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Search Results: 1 - 10 of 21858 matches for " Jae-Ryong Kim "
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Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells
Kyung Lee, Sang Kim, Jae-Ryong Kim
Journal of Experimental & Clinical Cancer Research , 2009, DOI: 10.1186/1756-9966-28-73
Abstract: Intracellular ROS, as determined using the fluorescent probe, 2'-7' dichlorofluorescein diacetate, decreased after treatment with hepatocyte growth factor (HGF). We confirmed that Rac-1 regulated ROS production after activation of the AKT pathway with HGF. Exogenously added H2O2 promoted the expression of HGF, but not in a dose-dependent manner and also showed negative expression of HGF after co-treatment with H2O2 and HGF. Treatment with NAC, an intracellular free radical scavenger, decreased the enhancement of uPA production and tumor invasion in both cells. We clarified the downstream pathways regulated by ROS after treatment with H2O2, which showed negative control between FRK and p38 kinase activities for uPA regulation.HGF regulates Rac-1-induced ROS production through the Akt pathway and ROS regulates uPA production and invasion via MAP kinase, which provides novel insight into the mechanisms underlying the progression of gastric cancer.Gastric cancer is the second most common cause of cancer death worldwide despite of the improved prognosis. To understand the precise mechanisms underlying invasion and metastasis would be helpful in improving survival. ROS, such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO-), have emerged as highly toxic agents responsible for a wide variety of tissue damage [1] The involvement of these ROS in the pathogenesis of gastric diseases first became evident from the study of gastric mucosal injuries under normal conditions. ROS are relatively harmless, but when produced excessively or during deficient antioxidant defense, the oxidant and antioxidant balance is disturbed and the metabolites become toxic, which may lead to the initiation and promotion of cancer [2]. However, despite the positive correlation between the increased generation of ROS and the invasion of cancer, the specific mechanisms by which antioxidants act to suppress cancer development through ROS is unknown.HGF has multiple biologic
Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations
Seongwon Cha, Imhoi Koo, Sun Choi, Byung Park, Kil Kim, Jae-Ryong Kim, Hyoung Shin, Jong Kim
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-96
Abstract: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test.Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects.We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.INSIG2 is considered to be a candidate gene with respect to involvement in the development of obesity. A common variant located 10 kb upstream of the gene, rs7566605, was found to be associated with BMI in a recent genome-wide association study [1]. This association has been suitably replicated in several white [1-3], African-American [1], and Asian populations [4-6]. However, the SNP did not have a genetic effect on obesity according to other studies including white [2,7-14], Afro-Caribbean [12], and Asian populations [15-17]. Hence, the INSIG2 polymorphism may have an important effect in overweight populations under certain environmental circumstances, given several positive associations found in studies of overweight subjects [3,4].INSIG2 has attracted the attention of researchers due to its role in cholesterol metabolism [18]. The protein is known to reside in the endoplasmic reticulum, where it binds to SCAP to inhibit it from convoying SREBPs to the Golgi apparatus [18]. Eventually, INSIG2 prevents SREBP from activating cholesterol synthesis because SREBP cannot be processed and activated by the Golgi enzymes. These actions of INSIG2 were also reported in subsequent research involving mice [18
Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease
Joung Lee, Hong Namkoong, Hyun Kim, Sanghee Kim, Dong Hwang, Hae Na, Seon-Ah Ha, Jae-Ryong Kim, Jin Kim
BMC Neurology , 2007, DOI: 10.1186/1471-2377-7-14
Abstract: We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia.We demonstrated an elevated level of fibrinogen gamma-A chain precursor protein in CSF from patients with mild cognitive impairment and AD compared to the age-matched normal subjects. Moreover, its expression was more prominent in the AD group than in the MCI and correlated with disease severity and progression. In contrast, fibrinogen gamma-A chain precursor protein was detected very low in the age-matched normal group.These findings suggest that the CSF level of fibrinogen gamma-A chain precursor may be a candidate biomarker for AD.Neurodegenerative diseases are characterized by chronic, progressive, irreversible deterioration of neurological function affecting cognition and motor-sensory functions. Diagnosis of neurodegenerative disease largely depends on clinical manifestations; patients usually present to clinicians when their symptoms interfere with activities of daily living (ADL). By the time patients present with these complaints, nerve cells have already been damaged irreversibly and progression of disease may be inevitable. For this reason, there is a need for a molecular-based diagnostic marker in biologic fluids that can identify neurodegenerative disease at an early or preclinical phase; this diagnostic marker could be a disease-modifying compound targeted to drug development [1].Biochemical changes in the brain are well reflected in the CSF which is in direct contact with the brain extracellular space. Biomarkers have been discussed as possible diagnostic tools but have not been frequently used in research on the elderly because of the general paucity of supportive scientific data. However, there is an obvious need for greater diagnostic specificity and sensitivity across many
Differential wedging of vertebral body and intervertebral disc in thoracic and lumbar spine in adolescent idiopathic scoliosis – A cross sectional study in 150 patients
Hitesh N Modi, Seung Suh, Hae-Ryong Song, Jae-Hyuk Yang, Hak-Jun Kim, Chetna H Modi
Scoliosis , 2008, DOI: 10.1186/1748-7161-3-11
Abstract: This cross sectional study in 150 patients of adolescent idiopathic scoliosis was done to evaluate vertebral body and disc wedging in scoliosis and to compare the extent of differential wedging of body and disc, in thoracic and lumbar area. We measured wedging of vertebral bodies and discs, along with two adjacent vertebrae and disc, above and below the apex and evaluated them according to severity of curve (curve < 30° and curve > 30°) to find the relationship of vertebral body or disc wedging with scoliosis in thoracic and lumbar spine. We also compared the wedging and rotations of vertebrae.In both thoracic and lumbar curves, we found that greater the degree of scoliosis, greater the wedging in both disc and body and the degree of wedging was more at apex supporting the theory of growth retardation in stress concentration area. However, the degree of wedging in vertebral body is more than the disc in thoracic spine while the wedging was more in disc than body in lumbar spine. On comparing the wedging with the rotation, we did not find any significant relationship suggesting that it has no relation with rotation.From our study, we can conclude that wedging in disc and body are increasing with progression on scoliosis and maximum at apex; however there is differential wedging of body and disc, in thoracic and lumbar area, that is vertebral body wedging is more profound in thoracic area while disc wedging is more profound in lumbar area which possibly form 'vicious cycle' by asymmetric loading to spine for the progression of curve.Scoliosis is a three-dimensional deformity involving coronal, sagittal and axial angulations. Extent of the disease progress, decision to change the treatment strategy and efficacy of the treatment are mainly dependent on the severity in coronal plane angle, commonly known as Cobb's angle as a primary interest. In idiopathic scoliosis, factors responsible for the progression of curve are still unclear and authors have their own point of vi
Furstenberg theorem for frequently hypercyclic operators
Eunsang Kim,Tae Ryong Park
Mathematics , 2014,
Abstract: In this paper, we show that if the direct sum $T\oplus T$ of frequently hypercyclic operators is frequently hypercyclic, then every higher direct sum $T\oplus\cdots\oplus T$ is also frequently hypercyclic.
Quality of Life (QOL) in Long-Term Survivors of Osteosarcoma  [PDF]
Jae Do Kim, Jae Man Kwak, So Hak Chung
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41018

We conducted this study to analyze the quality of life using the SF-36 health questionnaire and the MSTS scores depending on surgical method and the primary site of occurrence. On the surgical method, the limb salvage had more excellent outcomes (60.9) than the amputation (46.3). The tumor prosthetic replacement had notably higher scores (62.5) than any other methods. For the correlation coefficients on the MSTS and SF-36, the Physical Function had the highest degree of correlation. Excellent functions of the extremities would lead to a good quality of life.

FE analysis of laminated composite plates using a higher order shear deformation theory with assumed strains
Lee, Sang Jin;Kim, Ha Ryong;
Latin American Journal of Solids and Structures , 2013, DOI: 10.1590/S1679-78252013000300005
Abstract: a study on the finite element (fe) analysis of laminated composite plates is described in this paper. in order to investigate structural behavior of laminated composite plates, a four-node laminated plate element is newly developed by using a higher order shear deformation theory (hsdt). in particular, assumed natural strains are introduced in the present fe formulation to alleviate the locking phenomenon. several numerical examples are carried out and its results are then compared with the existing reference solutions. it is found to be that the proposed fe is very effective to remove the locking phenomenon and produces reliable numerical solutions for most laminated composite plate structures.
Effect of a seasonal di use pollution migration on natural organic matter behavior in a stratified dam reservoir

Soon Ju Yu,Jae Yil Lee,Sung Ryong Ha,

环境科学学报(英文版) , 2010,
Abstract: This article aims to describe the influence of di use pollution on the temporal and spatial characteristics of natural organic matter (NOM) in a stratified dam reservoir, the Daecheong Dam, on the basis of intensive observation results and the dynamic water quality simulation using CE-QUAL-W2. Turbidity is regarded as a comprehensive representation of allochothonous organic matter from di use sources in storm season because the turbidity concentration showed reasonable significance in a statistical correlation with the UV absorbance at 254 nm and total phosphorus. CE-QUAL-W2 simulation results showed good consistency with the observed data in terms of dissolved organic matter (DOM) including refractory dissolved organic carbon (RDOC) and labile DOC and also well explained the internal movement of constituents and stratification phenomenon in the reservoir. Instead turbidity and NOM were related well in the upper region of the reservoir according to flow distance, gradually as changing to dissolved form of organic matter, RDOM a ected organic matter concentration of reservoir water quality compared to turbidity. To control the increase of soluble organic matters in the dam reservoir, appropriate dam water discharge gate operation provided e ective measurement. Because of the gate operation let avoid the accumulation of organic matter within a dam reservoir by shorten of turbid regime retention time.
Overexpression of OsMAPK2 Enhances Low Phosphate Tolerance in Rice and Arabidopsis thaliana  [PDF]
Yeon Jae Hur, Doh Hoon Kim
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.54059

The mitogen-activated protein kinase (MAPK) cascade is the most important mechanism in environmental responses and developmental processes in plants. The OsMAPK2 gene has been found to function in plant tolerance to diverse biotic/abiotic stresses. This paper presents evidence that OsMAPK2 (Oryza sativa MAP kinase gene 2) is responsive to Pi deficiency and involved in Pi homeostasis. We found that full-length expression of OsMAPK2 was up-regulated in both rice plants and cell culture in the absence of inorganic phosphate (Pi). The transgenic rice and Arabidopsis plants overexpressing OsMAPK2 showed affected root development and increased plant Pi content compared with wild-type plants. Overexpression of OsMAPK2 controlled the expression of several Pi starvation-responsive genes. Our results indicated that OsMAPK2 enables tolerance phosphate deficiency and is involved in Pi homeostasis.

Treatment Outcome of Pelvic Osteosarcoma a 20 Year Experience in a Single Institution  [PDF]
Jae Do Kim, Cheung Kue Kim, So Hak Chung
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41037

Purpose: Osteosarcoma of limbs shows excellent therapeutic results due to development of diagnostic and treatment methods. However, osteosarcoma of pelvic bone is known to have lower incidence than those of limbs and poorer prognosis. This study is performed to research the diagnosis, treatment, treatment outcomes, and complications of osteosarcoma of pelvic bone and propose standards for adequate treatment. Objective and Method: 16 cases that were diagnosed as osteosarcoma of pelvic bone from January 1988 to October 2010 in Kosin University Gospel Hospital were analyzed. Follow-up periods were at least 2 months up to 60 months. There were 6 cases of male and 10 cases of female, and mean age was 44.3 (14 ~ 74) years old. 5 cases were accompanied by pulmonary metastasis at the time of the diagnosis. Surgical treatment including preoperative and postoperative chemotherapy was performed in 9 cases, and only chemotherapy and radiation were performed in 1 case. Among 9 cases having undergone surgical treatment, 3 cases were performed with biological reconstruction using autogenous bone graft and total hip replacement together, 1 case was performed with extracorporeal irradiated recycled autogenous bone graft, 1 case was performed with reconstruction using tumor prosthesis, and 4 cases were performed with wide excision. Retrospective review was done about diagnostic procedures, treatment methods and results, and complications. Results: Mean period from the onset of symptoms to the time of the diagnosis was 6.3 (3 ~ 12) months, and the symptoms were 7 cases of hip pain, each 3 cases of lumbar pain and radiating pain to lower limbs, pelvic mass, each 2 cases of inguinal pain, and each 1 case of thigh pain, Among the 9 cases performed with preoperative and postoperative chemotherapy and surgical treatment, there were 6 cases of T-10 protocol, 2 cases of T-20 protocol, and 1 case of IA (Intraarterial) Cis protocol. In the 1 case that haven’t undergone surgical treatment, T-10 protocol was performed. 13 of the 16 cases were expired, with the mean time of 15 (2 ~ 47 months) from the time of the diagnosis to death. Complications were 4

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