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Search Results: 1 - 10 of 1372 matches for " Jasmin Schmid "
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The Wide and Complex Field of NAFLD Biomarker Research: Trends
Erika Wichro,Tanja Macheiner,Jasmin Schmid,Barbara Kavsek,Karine Sargsyan
ISRN Hepatology , 2014, DOI: 10.1155/2014/846923
Abstract: Background. Nonalcoholic fatty liver disease is now acknowledged as a complex public health issue linked to sedentary lifestyle, obesity, and related disorders like type 2 diabetes and metabolic syndrome. Aims. We aimed to retrieve its trends out of the huge amount of published data. Therefore, we conducted an extensive literature search to identify possible biomarker and/or biomarker combinations by retrospectively assessing and evaluating common and novel biomarkers to predict progression and prognosis of obesity related liver diseases. Methodology. We analyzed finally 62 articles accounting for 157 cohorts and 45,288 subjects. Results. Despite the various approaches, most cohorts were considerably small and rarely comparable. Also, we found that the same standard parameters were measured rather than novel biomarkers. Diagnostics approaches appeared incomparable. Conclusions. Further collaborative investigations on harmonizing ways of data acquisition and identifying such biomarkers for clinical use are necessary to yield sufficient significant results of potential biomarkers. 1. Introduction Nonalcoholic fatty liver disease (NAFLD) is acknowledged as a (public) health issue with an estimated prevalence of 30% in adults [1], of which approximately 25% progresses to nonalcoholic steatohepatitis (NASH) [2]. Sedentary lifestyle and high-fat and high-caloric dietary intake are strongly associated with NAFLD and nonalcoholic steatohepatitis (NASH). NAFLD and NASH occur not only in adults but also increasingly in childhood [3–5], accounting for a tremendous economic health burden [6]. The pathways of NAFLD/NASH and their alcohol-induced counterpart diseases are multifactorial, involving the liver metabolism key players: cytokines, adipokines, and apoptosis [7]. Alternative tools such as ultrasound or magnetic resonance imaging (MRI) [8] are becoming common in clinical routine; anyway in NAFLD/NASH diagnostics liver biopsy still remains the golden standard [9, 10]. In the context of personalized medicine, the research on biomarker to identify NAFLD and its development and progression is high priority for clinical routine. Our systematic data analysis of NAFLD research conducted in the last year, based on evaluation of extensive literature search, provided an overview of the most commonly published potential biomarkers for NAFLD. 2. Methodology We performed an extensive literature assessment to evaluate known and novel biomarkers for progression and prognosis of NASH/NAFLD. In this context, we extracted and evaluated cohorts and parameters and consolidated
Circulating CD36 Is Reduced in HNF1A-MODY Carriers
Siobhan Bacon, Ma P. Kyithar, Jasmin Schmid, Andre Costa Pozza, Aase Handberg, Maria M. Byrne
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074577
Abstract: Introduction Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor; hepatocyte nuclear factor 1 alpha (HNF1A) accounting for the majority of MODY cases. There is somewhat limited data available on the prevalence of macrovascular disease in HNF1A-MODY carriers with diabetes. Marked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers. The scavenger protein CD36 has been shown to play a substantial role in the pathogenesis of atherosclerosis, largely through its interaction with oxidised LDL. Higher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes. The aim of this study was to determine levels of sCD36 in participants with HNF1A-MODY diabetes and to compare them with unaffected normoglycaemic family members and participants with type 2 diabetes mellitus. Methods We recruited 37 participants with HNF1A-MODY diabetes and compared levels of sCD36 with BMI-matched participants with type 2 diabetes mellitus and normoglycaemic HNF1A-MODY negative family controls. Levels of sCD36 were correlated with phenotypic and biochemical parameters. Results HNF1A-MODY participants were lean, normotensive, with higher HDL and lower triglyceride levels when compared to controls and participants with type 2 diabetes mellitus. sCD36 was also significantly lower in HNF1A-MODY participants when compared to both the normoglycaemic family controls and to lean participants with type 2 diabetes mellitus. Conclusion In conclusion, sCD36 is significantly lower in lean participants with HNF1A-MODY diabetes when compared to weight-matched normoglycaemic familial HNF1A-MODY negative controls and to lean participants with type 2 diabetes mellitus. Lower levels of this pro-atherogenic marker may result from the higher HDL component in the lipid profile of HNF1A-MODY participants.
Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward
Siobhan Bacon, Ma Peyh Kyithar, Jasmin Schmid, Syed R Rizvi, Caroline Bonner, Rolf Graf, Jochen HM Prehn, Maria M Byrne
BMC Endocrine Disorders , 2012, DOI: 10.1186/1472-6823-12-13
Abstract: We analysed serum PSP/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY), and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed.PSP/reg1A serum levels were significantly elevated in HNF1A-MODY (n?=?37) subjects compared to controls (n?=?60) (median?=?12.50?ng/ml, IQR?=?10.61-17.87?ng/ml versus median?=?10.72?ng/ml, IQR?=?8.94-12.54?ng/ml, p?=?0.0008). PSP/reg1A correlated negatively with insulin levels during OGTT, (rho?=??0.40, p?=?0.02). Interestingly we noted a significant positive correlation of PSP/reg1A with age of the HNF1A-MODY carriers (rho?=?0.40 p?=?0.02) with an age of 25?years separating carriers with low and high PSP/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP/reg1A compared to controls, however this was independent of the duration of diabetes.Our data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25?years and over. PSP/reg1A may be developed as a serum marker to detect increased beta-cell apoptosis, or its therapeutic response.
High Precision Bidirectional Heat Pulsed Flow Sensor  [PDF]
Jasmin Radadia, Maher E. Rizkalla
Journal of Software Engineering and Applications (JSEA) , 2014, DOI: 10.4236/jsea.2014.73015
Abstract:

In this work we have designed and simulated a thermal bi-directional integrated circuit mass flow sensor. The approach used here was an extension to the gas flow model given by Mayer and Lechner [1]. The design features high precision response received from analog integrated circuits. An established mathematical model for the heat flow equation including CFD parameters were used within COMSOL simulation (COMSOL Multiphysics, Sweden). Heat pulses of 55°C for a period of nearly 120 seconds and 50% duty cycles were applied as thermal sources to the flowstream. The boundary conditions of the heat equations at the solid (heating element) fluid interface were set up in the software for the thermal response. The hardware design included one heating element and two sensing elements were used to detect the bi-directional mass flow. Platinum sensors were used due to their linear characteristics within 0°C to 100°C range, and their high temperature coefficient (0.00385 Ω/°C). Polyimide thin film heater was used as the element due to its high throughput and good thermal efficiency. Two bridge circuits were used to sense the temperature distribution in the vicinity of the sensing elements.

The Relation of Sleep, Distress, and Coping Strategies—What Male and Female Students Can Learn from Each Other?  [PDF]
Jasmin Faber, Angelika A. Schlarb
Health (Health) , 2016, DOI: 10.4236/health.2016.813136
Abstract: Sleep quality, distress, and coping strategies differ between male and female students. However, effects of gender on their relation have not been evaluated. Therefore, the primary aim of this study was to confirm gender differences on sleep quality, chronic distress, and various coping strategies, as well as to examine gender differences in their relation to each other. A cross-sectional online study including several sleep-related self-report measures was completed by 6379 German students. After excluding all cases with missing data on the variables gender, psychiatric disorder, and medication, the final sample consisted of 5889 students with a mean age of 23.10 years (SD = 2.67) for men and 22.64 years (SD = 2.56) for women. Data from the Pittsburgh Sleep Quality Index, the Trier Inventory for Chronic Stress, and the Proactive Coping Inventory were analyzed. Results showed that women reported to have a poorer sleep quality, a higher level of chronic distress, and use social support more often than men. The hypothesized model revealed gender differences on the model level. However, these differences only occurred between avoidance coping and distress, as well as between various coping strategies. The biological gender influenced each of those three variables, but barely their relation to each other. Participants’ gender role might explain gender differences in coping strategies and their impact on distress. Furthermore, the type of stressor and subjective or objective measured sleep parameters might show more gender differences on this relation. Conclusively, gender-specific trainings or interventions are not necessary, however, gender differences should be considered during the implementation process.
Communication by unvoiced speech: the role of whispering
Cirillo, Jasmin;
Anais da Academia Brasileira de Ciências , 2004, DOI: 10.1590/S0001-37652004000200034
Abstract: most studies on whispering deal with its production and perception, neglecting its communicative role. i have focused on this, especially some social and psychobiological objectives. i have combined a general inquiry into the use of unvoiced speech with stimulus-response experiments on particular signal properties. (1) analyses of answers to queries revealed that judgments about whispering depend on the social contexts. in the private domain it plays a clearly positive role, but in the public domain it is more problematical. two causative factors were identified as relevant: (a) an 'ingroup' function of whispering which could induce negative 'outgroup' effects in co-listeners, and (b) a psychobiological component of whispering which could affect the auditory vigilance of co-listeners who were not addressed personally by the signaling, but often wanted to understand a whispered message. (2) analyses of experimental data confirmed the relevance of these factors. additionally, they showed that unvoiced speech has a limited transmission range, and is easily masked by background noise. taken together, the results suggest that whispering is explained best as a close-distance signal adapted for private use among partners.
Organisationskulturen neu betrachtet: Ein interpretativ-ethnologischer Blick auf Unternehmensnarrative Redefining Organizational Cultures: An Interpretative Anthropological Approach to Corporate Narratives Hacia una redefinición de culturas de la organización: Un planteamiento interpretativo antropológico en cuanto a las narrativas empresariales
Jasmin Mahadevan
Forum : Qualitative Social Research , 2008,
Abstract: So gut wie jede moderne Managementtheorie tr gt dem Faktor Kultur Rechnung. Basis dieses Vorgehens ist die Annahme, dass die interkulturelle Grenze von au en – mittels der etischen Perspektive – definiert werden kann. Im meinem Artikel zeige ich auf, wie sehr sich die organisatorische Realit t aus der Innensicht – also der emischen Perspektive auf Kultur – von den von au en angenommenen kulturellen Grenzen unterscheiden kann. Hierbei beziehe ich mich auf eine zweij hrige Feldforschung, die ich in einem global agierenden High-Tech-Unternehmen in Deutschland, sterreich und Indien durchgeführt habe. Den ethnografischen Ansatz habe ich gew hlt, um Kultur als einem offenen Prozess des Sinnmachens in der Praxis nachzuspüren. Durch die gew hlten interpretativen ethnologischen Ans tze konnte ich mehrere Diskurse kollektiver Identit t im Feld identifizieren, die narrativ konstruiert wurden und oftmals die nationalkulturelle Dimension "Deutsche" vs. "Inder" nicht berührten. Zusammenfassend leistet dieser Artikel die folgenden Beitr ge: Erstens zeigt er auf, wie und in welchem Ausma sich emische und etische Kategorisierungen des kulturell Fremden in einem komplexen Umfeld unterscheiden k nnen. Zweitens werden die emischen Kategorisierungen des "Anderen" und deren narrative Konstruktion in deren Tiefe beleuchtet. Drittens werden hieraus Ableitungen für das Feld der interkulturellen Kommunikation getroffen. URN: urn:nbn:de:0114-fqs0901440 Hardly any management theory nowadays fails to take culture's influence on today's organizations into account. At the very foundation lies the belief that the intercultural boundary can be determined externally—by etic view. In my paper I show how much emic organizational reality differs from etic view. Hereby, I refer to two years of fieldwork that I conducted in a global high-tech company at sites in Germany, Austria and India. I choose this approach to trace culture as an open process of sense-making in practice. Through interpretative anthropological means, I identified several discourses of collective identity that were constructed narratively—often regardless of the presumed etic border of "Germans" vs. "Indians." In summary, this paper makes the following contributions: Firstly, it shows how emic and etic categorizations of the cultural other can differ in a complex environment. Secondly, it looks in depth into the emic categorizations of "the Other" and how they are constructed narratively. Thirdly, it draws conclusions for the field of intercultural communication. URN: urn:nbn:de:0114-fqs0901440 Prácticamente todas las te
Conference Report: Methodologies of Systems—How to Get to the Case and How to Get Behind It. Organized by Arbeitskreis Funktionale Analyse [Research Group Functional Analysis] Nota sobre la conferencia: Metodologías de sistemas: Cómo conseguir el caso y cómo conseguir lo que hay detrás de él. Organizado por el Grupo de de Investigación en Análisis Funcional Tagungsbericht: "Methodologien des Systems – Wie kommt man zum Fall und wie dahinter?"
Jasmin Siri
Forum : Qualitative Social Research , 2009,
Abstract: The international conference on "Methodologies of the System" provided an inventory of empirical research informed by systems theory. In eight parallel workshops on topics such as "Organization," "Interaction," and "Semantics," more than twenty different empirical research projects were discussed. The workshops were framed by eight keynote lectures on "Methodology and Systems Theory," "Theory as Methodology," "Method and Methodology," as well as "Methodological Imports." In this conference report I will summarize the main topics of the conference and connect them with current approaches to empirical research with systems theory. The following questions will be answered: Which position do studies inspired by systems theory take within the sociological discussions about methods? Which analytical advancements are possible and necessary? Does a "unity" of systems theoretical research exist? Did the conference produce an appearance of unity, which does not represent the plurality of different approaches? Systems theoretical approaches seek access to empirical fields in very different ways. In the process, those approaches seem particularly productive which focus on the empirical interest and not on the faithfulness to their own theory. Given that different approaches presented at this conference produced sound arguments about how to deal with empirical data, it would be counterproductive to implement a rigid canon of method systems theoretical research. The commensurability of a specific method or methodology needs to be extracted from the empirical case and its needs. The conference showed that systems theoretical research and empirical concerns mate. However, it showed as well the misunderstandings that this approach possibly feeds by its terminology and self-descriptions. URN: urn:nbn:de:0114-fqs0902223 La conferencia internacional sobre "Metodologías del sistema" brindó un inventario de investigación empírica formado intelectualmente por la teoría de sistemas. En ocho grupos paralelos de trabajo sobre tópicos tales como "Organización", "Interacción" y "Semántica", se discutieron más de veinte diferentes proyectos de investigaciones empíricas. Los grupos de trabajo fueron armados en función de ocho conferencias magistrales sobre "Metodología y teoría de sistemas", "Teoría como metodología", "Método y metodología", así como "Importaciones metodológicas". En este reporte de conferencia se hace un resumen de los principales tópicos de la conferencia y se conectan a los enfoques actuales sobre investigación empírica y teoría de sistemas Las siguientes pregunta
Review: Sebastian Ziegaus (2009). Die Abh ngigkeit der Sozialwissenschaften von ihren Medien. Grundlagen einer kommunikativen Sozialforschung Review: Sebastian Ziegaus (2009). Die Abh ngigkeit der Sozialwissenschaften von ihren Medien. Grundlagen einer kommunikativen Sozialforschung [The Social Sciences' Dependency on their Media. Foundations of Communicative Social Research] Rese a: Sebastian Ziegaus (2009). Die Abh ngigkeit der Sozialwissenschaften von ihren Medien [[La dependencia de las ciencias sociale
Jasmin Siri
Forum : Qualitative Social Research , 2010,
Abstract: Sebastian ZIEGAUS interessiert sich in seiner Dissertation für die kommunikative Herstellung der wissenschaftlichen Praxis im Zusammenspiel von Forschenden und technischen Medien. Durch neue Vernetzungstechnologien wie Datenbanken und das Internet entstehen neue Interaktionen in Forschungssystemen, was, so ZIEGAUS, methodisch jedoch meist nicht ausreichend reflektiert werde. Anhand eines kommunikationstheoretischen Modells untersucht er die Selbstbeschreibung sozialwissenschaftlicher Theorien und Methoden. Darüber hinaus will er nicht weniger leisten als eine Neubestimmung der Selbstbeschreibung der Sozialwissenschaften als "kommunikative Sozialforschung". Er schreibt dabei nicht aus der Position eines Sozialwissenschaftlers, sondern als historisch und theoretisch interessierter Medien- und Kommunikationswissenschaftler. Daraus resultieren aus einer soziologischen Perspektive gleichsam St rken und Schw chen des hier besprochenen Bandes. So bietet ZIEGAUS im empirischen Teil eine kreative Untersuchung des erkenntnistheoretischen Zugangs sozialwissenschaftlicher Schulenbildung an und deutet diese als Form des Komplexit ts-managements. Die normative Forderung nach der Durchsetzung einer kommunikativen Sozialforschung und deren emphatische Einforderung sind hingegen weniger überzeugend und schlie en nicht an die empirischen Ergebnisse der durchgeführten Untersuchung an. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1101134 In this study Sebastian ZIEGAUS analyzes the communicative construction of scientific practice. With developments in new media and the internet, new means of interaction in research systems evolve. ZIEGAUS's interest lies in the interaction between researcher and research object. He points to a lack of methodological reflection regarding interactional and medial effects in the social sciences. He thus argues that the self-description of social sciences must change through the implementation of the ideal of "communicative social research." ZIEGAUS does not adopt the perspective of a social researcher, but that of a theoretically interested communication scientist—giving rise to both the merits and shortcomings of the book. The empirical part of the study includes a creative exploration of the epistemological foundations of various social theories and their handling of complexity. However, his call for the social sciences to unite under the flag of "communicative social research" is somewhat unconvincing, and fails to tie in satisfactorily with the empirical findings. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1101134 Sebastian ZIEGAU
Communication by unvoiced speech: the role of whispering
Cirillo Jasmin
Anais da Academia Brasileira de Ciências , 2004,
Abstract: Most studies on whispering deal with its production and perception, neglecting its communicative role. I have focused on this, especially some social and psychobiological objectives. I have combined a general inquiry into the use of unvoiced speech with stimulus-response experiments on particular signal properties. (1) Analyses of answers to queries revealed that judgments about whispering depend on the social contexts. In the private domain it plays a clearly positive role, but in the public domain it is more problematical. Two causative factors were identified as relevant: (a) an 'ingroup' function of whispering which could induce negative 'outgroup' effects in co-listeners, and (b) a psychobiological component of whispering which could affect the auditory vigilance of co-listeners who were not addressed personally by the signaling, but often wanted to understand a whispered message. (2) Analyses of experimental data confirmed the relevance of these factors. Additionally, they showed that unvoiced speech has a limited transmission range, and is easily masked by background noise. Taken together, the results suggest that whispering is explained best as a close-distance signal adapted for private use among partners.
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