1 avian flu virus [1], than to the fundamental question of where viruses come from. This is now rapidly changing, as a result of the coincidence of bold new ideas (and the revival of old ones), the unexpected spectacular features of some recently isolated giant viruses [2,3], as well as the steady increase in the numbers of genomic sequences for 'regular' viruses and cellular organisms, which enhances the power of comparative genomics [4]. After being considered non-living and relegated to the wings by most biologists, viruses are now center stage: they might have been there at the origin of DNA, might have played a central role in the emergence of the eukaryotic cell, and might even have been the cause of partitioning of biological organisms into the three domains of life: Bacteria, Archaea and Eukarya. In this article, I shall briefly survey some of the recent discoveries and the new evolutionary thoughts they have prompted, before adding to the discussion with a question of my own: what if we have totally missed the true nature of (at least some) viruses?As of April 2006, more than 1,600 viral genomes have been sequenced, approximately equally divided between RNA and DNA viruses. In view of this fundamental difference in their genetic material (and thus in their replication mechanisms, size, genetic complexity, host range and other features) it is tempting to immediately rule out the idea that viruses are monophyletic, that is, that they derive from a common ancestor. That might not be so easy to do, however. Although there are many arguments in favor of the idea that RNA and DNA viruses were generated independently - RNA viruses first, in the context of the 'RNA world' theory - their genesis might
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