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Search Results: 1 - 10 of 26 matches for " Janhavi Sirsat "
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Case Report on Epilepsy with Cough Aura  [PDF]
Mohamed Hamdy Ibrahim, Ahmed El Mansory, Shivram Kumar, Janhavi Sirsat
Neuroscience & Medicine (NM) , 2015, DOI: 10.4236/nm.2015.61001
Abstract:
The case study is aimed at providing a more thorough analysis of a case of Epilepsy presented with an unusual aura of cough. The study hopes to generate an interest for further studies into the topic and focuses on abnormal unusual presentations of auras. Cough as an aura is not a common presentation. Any stereotyped repeated clinical phenomenon should consider being epileptic in its origin.
Resistant Tremors and Unexplained Weight Loss Could Also Be a Sign of HIV  [PDF]
Mohammed Hamdy Ibrahim, Shivram Kumar, Janhavi Sirsat, Mohamed Khalid, Kiran Kumar
Neuroscience & Medicine (NM) , 2015, DOI: 10.4236/nm.2015.63014
Abstract: This case study is done to show a different type of presentation of a HIV (Human Immunodeficiency Virus) patient. Neurological symptoms in HIV are normally due to Progressive Multifocal Leukoencephalopathy (PML) which is a reactivated infection caused by John Cunningham virus (JC virus). The disease causes fatal demyelination of the central nervous system (CNS). This case presented a 51-year-old Nigerian man who complained of resistant tremors and unexplained weight loss. The patient was suspected to have HIV when a MRI scan revealed T2/FLAIR hyper intensity of white matter which was a sign of PML. HIV ELISA was done and came back with a positive result. PML presenting in the form of tremors is very rare and more research is required to focus on the neurological presentation of HIV.
Case Report on Hiccup and Lateral Medullary Syndrome  [PDF]
Mohamed Hamdy Ibrahim, Alyaa Fadhil, Sameh Saied Ali, Salma Fathy Abdel Kader, Mohamed Khalid, Kiran Kumar, Shivram Kumar, Janhavi Sirsat
Neuroscience & Medicine (NM) , 2015, DOI: 10.4236/nm.2015.62010
Abstract:
The case study is aimed at providing a more thorough analysis of a case of lateral medullary syn-drome presented only with persistent hiccup after eating lunch the study hopes to generate an interest for further studies into the topic and focuses on abnormal unusual presentations of lateral medullary syndrome. Ethical committee has approved this case after taking consent from the patient and explaining to him the importance of the case in clinical practice.
Could Dystonia Be Initial Presentation of Corpus Callosum Infarction in Young Age Patients? A Case Report Study  [PDF]
Mohamed Hamdy Ibrahim, Alyaa Fadhil, Sameh Saied Ali, Salma Fathy Abdel Kader, Mohamed Khalid, Kiran Kumar, Shivram Kumar, Janhavi Sirsat
Neuroscience & Medicine (NM) , 2015, DOI: 10.4236/nm.2015.62011
Abstract:
Focal dystonia in young aged patients is considered to be the uncommon clinical presentation, unless a secondary cause is to be considered. Infarcts of the corpus callosum are rare and have not been well documented previously. As for a variety of signs and symptoms due to corpus callosum lesion, focal dystonia can be easily overlooked. The case is approved by ethical committee and explained to the patient with patient approval.
Extraction of Core Contents from Web Pages
Sandeep Sirsat
Computer Science , 2014, DOI: 10.14445/22315381/IJETT-V8P285
Abstract: The information available on web pages mostly contains semi-structured text documents which are represented either in XML, or HTML, or XHTML format that lacks formatted document structure. The document does not discriminate between the text and the schema that represent the text. Also the amount of structure used to represent the text depends on the purpose and size of text document. No semantic is applied to semi-structured documents. This requires extracting core contents of text document to analyse words or sentences to generate useful knowledge. This paper discusses several techniques and approaches useful for extracting core content from semi-structured text documents and their merits and demerits
Study of Selectivity and Permeation In Voltage-Gated Ion Channels
Janhavi Giri
Physics , 2012,
Abstract: Ion channels are membrane proteins responsible for an enormous range of biological functions. Ion selectivity and permeation are based on simple laws of physics and chemistry. Ion channels are therefore ideal candidates for physical investigation. A reduced model generates the selectivity of voltage-gated L-type calcium channel under a wide range of ionic conditions using only two parameters with unchanging values. The reasons behind the success of this reduced model are investigated. Monte Carlo simulations are performed investigating the role of flexibility of the side chains in the selectivity of calcium channels under a wide range of ionic conditions. Results suggest that the exact location and mobility of oxygen ions have little effect on the selectivity behavior of calcium channels. The first order determinant of selectivity in calcium channels is the density of charge in the selectivity filter. Flexibility seems a second order determinant. Single channel planar lipid bilayer experiments are performed to determine the selectivity, permeation, and sialic acid specificity of a bacterial outer-membrane channel NanC of Ecoli. NanC exhibits a large unit conductance varying with the applied voltage polarity, anion selectivity, and voltage gating. Unitary conductance of NanC decreases significantly in presence of the buffer HEPES. Alternate buffers are tested. Results suggest that the sialic acid specificity of NanC should be performed in low concentration salt solutions without pH buffers adjusted to neutral pH 7.0. Neu5Ac changes the gating and considerably increases the ionic conductance of NanC. The effect of Neu5Ac on the unitary current through NanC saturates at higher Neu5Ac concentrations. Interestingly, Neu5Ac reduces the ionic conductance of OmpF: frequent, long closures are seen. Thus, in E.coli sialic acid translocation is specifically facilitated by NanC, and not by OmpF.
Multiple myeloma presenting as proliferative (crescentic) glomerulonephritis.
Sirsat R,Deshpande R
Journal of Postgraduate Medicine , 1994,
Abstract: Glomerular extracapillary cellular proliferation with crescent formation initially presenting as rapidly progressive glomerulonephritis is a rare clinical manifestation of multiple myeloma. We report here a case of a 58 year old female who initially presented with haematuria, loss of weight and appetite and history of febrile episodes and was diagnosed following renal biopsy as rapidly progressive glomerulonephritis. Haemodialysis was carried out a month later because of uremic symptoms and maintained with monitoring of serum, calcium, phosphate, alkaline phosphatase, albumin and iPTH levels. After 6 months, she complained of bone pains over anterior chest wall which persisted even with low calcium haemodialysis. Serum protein electrophoresis and bone marrow aspiration revealed multiple myeloma. On starting chemotherapy, bone pain subsided but the patient expired within 15 days of therapy.
Microbial Profile of Soil-Free versus In-Soil Grown Lettuce and Intervention Methodologies to Combat Pathogen Surrogates and Spoilage Microorganisms on Lettuce
Sujata A. Sirsat,Jack A. Neal
Foods , 2013, DOI: 10.3390/foods2040488
Abstract: Aquaponics is an effective method to practice sustainable agriculture and is gaining popularity in the US; however, the microbial safety of aquaponically grown produce needs to be ascertained. Aquaponics is a unique marriage of fish production and soil-free produce (e.g., leafy greens) production. Fish are raised in fresh water tanks that are connected to water filled beds where fruits and vegetables are grown. The fish bi-products create nutrient-rich water that provides the key elements for the growth of plants and vegetables. The objective of this study was to perform a comparative analysis of the microbial safety and quality of aquaponic lettuce and soil grown lettuce (conventional, bagged, certified organic, and field lettuce). Following this, an intervention study was performed to combat foodborne pathogen surrogates ( Salmonella and E. coli), spoilage, and fecal microorganisms using 2.5% acetic acid. The results of the comparative analysis study showed that aquaponically grown lettuce had significantly lower concentration of spoilage and fecal microorganisms compared to in-soil grown lettuce. The intervention study showed that diluted vinegar (2.5% acetic acid) significantly reduced Salmonella, E. coli, coliforms, and spoilage microorganisms on fresh lettuce by 2 to 3 log CFU/g. Irrespective of growing methods (in-soil or soilless), it is crucial to incorporate good agricultural practices to reduce microbial contamination on fresh produce. The intervention employed in this study can be proposed to small farmers and consumers to improve quality and safety of leafy greens.
Research: VALIDATED HPTLC METHOD FOR SIMULTANEOUS QUANTITATION OF CEFIXIME AND OFLOXACIN IN BULK DRUG AND IN PHARMACEUTICAL FORMULATION
Janhavi Rao*,Kamini Sethy,Savita Yadav
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: This work is concerned with the simultaneous determination of cefixime and ofloxacin in a bulk drug and pharmaceutical formulations by high performance thin layer chromatographic (HPTLC) method. Chromatographic separation was achieved on aluminum foil plates precoated with silica gel 60GF-254, with n-butanol: ammonia: water: DMSO (8:3:1:2, v/v/v/v) as mobile phase. Detection was performed densitometrically at 297 nm. The RF of cefixime and ofloxacin were 0.55 and 0.65, respectively. The reliability of the method was assessed by evaluation of linearity (30-180 ng/spot for both cefixime and ofloxacin respectively. Accuracy (99.82 % for cefixime and 99.84 % for ofloxacin), and specificity, in accordance with ICH guidelines. The method is simple, accurate, and rapid and can therefore be used for routine analysis of both drugs in quality control laboratories.
Reaearch: SIMULTANEOUS HPTLC ANALYSIS OF ATENOLOL AND INDAPAMIDE IN TABLETS
Savita S Yadav,Janhavi R Rao*
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: A simple, fast, precise, selective and accurate HPTLC method was developed and validated for the simultaneous determination of atenolol and indapamide from bulk and formulations. Chromatographic separation was achieved on aluminum foil plates precoated with silica gel 60F254, with toluene: ethyl acetate: methanol: ammonia 5:3:3:0.1 (v/v) as mobile phase. Detection was performed densitometrically at 229 nm. The RF of atenolol and indapamide were 0.27 and 0.71, respectively. Linearity was observed in the concentration range of 200-1200 ng/spot for atenolol and 100-600 ng/spot for indapamide. Percent recoveries obtained for both the drugs were 99.95 ± 0.18% and 99.67 ± 0.80%, respectively. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness. The method developed can be used for the routine analysis of atenolol and indapamide from their combined dosage form.
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