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Search Results: 1 - 10 of 5321 matches for " Jason Nikitczuk "
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Smart portable rehabilitation devices
Constantinos Mavroidis, Jason Nikitczuk, Brian Weinberg, Gil Danaher, Katherine Jensen, Philip Pelletier, Jennifer Prugnarola, Ryan Stuart, Roberto Arango, Matt Leahey, Robert Pavone, Andrew Provo, Dan Yasevac
Journal of NeuroEngineering and Rehabilitation , 2005, DOI: 10.1186/1743-0003-2-18
Abstract: In this paper we present several new advancements in the area of smart rehabilitation devices that have been developed by the Northeastern University Robotics and Mechatronics Laboratory. They are all compact, wearable and portable devices and boast re-programmable, real time computer controlled functions as the central theme behind their operation. The sensory information and computer control of the three described devices make for highly efficient and versatile systems that represent a whole new breed in wearable rehabilitation devices. Their applications range from active-assistive rehabilitation to resistance exercise and even have applications in gait training. The three devices described are: a transportable continuous passive motion elbow device, a wearable electro-rheological fluid based knee resistance device, and a wearable electrical stimulation and biofeedback knee device.Laboratory tests of the devices demonstrated that they were able to meet their design objectives. The prototypes of portable rehabilitation devices presented here did demonstrate that these concepts are capable of the performance their commercially available but non-portable counterparts exhibit.Smart, portable devices with the ability for real time monitoring and adjustment open a new era in rehabilitation where the recovery process could be dramatically improved.During the last several decades a great deal of work has been undertaken for developing devices to accelerate recovery from injuries, operations and other complications. Many successful devices and methods have come out of this work. This included a general division of the recovery process into several phases.In the early stages of therapy, passive rehabilitation is often a preferred method for reducing swelling, alleviating pain, and restoring range of motion. This consists of moving the limb with the muscles remaining passive and often involves devices such as Continuous Passive Motion (CPM) machines. The next stage of rehab
PLGA-Polymer Encapsulating Tumor Antigen and CpG DNA Administered into the Tumor Microenvironment Elicits a Systemic Antigen-Specific IFN-γ Response and Enhances Survival  [PDF]
Kevin P. Nikitczuk, Rene S. Schloss, Martin L. Yarmush, Edmund C. Lattime
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41035
Abstract:

Critical to the generation of an effective therapeutic antitumor immune response is the elicitation of effective antigen presentation coupled with overcoming tumor-immune escape mechanisms. Towards this end, we aimed to understand the therapeutic effectiveness of a polymer based vaccine approach at enhancing the anti-tumor responses in a tumor-bearing mouse model. While we and others have previously demonstrated the effectiveness of PLGA based systems in delivering antigen etc., studies scarcely focus on understanding the immunological mechanisms of polymer based therapies in tumor bearing treatment models. Considering tumors modulate the immune system and consequently the efficacy of therapies, understanding treatment mechanisms in the presence of tumor will help lead to more efficacious treatment options. We demonstrate here that a poly(lactic-co-glycolic acid) (PLGA) based delivery system encapsulating tumor antigen (OVA) and the TLR9 agonist CpG motif DNA administered into the tumor microenvironment initiates an effective type 1 mediated (IFN-γ producing) anti-tumor response in a syngeneic murine model of T cell lymphoma (E.G7-OVA). Although E.G7-OVA tumors spontaneously generate antigen specific CTLs in draining lymph nodes (LN), tumors progress rapidly. Modulation of the tumor microenvironment via local PLGA based therapy led to the generation of a systemic antigen specific Th1 response, absent in the non-polymer delivery method, subsequently associated with reduced tumor growth and prolongation of survival. These studies provide further insight into the use of a PLGA-based therapeutic approach at modulating the tumor microenvironment and highlight the need for analyzing the treatment effects in a tumor bearing model.

Discretionary Fiscal Policy and the European Monetary Union  [PDF]
Jason Jones
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.36095
Abstract: A model of circumstances that can lead to changes in the way a fiscal authority conducts policy after joining a monetary union is presented and empirically tested for the euro area. According to the model consolidation fatigue, shock asymmetry, or differences in the relative weight placed on output/price stabilization between the new and old monetary authority can lead to greater reliance on fiscal policy. Empirical evidence suggests that there has been a change in the conduct of fiscal policy in the euro area which is most likely due to consolidation fatigue and a stronger emphasis on price stabilization by the European Central Bank.
Genetic Relationships in Advanced Generation Hybrids Derived from Crosses between Texas (Poa arachnifera) and Kentucky (Poa pratensis) Bluegrass Using ISSR Markers  [PDF]
Jason Goldman
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.412303
Abstract:

Fertile, advanced generation hybrids derived from crosses between Texas (Poa arachnifera Torr.) and Kentucky (Poa pratensis L.) bluegrass have been selected. The hybrids are currently being evaluated for low-input turf potential. Since they are derived from hand-harvested seed from first-generation hybrids located in field nurseries their exact genetic origin is unknown. This experiment was conducted to determine if there are still genetic relationships among the advanced generation hybrids and some of the Texas and Kentucky parents in their pedigrees. Four Inter Simple Sequence Repeat (ISSR) primer combinations resolved on 6% nondenaturing polyacrylamide gels resulted in 179 polymorphic bands that were scored to create a genetic similarity matrix and dendrogram based on Jaccard’s coefficient. The clustering of the advanced generation hybrids was generally in agreement with what would be expected based on their pedigrees and indicated it was more likely to select a fertile hybrid from an advanced generation, rather than the F1 generation.

Sickrole Compliance and Sickrole Deviance among Tuberculosis Patients on Treatment in Kanyama, a Zambian Shanty Compound  [PDF]
Jason Mwanza
Advances in Applied Sociology (AASoci) , 2016, DOI: 10.4236/aasoci.2016.61001
Abstract: Background: Kanyama compound has had a DOTS community based programme since 2012 where TB supporters in the community have been fostering the DOTS programme. Prior to this study, research had not been done using Parsonian sickrole behaviour concept to determine the pattern of deviance especially the sickrole behavioural responses on the part of people who were on TB treatment. Methods: This was an exploratory study and the study sample was drawn from a large mixed methods study (quan + QUAL) comprising of 457 men and women ≥15 years. Enrolees were disproportionately sampled using systematic sampling from a population of 1126 men and women who were on multi drug therapy over a two-year period. Categorical and numeric data from the tool was cleaned and analyzed by using SPSS version 21 (Inc., Chicago, USA). Statistical analysis was done using Pearson’s Chi square test and ANOVA. A p value of <0.05 was considered to be significant. Results: 18.5% of the enrolees honoured medical appointments when due whereas 81.5% did not. There was a significant association p < 0.05 with case type and marital status. 39.6% of the enrolees honoured the medical regimen by taking the prescribed drugs, 33.3% failed to honour and 27.1% were not sure. There was a significant association p < 0.05 between case type and marital status. Conclusions: Strengthening DOTS programs at community level through volunteers to enhance patient adherence to TB treatment and giving personalised attention to men and women who may be at risk of developing secondary tuberculosis, or risk for drug resistance and even dying is recommended. There is evidence to laud the great effort being expended by volunteer community based tuberculosis supporters in ensuring that what DOTS stands for is met.
Large Scale Simulation for Education in Forensic DNA Science  [PDF]
Jason M. Kinser
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.21003
Abstract: Forensic science education is a rapidly expanding field with several universities adding degrees in many forensic science disciplines. Concurrently, with this expansion is a new push for forensic science education in the secondary schools. This generation of students is also very adept at computer generated environments. The logical progression is therefore to provide students and instructors with a simulated environment to immerse students into forensic science investigations. The Island of Tir Ebensëa is a developing system that generates a large scale population and forensic scenarios and places the students as the investigators. Students are provided with a scenario and then generate queries to gain information about the people involved in the case. They can then draw conclusions about the scenario and compare these conclusions to the known answer. The simulation is available to educational institutions.
Towards a Sociology of Trust: Community Care and Managing Diversity  [PDF]
Jason L. Powell
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.12003
Abstract: The paper is a critical review of the problems and implications of managing diversity in the British community care system. It is a system in need of strong diversity management in the light of the world economic downturn in recent years. Despite raft of policies on leadership in social care in the UK, the structural issues for why the needs of diverse groups are not met are difficult to understand at particular levels of analysis. The central problem has been lack of ‘trust’.
Evolution and the Prevention of Violent Crime  [PDF]
Jason Roach, Ken Pease
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24062
Abstract: This paper suggests how violence prevention can be better informed by embracing an evolutionary approach to understanding and preventing violent crime. Here, ethical crime control through an evolutionary lens is considered and speculation is offered as to what an evolution-evidenced crime reduction programme might look like. The paper begins with an outline of the current landscape of crime prevention scholarship within criminology and presents some possible points of contact with actual or possible violence reduction practice, including child homicide and violence against women. The paper concludes with suggestions for an ethical research agenda for reducing violence, whereby it is hoped that an audience of open-minded criminologists and diverse students of evolution may lend a hand in increasing the sophistication of the criminological study of violence prevention.
"Close Encounters of the Third Kind" Volunteering,Infrastructure and Governance  [PDF]
Jason L. Powell
Sociology Mind (SM) , 2011, DOI: 10.4236/sm.2011.14028
Abstract: This paper explores the relationship between voluntary sector and governance using England as a case study. One of the key issues in recent times is how voluntary organizations sustain themselves. Although the spate of studies have undoubtedly advanced the state of knowledge about voluntary organisations, we still know very little about the internal composition and operation of volunteer organisations and even less about the way in which internal factors interact within the external world. This research article assesses the factors such as governance and quality, leadership, workforce, performance, partnerships and finance and funding. These different critical success factors are part of the inter-locking infrastructure tools of voluntary organizations that keeps them sustained.
Appendiceal Colic in Children: Is It A True Surgical Entity?  [PDF]
Jason Marone, Domingo Alvear
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.38079
Abstract: Background/Purpose: For decades children have been crowding the offices of Pediatricians’ and Pediatric Surgeons with a common complaint of unexplained recurrent right lower quadrant pain. For years the topic of appendiceal colic as a cause for this recurrent abdominal pain has remain controversial. This paper highlights the experience of a single surgeon over a 5 years period using an algorithmic approach to diagnose and treat children with appendiceal colic. Methods: This is a retrospective review of 31 consecutive cases of patients experiencing recurrent unexplained right lower quadrant abdominal pain for greater than three weeks. All patients were evaluated by a single surgeon at the same institution. The patients meeting the criteria for appendiceal colic had an elective open appendectomy. The data included was compiled by a retrospective chart review from Jan 1, 2006 to December 31, 2010. Results: Twelve percent or 31 of the 238 elective appendectomies done between Jan. 2006 to Dec. 2010 where done for appendiceal colic. Sixteen were females and 15 where males ranging in age from 5-17 years of age. Average duration of symptoms was 3 weeks to 5 years. All patients had previous work up most of which where inconclusive for an organic cause. All patients presented with colic and McBurney’s point tenderness. On pathological examination the presence of a fecalith, inspissated stool or fibrosis were the most common findings. A normal appendix was observed in 14% of the cases. 100% of the patients were symptom free with three months of operation. Conclusion: Appendiceal colic proves to be true in a small subset of patients presenting with unexplained right lower quadrant abdominal pain. A high index of suspicion coupled with a thorough history and physical exam is needed to identify these patients. Classically they will present with recurrent right lower abdominal pain at McBurney’s. In our experience an elective appendectomy has been curative.
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