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Search Results: 1 - 10 of 301342 matches for " Jacob J. Reed "
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On the Significance of Cryptography as a Service  [PDF]
Nick Rahimi, Jacob J. Reed, Bidyut Gupta
Journal of Information Security (JIS) , 2018, DOI: 10.4236/jis.2018.94017
Abstract: Cryptography as a service is becoming extremely popular. It eases the way companies deal with securing their information without having to worry about their customer’s information being accessed by someone who should not have access to it. In this overview, we will be taking a closer look at Cryptography as a Service. The ground we will be examining is the effectiveness of it for mobile/wireless and desktop computing. Since we will be looking at something that operates as a service, we will need to first cover the application program interface (API) basics [1] or standard software as a service (SaaS) [2]. Next, what exactly cryptography as a service means for each of the aforementioned platforms. Lastly, other possible solutions and how they compare to CaaS. For the purpose of this review, we will be looking at CaaS in a cloud environment since typical SaaS is used that way. Subsequently most cloud environments utilize a UNIX based operating system or similar solution, which will be the target environment for the purpose of this paper. Popular algorithms that are used in CaaS will be the final part that will be examined on the grounds of how they perform, level of security offered, and usability in CaaS. Upon reading this paper the reader will have a better understanding of how exactly CaaS operates and what it has to offer for mobile, desktop, and wireless users in the present and future.
Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
Cameron G. McCarthy, Robert E. Canale, Rick J. Alleman Jr., Jacob P. Reed and Richard J. Bloomer
Nutrition and Metabolic Insights , 2012, DOI: 10.4137/NMI.S8566
Abstract: Background: We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro in a single dose. We have also noted a reduction in appetite when subjects were treated with this supplement for 14 consecutive days. It is possible that such findings may favor body weight and fat loss over time. Therefore, the purpose of the present study was to determine the effects of this dietary supplement on weight loss and associated markers using an eight week intervention. Methods: Exercise-trained subjects were randomly assigned in double blind manner to ingest either the dietary supplement (n = 16; aged 22.8 ± 0.7) or a placebo (n = 16; 22.5 ± 0.5) every day for eight weeks. Body weight, body composition, skinfold thickness, serum lipids, and appetite were measured as the primary outcome variables. As measures of supplement safety, a complete blood count and comprehensive metabolic panel were performed, and resting heart rate and blood pressure were measured (pre and post intervention). Results: No interactions or main effects were noted for our primary outcome measures (P > 0.05). However, when comparing pre and post intervention values for the supplement, significant decreases were noted in appetite, body weight, body fat percentage, and skinfold thickness (P < 0.05), while increases were noted for total and HDL-C, as well as for resting heart rate (P < 0.05). No changes were noted for placebo from pre to post intervention (P > 0.05), with the exception of an increase in HDL-C (P < 0.05). Blood pressure and bloodborne safety variables were not differently impacted by supplement or placebo (P > 0.05), with the exception of monocytes, for which an interaction effect was noted (P = 0.04). Conclusion: These data indicate that the dietary supplement OxyELITE Pro may assist in weight and body fat loss in a sample of exercise-trained men and women. The supplement does not result in any adverse effects pertaining to resting blood pressure or bloodborne markers of safety; however a small increase in resting heart rate is observed.
Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
Cameron G. McCarthy,Robert E. Canale,Rick J. Alleman Jr.,Jacob P. Reed
Nutrition and Metabolic Insights , 2011,
Abstract:
Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen
Elizabeth R. Sharlow,David Close,Tongying Shun,Stephanie Leimgruber,Robyn Reed,Gabriela Mustata,Peter Wipf,Jacob Johnson,Michael O'Neil,Max Gr?gl,Alan J. Magill,John S. Lazo
PLOS Neglected Tropical Diseases , 2009, DOI: 10.1371/journal.pntd.0000540
Abstract: Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. Rapid expansion in the diversity of available cutaneous leishmanicidal chemotypes is the initial step in finding alternative efficacious treatments. To this end, we combined a low-stringency Leishmania major promastigote growth inhibition assay with a structural computational filtering algorithm. After a rigorous assay validation process, we interrogated ~200,000 unique compounds for L. major promastigote growth inhibition. Using iterative computational filtering of the compounds exhibiting >50% inhibition, we identified 553 structural clusters and 640 compound singletons. Secondary confirmation assays yielded 93 compounds with EC50s ≤ 1 μM, with none of the identified chemotypes being structurally similar to known leishmanicidals and most having favorable in silico predicted bioavailability characteristics. The leishmanicidal activity of a representative subset of 15 chemotypes was confirmed in two independent assay formats, and L. major parasite specificity was demonstrated by assaying against a panel of human cell lines. Thirteen chemotypes inhibited the growth of a L. major axenic amastigote-like population. Murine in vivo efficacy studies using one of the new chemotypes document inhibition of footpad lesion development. These results authenticate that low stringency, large-scale compound screening combined with computational structure filtering can rapidly expand the chemotypes targeting in vitro and in vivo Leishmania growth and viability.
Power-Law Adjusted Failure-Time Models
William J. Reed
Lecture Notes in Engineering and Computer Science , 2012,
Abstract:
Gerber Shiu Function of Markov Modulated Delayed By-Claim Type Risk Model with Random Incomes  [PDF]
G. Shija, M. J. Jacob
Journal of Mathematical Finance (JMF) , 2016, DOI: 10.4236/jmf.2016.64039
Abstract: This paper analyses the Gerber-Shiu penalty function of a Markov modulated risk model with delayed by-claims and random incomes. It is assumed that each main claim will also generate a by-claim and the occurrence of the by-claim may be delayed depending on associated main claim amount. We derive the system of integral equations satisfied by the penalty function of the model. Further, assuming that the premium size is exponentially distributed, an explicit expression for the Laplace transform of the expected discounted penalty function is derived. For a two-state model with exponential claim sizes, we present the explicit formula for the probability of ruin. Finally we numerically illustrate the influence of the initial capital on the ruin probabilities of the risk model using a specific example. An example for the risk model without any external environment is also provided with numerical results.
Light Meter for Measuring Photosynthetically Active Radiation  [PDF]
Alexander Kutschera, Jacob J. Lamb
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.912175
Abstract: Measurement of photosynthetically active radiation (PAR) incident on photosynthetic organisms is a crucial measurement for understanding how organisms respond to various light conditions, and for calculating electron flow through the photosynthetic machinery. Measurements of PAR are typically performed in the region of the electromagnetic spectrum between 400 - 700 nm, which is the region of radiation that is responsible for promoting photosynthesis. Typically, to ensure that the sensor measures in this range, the implementation of long- and short-pass filters is required. Although this allows the exclusion of radiation outside of the PAR region, such filters can be expensive. Additionally, the implementation of autonomous PAR measurements requires costly commercial instruments. Here, a straight-forward, inexpensive apparatus has been designed and constructed using a sensor that can distinguish between red, green, blue and white light. The constructed apparatus was able to perform comparably to a commercial PAR sensor. Furthermore, the implementation of the device to measure PAR intensity over a three-day period shows how the apparatus can be implemented for use as a constant light monitor.
Accessible High-Throughput Virtual Screening Molecular Docking Software for Students and Educators
Reed B. Jacob,Tim Andersen,Owen M. McDougal
PLOS Computational Biology , 2012, DOI: 10.1371/journal.pcbi.1002499
Abstract: We survey low cost high-throughput virtual screening (HTVS) computer programs for instructors who wish to demonstrate molecular docking in their courses. Since HTVS programs are a useful adjunct to the time consuming and expensive wet bench experiments necessary to discover new drug therapies, the topic of molecular docking is core to the instruction of biochemistry and molecular biology. The availability of HTVS programs coupled with decreasing costs and advances in computer hardware have made computational approaches to drug discovery possible at institutional and non-profit budgets. This paper focuses on HTVS programs with graphical user interfaces (GUIs) that use either DOCK or AutoDock for the prediction of DockoMatic, PyRx, DockingServer, and MOLA since their utility has been proven by the research community, they are free or affordable, and the programs operate on a range of computer platforms.
The National Oceanographic Partnership Program: A Decade of Impacts on Oceanography
Cynthia J. Decker,Colin Reed
Oceanography , 2009,
Abstract: The National Oceanographic Partnership Program (NOPP) was created by the Fiscal Year 1997 Defense Authorization Act. It called for the establishment of a partnership program to promote the national goals of assuring national security, advancing economic development, protecting quality of life, and strengthening science education and communication through improved knowledge of the ocean. Fifteen US federal agencies comprise this partnership, which has expended more than $295M over ten years on a variety of activities. NOPP has been a true partnership among equals that has substantially moved the United States forward in the areas of ocean research, operations, technology, education, and natural resource management. NOPP's funding requirements have spurred the ocean research and education communities to develop strong, long-term collaborations among different sectors—academia, government, industry, and nongovernmental organizations. NOPP has allowed agencies to leverage their funds, increasing the impact of individual agency investment and accelerating the agencies' abilities to meet their high-priority goals. This leveraged investment results in more high-priority tasks getting done in the same time period than would occur if each agency were to fund the work individually. The combination of enhanced, effective partnerships among both funders and performers has resulted in accelerated research in some areas and a stronger voice for oceanography in the research and education communities. This article provides a history of NOPP. It also identifies and discusses specific areas in which NOPP involvement and/or influence has led to significant accomplishment, both through funded research and through intellectual stimulation and inspiration.
Traceback of DOS Over Autonomous Systems
Mohammed Alenezi and Martin J Reed
International Journal of Network Security & Its Applications , 2013,
Abstract: Denial of service (DoS) is a significant security threat in open networks such as the Internet. The existing limitations of the Internet protocols and the common availability tools makea DoS attack both effective and easy to launch. There are many different forms of DoS attack and the attack size could be amplified from a single attacker to a distributed attack such as a distributed denial of service (DDoS). IP traceback is one important tool proposed as part of DoS mitigation and a number of traceback techniques have been proposed including probabilistic packet marking (PPM). PPM is a promising technique that can be used to trace the complete path back from a victim to the attacker by encoding of each router's 32-bit IP address in at least one packet of a traffic flow. However, in a network with multiple hops through a number of autonomous systems (AS), as is common with most Internet services, it may be undesirable for every router to contribute to packet marking or for anAS to reveal its internal routing structure. This paper proposes two new efficient autonomous system (AS) traceback techniques to identify the AS of the attacker by probabilistically markingthe packets. Traceback on the AS level has a number of advantagesincluding areduction in the number of bits to be encoded and a reduction in the number of routers that need to participate in the marking. Our results show a better performance comparing to PPM and other techniques.
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