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Search Results: 1 - 10 of 890 matches for " Javed Akhter "
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Magnetic Method Surveying and Its Application for the Concealed Ore-Bodies Prospecting of Laba Porphyry Molybdenum Ore Field in Shangri-La, Northwestern Yunnan Province, China  [PDF]
Nguyen Ba Dai, Chuan Dong Xue, Kun Xiang, Kun Xiang, Tran Trong Lap, Qureshi Javed Akhter, Shi Lei Li
Journal of Geoscience and Environment Protection (GEP) , 2014, DOI: 10.4236/gep.2014.23006
Abstract:

Recently, a number of large molybdenum (-copper) deposits have been discovered successively in the Laba area, Shangri-La county, northwestern Yunnan province. The investigation confirmed that there is a superlarge porphyry-skarn hydrothermal vein type molybdenum-polymetallic- metallogenic system with the total prediction reservoir of more than 150 mt molybdenum. The porphyry intrusions contributed to the mineralization closely, the superficial little vein molybdenum (-copper, lead, silver) ore-bodies are usually located in faults and fractures, and the deep porphyry type ore-bodies occurred in the granodiorite porphyries, the skarn type ore-bodies occurred in the contact zone intrused into Triassic limestone or Permian basalts. Laba ore block is a new exploration area with great prospecting potential. In order to reduce the target area and guide the further exploration work, the magnetic method measurement about 3.3 square kilometres was carried out in the ore field. This paper presents an application of analyzing the horizontal and vertical derivative, using Fast Fourier Transform (FFT) filter (FFT high-pass, low-pass, cosine roll-off, suscepbility), calculated spectra frequency energy to predict the depth and intensity of the apparent remanence magnetization of source (Hilbert). The calculated results and magnetic anomalous show that the remanence anomaly is caused by the intrusions into the Triassic limestone and Permian basalts with small anomalies, and the depth of located source is not great. We have identified a number of positions to the three drilled well, the drilled result specify interpretation with very high accuracy. The magnetic method is helpful to identify porphyry mineralization, and judge the shape and depth of the concealed ore-bearing intrusive bodies under the similar geological condition.

Peritoneal mesothelioma in a woman who has survived for seven years: a case report
Krishna Pillai, Javed Akhter, Mohammad H Pourgholami, David L Morris
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-36
Abstract: We report the case of a 48-year-old Caucasian woman who is alive and disease-free seven years after the initial diagnosis and treatment of malignant peritoneal mesothelioma.This patient's long survival may be attributable to a combination of factors, including minimal disease, complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy plus the estrogen receptor β positivity of the tumor.Peritoneal mesothelioma is a rare but fatal disease; the incidence is approximately one per million, and peritoneal mesothelioma accounts for about 20% to 30% of all cases of mesothelioma [1]. Although asbestos has been implicated as the main carcinogen [2,3], other factors such as radiation, peritonitis and SV40 have all been implicated [4].Peritoneal mesothelioma progresses with unspecific symptoms, and when presented, it is commonly in the form of increased abdominal girth, pain and weight loss; hence, diagnosis is late, with a poor prognosis. A number of therapeutic regimens have been used to improve prognosis [5], and currently debulking surgery is followed by hyperthermic intraperitoneal chemotherapy (HIPEC). This has led to marked improvement in patients who were once classified as preterminal [6]. The current median survival is around 10 months, and relative five-year survival is in approximately 16% [7]. Hence, more information on the disease and more effective therapies are needed to improve prognosis.A Caucasian women, now aged 48 years, presented herself at the age of 40 years with abdominal pain (four to five days), a bad taste in her mouth and tiredness. She had epigastric discomfort caused by abdominal distension for the past four to five years and had multiple upper and lower gastrointestinal endoscopic examinations. Her medical history involved obesity, treatment for a blocked salivary duct, hypertension, endometriosis, appendectomy, Bell's palsy and hormone replacement therapy. Recent laproscopic cholecystectomy showed areas of abnormality, and a b
RELATIONSHIPS BETWEEN CARBON ISOTOPE DISCRIMINATION AND GRAIN YIELD, WATER-USE EFFICIENCY AND GROWTH PARAMETERS IN WHEAT (TRITICUM AESTIVUM L.) UNDER DIFFERENT WATER REGIMES
JAVED AKHTER,S. ALI SABIR,ZAHID LATEEF,M. YASEEN ASHRAF
Pakistan Journal of Botany , 2008,
Abstract: The present studies were conducted to identify high yielding wheat genotypes for target environments and establish relationship between carbon isotope discrimination (Δ), grain yield (GY) and water use efficiency (WUE), and other parameters. A set of eight wheat genotypes screened previously for variation in Δ and higher GY were grown under four water regimes; well-watered (WW), medium-watered (MW), low-watered (LW) and stored soil moisture (SSM) conditions. Early leaf and grain samples collected at maturity were analysed for Δ. Plant parameters, such as number of tillers (NT), plant height (PH) heading days (HD), and maturity days (MD) were recorded. At harvesting spike length (SL), number of grains per spike (NGPS), thousand grains weight (TGW), biomass yield (BY), GY, harvest index (HI) and WUE on biomass basis (WUEB) and grain basis (WUEG) were determined. Significant effects of genotype and treatments on Δ of leaf ( L) and grain (ΔG), BY, GY, HI, WUEB, WUEG, HD, NT, PH, NGPS, TGW and SL were observed. Genotype x treatment interaction had a significant effect on HI, PH, SL, TGW, HD and MD, but the effect was non-significant on other traits. In all these genotypes L and ΔG showed a variation of 1.3 and 0.91‰, respectively. All genotypes exhibited higher L than ΔG under different water regimes. Water stress reduced both L and ΔG and highly significant correlation (0.946**) was found between L and ΔG. GY showed a wide variation among these genotypes and water stress resulted in a marked decrease in GY. Genotype Sitta produced highest mean GY (4.4 Mg ha-1) with highest WUEG (16.99 kg ha-1 mm-1) averaged across the treatment. GY showed significant positive correlations with L (r=0.779*) and ΔG (r=0.753*). GY was also strongly and positively correlated with HI (r=0.845**), SL (r=0.779**) and TGW (r=0.899**). GY had a significant negative correlation with NT (r=-0.884*) and HD (r=-0.708*). WUEG was positively correlated with L (r=0.846*), ΔG (0.707*), HI (r=0.846**), SL (r= 0.784*), TGW (r=0.892**). WUEG was negatively correlated with NT (r=-0.814*) and HD (r= -0.743*). Sitta and FD-83 genotypes were found high yielder with greater increase in WUE under water stress and can be exploited to obtain high GY in rain-fed and water limited environments of the country. The results highlight significant positive correlations between Δ and GY or WUEG in bread wheat and carbon isotope discrimination as indirect selection criterion for grain yield in Pakistan.
Stem cells and liver disease
Javed Akhter,Ashraf Ali Aziz,Abdulaziz Al Ajlan
Internet Journal of Medical Update - EJOURNAL , 2011,
Abstract: Liver transplantation is the primary treatment for various end-stage hepatic diseases but is hindered by the lack of donor organs, complications associated with rejection and immunosuppression. An increasingly unbridgeable gap exists between the supply and demand of transplantable organs. Hence stem cell research and regenerative medicine have the potential to revolutionize the future of medicine with the ability to regenerate damaged and diseased organs. Stem cells serving as a repair system for the body, can theoretically divide without limit to replenish other cells. These cells could relieve the symptoms of liver disease or the genetic error could potentially be corrected by gene therapy. In cases of acute liver failure in adults, stem cell therapies might be used to support the liver, allowing it time to recover.
Improvement in nutrient uptake and yield of wheat by combined use of urea and compost
Muhammad Akhtar, Asif Naeem*, Javed Akhter, Syed Atif Bokhari and Wajid Ishaque
Soil & Environment , 2011,
Abstract: Organic city wastes are recycled to prepare composts with improved physical properties and enriched with nutrientsfor their better utilization. Combined application of composts along with inorganic fertilizers may sustain cropproductivity and soil fertility. Present study was conducted to assess the impact of 3 city waste composts (2 nonenrichedand 1 enriched with 25% N requirement of crop) on the economical utilization of urea in wheat. Generally,fertilizer application along with compost increased the yield, N and P uptake by wheat compared to the fertilizeralone. Performance of the treatments was found in the order: NEC (nitrogen enriched compost) + fertilizer > nonenrichedcompost + fertilizer > fertilizer. The NEC along with lower fertilizer-N rate (75 mg kg-1 soil) was found atpar with that of the highest fertilizer rate (175 mg N kg-1 soil) alone. The results showed that the use of NEC (200mg kg-1 soil) for wheat production could be a useful tool to improve the efficiency of commercial N-fertilizer.
Hepatocytes isolated from neoplastic liver-immunomagnetic purging as a new source for transplantation
Aravin Gunasegaram, Javed Akhter, Peng Yao, Loreena A Johnson, Stephen M Riodan, David L Morris
World Journal of Gastroenterology , 2008,
Abstract: AIM: To investigate whether hepatocytes isolated from macroscopically normal liver during hepatic resection for neoplasia could provide a novel source of healthy hepatocytes, including the development of reliable protocols for malignant cells removal from the hepatocyte preparation.METHODS: Hepatocytes were procured from resected liver of 18 patients with liver tumors using optimised digestion and cell-enrichment protocols. Suspensions of various known quantities of the HT-29 tumor cell line and patient hepatocytes were treated or not with Ep-CAM-antibody-coated immunomagnetic beads in order to investigate the efficacy of tumor-purging by immunomagnetic depletion, using a semi-quantitative RT-PCR method developed to detect tumor cells. Immunomagnetic bead-treated or bead-untreated tumor cell-hepatocyte suspensions were transplanted intra-peritoneally in Balb/C nude mice to assess the rates of tumor development.RESULTS: Mean viable hepatocyte yield was 9.3 x 106 cells per gram of digested liver with mean viability of 70.5%. Immunomagnetic depletion removed tumor cells to below the RT-PCR detection-threshold of 1 tumor cell in 106 hepatocytes, representing a maximum tumor purging efficacy of greater than 400 000-fold. Transplanted, immunomagnetic bead-purged tumor cell-hepatocyte suspensions did not form peritoneal tumors in Balb/C nude mice. Co-transplantation of hepatocytes with tumor cells did not increase tumorigenesis of the tumor cells.CONCLUSION: Immunomagnetic depletion appears to be an effective method of purging contaminating tumor cells to below threshold for likely tumorigenesis. Along with improved techniques for isolation of large numbers of viable hepatocytes, normal liver resected for neoplasia has potential as another clinically useful source of hepatocytes for transplantation.
Prevalence of antimicrobial resistance among gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia
Al Johani Sameera,Akhter Javed,Balkhy Hanan,El-Saed Ayman
Annals of Saudi Medicine , 2010,
Abstract: Background and Objectives: Patients in the ICU have encountered an increasing emergence and spread of antibiotic-resistant pathogens. We examined patterns of antimicrobial susceptibility in gram-negative isolates to commonly used drugs in an adult ICU at a tertiary care hospital in Riyadh, Saudi Arabia. Methods: A retrospective study was carried out of gram-negative isolates from the adult ICU of King Fahad National Guard Hospital (KFNGH) between 2004 and 2009. Organisms were identified and tested by an automated identification and susceptibility system, and the antibiotic susceptibility testing was confirmed by the disk diffusion method. Results: The most frequently isolated organism was Acinetobacter baumannii, followed by Pseudomonas aeruginosa, Escherichia coli, Klebsiella pnemoniae, Stenotrophomonas maltophilia, and Enterobacter. Antibiotic susceptibility patterns significantly declined in many organisms, especially A baumannii, E coli, S marcescens, and Enterobacter. A baumannii susceptibility was significantly decreased to imipenem (55% to 10%), meropenem (33% to 10%), ciprofloxacin (22% to 10%), and amikacin (12% to 6%). E coli susceptibility was markedly decreased (from 75% to 50% or less) to cefuroxime, ceftazidime, cefotaxime, and cefepime. S marcescens susceptibility was markedly decreased to cefotaxime (100% to 32%), ceftazidime (100% to 35%), and cefepime (100% to 66%). Enterobacter susceptibility was markedly decreased to ceftazidime (34% to 5%), cefotaxime (34% to 6%), and pipracillin-tazobactam (51% to 35%). Respiratory samples were the most frequently indicative of multidrug-resistant pathogens (63%), followed by urinary samples (57%). Conclusion: Antimicrobial resistance is an emerging problem in the KFNGH ICU, justifying new more stringent antibiotic prescription guidelines. Continuous monitoring of antimicrobial susceptibility and strict adherence to infection prevention guidelines are essential to eliminate major outbreaks in the future.
PROTEOMICS: AN EVOLVING TECHNOLOGY IN LABORATORY MEDICINE
Dr. Javed Akhter,Dr. Waleed Al Tamimi,Dr. Abubaker El Fatih,Dr. D J Venter
Internet Journal of Medical Update - EJOURNAL , 2010,
Abstract: The rapid developments in both genomics and proteomics will allow scientists to define the molecular pathways in normal and diseased cells. With these models, researchers will have the ability to predict previously unknown interactions and verify such predictions experimentally. Novel proteins, cellular functions, and pathways will also be unravelled. It is hoped that understanding the connections between cellular pathways and the ability to identify their associated biomarkers will greatly reduce the suffering and loss of life due to diseases.
Clinical Implications of Tumor Necrosis Factor-Alpha, Interleukin-6 and Resistin in Coronary Artery Disease  [PDF]
Qamar Javed
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.49052
Abstract:

Tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) are involved in the progression of coronary artery disease (CAD). The cytokines’ levels are associated with the severity of CAD. We have recently reported on the association of resistin, a relatively novel cytokine with the pathogenesis of cardiovascular disease (CVD). Although the inflammatory cytokines’ impact on atherosclerosis is widely accepted, yet some controversy exists regarding the involvement of these factors in atherogenesis. The current review highlights the potential association of TNF-alpha, IL-6 and resistin SNPs (single nucleotide polymorphisms) with CAD. Molecular genetics data along with the intracellular signaling cascade mechanisms may have important clinical implications in the treatment of CAD.

Land Characterization Analysis of Surface Temperature of Semi-Arid Mountainous City Abha, Saudi Arabia Using Remote Sensing and GIS  [PDF]
Javed Mallick
Journal of Geographic Information System (JGIS) , 2014, DOI: 10.4236/jgis.2014.66055
Abstract: This knowledge of land surface temperature and its spatial variations within a city environment is of prime importance to the study of urban climate and human-environment interactions. Few studies have examined the influence of land use and terrain on the surface temperature effects of semi-arid mountainous urban areas. This study investigates the urban environment characterization and its effects on surface temperature using remote sensing. The methodologies adapted for this study are geometric and radiometric corrections of satellite data, extraction of land use/land cover and digital elevation model, estimation of vegetation density using Normalized Difference Vegetation Index (NDVI), and estimation of surface temperature and emissivity using temperature emissivity separation (TES) algorithm. Finally geospatial model and statistical techniques are used for assessing the overall impact of urban environmental characterization on urban climate of semi-arid region of Abha, Kingdom of Saudi Arabia. Herein, results reveal that the spatial distribution of surface temperature was affected by land use/land cover (LULC) and topography. The high dense built-up and commercial/industrial areas display higher surface temperature in comparison with surrounding lands. There is gradual decrease of LULC classes’ surface temperature with the increase in altitude. The cooling effect towards the surrounding urban built-up area is found increasing at the hill located vegetated area, the downward slope and valley terrain inside the recreational park. Therefore the spatial variation in surface temperature also reflected the effects of topography on LULC classes. Suitable mountainous land use utilization would help to expand the cooling effect. In the future, the outcomes of this study could be used to build environmentally sustainable urban planning suitable to semi-arid regions and to create practices that consider the local weather environment in urban planning.
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