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Search Results: 1 - 10 of 204242 matches for " Jacob P. Thyssen "
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Clinical Presentation of Atopic Dermatitis by Filaggrin Gene Mutation Status during the First 7 Years of Life in a Prospective Cohort Study
Charlotte Giwercman Carson, Morten Arendt Rasmussen, Jacob P. Thyssen, Torkil Menné, Hans Bisgaard
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048678
Abstract: Background Filaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease. We aimed to characterize the clinical presentation and course of atopic dermatitis associated with filaggrin mutations within the first 7 years of life. Method The COPSAC cohort is a prospective, clinical birth cohort study of 411 children born to mothers with a history of asthma followed during their first 7 years of life with scheduled visits every 6 months, as well as visits for acute exacerbations of dermatitis. Atopic dermatitis was defined in accordance with international guidelines and described at every visit using 35 predefined localizations and 10 different characteristics. Results A total of 170 (43%) of 397 Caucasian children developed atopic dermatitis. The R501X and/or 2282del4 filaggrin null mutations were present in 26 (15%) of children with atopic dermatitis and were primarily associated with predilection to exposed skin areas (especially the cheeks and back of the hands) and an up-regulation of both acute and chronic dermatitis. Furthermore, we found the filaggrin mutations to be associated with a higher number of unscheduled visits (3.6 vs. 2.7; p = 0.04) and more severe (moderate-severe SCORAD 44% vs. 31%; p = 0.14), and widespread dermatitis (10% vs. 6% of the body area, p<0.001) with an earlier age at onset (246 vs. 473 days, p<0.0001) compared to wild-type. Conclusion In children, filaggrin mutations seem to define a specific endotype of atopic dermatitis primarily characterized by predilection to exposed areas of the body, in particular hands and cheeks, and an up-regulation in both acute and chronic morphological markers. Secondary, this endotype is characterized by an early onset of dermatitis and a more severe course, with more generalized dermatitis resulting in more frequent medical consultations.
No Association between Loss-of-Function Mutations in filaggrin and Diabetes, Cardiovascular Disease, and All-Cause Mortality
Lise Lotte N. Husemoen, Tea Skaaby, Torben J?rgensen, Jacob P. Thyssen, Michael Meldgaard, Pal B. Szecsi, Steen Stender, Jeanne Duus Johansen, Allan Linneberg
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084293
Abstract: Background Common loss-of-function mutations in the filaggrin gene (FLG) are a major predisposing risk factor for atopic disease due to reduced epidermal filaggrin protein levels. We previously observed an association between these mutations and type 2 diabetes and hypothesized that an inherited impairment of skin barrier functions could facilitate low-grade inflammation and hence increase the risk of diabetes and cardiovascular disease. We examined the association between loss-of-function mutations in FLG and diabetes, stroke, ischemic heart disease (IHD), and all-cause mortality in the general population. Methods The R501X and 2282del4 loss-of function mutations in FLG were genotyped in four Danish study populations including a total of 13373 adults aged 15-77 years. Two of the studies also genotyped the R2447X mutation. By linkage to Danish national central registers we obtained information for all participants on dates of diagnoses of diabetes, stroke, and IHD, as well as all-cause mortality. Data were analyzed by Cox proportional hazard models and combined by fixed effect meta-analyses. Results In meta-analyses combining the results from the four individual studies, carriage of loss-of-function mutations in FLG was not associated with incident diabetes (hazard ratio (HR) (95% confidence intervals (CI)) = 0.95 (0.73, 1.23), stroke (HR (95% CI) = 1.27 (0.97, 1.65), ischemic heart disease (HR (95%CI) = 0.92 (0.71, 1.19), and all-cause mortality (HR (95%CI) = 1.02 (0.83, 1.25)). Similar results were obtained when including prevalent cases in logistic regression models. Conclusion Our results suggest that loss-of-function mutations in FLG are not associated with type 2 diabetes, cardiovascular disease, and all-cause mortality. However, larger studies with longer follow-up are needed to exclude any associations.
Associations of Filaggrin Gene Loss-of-Function Variants and Human Papillomavirus-Related Cancer and Pre-Cancer in Danish Adults
Tea Skaaby, Lise Lotte N. Husemoen, Torben J?rgensen, Jeanne D. Johansen, Torkil Menné, Pal B. Szecsi, Steen Stender, Peter Bager, Jacob P. Thyssen, Allan Linneberg
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099437
Abstract: Purpose Filaggrin proteins are expressed in the skin, oral cavity, oesophagus, and cervical mucose. Loss-of-function mutations in the filaggrin gene (FLG) reduce filaggrin expression and cause an impaired skin barrier function. We hypothesized that FLG mutation carriers would be more susceptible to human papillomavirus (HPV) infection and thus a higher risk of HPV-related cancer and pre-cancer. We investigated the association of the FLG genotype with incidence of HPV-related cancer of cervix, vagina, vulva, penis, anus and head and neck, and pre-cancer of the cervix. Methods We included 13,376 persons from four population-based studies conducted in the same background population in Copenhagen, Denmark. Participants were genotyped for the most common FLG mutations in Europeans. Information on cancer was obtained from The Danish Cancer Registry until 11 July 2011. Results There were 489 cases of prevalent and 97 cases of incident HPV-related cancer and pre-cancer (median follow-up 11.5 years). There was a statistically significant association between FLG genotype and incident HPV-related cancer and pre-cancer with a hazard ratio, HR = 2.1 (95% confidence intervals, CI: 1.2, 3.7) for FLG mutation carriers vs. wild types. Conclusions FLG loss-of-function mutations were associated with higher incidence of HPV-related cancers and pre-cancers that are potentially screening and vaccine preventable.
DNA Hairpins as Temperature Switches, Thermometers and Ionic Detectors
Anette Thyssen Jonstrup,Jacob Freds?e,Anni Hangaard Andersen
Sensors , 2013, DOI: 10.3390/s130505937
Abstract: Temperature is of major importance in most branches of science and technology as well as in everyday life, and with the miniaturization of electronic devices and the increasing ability to make research into small-scale systems, a specific need for very small thermostats and thermometers has been created. Here we describe how DNA molecules can be used as nanoscale sensors to meet these requirements. We illustrate how the hybridization kinetics between bases in DNA molecules combined with conformational changes of the DNA backbone can be exploited in the construction of simple but versatile temperature switches and thermometers, which can be built into electronic systems. DNA based sensors are at the same time applicable as ion detectors to monitor the chemical environment of a specific system.
Vitamin D Status, Filaggrin Genotype, and Cardiovascular Risk Factors: A Mendelian Randomization Approach
Tea Skaaby, Lise Lotte Nystrup Husemoen, Torben Martinussen, Jacob P. Thyssen, Michael Melgaard, Betina Heinsb?k Thuesen, Charlotta Pisinger, Torben J?rgensen, Jeanne D. Johansen, Torkil Menné, Berit Carlsen, Pal B. Szecsi, Steen Stender, Runa Vavia Fenger, Mogens Fenger, Allan Linneberg
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057647
Abstract: Background Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a Mendelian randomization approach to estimate the causal effect of vitamin D status on serum lipids, blood pressure, body mass index, waist circumference, and the metabolic syndrome. Methods Three population based studies were included, Monica10 (2,656 individuals aged 40–71 years), Inter99 (6,784 individuals aged 30–60 years), and Health2006 (3,471 individuals aged 18–69 years) conducted in 1993–94, 1999–2001, and 2006–2008, respectively. Participants were genotyped for the two most common filaggrin gene mutations in European descendants R501X and 2282del4, in all three studies and further for the R2447X mutation in the Inter99 and Health2006 studies. Filaggrin genotype was used as instrumental variable for vitamin D status. Baseline measurements of serum 25-hydroxyvitamin D were performed in all three studies. Results Instrumental variable analyses showed a 23.8% (95% confidence interval, CI 3.0, 48.6) higher HDL cholesterol level and a 30.5% (95% CI: 0.8, 51.3) lower serum level of triglycerides per doubling of vitamin D. These associations were, however, not statistically significant when applying the Bonferroni adjusted significance level. The remaining lipids showed non-significant changes in a favorable direction. Doubling of vitamin D gave a non-significantly lower odds ratio = 0.26 (95% CI: 0.06, 1.17) of the metabolic syndrome. There were no statistically significant causal effects of vitamin D status on blood pressure, body mass index, or waist circumference. Conclusion Our results support a causal effect of higher vitamin D status on a more favorable lipid profile, although more studies in other populations are needed to confirm our results.
Miíase primária em coelho doméstico causada por Lucilia eximia (Diptera: Calliphoridae) no Brasil: relato de caso
Moretti, T.C.;Thyssen, P.J.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2006, DOI: 10.1590/S0102-09352006000100005
Abstract: the occurrence of primary myiasis in a domestic rabbit oryctolagus cuniculus (lagomorpha: leporidae) caused by lucilia eximia (diptera: calliphoridae) is reported in an urban area in the city of campinas, s?o paulo, brazil.
A Novel Multilevel Inverter Employing Additive and Subtractive Topology  [PDF]
V. Prasannamoorthy, P. Sundaramoorthi, Merin Jacob
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79209
Abstract: As the demand for high voltage, high power inverters are increasing and there is a problem of connecting a power semiconductor switch directly to a high voltage network. As a part of this the multilevel inverters had been introduced. As a part of this, several researches had been done for the development of multilevel inverters. The commercially available and extensively studied topologies for multilevel voltage output are Neutral Point Clamped (NPC), Cascaded Half Bridge (CHB) and Flying Capacitor (FC) converters. However, with these existing topologies, there is a significant increase in the number of power switches and passive components. Thus it leads to more complex control circuitry and overall cost of the system increase with increase in the output levels. In this paper, a novel multilevel inverter is proposed in which it employs additive and subtractive topology to get higher output levels. This approach significantly reduces the number of power switches needed as compared to existing topology. The present developed multilevel inverter can generate only five voltage levels. With this proposed topology the multilevel inverter can be modified to nine-level inverter. Moreover modified hybrid multicarrier Pulse Width Modulation (PWM) technique can be implemented in the proposed multilevel inverter in order to obtain uniform switch utilization and lower THD. An appropriate modulation scheme is presented and also the proposed concept is analyzed through simulation studies.
Fermi-gas interpretation of the RSOS path representation of the superconformal unitary minimal models
P. Jacob,P. Mathieu
Physics , 2008, DOI: 10.1016/j.nuclphysb.2008.07.004
Abstract: We derive new finitized fermionic characters for the superconformal unitary minimal models by interpreting the RSOS configuration sums as fermi-gas partition functions. This extends to the supersymmetric case the method introduced by Warnaar for the Virasoro unitary mimimal models. The key point in this construction is the proper identification of fermi-type charged particles in terms of the path's peaks. For this, an instrumental preliminary step is the adaptation to the superconformal case of the operator description of the usual RSOS paths introduced recently.
Parafermionic character formulae
P. Jacob,P. Mathieu
Physics , 2000, DOI: 10.1016/S0550-3213(00)00454-5
Abstract: We study various aspects of parafermionic theories such as the precise field content, a description of a basis of states (that is, the counting of independent states in a freely generated highest-weight module) and the explicit expression of the parafermionic singular vectors in completely irreducible modules. This analysis culminates in the presentation of new character formulae for the $Z_N$ parafermionic primary fields. These characters provide novel field theoretical expressions for $\su(2)$ string functions.
Nonlocal operator basis from the path representation of the M(k+1,k+2) and the M(k+1,2k+3) minimal models
P. Jacob,P. Mathieu
Physics , 2008, DOI: 10.1088/1751-8113/41/38/385201
Abstract: We reinterpret a path describing a state in an irreducible module of the unitary minimal model M(k+1,k+2) in terms of a string of charged operators acting on the module's ground-state path. Each such operator acts non-locally on a path. The path characteristics are then translated into a set of conditions on sequences of operators that provide an operator basis. As an application, we re-derive the vacuum finite fermionic character by constructing the generating function of these basis states. These results generalize directly to the M(k+1,2k+3) models, the close relatives of the unitary models in terms of path description.
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