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Search Results: 1 - 10 of 27850 matches for " Jean Marie Ntumba Kayembe "
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Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa  [PDF]
Christophe Mbombo Mulenga, Jean-Marie Ntumba Kayembe, Benoit Obel Kabengele, Alain Bakebe
Journal of Tuberculosis Research (JTR) , 2017, DOI: 10.4236/jtr.2017.54026
Abstract: Context: The burden of TB in Africa tends to be exacerbated by the socio-economic situation and the high prevalence of intercurrent infections such as HIV, malaria and non-specific bacterial infections. These factors often result in anemia, making patients at high risk for anemia. Objective: We aimed to gain insights into the characteristics of anemia, hematologic variations and socio-economic status in untreated pulmonary TB patients (PTB) in Kinshasa, the Democratic Republic of Congo. Methods: We conducted a cross-sectional analysis of 200 smear-positive pulmonary TB patients (PTB) recruited at the initiation of TB treatment. Complete Blood Count, Iron profile, BMI, CRP and albuminemia were assessed. Data were analyzed using Student t or Mann Whitney tests as appropriate, and logistic regression was performed to assess the strength of associations. Results: Anemia was a regular finding in (69%). This anemia was mostly moderate (92.2%) and with iron deficiency pattern (48%). Hypoalbuminemia was observed in half of the subjects and appears to be correlated with the severity of anemia. Surprisingly, the severity of inflammation, as reflected by the CRP, was inversely correlated with the anemia. In the multivariate analysis, alcohol intake (OR: 2.38; IC 95%: 1.05 - 5.38), hypoalbuminemia (OR: 1.98; IC 95%: 1.02 - 3.82) and CRP rate were significantly associated with the presence of anemia among pulmonary tuberculosis at the diagnostic. Conclusion: This study demonstrates the heavy burden of the iron responsive anemia and risky life conditions in newly diagnosed TB patients, and underscores the potential usefulness of iron supplementation in the Congolese context.
Multidrug-Resistant Tuberculosis in the Democratic Republic of Congo: Analysis of Continuous Surveillance Data from 2007 to 2016  [PDF]
Serge Bisuta-Fueza, Jean Marie Kayembe-Ntumba, Marie-Jose Kabedi-Bajani, Pascale Mulomba Sabwe, Hippolyte Situakibanza-Nani Tuma, Jean-Pierre Simelo, Ernest Sumaili-Kiswaya, John Ditekemena-Dinanga, Patrick Kayembe-Kalambayi
Journal of Tuberculosis Research (JTR) , 2019, DOI: 10.4236/jtr.2019.71004
Abstract: Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done primarily among at-risk groups. The knowledge of the true extent of the MDR-TB remains a major challenge. This study tries to determine the proportion of MDR-TB in each group of presumptive MDR-TB patients and to identify some associated factors. Methods: This is an analysis of the DRC surveillance between 2007 and 2016. The proportions were expressed in Percentage. The logistic regression permits to identify the associated factors with the RR-/MDR-TB with adjusted Odds-ratio and 95% CI. Significance defined as p ≤ 0.05. Results: Overall, 83% (5407/6512) of the MDR-TB presumptive cases had each a TB test. 86.5% (4676/5407) had each a culture and drug sensitive testing (DST) on solid medium, and 24.3% (1312/5407) had performed an Xpert MTB/RIF test. The proportion of those with at least one first-line drug resistance was 59.3% [95% CI 57.2 - 61.4] among which 50.1%, [95% CI 47.9 - 52.3] for the isoniazid, 45.6% [95% CI 43.4 - 47.8] for the rifampicin, 49.9% [95% CI 47.8 - 52.1] for ethambutol and 35.8% [95% CI 33.7 - 37.9] for streptomycin. The confirmation of MDR-TB was 42.8% [95% CI 38.4 - 47.8]. Combining both tests, the proportion of RR-/MDR-TB was 49.6% [95% CI 47.9 - 51.4] for all presumptives. This proportion was 60.0% for failures, 40.7% for relapses and 34.7% for defaulters. Associated factors with the diagnosis of MDR-TB were: aged less than 35 years; prior treatment failure; defaulters; the delay between the collection of sputum and the test completion. Conclusion: The proportion of RR-/MDR-TB among the presumptives has been higher than those estimated generally. The National tuberculosis programme (NTP) should improve patient follow-up to reduce TB treatment failures and defaulting. Moreover, while increasing the use of molecular tests, they should reduce sample delivery times when they use culture and DST concomitantly.
Effects of Judo Strength-Velocity Training during Precompetition on Cardiorespiratory Responses in Congolese Judoists Aged 15 - 17 Years Old  [PDF]
Jean Georges André Moulongo, Alphonse Massamba, Jean Marie Kayembe Ntumba, Fran?ois Lepira Bompeka, Félix Lotoko Lisule, Bernard Packa-Tchissambou
Journal of Biosciences and Medicines (JBM) , 2016, DOI: 10.4236/jbm.2016.410006
Abstract: Objective: To evaluate the effects of “strength-velocity” training on the evolution of some cardiorespiratory parameters in postpubertal judoists of the Congolese national elite. Methods: The survey, exploratory, experimental and longitudinal, was about 14 boys, belonging to seven categories of weight of the International Federation of Judo. These judoists, at the level belonged to stages 3, 4 and 5 of the classification to Tanner, of pubertal maturation. Their median age was 16 years (range: 15 - 17 years). All topics have been submitted to “strength-velocity” training, focused around exercises bound to the development of the power and automatisms, from plyometric and isometric training. Three assessments have been realized in the beginning, to mid-training (3 months) and at the end of the program (6 months). The measured values were cardiorespiratory parameters. Results: The heart rate to the doorstep was decreased significantly (p = 0.048), so VO2 max (p = 0.046), FVC (p = 0.0244) and ratio VEMS/FVC (p = 0.046) as function of pubertal stage. In contrast, increase was not significant for VEMS (p = 0.205) and absolute VO2 to doorstep (p = 0.097). No significant effect of pubertal state on respiratory frequency was found. On the other hand, strength-velocity training improved cardiorespiratory data. To the recovery of the “strength-velocity test”, the decrease of the VO2 took place more quickly that the one of the VE, the VCO2 and the HR, variations linked to the category of topic weight. Conclusion: Among high level Congolese postpubertal judoists, the cardiorespiratory modifications induce faculty to the realization of a good performance and pursue objectives of health. However, it is necessary to be heedful as for situations to put in place in sittings at the time of such of “strength-velocity” training.
First Use of Bedaquiline in Democratic Republic of Congo: Two Case Series of Pre Extensively Drug Resistant Tuberculosis  [PDF]
Murhula Innocent Kashongwe, Leopoldine Mbulula, Brian Bakoko, Pamphile Lubamba, Murielle Aloni, Simon Kutoluka, Pierre Umba, Luc Lukaso, Michel Kaswa, Jean Marie Ntumba Kayembe, Zacharie Munogolo Kashongwe
Journal of Tuberculosis Research (JTR) , 2018, DOI: 10.4236/jtr.2018.62012
Abstract: In this manuscript the authors have studied the first two patients who were successfully treated with the treatment regimen containing Bedaquiline as second-line drug. The patients were diagnosed with pre-extensively drug-resistant tuberculosis (preXDR TB) whose prognosis was fatal in Democratic Republic of Congo (DRC). Bedaquiline is arguably one of the molecules of the future in the management of ultra-resistant tuberculosis. However, a larger cohort study may help to establish its effectiveness. Case report: Patients 1, 29 years old, with a history of multidrug-resistant TB (MDR-TB) one year previously. He showed signs of TB impregnation again 6 months after the last treatment. Bascilloscopy was positive again. The pre-extensively tuberculosis (pre-XDR TB) diagnosis was made by the Hain test (GenoType® MTBDRsl, Hain Lifescience). Patient 2, brother of the first patient, with a history of MDR TB a year before. He had low back pain with right parietal dorso swelling four months after the last treatment. The x-ray of the column showed L4-L5 disc disease. Parietal ultrasound showed a parietal abscess to the right of thoracic vertebrae with fistulization. Surgical biopsy and pus culture confirmed the diagnosis of Pre-XDR Extrapulmonary TB. The treatment regimen was the same for both patients: 6 months with Amikacin (Am) Bedaquiline (Bdq) Prothionamide (Pto) Paraamino Salicylic acid (PAS) Linezolid (Lzd) Cycloserine (Cs) Pyrazinamide (Z) and 14 months with PAS Lzd Cs Z. The side effects were minor. Bacteriological controls (smears and cultures) after 20 months of treatment are negative to date.
Determination of the Root Canal Length of Teeth of Bantu Patients Attending the Teaching Hospital of Kinshasa University  [PDF]
Jean Marie Kayembe Bukama, Jean Paul Sekele Issourdi, Fidele Nyimi Bushabu, Augustin Mantshumba Milolo, Steve Sekele Masin, M. A. Agbor, Dieudonne Nyembue Tshipukana, Alain Nyengele Kayembe, Hubert Ntumba Mulumba
Open Journal of Stomatology (OJST) , 2018, DOI: 10.4236/ojst.2018.81002
Abstract: Background: There is paucity of literature on the determination of the root canal length of Bantu subjects in dental professional practicing in Africa and Democratic Republic of Congo in particular. Aims: The aim of the present study was to determine the root canal length of teeth of Bantu patients extracts attending the Teaching Hospital of Kinshasa University. Methods and Material: Prospective cross-sectional study was carried out in the service of Conservative Dentistry. The patients suffering with pulpitis of permanent teeth which were selected for root canal treatment during the period of January 2014 to December 2016 were included. All patients whose main root canals were inaccessible, teeth carrying prosthesis, teeth with large coronal decay, teeth having periapical periodontitis, supernumerary teeth, wisdom and primary teeth were excluded. Results: The upper canines presented some significant longer canals compared to the lower canine (23.4 ± 2.3 mm and 21.6 ± 1.8 mm). Palatal canals of the first and second molar were respectively longer as compared to the superior teeth canals (21.5 ± 1 mm, 21.3 ± 2 mm). The distal canals of the first and second molar were the longest in the mandibular arch respectively measuring 20.7 ± 2.0 mm and 21.5 ± 1.7 mm. Conclusion: Data obtained from Bantu patients show slightly shorter roots compared to some European populations, but longer than some Asian populations.
Low Detection Rate of Multidrug-Resistant and Rifampicin-Resistant Tuberculosis in the Democratic Republic of Congo: Trend Analysis 2013-2017  [PDF]
Innocent Kashongwe Murhula, Fina Mawete, Lay Ofali, Michel Kaswa, Francois Lepira Bompeka, Jean Marie Kayembe Ntumba, Zacharie Kashongwe Munogolo
Journal of Tuberculosis Research (JTR) , 2019, DOI: 10.4236/jtr.2019.74020
Abstract: The Democratic Republic of Congo is one of the countries with a high preva-lence of multidrug-resistant tuberculosis (MDR-TB) in Africa and worldwide. This study aims to describe the trends and level of screening since 2013. This is a retrospective descriptive study based on quarterly reports from the provinces. The number of cases, past histories, age, sex and HIV Co-infection was identi-fied. It emerges that the number of cases increases significantly but does not reach the forecasts yet (912 cases of MDR/RR and XDR diagnosed in 2017 out of 3948 cases expected with a gap of 77%). Patients with a history of TB pre-dominate (63.5% in 2017); but the proportion of patients with no history of TB increases (36.5% in 2017). This suggests high rates among contacts. Women (37.8%) and children under 15 (2.7%) are less represented. TB/HIV Co-infection is 12% as for sensitive cases. Efforts still need to be made to improve screening.
Maternal Knowledge of Tuberculosis and Bacillus Calmette Guerin Vaccination in Pediatric Health Services in Kinshasa  [PDF]
Loukia Aketi, Joseph Shiku Diayisu, Zacharie Kashongwe, Grace Nkabikueni, Patrick Kayembe Kalambay, Jean-Marie Kayembe
Journal of Tuberculosis Research (JTR) , 2017, DOI: 10.4236/jtr.2017.51004
Abstract: Introduction: To participate effectively in the fight against tuberculosis (TB), mothers need to have a good knowledge of TB and its prevention. The objective of this study was to evaluate the knowledge of mothers about TB and Bacillus Calmette Guérin (BCG). Methods: This was a cross-sectional survey performed from September to December 2015 in 4 health care facilities of Kinshasa. It concerned mothers of children who received BCG vaccine. The frequencies and chi-square of Pearson were used to report results. Results: A total of 380 couples of the children and their mothers were recruited. The median age of children was 16 months (ranges: 6 days to 59 months); 224 (58.9%) of them received BCG during the period recommended; 62 (16.3%) experienced a side effect. There was a significant association (p = 0.00) between sides effects and the delayed vaccination. The average age of the mothers was 29.3 ± 6.4 years; 352 (92.6%) had heard about TB; 28 (7.4%) never heard about it; 168 (44.2%) knew that TB is a contagious disease; only 111 (29.2%) knew the mode of transmission; 87 (22.9%) did not know any signs of TB, and 54 (14.2%) knew about prevention with the BCG vaccine. Factors significantly associated with the mothers’ lack of knowledge were a low level of education (p = 0.01), young age (p = 0.02), and place of residence (p = 0.04). Conclusion: There is an urgent need to improve the education of the population, particularly those who lives in poor conditions and who are uneducated.
Seroprevalence of Infectious Markers in Blood Donors in Mbujimayi “Case of Kansele General Hospital” (Democratic Republic of Congo)  [PDF]
Kabambi Bukasa Valentin, Kanyiki Katala Moise, Kaseka Cisuaka Jeanne, Kayembe Menji Jean-Pierre, Tshibanda Tshibanda Etienne, Mutombo Mutombo Albert, Katuku Ciala Charles, Ciamala Mukendi Paul, Ntumba Muamba Alidor
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105901
Abstract:
Blood transfusion is a life-saving act because in some cases, it is the last resort to save an individual’s life. However, the seroprevalence of infectious markers in blood donors is a major public health problem, both in developed and developing countries, in its magnitude. The purpose of this study was to determine the seroprevalence of infectious markers in blood donors. This is a descriptive study conducted in the city of Mbujimayi at kansele Hospital among registered blood donors (family volunteers and paid) from the period 12/01/2017 to 13/01/2018. The data were collected in a cross-sectional manner. The following observations were made: in the study period, 522 blood donors were registered. After analyzing the data, the seroprevalence of HIV/AIDS in blood donors is 4.4%, 2.1% of cases have an HCV serological status and 5.9% a HBS positive serological status, and 2.1% a positive RPR HIV status, the male sex predominated with 85.4% was male.
Fuzzy Logic Strategy for Solving an Optimal Control Problem of Glucose and Insulin in Diabetic Human  [PDF]
Jean Marie Ntaganda
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.37052
Abstract:

This paper aims at the development of an approach integrating the fuzzy logic strategy for a glucose and insulin in diabetic human optimal control problem. To test the efficiency of this strategy, the author proposes a numerical comparison with the indirect method. The results are in good agreement with experimental data.

Hopf Bifurcation of a Two Delay Mathematical Model of Glucose and Insulin during Physical Activity  [PDF]
Jean Marie Ntaganda
Open Journal of Applied Sciences (OJAppS) , 2014, DOI: 10.4236/ojapps.2014.42006
Abstract: In this paper, we are interested in looking for Hopf bifurcation solutions for mathematical model of plasma glucose and insulin during physical activity. The mathematical model is governed by a system of delay differential equations. The algorithm for determining the critical delays that are appropriate for Hopf bifurcation is used. The illustrative example is taken for a 30 years old woman who practices regular three types of physical activity: walking, jogging and running fast.
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