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Search Results: 1 - 10 of 24956 matches for " Jan Pawel Andrade;Czeczko "
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Avalia??o imunoistoquímica dos receptores de estrogênio e progesterona no cancer de mama, pré e pós-quimioterapia neoadjuvante
Pachnicki, Jan Pawel Andrade;Czeczko, Nicolau Gregori;Tuon, Filipe;Cavalcanti, Tereza Santos;Malafaia, Andressa Bressan;Tuleski, Ana Maria;
Revista do Colégio Brasileiro de Cirurgi?es , 2012, DOI: 10.1590/S0100-69912012000200002
Abstract: objective: to evaluate the immunoexpression of estrogen and progesterone receptors in biopsies and surgical specimens of patients with breast cancer before and after neoadjuvant chemotherapy and to correlate their changes with the pattern of response to chemotherapy and diagnosis of menopause. methods: we selected 47 patients with histological diagnosis of locally advanced primary breast carcinoma. for each patient there were two blocks: the biopsy specimen and surgical resection one. from these blocks hormone receptor expression was assessed by immunohistochemistry using the technique of streptoavidin-biotin-immunoperoxidase and anti-er and anti-pr primary antibodies. the statistical analysis used the student's t test and the nonparametric fisher's exact test, with significance level of 5%. results: of the 47 patients, 30 showed positive immunostaining for hormone receptors. there was significant reduction in the levels of both estrogen and progesterone receptors and in their immunoreactivity. in 53.3% we observed changes in levels of estrogen receptor expression, 56.6% in the progesterone receptor, 26.6% in the immunoexpression of estrogen receptor immunoreactivity and 33.3% in the immunoreactivity of the progesterone receptor. there was no statistical correlation between the influence of the response to chemotherapy and the diagnosis of menopause in women with variation in the expression of hormone receptors. conclusion: neoadjuvant chemotherapy has significantly altered hormone receptor immunoreactivity in patients in the sample, reducing its positivity in tumor cells.
Comparative study in swines' vocal cords healing after excision of fragment with CO2 laser with mitomycin and 5-fluorouracil postoperative topical application
Baptistella, Eduardo;Malafaia, Osvaldo;Czeczko, Nicolau Gregori;Ribas-Filho, Jurandir Marcondes;Nassif, Paulo Afonso Nunes;Nascimento, Marcelo Mazza do;Pachnicki, Jan Pawel Andrade;
Acta Cirurgica Brasileira , 2009, DOI: 10.1590/S0102-86502009000100004
Abstract: purpose: to evaluate the deposition of collagen fibers at pig's vocal folds after topical use of mitomycin or 5-fluorouracil, when partial exeresis of mucosa layer had been promoted by co2 laser. methods: there were used 18 larger white pigs which were anesthetized and submitted to mucosa fragment's exeresis, bilaterally, at its free border. the animals were divided into 3 groups, each one with 6 animals: control group, without topical drug application; mitomycin group; and 5-fluorouracil group. after 30 days, the animals were subjected to euthanasia, and samples of the vocal folds were collected and stained by picrosirius red technique with polarization for quantification of total collagen deposition. results: in control group, the mean rate of right vocal fold's collagen deposition at submucosa consisted in a 3428.66 micrometers area. there was found an area whose size had, in average, 2196.36 micrometers, in mitomycin group, and 2269.19 micrometers, in 5-fluorouracil group. conclusion: mitomycin and 5-fluorouracil had promoted beneficial change in vocal fold's cicatrization with less collagen deposition, but there was no significant statistically difference when they were compared between themselves.
Estudo da correla??o do IMC e comprimento do intestino delgado em pacientes obesos submetidos à cirurgia bariátrica
Nassif, Paulo Afonso Nunes;Malafaia, Osvaldo;Ribas, Carmen Australia Paredes Marcondes;Pachnicki, Jan Pawel Andrade;Kume, Márcio Hiroaki;Macedo, Larissa Maria;Rikimaru, Tiele Assis;
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S?o Paulo) , 2009, DOI: 10.1590/S0102-67202009000300004
Abstract: background: according to the hypothesis of long bowel, the length of small intestine is related to obesity. there are evolutionary, anatomics, neuroendocrines evidences in favor of this assertion. aim: to check the measure of the small intestine length in overweight patients submitted to bariatric surgery and to analyze the correlation between the intestine size and body mass index (bmi). methods: the sample was composed of 30 patients of hospital universitário evangélico de curitiba, obesity service, which had been submitted to bariatric surgery in the period between march and june, 2009. these patients previously had been evaluated, according to their weight, height and bmi. the surgical technique was fobi-capella. the measurement of small bowel was carried through the treitz angle towards the ileocecal junction, during the operation. the instrument used was an intestinal manipulation clamp, which was marked with the measure of 10 cm. the intestinal handles had been measured in the anti-mesenteric edge, applying minimum tension necessary to rectify them. the data were statistically correlated and automatically tabulated, using the pearson correlation method. results: the average intestinal length for males was 582,5 cm and for 509,1 cm, medium length 528,7 cm. pearson correlation coefficient, confirmed the absence of correlation between bmi and the intestinal length. conclusion: the medium length of small intestine was 528,7 cm and it did not have correspondence to bmi.
Contagem de plaquetas e caracteriza??o clínica de úlceras de perna anticardiolipinas positivas
Skare, Thelma Laroka;Ribas, Carmen Autralia Paredes Marcondes;Malafaia, Osvaldo;Ribas Filho, Jurandir Marcondes;Nassif, Paulo Afonso Nunes;Nascimento, Marcelo Mazza do;Pachnicki, Jan Pawel Andrade;
Revista do Colégio Brasileiro de Cirurgi?es , 2009, DOI: 10.1590/S0100-69912009000500010
Abstract: objective: to study the prevalence of anticardiolipin antibodies in patients with venous, diabetic and arterial leg ulcers and to verify if platelet count, previous history of venous thrombosis, obstetrical history and the finding of livedo reticularis are markers of this autoantibody positivity. methods: 151 patients with leg ulcer (81 with venous, 50 with diabetic and 20 with arterial ulcers) and 150 controls were included. in both groups search for the presence of igg and igm anticardiolipin and platelet count was done. in the leg ulcer group demographic data, obstetrical history, previous history of venous thrombosis as well as presence of livedo reticularis by physical examination were pointed out. data was grouped in contingency and frequency tables and the tests of fisher and chi-squared were used for nominal variables and mann whitney and kruskall wallis for numerical variables. the adopted significance was of 5%. results: it was found an anticardiolipin prevalence of 7.2% (n=12) in the leg ulcer group and of 1.3% (n=2) in the control group (p=0.01). leg ulcer patients with anticardiolipin did not differ from those without it in gender (p=0.98), previous history of venous thrombosis (p=0.69), previous history of abortions (p=0.67) and platelet count (p=0.67). only two patients had livedo reticularis which precluded any conclusion on this data. conclusion: there is an increased prevalence of anticardiolipin antibodies in the general population with leg ulcers. clinical characteristics of ulcers as well as platelet count do not help in the identification of these patients.
Regenera??o do fígado de ratos após oclus?o parcial da drenagem venosa hepática
Aguiar, Luiz Roberto Farion de;Nassif, Paulo Afonso Nunes;Ribas, Carmen Australia Paredes Marcondes;Nascimento, Marcelo Mazza do;Wiederker, Julio Cesar;Pachnicki, Jan Pawel Andrade;Stieven-Filho, Edmar;
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S?o Paulo) , 2009, DOI: 10.1590/S0102-67202009000200005
Abstract: background: hepatic regeneration is a mechanism to overcome the loss of liver functional tissue. this process has been studied through different methods. aim: to evaluate the effect of the partial occlusion of the hepatic venous drainage on the regeneration of the remainder livers in rats submitted to partial hepatectomy.method: liver biopsies from 30 male wistar rats were collected, and after they were submitted two-third hepatectomy. the animals were divided in three groups: a control group and two study groups, which were submitted to different degrees of the right hepatic vein stenosis. after 96 hours of the stimulation for regeneration all rats were submitted to another hepatic biopsy. the analysis of the fragments was performed by immunohistochemistry for the ki-67 and von willebrand factor markers. the reading of the samples was done using the samba 4000 system. collagen deposition was evaluated by the trichromic masson's staining.result: the cellular proliferation of the animals submitted to partial hepatectomy and stenosis of the right hepatic vein persists higher when compared to control group. the label index for ki-67 was significantly higher post-hepatectomy in groups submitted to hepatic vein partial occlusion. the expression of von willebrand factor was strongly decreased after the hepatectomy in all groups. there was little deposit of collagen in the hepatic tissue of animals with hepatic vein stenosis. conclusion: partial occlusion of the hepatic venous drainage in rats submitted to partial hepatectomy prolongs the time of hepatic cells proliferation when compared to the animals with vein of normal caliber. consequently, there will be also a delay in the restoration of the extracellular matrix and in the formation of new sinusoidal vessels.
Taming the zoo - about algorithms implementation in the ecosystem of Apache Hadoop
Piotr Jan Dendek,Artur Czeczko,Mateusz Fedoryszak,Adam Kawa,Piotr Wendykier,Lukasz Bolikowski
Computer Science , 2013,
Abstract: Content Analysis System (CoAnSys) is a research framework for mining scientific publications using Apache Hadoop. This article describes the algorithms currently implemented in CoAnSys including classification, categorization and citation matching of scientific publications. The size of the input data classifies these algorithms in the range of big data problems, which can be efficiently solved on Hadoop clusters.
How to perform research in Hadoop environment not losing mental equilibrium - case study
Piotr Jan Dendek,Artur Czeczko,Mateusz Fedoryszak,Adam Kawa,Piotr Wendykier,Lukasz Bolikowski
Computer Science , 2013,
Abstract: Conducting a research in an efficient, repetitive, evaluable, but also convenient (in terms of development) way has always been a challenge. To satisfy those requirements in a long term and simultaneously minimize costs of the software engineering process, one has to follow a certain set of guidelines. This article describes such guidelines based on the research environment called Content Analysis System (CoAnSys) created in the Center for Open Science (CeON). Best practices and tools for working in the Apache Hadoop environment, as well as the process of establishing these rules are portrayed.
Bifurcations of planar sliding homoclinics
Jan Awrejcewicz,Michal Fe kan,Pawel Olejnik
Mathematical Problems in Engineering , 2006, DOI: 10.1155/mpe/2006/85349
Abstract: We study bifurcations from sliding homoclinic solutions to bounded solutions on ℝ for certain discontinuous planar systems under periodic perturbations. Sufficient conditions are derived for such perturbation problems.
The method of integration of silicon – micromachined sensors and actuators to microreactor made of Foturan glass
Pawel KNAPKIEWICZ,Rafal WALCZAK,Jan A. DZIUBAN
Optica Applicata , 2007,
Abstract: In this article results of unique low temperature anodic bonding silicon and Foturan glass are presented. The new method of anodic bonding can be useful in designing and fabrication of intelligent microreactors equipped with microsensors and other microdevices suitable both to control and to steer chemical process. Direct assembling onto microreactors allows to think about integrated microreactors equipped with set of sensors, i.e., pressure sensors and other devices, i.e., valves, flow meters, etc. The demand for integration microreactor with measuring /steering setup, following the technology of low temperature anodic bonding and application of this technique are described.
Bifurcations of planar sliding homoclinics
Jan Awrejcewicz,Michal Fe?kan,Pawel Olejnik
Mathematical Problems in Engineering , 2006,
Abstract: We study bifurcations from sliding homoclinic solutions to bounded solutions on for certain discontinuous planar systems under periodic perturbations. Sufficient conditions are derived for such perturbation problems.
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