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Search Results: 1 - 10 of 506140 matches for " Jean Jorge S. de;Bezerra "
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Bioequivalência de Prepara es Comerciais de L-Tiroxina (100 e 200μg): Avalia o em Pacientes Hipotireóideos Previamente Tireoidectomizados
Camargo Rosalinda Y.A.,Souza Jean Jorge S. de,Bezerra Ana K.M.,Seidenberger Katia
Arquivos Brasileiros de Endocrinologia & Metabologia , 2002,
Abstract: A bioequivalência e biodisponibilidade das prepara es comerciais de L-tiroxina podem apresentar diferen as significativas entre si. O objeto do presente trabalho foi comparar variáveis séricas tireóideas (T4 e T3 totais, T4 livre e TSH endógeno) em pacientes previamente tireoidectomizados (há mais de 5 anos) e sem evidência clínica ou ecográfica de tecido glandular cervical remanescente. Os referidos parametros foram medidos, por 15 dias, a intervalos de tempo regulares, durante administra o de solu o oral de L-tiroxina (100mg), presumivelmente de absor o e biodisponibilidade ideais. Comparou-se, em seguida, a oscila o das mesmas variáveis com duas outras prepara es comerciais, sob forma de comprimidos de L-tiroxina (LT4A e LT4B) nas doses de 100mg/dia e a seguir 200mg/dia. N o se observou diferen a significativa entre a solu o oral e as duas prepara es comerciais nos vários tempos de medida. Tampouco houve diferen a significativa entre os comprimidos de L-T4A e L-T4B em doses de 100mg ou de 200mg/dia. Concluímos que ambas as prepara es apresentam biodisponibilidade e bioequivalência adequadas nas condi es utilizadas neste estudo.
Bioequivalência de Prepara??es Comerciais de L-Tiroxina (100 e 200μg): Avalia??o em Pacientes Hipotireóideos Previamente Tireoidectomizados
Camargo, Rosalinda Y.A.;Souza, Jean Jorge S. de;Bezerra, Ana K.M.;Seidenberger, Katia;Tomimori, Eduardo;Cardia, Maria Silvia;Knobel, Meyer;Brand?o, Lenine;Medeiros-Neto, Geraldo;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2002, DOI: 10.1590/S0004-27302002000500006
Abstract: a major issue influencing prescribing patterns of physicians has been the relative bioavailability and bioequivalence of commercial levothyroxine preparations. some studies have suggested similar bioequivalence between various l-t4 tablets while other reports have found differences. some of these studies have been criticized for methodological defects in patients' selection or study design, which have become appreciated only in retrospect. moreover the us pharmacopeia has proposed that commercial tablets of l-t4 should be tested for its dissolution in two different solutions. each manufacturer should periodically test batches of tablets as indicated. in the present study, we have compared serum thyroid function parameters (total t4, total t3, free t4, and serum tsh) in previously totally thyroidectomized patients, without sonographic evidence for reminiscent thyroid tissue in the cervical area. the above parameters were measured, as function of time, for 15 days of either an oral solution of l-t4 (100μg) or tablets of l-t4a and l-t4b (100μg/tablet). there was no significant difference between the various parameters, in relation to time, for each of the different preparations. moreover l-t4a tablets did not differ from l-t4b tablets, when those parameters were tested, either at the concentration of 100 or 200μg/day. we conclude that the two oral formulations of l-thyroxine have similar bioavailability and bioequivalence under the present experimental conditions.
Fenólicos totais e capacidade antioxidante in vitro de polpas de frutos tropicais
Vieira, Luanne Morais;Sousa, Mariana Séfora Bezerra;Mancini-Filho, Jorge;Lima, Alessandro de;
Revista Brasileira de Fruticultura , 2011, DOI: 10.1590/S0100-29452011005000099
Abstract: the consumption of fruit, pulps has been highly recommended for its nutritional value, high-fiber, vitamin c and carotenoids. recent studies have demonstrated these foods as sources of phenolic compounds with antioxidant activity, therefore, free radical scavengers, with a protective effect against the emergence anddevelopment or degenerative processes that lead to chronic diseases. due to the increasing commercializationand consumption of fruit pulp in brazil, especially in the city of teresina, piauí, this study selected a group of fruit pulp of high local consumption to evaluate the total phenolic content and antioxidant activity in vitro by the method of capture of free radicals: dpph (1,1-radical diphenil-2-picrilhydrazil) and abts (2,2 'azinobis-(3-ethylbenzthiazoline-6-sulfonic acid)). the fruit were selected acerola (malpighia emarginata dc.) bacuri (platonia insignis mart.) caja (spondias mombin l.), cashew (anacardium occidentale), guava(psidium guajava) and tamarind (tamarindus indica l.). the levels of phenolics found in the frozen pulp of fruit exhibited relevant quantities of polyphenols, especially if the pulp with 835.25 ± 32.44 and 449.63 ± 10.24 mg / 100g in hydroalcoholic and aqueous extracts, respectively followed by cashew pulp with 201.61 ± 19.15 and 165.07 ± 4.10 mg / 100g. the pulp of tamarind bacuri showed the lowest levels of total phenolics. regarding the antioxidant activity in vitro, the best results were found for aqueous and ethanolic of pulp of acerola, cashew and guava. the antioxidant activity of these pulps (ec50 in mg / ml) rangedfrom 24.42 to 413.36 and 1.74 to 259.18 for the hydroalcoholic and aqueous extracts, respectively. using the abts radical, the antioxidant activity for these same fruit pulps showed that teac values ranged from 3.69 ± 0.209 to 0.052 ± 0.013 (mm trolox / g of pulp). we observed that a direct correlation exists between the amount of total phenolics and antioxidant activity in the analyzed pulps.
Efectos crónicos de un programa de alargamiento pasivo sobre los valores de la presión arterial sanguinea y el estrés en adultos con hipertensión arterial. Chronics effects of a passive stretching program on the blood pressures and stress levels of hypertensions adults.
Acosta González, Jorge Isaac,Bacelar , Sílvia,Bezerra da Silva, Elirez,Carielo de Albuquerque, Alessandro
RICYDE : Revista Internacional de Ciencias del Deporte , 2007,
Abstract: Resumen El objetivo de este estudio fue analizar los efectos crónicos de un programa de alargamiento pasivo sobre la presión arterial sanguínea y estrés en adultos con hipertensión arterial. Participaron de este estudio, 12 personas de ambos sexos, con edad media de 52,12±5,5 a os, sedentarios y con diagnóstico médico de hipertensión arterial. Las variables recolectadas para la realización de la investigación fueron la presión arterial sanguínea y el estrés de dichas personas. El tratamiento estadístico fue realizado por análisis descriptivos y análisis de inferencia. Los tests estadísticos de naturaleza comparativa fueron realizado a través de los análisis de variancia (ANOVA one-way) yuxtapuesto con el test de Post hoc de Tukey, para identificar las posibles diferencias entre los datos de la presión arterial sanguínea. El test de Kruskal-Wallis fue usado para comparar las respuestas del cuestionario de estrés. Fue admitido el valor de p<0,05 como significativo para todos los análisis estadísticos utilizados. Los resultados revelaron que, después de ocho semanas de tratamiento, los individuos presentaron mejoras significativas (p<0,05) en la presión arterial sanguínea sistólica (%=-15,39?13,79; p=0,01<0,05) y diastólica (%=-14,21?12,98; p=0,00<0,05). Con relación al estrés durante el protocolo de alargamiento usado, los sujetos demostraran reducción en el número de individuos que se encontraban en la fase exhaustiva. Sin embargo, se obtuvo un aumento expresivo en el número de individuos clasificados en la fase de resistencia. De acuerdo con las evidencias constatadas en el estudio en discusión, hemos concluido que los ejercicios de alargamiento pasivo presentaron efectos significativos y positivos en la reducción de la presión arterial sanguínea y en la fase del estrés, en as personas con hipertensión arterial, después de ocho semanas de tratamiento. Abstract Purpose of this study was verifier the chronics effects of passive stretching programs on the stress and blood pressure levels of adults with arterial hypertension. 12 subjects of both gender, age average of 52,12 52,12±5,52 year, sedentary and with screening of arterial hypertension, volunteered to participate this study. The variables identified to the conduction of the respective study were the blood pressure, physical activity level and stress of the subjects. Statistic treatment was compost for descriptive and inferential analysis across of the variance analysis test (ANOVA two-way), concomitant with Post hoc test of Tukey, to estimate the differences in the average of the variables during th
Avalia??o da resistência adesiva e do padr?o de descolagem de diferentes sistemas de colagem de braquetes associados à clorexidina
Ribeiro, Jorge Luís de Oliveira;Bezerra, Rebeca Barroso;Campos, Elisangela de Jesus;Freitas, Aline Andrade de;
Revista Dental Press de Ortodontia e Ortopedia Facial , 2008, DOI: 10.1590/S1415-54192008000400014
Abstract: aim: the objective of this in vitro study was to evaluate the bond strength and the debonding pattern of different bracket bonding systems (transbond xt system / 3m-unitek and enlight system / ormco) whose respective adhesives were pre-mixed with chlorhexidine varnish (cervitec / ivoclar-vivadent). methods: the sample used consisted of sixty human pre-molars extracted for orthodontic purposes, included in pvc cylinder and randomly divided in four experimental groups: group 1 - transbond xt system according to the manufacturer?s instructions; group 2 - transbond xt system combined with chlorhexidine varnish; group 3 - enlight system according to the manufacturer?s instructions; group 4 - enlight system combined with chlorhexidine varnish. the bond strength evaluation was obtained through the shear bond strength test by emic universal test machine (0.5mm/minute); the debonding pattern evaluation was obtained by stemi 2000-c/zeiss (20x) stereoscopic microscope through observation of the adhesive remnant index (ari) on the tooth?s enamel surface after bracket debonding. results: between the experimental groups (groups 2 and 4) and the respective control groups (groups 1 and 3) there was no significant statistical difference (p < 0.05). conclusions: the bond strength and the debonding pattern were not altered for association of the chlorhexidine varnish with respective adhesives of the tested bonding systems.
Indicadores de qualidade do solo em sistemas de cultivo organico e convencional no semi-árido cearense
Lima, Herdjania Veras de;Oliveira, Teógenes Senna de;Oliveira, Maria Matutina de;Mendon?a, Eduardo de Sá;Lima, Pedro Jorge Bezerra Ferreira;
Revista Brasileira de Ciência do Solo , 2007, DOI: 10.1590/S0100-06832007000500024
Abstract: soil quality can change along the time due to natural events or anthropic activities. the use of organic management practices reduces soil tillage and favors the recovery of soil physical and chemical properties. the objective of this study was to compare the physical, chemical and biological properties of cultivated soils under organic system or conventional tillage system. six organic and three conventional cultivated areas were selected and soil samples collected in the layers 0-10, 10-20 and 20-30 cm. physical, chemical and biological (macro and mesofauna) soil properties were evaluated and analyzed by univariate and multivariate statistical techniques. individually, the physical and chemical parameters were not sensitive enough to differentiate organic from conventional production systems. the multivariate analyses (principal components and anderson discriminant) obtained satisfactory results, distinguishing organic from conventional management areas and from those in transition. areas cultivated under organic systems were distinguished satisfactorily and most precisely from areas under conventional systems based on difference in soil fauna
Determinantes clínicos com influência no prognóstico da discectomia lombar: análise multifatorial
Carvalho, Paulo Jorge Da Rocha;Sá, Paulo Jorge Correia De;Freitas, Rolando Manuel Bezerra;Gon?alves, Jo?o Pedro Maia;Macedo, Sara Lemos Costa Lobo;Neves, José De Morais;
Coluna/Columna , 2010, DOI: 10.1590/S1808-18512010000100008
Abstract: inappropriate patient selection and timing for lumbar disc surgery are still the the major causes of failures. objective: we evaluated the clinical outcome and predictive factors that influence the prognosis of patients submitted to lumbar discectomy using a multivariate analysis model. methods: we report a prospective series of 68 patients with herniated lumbar disc who underwent limited discectomy during 2003 to 2007. the average follow-up period was 3.9±0.1 years. clinical findings were evaluated using japonese orthopaedic association assessment scoring system (joa=29). results: excellent and good postoperative improvement rates were obtained in 75% of the patients. male gender and preponderance of subjective symptoms over clinical signs were associated with better clinical outcomes and faster return to work. waiting time for surgery had no consistent effect on the outcome. the need for immediate surgery was questionable in the absence of significant neurological disturbance (joa for clinical signs >3/6). joa scoring had predictive value for preoperative assessment for lumbar disc surgery, i.e. preoperative joa >15 (low initial disability) correlated with poor surgery outcome. conclusions: joa scoring is easily performed for patients and clinicians, standardizes subjective data and presents high predictive value of patients' outcome after lumbar discectomy.
Tratamento cirúrgico da aorta ascendente e arco com perfus?o cerebral anterógrada e hipotermia moderada
Martins, Marcelo Sávio da Silva;Sá, Mauro Paes Leme de;Abad, Leonardo;Bastos, Eduardo Sérgio;Franklin Junior, Ney;Baptista, Alvaro Luiz Xavier de B. M.;Annibal, Jorge Viana;Bezerra, Alvaro Barde;
Revista Brasileira de Cirurgia Cardiovascular , 2006, DOI: 10.1590/S0102-76382006000400017
Abstract: objective: to retrospectively evaluate the technique of antegrade cerebral perfusion via the innominate artery associated with moderate systemic hypothermia (28-30oc) in adults operated on for aneurysms or proximal aortic dissections. method: twelve consecutive adult patients who presented with proximal aortic dissections or aneurysms were operated on. of these, seven presented with aortic dissections and five presented with ascending aortic or aortic arch aneurysms. arterial perfusion was achieved using an 8.0 mm ptfe graft anastomosed to the innominate artery; the brachiocephalic trunk was occluded proximally for antegrade cerebral perfusion. systemic hypothermia of 28-30oc was used during circulatory arrest with the mean arterial pressure of the right radial artery maintained between 50-60 mmhg. results: there were no neurological or bleeding complications. in ten cases, the aortic valve was preserved by resuspension or remodeling. the mean time of circulatory arrest with antegrade cerebral perfusion was 24 minutes (range from 20 to 35 minutes). conclusion: antegrade cerebral perfusion through the innominate artery associated with moderate hypothermia (28-30oc) seems to be effective to protect the central nervous system and possibly to avoid excessive bleeding in the post operative period.
S-Score: A Scoring System for the Identification and Prioritization of Predicted Cancer Genes
Jorge E. S. de Souza, André F. Fonseca, Renan Valieris, Dirce M. Carraro, Jean Y. J. Wang, Richard D. Kolodner, Sandro J. de Souza
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094147
Abstract: A new method, which allows for the identification and prioritization of predicted cancer genes for future analysis, is presented. This method generates a gene-specific score called the “S-Score” by incorporating data from different types of analysis including mutation screening, methylation status, copy-number variation and expression profiling. The method was applied to the data from The Cancer Genome Atlas and allowed the identification of known and potentially new oncogenes and tumor suppressors associated with different clinical features including shortest term of survival in ovarian cancer patients and hormonal subtypes in breast cancer patients. Furthermore, for the first time a genome-wide search for genes that behave as oncogenes and tumor suppressors in different tumor types was performed. We envisage that the S-score can be used as a standard method for the identification and prioritization of cancer genes for follow-up studies.
Uma área de relevante interesse biológico, porém pouco conhecida: a Reserva Florestal do Morro Grande
Metzger, Jean Paul;Alves, Luciana F.;Goulart, William;Teixeira, Ana Maria de Godoy;Sim?es, Sílvio Jorge C.;Catharino, Eduardo Luís Martins;
Biota Neotropica , 2006, DOI: 10.1590/S1676-06032006000200003
Abstract: the morro grande forest reserve (10,870 ha) is one of the biggest forest areas in the atlantic plateau. this region was intensively deforested for agriculture, wood and charcoal production, and more recently by the expansion of urban areas. the reserve is located in the cristalline plateau of ibiúna, just above the paranapiacaba mountain (860 1075 m above sea level), in a transition region between the rainy climate from the atlantic coast, and the seasonal climate from inland s?o paulo state. as a consequence, species composition in morro grande reserve combines elements from the tropical rainforest and the semideciduous forest. despite this particularity, few studies were carried out in the forests from morro grande. it is only in 2000 that a group of scientist related to the biota/fapesp program began a systematic analysis of the species composition of different taxonomic groups, as well as the analysis of ecological processes related with forest regeneration. the present manuscript introduces a series of nine articles with the biological data obtained in the reserve these last four years, and aims also to present an historical and abiotic description of the reserve, highlighting aspects of the relief, geologic and pedological conditions, climate, hydrography, land use and land cover.
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