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Search Results: 1 - 10 of 23194 matches for " Jean Claude Barthelemy "
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Autonomic nervous system activity in patients with Fabry disease  [PDF]
Eric Alamartine, Aurore Sury, Frédéric Roche, Vincent Pichot, Jean-Claude Barthelemy
Open Journal of Internal Medicine (OJIM) , 2012, DOI: 10.4236/ojim.2012.22021
Abstract: Background: Fabry disease is an inherited, multisystemic and progressive lysosomal storage disorder. The first symptoms of Fabry neuropathy reflect progressive loss of function of both peripheral somatic and autonomic nerve cells. We aimed to evaluate autonomic nervous system (ANS) activity in a cohort of patients with Fabry disease. Methods: ANS activity was evaluated by determining heart rate variability, spontaneous baroreflex sensitivity and ambulatory blood pressure in 9 patients with Fabry disease. Possible correlations between ANS activity and clinical phenotype were investigated. Results: Indices of global activity were frequently high, while ANS balance was disturbed only in a few patients. Sympathetic nervous system parameters were within normal ranges, but indices of parasympathetic parameters were highly variable. Baroreflex sensitivity was significantly correlated with glomerular filtration rate. Conclusion: Distribution of ASN activity indices is wide in patients with Fabry disease. Autonomic imbalance has been associated with non-Fabry chronic kidney disease and cardiovascular risk. In Fabry disease, monitoring of ANS activity may contribute to comprehensive disease staging, and may be of value in identifying patients at high risk of developing renal and cardiac events.
Fluctuation effects in metapopulation models: percolation and pandemic threshold
Marc Barthelemy,Claude Godreche,Jean-Marc Luck
Quantitative Biology , 2010,
Abstract: Metapopulation models provide the theoretical framework for describing disease spread between different populations connected by a network. In particular, these models are at the basis of most simulations of pandemic spread. They are usually studied at the mean-field level by neglecting fluctuations. Here we include fluctuations in the models by adopting fully stochastic descriptions of the corresponding processes. This level of description allows to address analytically, in the SIS and SIR cases, problems such as the existence and the calculation of an effective threshold for the spread of a disease at a global level. We show that the possibility of the spread at the global level is described in terms of (bond) percolation on the network. This mapping enables us to give an estimate (lower bound) for the pandemic threshold in the SIR case for all values of the model parameters and for all possible networks.
Can subjective sleep quality, evaluated at the age of 73, have an influence on successful aging? The PROOF study  [PDF]
Emilie Crawford-Achour, Virginie Dauphinot, Magali Saint Martin, Magali Tardy, Régis Gonthier, Jean Claude Barthelemy, Frédéric Roche
Open Journal of Preventive Medicine (OJPM) , 2014, DOI: 10.4236/ojpm.2014.42008

Objective: Sleep complaints are recurrent in Geriatrics and are often attributed to physiological aging. The aim of this work is to describe subjective sleep quality and its impact on successful aging. Methods: Subjective sleep quality was evaluated by using the Pittsburgh subjective sleep quality questionnaire. Two visual analogical scales (graduate from 0 to 10) were used to quantify perceived state of health and life satisfaction. Objective respiratory sleep parameters were also collected. Results: 370 data were analysed (46.2% of males). The average age was 73.2 +/- 1. The level of perceived state of health was 6.9 +/- 2, and life satisfaction level was 7.7 +/-2. Subjective sleep quality was significantly related to perceived health status (p = 0.034) and life satisfaction (p = 0.005). There was no significant association between sleep quality and objective respiratory sleep parameters. Conclusion: The assessment of sleep quality plays an important role in the management of elderly persons and can help them to age more successfully.

The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole  [PDF]
Jean-Claude Perez
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.410A2004

This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossil genome with multiple symmetries persists. This recalls the intermingling of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, which characterize it and its 64 codon populations with correlations greater than 99%. The number “1” is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then “imagine” a kind of hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome: we will show that—simultaneously with the duality between genes and junk DNA—there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information/redundancy involving golden ratio proportions.

Urban Planning in Africa: Which Alternative for Poor Cities? The Case of Koudougou in Burkina Faso  [PDF]
Jean-Claude Bolay
Current Urban Studies (CUS) , 2015, DOI: 10.4236/cus.2015.34033
Abstract: The efforts made to plan cities in emerging and developing countries are confronted to multiple issues, especially in small and middle sized cities which can be considered as poor through several criteria: socio-economic level of majority of population; low levels of public investments, weak quality of local administration, and large dependence of external donors. Following several authors, one of the main reason is that philosophy and methods of urban planning applied to these specific contexts are directly reproduced from a Western tradition which doesn’t correspond to the local and national context in terms of needs, priorities and organization of the financial resources. The case of Koudougou, a medium sized city in one of the poorest countries in the world, Burkina Faso, will give the opportunity to understand concretely how these deficiencies are translated in an urban context, and foresee, more globally, alternative models of urban planning better adapted to poor cities, whose number of inhabitants is growing steadily.
Prosperity and Social Inequalities: Montes Claros, How to Plan an Intermediary City in Brazil  [PDF]
Jean-Claude Bolay
Current Urban Studies (CUS) , 2016, DOI: 10.4236/cus.2016.42013
Abstract: According to international statistics, nearly 50% of the world’s urban population live nowadays in cities of less than 500,000 inhabitants. These small and medium-sized cities play a role of intermediation between rural regions, local economy and more extensed urban networks, with three spheres of influence: micro-regional, national and international. In many of these “intermediate cities”, the main problem to reinforce them in their action is a lack of financial and human resources for managing the city in a comprehensive way, in order to tackle the demographic and spatial extension of these urban settlements, and avoid an increase of social segregation and fragmentation of territory. The example of Montes Claros, in the State of Minas Gerais, Brazil, helps us understand how a city of nearly 400,000 inhabitants, at the center of an economically prosperous region, tackles these issues through a current process of urban planning, having to take into account its historical, social and spatial context. Like most Brazilian and Latin American cities, Montes Claros-which acts as a transit hub at the State and national levels-is a rapidly growing intermediary city that has seen continued economic growth over the past two decades. However, this industrial and business growth has not resulted in a more inclusive distribution of the urban population. Considering the resulting growth from rural migration and new urban residents, the urban area of Montes Claros remains fragmented territorially, with neighborhoods more or less well equipped and served by public transport depending on the socio-economic status of their inhabitants. The current process of urban planning raises many issues, among them three crucial elements to improve in order to re-introduce planning as appropriate approach and instruments able to guide the decision makers towards the future of a city and its region: a medium and long-term vision for Montes Claros, its hinterland and the Northern region of Minas Gerais; a biased perception of Montes Claros in which only the dense areas in the city center are taken into account, with suburban areas still disconnected from the rest of the city and poorly integrated; a participatory process of urban planning involving all stakeholder and population, from the diagnostic till the definition of priorities in terms of urban policies, strategies and investments.
Planning the Intermediate City, or How to Do Better with Little: The Case of the City of Nueve de Julio, Argentina  [PDF]
Jean Claude Bolay
Current Urban Studies (CUS) , 2018, DOI: 10.4236/cus.2018.63020
With 92% of its population living in urban areas, Argentina is one of the most urbanized countries on the planet. Like in many South Countries, the populations of the small and medium-sized cities, which serve as intermediate centers between the countryside and the urban network, are growing steadily. Such cities in Argentina offer services and infrastructures to both urban and rural populations, as well as a residential alternative to the Greater Buenos Aires metropolitan area. These cities, however, are facing specific problems that require appropriate responses. In this respect, Nueve de Julio is emblematic of the challenges facing these intermediate cities. As one of the hundred cities created in the 19th century by the Argentinian government, Nueve de Julio is today a city whose population is increasing, and territory is expanding, but that lacks any foresight to anticipate the next 20 or 30 years. Our purpose is to analyze the reasons of this stagnation, explain the serious development problems the city confronts, with disparities in the organization of its territory and 20% of population living in poverty, and foresee an open system of urban planning, capable to guide the urban authorities and its partners in the identification of priorities and investments in favor of all the inhabitants. The government seems helpless in dealing with this. Political activism prevails over planning and varies from one election to the next depending on the party in power. Means are lacking, both financially and in terms of technical skills. Establishing an open system of urban planning is imperative. Based on the collaboration of citizen, the goals of the planning should include social, economic and spatial integration, efforts to include the city’s poor and more rational, less costly development of the suburban periphery. This will enable Nueve de Julio to better play its role as an intermediate city for the entire urban and regional population with regard to business, administration, education and health services.
Silent myocardial ischemia screening in patients with diabetes mellitus
Barthelemy, Olivier;Le Feuvre, Claude;Timsit, José;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000200018
Abstract: the prevalence of diabetes mellitus is fairly increasing, especially in the developing countries. diabetes is a major cardiovascular risk factor; it often leads to severe cardiovascular complications, and coronary artery disease (cad) is the main cause of death in diabetic patients. silent myocardial ischemia (smi) is more frequent in diabetic patients. the progress made in detection and treatment of cad allows reconsidering the screening of smi, in the hope that early cad diagnosis leads to a more effective therapy and the decrease of cardiovascular complications and mortality. however, the benefit of systematic smi screening remains discussed. current guidelines recommend screening smi in asymptomatic diabetic patients selected for high cardiovascular risk (i.e. with two or more other cardiovascular risk factors, or peripheral or carotid arterial disease, or proteinuria). ecg stress test can be recommended in first intention if maximal heart rate can be achieved. for patient with inconclusive ecg stress test, myocardial scintigraphy seems more accurate than stress echocardiography. coronary angiogram should be performed in case of positive stress test. further evaluations of systematic screening have to be conducted on broad randomized trial.
A New Method for the Determination of Cyanide Ions and Their Quantification in Some Senegalese Cassava Varieties  [PDF]
Younoussa Diallo, Momar Talla Gueye, Cheikh Ndiaye, Mama Sakho, Amadou Kane, Jean Paul Barthelemy, Georges Lognay
American Journal of Analytical Chemistry (AJAC) , 2014, DOI: 10.4236/ajac.2014.53022

Cassava (Manihot esculenta Crantz) is a starchy staple food that previous researches have showed to contain cyanogenic compounds, precursors of hydrocyanic acid, undoubtedly toxic for humans. With the aim to determine food security in cassava, this study developed a simple, fast and less expensive step for quantifying cyanide ions by using micro-diffusion with modified Conway cells. After an enzymatic degradation, the cyanide ions were quantified by electrochemical procedures. The validation of this method is estimated. The concentration of cyanide ions at different part of the samples was determined. The results showed high toxicity in some fresh Senegalese consumed cassava varieties (>100 mg HCN·kg﹣1). However, in the processed cassava products, less than 10 mg HCN·kg﹣1 was found in the different varieties studied except for the chips where the levels of CN contents were important (>49 mg HCN·kg﹣1).

The Role of Cultural Promotion As an Integral Component of Leipzig’s Urban Development  [PDF]
Jean-Claude Garcia-Zamor
Current Urban Studies (CUS) , 2013, DOI: 10.4236/cus.2013.14009
Abstract: After the reunification in 1990, Leipzig—as well as other East German cities—had to face the challenges of the new political-administrative system and an open global economy. Through the systematic implementation of its evolving urban development strategies, the city has developed positively in many areas. After the German reunification, most of Leipzig’s districts lacked cultural leisure services that would have been fit for all age groups and close to their homes. In the early 1990s, the establishment of such urgently needed socio-cultural centers was initiated on the one hand by official authorities and on the other by the citizens themselves. Many newly founded associations and initiatives strove hard to maintain the existing or to develop new cultural activities. In order to implement the latter, they were not only interested in the already established cultural sites, but particularly in former industrial structures or other buildings with a rich historical background. The best project in this effort is the world-famous Spinnerei. These urban environments offered vast opportunities for artists, the independent scene, cultural workers and creative industries alike. A large number of Leipzig’s cultural institutions originated from civic engagement and were then, in times of economic recovery, incorporated into municipal ownership. Nowadays, they are threatened to be re-privatized as the city’s means of cultural funding are gradually reaching their limits. But Leipzig planning officials still think that the promotion of cultural projects in the neighborhoods provides a climate where culture is respectfully seen as a precious opportunity for urban development. Through an extensive and varied offer of cultural activities, otherwise marginalized citizens can be integrated in social life and participate in democratic processes.
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