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Search Results: 1 - 10 of 208 matches for " JN Mahlangu "
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Point-of-care estimation of haemoglobin concentration in neonates and infants
E Schapkaitz, JN Mahlangu, M Letsoalo
South African Journal of Child Health , 2012,
Abstract: Objective. The HemoCue is a point-of-care analytical system for haemoglobin concentration (Hb) measurement. Point-of-care testing has been validated in hospitals and outpatient departments to assist with urgent patient management by providing rapid laboratory test results. Method. In this prospective study we compared the analytical performance of the HemoCue with that of the Advia 120 haematology analyser with regard to accuracy, precision and linearity in the measurement of Hb in neonates and infants. Results. Samples from 44 patients were analysed by both instruments and the results compared using difference plots. The mean Hb value for the HemoCue (11.8 g/dl; range 4.8 - 18.7) was comparable to that for the Advia (11.8 g/dl; range 5.2 - 19.2). The Bland-Altman difference plot revealed good agreement. Bias between the two methods was small and the imprecision was within acceptable limits. Hb measurement was linear in the range 4.8 - 20 g/dl. Conclusion. In neonates and infants, the diagnostic accuracy of the HemoCue point-of-care device is comparable with that of the Advia 120 analyser. In neonatal and paediatric units, where the volume of blood available is limited and turnaround time critical, an appropriately quality-assured HemoCue can replace standard haematology analysers in the measurement of Hb.
Point-of-care estimation of haemoglobin concentration in all age groups in clinical practice
E Schapkaitz, J Mahlangu
South African Family Practice , 2011,
Abstract: Background: The measurement of haemoglobin (Hb) concentration provides a reliable, primary screening test for the presence and severity of anaemia. The HemoCue is a point-of-care test for Hb measurement. The introduction of point-of-care testing in hospitals and general practice has improved patient care and accessibility. This study was performed to evaluate the utility of point-of-care Hb measurement with the HemoCue device for the diagnosis of anaemia. Method: In this prospective study, we compared the analytical performance of the HemoCue to the Coulter LH 750 automated haematology analyser with regard to accuracy, precision and linearity in the measurement of Hb in adult and paediatric patient samples, referred for routine laboratory testing. Results: Samples from 100 patients were analysed with both instruments, and the results were compared using standard scatter and difference plots. The mean Hb value of the HemoCue (11.3 g/dl; range 4.6-16.7) was comparable to the Coulter LH 750 (11.3 g/dl; range 4.7-17.2). The Bland-Altman difference plot revealed good correlation. Bias between the two methods was small, and the imprecision was within acceptable limits. Hb measurement was linear in the range of 4.8-20 g/dl. Conclusion: In all age groups, the HemoCue point-of-care device can be used to provide accurate and reliable Hb measurements with a smaller sample volume, improved turnaround time, and long-term cost saving.
A comparative assessment of chemical contaminant removal by three household water treatment filters
TO Mahlangu, BB Mamba, MNB Momba
Water SA , 2012,
Abstract: This study was aimed at modifying the design of, constructing, evaluating and comparing chemical contaminant removal efficiency by, 3 household water treatment filters. The filters were: 1) biosand filter (BSF); 2) the ceramic candle filter (CCF); 3) bucket filter (BF). The filters were evaluated for their efficiency in removal of calcium, magnesium, iron and arsenic, nitrates, phosphates, fluorides, total organic carbon and turbidity, by determining levels of these contaminants in water before and after filtration through the filters. The effects of chlorophyll a concentration(mg/m3) of intake water, as well as the effects of turbidity of intake water, on the flow rates of the filters was quantified and recommendations on the quality of water that could be filtered through these filters were made. Chlorophyll a concentrations in intake water had a positive correlation with the turbidity of the unfiltered water (r = 0.607).The flow rates of the filters were 0.8 /h - 6.48 /h (BSF), 0.05 /h - 2.495 /h (CCF) and 106.5 /h - 160.5 /h (BF). Because of the large particle size materials used in constructing the BF and the design, which caused it to be a rapid sand filter, the biosand filter (BF) was found to have flow rates significantly higher than those of BSF and CCF (p ≥ 0.05). There was no difference in the efficiency of removal of metals (average 40% - 50%) by the filters (p ≥ 0.05), as the same removal mechanisms (straining, ammonification, fixation and adsorption) were believed to be taking place in all of the filters. The CCF removed total organic carbon (TOC) (up to 39%) better than the BSF and BF (p ≤ 0.05). The filters removed turbidity effectively with the BSF having the highest reduction (70%). The average turbidity reduction efficiency was in the order BSF (70%) > BF (51%) > CCF (44%). The BSF, CCF and BF reduced turbidity and other contaminants even after filtering a total cumulative volume greater than 1 000 .
The dilemmas of plastic wastes in a developing economy: Proposals for a sustainable management approach for Ghana
JN Fobil, JN Hogarh
West African Journal of Applied Ecology , 2006,
Abstract: Plastics have been used extensively in both food and water packaging because of their inherent properties such as low bulk densities and inertness that make them convenient carrier materials and low risk contaminants. Plastic bottles and sachets used to package iced water that is sold to people in transit points and in moving vehicles have become widespread in the sub-region. However, the packaging revolution has not been correspondingly backed by appropriate plastic waste management policy, which has left many cities in sub-Sahara Africa littered with plastic wastes; thus, creating disgusting visual nuisances and other public health problems. The paper discusses the experiences, challenges and prospects of plastic waste management schemes in Ghana and proposes a new model of fractional levy and polluter tax system to address this environmental eye sore. It is concluded that the current rate of environmental deterioration is likely to persist unless a long term remedial such as the polluter taxation system is carefully worked into plastic wastes management schemes in the region.
Efficiency of Silver Impregnated Porous Pot (SIPP) Filters for Production of Clean Potable Water
Oranso Mahlangu,Bhekie Mamba,Maggie Momba
International Journal of Environmental Research and Public Health , 2012, DOI: 10.3390/ijerph9093014
Abstract: The Silver Impregnated Porous Pot (SIPP) filter is a product of the Tshwane University of Technology manufactured for the production of safe drinking water at a household (home) level. Two SIPP devices were assessed for the reduction efficiency of chemical contaminants such as calcium, magnesium, iron, arsenic, fluorides and total organic carbon (TOC) as well as microbial contaminants from environmental samples. Turbidity change after filtration, together with correlation between chlorophyll a in the feed water and SIPP’s flow rates were also evaluated in order to give comprehensive guidelines on the quality of intake water that could be filtered through the filter without causing a significant decrease in flow rate. The SIPP filters removed contaminants from environmental water samples as follows: 70% to 92% iron, 36% to 68% calcium, 42% to 82% arsenic, 39% to 98% magnesium, 39% to 95% fluorides, 12% to 35% TOC and 45% to 82% turbidity. The SIPP filters had initial flow rates of 1 L/h to 4 L/h but the flow rates dropped to 0.5 L/h with an increase in cumulative volume of intake water as the filter was used. Turbidity and chemical contaminant reduction rates decreased with accumulating volume of intake water but the filter removed Ca, Fe and Mg to levels that comply with the South African National Standards (SANS 241) and the World Health Organization (WHO) guideline values. However, the SIPP filters cannot produce enough water to satisfy the daily drinking water requirement of a typical household (25 L/p·d). Chlorophyll a was associated with a decrease in the flow rate through the SIPP filters.
Lieux de vente de vin de palme et débats publics : une autre face de l’espace public à Kisangani
JN Lipambala
Africa Development , 2010,
Abstract: A Kisangani, les conditions socio-économiques défavorables poussent certains individus à se défouler dans les lieux de consommation de vin de palme appelé libondo en jargon local. Ces lieux sont devenus des sites où les hommes et les femmes se rencontrent après le marché, le service ou les travaux de champs. Au-delà de la prise du vin de palme dont le co t répond bien à la bourse de chacune d’entre elles, les personnes qui fréquentent ces lieux profitent de l’ambiance qui y règne pour s’exprimer sur les grandes questions de la ville, de la province, du pays voire même de la planète. Car, les bonnes informations, estiment-elles, sont celles qui sont transmises dans de tels endroits. Ainsi, les points de vente de libondo sont devenus à Kisangani des espaces publics où s’organisent les débats et discussions, de fa on spontanée et sans aucune formalité, sur les questions d’actualité. Tout peut donc se dire dans ces sites et il n’existe pas de sujet tabou ni de contrainte sécuritaire. Cela parce qu’on se croit être en face de celui ou de celle avec qui on partage le même niveau de vie et par conséquent les mêmes difficultés. L’on ne devrait donc pas se créer de problèmes ; au contraire on doit considérer ce cadre comme la seule chance où la libre expression est permise.
Editorial: Journal of Surgical Technique and Case Report: Maiden Edition
JN Legbo
Journal of Surgical Technique and Case Report , 2009,
Abstract: No
Evaluation of tafamidis as first-line therapeutic agent for transthyretin familial amyloidotic polyneuropathy
Buxbaum JN
Degenerative Neurological and Neuromuscular Disease , 2012, DOI: http://dx.doi.org/10.2147/DNND.S24624
Abstract: luation of tafamidis as first-line therapeutic agent for transthyretin familial amyloidotic polyneuropathy Review (896) Total Article Views Authors: Buxbaum JN Published Date October 2012 Volume 2012:2 Pages 165 - 173 DOI: http://dx.doi.org/10.2147/DNND.S24624 Received: 25 July 2012 Accepted: 30 August 2012 Published: 23 October 2012 Joel N Buxbaum Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA Abstract: Almost 100 mutations in the human transthyretin (TTR) gene cause the autosomal dominant disorders of familial amyloidotic polyneuropathy (FAP) and familial amyloidotic cardiomyopathy. While these have been clinically classified as separate disorders, the peripheral and autonomic nervous systems and the heart are frequently involved in the same patient. Deposition of amyloid derived from a kinetically or thermodynamically unstable mutant TTR precursor produces an ascending sensorimotor polyneuropathy with marked autonomic involvement. Since 1990, treatment has been liver transplantation from a donor carrying two wild-type TTR genes, providing a crude form of gene therapy. Multiple studies have shown that small molecules fitting in the T4-binding pocket of TTR can stabilize the molecule, reducing its capacity to release the fibril precursor. Tafamidis is the first molecule to be tested in a placebo-controlled trial in patients with TTR-associated FAP. While the trial did not achieve its primary endpoints, it did stabilize TTR in vivo and had a favorable effect on some aspects of disease progression, particularly when administered early in the course. It may represent an alternative to liver transplantation, particularly in patients with early disease related to the V30M mutation. Longer-term studies are required to determine whether it represents a stabilizing or remittive form of treatment.
Meaning and the Second Language Learner
JN Ifechelobi
UJAH: Unizik Journal of Arts and Humanities , 2012,
Abstract: Meaning is about the most elusive and controversial phenomenon in the study of language .The ambiguous nature of meaning is manifest in the fact that in almost any language, one expression can be subject to a number of interpretations depending on the speaker, the hearer and the situation where the expression is used. Meanings are ultimately determined not by words but by people [Hybels and Weaver26]. Most often the second language learner seeks to interpret word meaning without reference to the person who uses it and the community in which it is used. The concern of this paper is to bring out the complexity between meaning and the second language learner, because meaning lies on the interpreter and not on the user of the language.
Teaching and Learning Spanish in the Kenyan multilingual Society: Strengths and Challenges
JN Muasya
Journal of Language, Technology & Entrepreneurship in Africa , 2007,
Abstract: The fact that there are persons who show an interest in learning a foreign language shows that the human person is not satisfied with communicating only with members of his linguistic society. It can be said that he feels the urge to cross physical, social and mental barriers in order to establish interpersonal relations for the purpose of communicating and sharing ideas, sentiments, etc. This interaction results in man's personal growth and of the knowledge of the world around him, and this will in turn work towards bringing about the reality of the global village that modern man is in search of establishing. Journal of Language, Technology and Entrepreneurship in Africa Vol. 1 (1) 2007 pp. 38-54
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