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Search Results: 1 - 10 of 1168 matches for " Jasmina Mimi -Oka "
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The Role of GSTM1 and GSTT1 Polymorphism in Patients with Renal Cell Carcinoma
Vesna ori , Marija Plje a-Ercegovac, , Marija Mati , , Biljana Krivi , Sonja uvakov, , Cane Tuli , , Jasmina Mimi -Oka, , Tatjana Simi
Journal of Medical Biochemistry , 2010, DOI: 10.2478/v10011-010-0025-8
Abstract: Members of the glutathione S-transferase (GST) superfamily exhibit polymorphic expression. GSTs are investigated as biomarkers of risk for various cancers, including renal cell carcinoma (RCC). The aim of this study was to test the association between GSTM1 and GSTT1 polymorphism and susceptibility to RCC, independently or in conjunction with known risk factors. Genomic DNA was isolated from 182 controls and 76 patients with RCC. GSTM1 and GSTT1 genotypes were determined by multiplex PCR. Data obtained were analyzed with respect to RCC risk factors including smoking and occupational exposure. The frequency of GSTM1-null genotype was higher in patients with RCC (60.5%) compared to controls (47.2%). GSTT1-null genotype was found in 28.6% controls and 27.6% of cases. GSTM1-null individuals exhibit 1.9-fold increased risk of RCC (95% CI: 1.06-3.33). The presence of GSTT1 active genotype was associated with increased risk of RCC in occupationally exposed subjects when unexposed GSTT1-null subjects were used as a comparison group (OR: 2.48; 95% CI: 1.05-5.86). No association was found between the inactive form of GSTM1 and GSTT1 and smoking in RCC patients. In a Serbian cohort of patients, the presence of a GSTM1 active genotype is protective against RCC, whereas a GSTT1 active genotype increases RCC risk in occupationally exposed subjects.
Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity
Marija Plje a-Ercegovac, Jasmina Mimi -Oka, Dejan Dragi evi , Ana Savi -Radojevi , Marija Mati , Tatjana uki , Tatjana Simi
Journal of Medical Biochemistry , 2009, DOI: 10.2478/v10011-009-0009-8
Abstract: The objective was to get insight into the role of executive apoptotic enzyme caspase 3 (CPP32) and regulatory antiapoptotic protein Bcl-2 in the malignant phenotype of TCC. Samples were obtained from 84 TCC patients, who underwent transurethral resection, partial or radical cystectomy. Staging showed a superficial growth pattern in 41 patient, while other 43 showed invasive characteristics. Expression of CPP32 and Bcl-2 was determined by immunocytochemistry. Levels of expression were correlated with tumor stage and grade. Expression of CPP32 was positive in 80% of TCC patients. Low-, medium- and high positive status were observed in 18%, 24% and 38% of patients, respectively. There was a signifficant difference in the CPP32 expression between groups with superficial and invasive TCC tumors (p = 0.032), with frequency of CPP32 negative samples being higher and CPP32 high-positive samples being lower in patients with muscle-invasive tumors. Significant association was also found between CPP32 expression and tumor stage (p = 0.043). The positive rate of Bcl-2 protein expression was 48%. There was a statisticaly signifficant difference in the rate of Bcl-2 positivity between superficial and invasive TCC (p = 0.005), with frequency of Bcl-2 positive patients being higher in muscle-invasive TCC. Significant association was also found between Bcl-2 expression and both tumor grade (p=0.032) and stage (p=0.007). Muscle invasive TCC of the urinary bladder is associated with down-regulated expression of CPP32 and Bcl-2 positivity. Down-regulation of CPP32 and up-regulated Bcl-2 might, at least partially, play a role in the development of invasive characteristics of TCC.
The Role of Glutathione S-Transferases in Urinary Tract Tumors
Tatjana Simi , Ana Savi -Radojevi , Marija Plje a-Ercegovac, Marija Mati , Tatjana Sa i , Dejan Dragi evi , Jasmina Mimi -Oka
Journal of Medical Biochemistry , 2008, DOI: 10.2478/v10011-008-0016-1
Abstract: Exposure to potential carcinogens is among the etiological factors for renal cell carcinoma (RCC) and transitional cell carcinoma (TCC) of the urinary bladder. RCC is very resistant, while TCC exhibits a high recurrence rate and multifocality. Cytosolic glutathione S-transferases (GST) are a superfamily of enzymes which protect normal cells by catalyzing conjugation reactions between electrophylic compounds, including carcinogens, and glutathione. Some GST enzymes posses hydroperoxidase activity. The most well characterized classes have been named Alpha (GSTA), Mu (GSTM), Pi (GSTP) and Theta (GSTT) and each of these classes contains several different isoenzymes. Several types of allelic variation have been identified within classes, among which GSTM1-null and GSTT1-null confer impaired catalytic activity. Individuals with the GSTM1-null genotype carry a substantially higher risk for bladder carcinogenesis. The effects of glutathione S-transferase T1 polymorphism on the increased susceptibility to RCC and TCC of urinary bladder depend on the presence of specific chemical exposures to compounds metabolized via the GSTT1-1 pathway. In the process of kidney cancerisation expression of GST alpha isoenzymes tends to decrease, consequently favoring a prooxidant environment necessary for the growth of RCC. GST pi enzyme activities are generally retained in RCC and might contribute to the chemotherapy resistance of RCC. In the malignant phenotype of TCC of the urinary bladder up regulation of various GST classes occurs. Up regulation of GSTT1-1 and GSTP1-1 might have important consequences on the tumor growth, by providing a reduced environment and inhibition of apoptotic pathways.
Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder
Pljesa-Ercegovac, Marija;Savic-Radojevic, Ana;Kravic-Stevovic, Tamara;Bumbasirevic, Vladimir;Mimic-Oka, Jasmina;Simic, Tatiana;
Genetics and Molecular Biology , 2010, DOI: 10.1590/S1415-47572010005000063
Abstract: transitional cell carcinoma (tcc) of urinary bladder belongs to glutathione s-transferase p1 (gstp1) overexpressing tumors. upregulated gstp1 in tcc is related to apoptosis inhibition. this antiapoptotic effects of gstp1 might be mediated through protein:protein interaction with c-jun nh2-terminal kinase (jnk). herein, we analyzed whether a direct link between gstp1 and jnk exists in tcc. the presence of gstp1/jnk complexes was analyzed by immunoprecipitation and western blotting in 20 tcc specimens, obtained after surgery. co-localization of gstp1 and jnk was also investigated in the 5637 tcc cell line by immunofluorescence confocal microscopy. by means of immunoprecipitation we show for the first time the presence of gstp1/jnk complexes in all tcc samples studied. a co-localization of gstp1 and jnk was also demonstrated in the 5637 tcc cell line by means of confocal microscopy. protein-protein interactions, together with co-localization between gstp1 and jnk provide evidence that gstp1 most probably inhibits apoptosis in tcc cells by non-covalent binding to jnk.
Poxviruses: smallpox vaccine, its complications and chemotherapy
Mimi Remichkova
Virus Adaptation and Treatment , 2010, DOI: http://dx.doi.org/10.2147/VAAT.S8563
Abstract: xviruses: smallpox vaccine, its complications and chemotherapy Review (5236) Total Article Views Authors: Mimi Remichkova Published Date April 2010 Volume 2010:2 Pages 41 - 46 DOI: http://dx.doi.org/10.2147/VAAT.S8563 Mimi Remichkova Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria Abstract: The threat of bioterrorism in the recent years has once again posed to mankind the unresolved problems of contagious diseases, well forgotten in the past. Smallpox (variola) is among the most dangerous and highly contagious viral infections affecting humans. The last natural case in Somalia marked the end of a successful World Health Organization campaign for smallpox eradication by vaccination on worldwide scale. Smallpox virus still exists today in some laboratories, specially designated for that purpose. The contemporary response in the treatment of the post-vaccine complications, which would occur upon enforcing new programs for mass-scale smallpox immunization, includes application of effective chemotherapeutics and their combinations. The goals are to provide the highest possible level of protection and safety of the population in case of eventual terrorist attack. This review describes the characteristic features of the poxviruses, smallpox vaccination, its adverse reactions, and poxvirus chemotherapy.
HEALTH CARE IN THE FIFTIES: PART 2. REMINISCENSES FROM OUR VETERAN COLLEAGUES
Mimi Omar
Malaysian Family Physician , 2007,
Abstract:
Poxviruses: smallpox vaccine, its complications and chemotherapy
Mimi Remichkova
Virus Adaptation and Treatment , 2010,
Abstract: Mimi RemichkovaDepartment of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, BulgariaAbstract: The threat of bioterrorism in the recent years has once again posed to mankind the unresolved problems of contagious diseases, well forgotten in the past. Smallpox (variola) is among the most dangerous and highly contagious viral infections affecting humans. The last natural case in Somalia marked the end of a successful World Health Organization campaign for smallpox eradication by vaccination on worldwide scale. Smallpox virus still exists today in some laboratories, specially designated for that purpose. The contemporary response in the treatment of the post-vaccine complications, which would occur upon enforcing new programs for mass-scale smallpox immunization, includes application of effective chemotherapeutics and their combinations. The goals are to provide the highest possible level of protection and safety of the population in case of eventual terrorist attack. This review describes the characteristic features of the poxviruses, smallpox vaccination, its adverse reactions, and poxvirus chemotherapy.Keywords: poxvirus, smallpox vaccine, post vaccine complications, inhibitors
Toward a Carribean cultural political economy
Mimi Sheller
New West Indian Guide , 2008,
Abstract: [First paragraph] The Caribbean Postcolonial: Social Equality, Post-Nationalism and Cultural Hybridity. Shalini Puri. New York: Palgrave Macmillan, 2004. ix + 300 pp. (Paper US$ 24.95) Miraculous Weapons: Revolutionary Ideology in Caribbean Culture. Joy A.I. Mahabir. New York: Peter Lang, 2003. ix + 167 pp. (Cloth US$ 58.95) The relation between cultural production and political struggle, and between the aesthetic and the material as expressions of social relations, are absolutely central themes within Caribbean studies in all of its disciplinary and interdisciplinary guises. A key question for the field as a whole is what role it might play in generating new approaches to “cultural political economy,” which is emerging as an effective bridging concept at the intersections of anthropology, sociology, economics, political theory, and literary and cultural studies.
The Army of Sufferers : peasant democracy in the early Republic of Haiti
Mimi Sheller
New West Indian Guide , 2000,
Abstract: Focuses on Haitian debates concerning popular political participation in the context of the Liberal Revolution of 1843 and the Piquet Rebellion of 1844. The liberal challenge to the regime of President Boyer gave room to a peasant movement, the 'Army of Sufferers' or the Piquets, calling for black civil and political rights. Author traces 3 phases of the revolutionary situation of 1843-44 to show how political actors within Haiti debated various institutional and constitutional arrangements.
Interrogating interiors. Denise Amy Baxter and Meredith Martin (eds), Architectural space in eighteenth-century Europe: Constructing identities and interiors, Ashgate, 2010
Mimi Hellman
Journal of Art Historiography , 2012,
Abstract: This essay reviews Architectural Space in Eighteenth-Century Europe: Constructing Identities and Interiors, edited by Denise Amy Baxter and Meredith Martin. Detailed accounts of the essays in the collection provide the basis for a broader exploration of some of the interpretative opportunities and challenges posed by the study of interiors. The review raises questions about the role of intentionality in decorative self-fashioning, the nature of sensory experience in historical interiors, and the scholarly conventions that may limit efforts to re-imagine the past.
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