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Search Results: 1 - 10 of 3747 matches for " Jane Durga "
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No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine
Audrey Y. Jung, Yvo Smulders, Petra Verhoef, Frans J. Kok, Henk Blom, Robert M. Kok, Ellen Kampman, Jane Durga
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024976
Abstract: A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There is growing evidence that modifications in DNA methylation can be brought about by altering the intake of methyl donors such as folate. We examined whether long-term daily supplementation with 0.8 mg of folic acid would increase global DNA methylation compared with placebo in individuals with elevated plasma homocysteine. We also investigated if these effects were modified by MTHFR C677T genotype. Two hundred sixteen participants out of 818 subjects who had participated in a randomized double-blind placebo-controlled trial were selected, pre-stratified on MTHFR C677T genotype and matched on age and smoking status. They were allocated to receive either folic acid (0.8 mg/d; n = 105) or placebo treatment (n = 111) for three years. Peripheral blood leukocyte DNA methylation and serum and erythrocyte folate were assessed. Global DNA methylation was measured using liquid chromatography-tandem mass spectrometry and expressed as a percentage of 5-methylcytosines versus the total number of cytosine. There was no difference in global DNA methylation between those randomized to folic acid and those in the placebo group (difference = 0.008, 95%CI = ?0.05,0.07, P = 0.79). There was also no difference between treatment groups when we stratified for MTHFR C677T genotype (CC, n = 76; CT, n = 70; TT, n = 70), baseline erythrocyte folate status or baseline DNA methylation levels. In moderately hyperhomocysteinemic men and women, long-term folic acid supplementation does not increase global DNA methylation in peripheral blood leukocytes. ClinicalTrials.gov NCT00110604
Modulation of cell death pathways in cancer stem cells: Targeting histone demethylases  [PDF]
Ravi Thakur, Durga Prasad Mishra
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.326093
Abstract: Cancer stem cells (CSCs) are tumor initiating cells within the tumor mass; that play a critical role in cancer pathogenesis. CSCs regulate cancer cell survival, metastatic potential, resistance to conventional radio-chemotherapy, disease relapse and poor prognosis. Recent studies have established that the drug resistant cancers and cancer cell lines possess high stem cell like traits compared to their drug sensitive counterparts. Histone demethylases are recently been linked to drug induced reversible tolerant state in cancers. Lysine histone demethylases are enzymes those demethylate lysines in histones and can act as transcriptional repressors or activators. Apart from histones other cellular proteins like E2F1, Rb, STAT3 and p53 are also regulated by methylation and demethylation cycles. In cancer cells these enzymes regulate cell survival, migration, invasion, and proliferation. This review summarizes the current progress of research on the role of histone demethylases in supporting drug tolerant cancer stem cell state and their potential as a drug target.
Design and Development of E-Governance Model for Service Quality Enhancement  [PDF]
Tulu Tilahun, Durga Prasad Sharma
Journal of Data Analysis and Information Processing (JDAIP) , 2015, DOI: 10.4236/jdaip.2015.33007
Abstract: Governance is a process of establishing policies or laws and continuously monitoring their implementation in the public. Citizens are the main stakeholders in this process. To make the governance process cost effective, easy and convenient to the citizens, information and communication technologies (ICTs) are playing a vital role. Using ICTs in governance domain can be referred as e-governance. It helps citizen to participate not only in policy making but also in service quality improvements and getting government services over network. Web technology is one of the major technologies that have been used in e-governance as a major contributor. Before invention of web, citizens used to write their opinions and send to concerned body via post mail or local suggestion box for improvements of services. After the invention of the web, it became possible to post or send the opinions/comments over organization’s web sites or portals. As the number of comments increases over the web, it is very difficult to have relevant information for furthering the decision making processes. In these study, text processing and data mining techniques have been used. The prototype system classifies citizen’s opinions in one of six service categories with the precision of 87.3% and recall of 85.8%. Further, the system determines opinions as appreciation with the precision of 100% for both depression and appreciation, and average recall of 90.85% for both depression and appreciation. The results obtained from the prototype system indicate that the techniques that have been applied are promising for real world application in e-governance.
Development and Validation of Stability Indicating HPLC Method for Simultaneous Estimation of Amoxicillin and Clavulanic Acid in Injection  [PDF]
Durga Mallikarjuna Rao Tippa, N. Singh
American Journal of Analytical Chemistry (AJAC) , 2010, DOI: 10.4236/ajac.2010.13013
Abstract: A simple, fast, precise, accurate and rugged stability indicating high performance liquid chromatography (HPLC) method has been developed for simultaneous estimation of Amoxicillin and Clavulanic acid from injectable dosage form. The stability indicating capability of the method was proven by subjecting the drugs to stress conditions as per ICH recommended test conditions such as alkaline and acid hydrolysis, oxidation, photolysis, thermal degradation and resolution of the degradation products formed therein. The separation was obtained using a mobile phase composition at a ratio of 95:5 (v/v) of pH 5.0 buffer and methanol on Inertsil C18 column (250 × 4.0 mm, 4 μm) with UV detection at 220 nm at a flow rate of 1 ml/minute. The photodiode array detector was used for stress studies. The order of elution of peaks was Clavulanic acid followed by Amoxicillin. The linear calibration range was found to be 79.51 to 315.32 μg/ml for Amoxicillin and 17.82 to 67.90 μg/ml for Clavulanic acid. The Amoxicillin and Clavulanic acid were found to be stable in solution up to 24 hours. The method validation data showed excellent results for precision, linearity, specificity, limit of detection, limit of quantification and robustness. The present method can be successfully used for routine quality control and stability studies.
Spontaneous Combustibility Characterisation of the Chirimiri Coals, Koriya District, Chhatisgarh, India  [PDF]
Durga Shankar Pattanaik, Purnananda Behera, Bijay Singh
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23036
Abstract: Representative coal samples were collected from different coal seams of the Chirimiri coalfield which covered the entire stratigraphic sequence. These samples were tested for Chemical analysis, Crossing Point Temperature (CPT), Petrography, Infrared studies (IR) and Differential Thermal Analysis (DTA). All the test results vindicated that the aforesaid parameters had a definite relationship with the stratigraphic disposition or the ranks of coal. The low rank coals found as younger seams in the stratigraphic sequence were more prone to spontaneous combustion whereas the higher rank coals found at the bottom of stratigraphic sequence were less prone to spontaneous combustion. Through combustibility characterisation by different tests, it was found that the upper Duman and Kaperti seams placed as younger seams in the stratigraphic sequence are highly prone to spontaneous combustion whereas the lower Karakoh and Sonawani seams seem to be least prone to spontaneous combustion.
A Novel Approach for a Two Area Load Frequency Control in a Competitive Electricity Market Adopting Unscheduled Interchange Price  [PDF]
Murugesan Bhavani, Kamatchi Selvi, Ravi Durga
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.77099
Abstract: This paper proposes a novel price based load frequency control scheme for a two area system, using an Unscheduled Interchange (UI) price signal, which is ideal and suitable for electricity market. The Government of India has introduced Availability Based Tariff (ABT) structure with an intention of ensuring grid security and to regulate grid indiscipline through Central Electricity Regulatory Commission Regulation. After the introduction of this regulation, the over or under injection by the generating companies (GENCOs) during off peak or peak hours are demoralized and the frequency is maintained at the nominal value. In this paper, the GENCOs instead of reacting to this price signal manually, an automated mode of frequency control is deployed in each area using UI price signal to achieve fast response to load change. The Distribution Company (DISCO) Participation Matrix (DPM) has also been employed in this work to relate the scenario under deregulation of electricity market. The proposed scheme has been verified for different cases by simulating it on a two area system, each having four GENCOs and one DISCO in MATLAB/SIMULINK environment. From the results, it is clearly observed that if the proposed method is employed by all GENCOs, it will certainly enhance the control of system frequency and at the same time throw down the UI liability of market participants. It also ensures that the GENCOs and DISCOs strictly adhere to the bilateral contract following the DISCO participation matrix.
Effect of Beryllium Aluminum Cyclosilicate on Thermal Expansion Behavior of Al-Based Composites  [PDF]
V. Bharat, B. Durga Prasad, K. Venkateswarlu
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2017, DOI: 10.4236/jmmce.2017.53012
Abstract: Beryllium aluminum cyclosilicate, an ore of beryllium was reinforced in Aluminum matrix to fabricate Al-beryl composites using powder metallurgy. Effect of the content of beryllium aluminum cyclosilicate on microstructural hardness and thermal expansion was studied. The coefficient of thermal expansion of Al-beryl composite was measured in the temperature range between 50oC to 360oC using dilatometer and was theoretically studied using thermo-elastic models, and these models were used to explain abnormalities observed experimentally. The hardness of Al-beryl metal matrix composites increased with the increase in beryl percentage. Vacuum sintering of Al-beryl metal matrix composites at 600oC inhibited excellent bonding between the matrix and the particulate increasing the strength of the composite. The result shows the CTE significantly increased with increasing temperature but decreased with increasing reinforcement. At higher temperatures, CTE of Al-beryl metal matrix composites with 5 wt%, 10 wt% and 15 wt% of beryllium aluminum cyclosilicate was 21 ppm/K, 18.2 ppm/K, and 16.8 ppm/K. The CTE values were found to be comparable with theoretical results. The turner model showed conformance with experimental results, was well suited to the experimental results.
Causes and Effect of Occupational Stress and Coping on Performance with Special Reference to Length of Service: An Empirical Study Using Multinomial Logistic Regression Approach  [PDF]
Kanaka Durga Veer Prasad, Rajesh Vaidya
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.910141
Abstract: The manuscript presents the outcome of our research study on effect of occupational stress, coping strategies adopted, length of service and their relation with performance of employees. A survey using an undisguised questionnaire was carried on the employees working in the International Agricultural Research Institute and Information Technology sector in Indian Metro, Hyderabad. The data from the 756 respondents, including 381 women and 375 men responses was used for analysis. The occupational stress was measured using 14 stress causing components—workload, co-workers, peer, peer-support, role ambiguity, role conflict, career, harassment, psychological factors, physiological factors, behavioural factors, social support, job control, approach coping and voidance coping, length of service on dependent factor Performance of the respondents from the International Agricultural Research Institute and IT sector. The effect on dependent variable performance with the independent factors length of service was divided into 4 groups in 1 - 5 years, 6 - 10 years, 11 - 15 years and >15 years of service, occupational stress factors, coping strategies were measured. The overall C-Alpha value is 0.92 for overall components, 0.91 for occupational stress components, 0.92 for overall coping, 0.69 for performance; whereas 0.69 for avoidance coping 0.69 for approach coping. The likely hood odds rations (ORs) were estimated to predict degree of association of occupational stress, coping strategies, length of service with performance of the employees, gender and age differences.
Study of Fruit Diversity and Selection of Elite Acid Lime (Citrus aurantifolia Swingle) Genotypes in Nepal  [PDF]
Ram Lal Shrestha, Durga Datta Dhakal, Durga Mani Gautum, Krishna Prasad Paudyal, Sangita Shrestha
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.38132
Abstract: Acid lime (Citrus aurantifolia) fruits are cultivated in terai, mid hill and high hill districts of Nepal. It is cross-pollinated crop and has a high variation in fruit characters within the species. Fruit character is the main basis of genotype selection. Study of fruit diversity is of utmost importance to select the elite genotypes for breeding and variety development program. Therefore, total of 620 fruit samples were collected and evaluated in the main production season of the year 2010 and 2011, from 62 bearing trees. Samples were collected from three agro-ecological domains, representing terai, mid hill and high hill areas of eastern Nepal. Elite landraces were selected on the basis of scoring fruit characters. High variation in vitamin C was observed between the terai (57.4 mg) and high hill (72.5 mg) samples. Amount of juice was 36.8% in mid hill and 44.1% in terai samples. Higher percent of juice and total soluble solids (TSS) observed in terai samples but tritable acidity (TA) and vitamin C was low as compare to high hills. There was significantly negative correlation found in fruit weight, fruit diameter, juice percent and seed number, whereas significantly positive correlation was in pulp and vitamin C, with altitude range. Total landraces were separated in five major cluster group. Variation in the level of similarity was observed among the cluster groups. The variability distance of fruit characters was highest in cluster group II (–17.45%) and lowest in cluster group V (58.5%). On the basis of scoring number of fruit characters, total four elite genotypes i.e. LD-49 from mid hills, LD-23 and LT-17 from higher hills and LM-44 from terai were selected for conservation, breeding and variety development purpose.
Genetic Diversity Assessment of Acid Lime (Citrus aurantifolia Swingle) Landraces in Nepal, Using SSR Markers  [PDF]
Ram Lal Shrestha, Durga Datta Dhakal, Durga Mani Gautum, Krishna Prasad Paudyal, Sangita Shrestha
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.312204
Abstract: Acid lime (Citrus aurantifolia) is an important commercial fruits crop, cultivated in terai to high hills of Nepal. High variation of acid lime fruits are observed in existing landraces due to crossing within the other citrus species. Determination of genetic variation is important to the plant breeders for development of high yielding variety and hybrids. Therefore, an attempt has been made to study the genetic diversity of 62 acid lime landraces, collected from different altitudinal range in the eastern part of Nepal, using SSR markers. Twelve Simple Sequence Repeat (SSR) primer pairs were used to assess the genetic diversity of acid lime. The average genetic similarity level among the 62 accessions was 0.77, ranging from 0.54 to 1.0 and separated five major cluster groups. Total of 33 alleles were detected by eleven primer pairs and size of alleles ranged from 50 to 225. Average polymorphic information content (PIC) value was 0.50, whereas highest 0.75 and lowest 0.18 was observed in CAT01 and GT03 loci respectively. The results of the study clearly indicated that, SSR markers are highly polymorphic and more informative for the assessment of genetic diversity of acid lime landraces.
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