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Search Results: 1 - 10 of 298912 matches for " J.;Coutinho "
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Anopheles (Shannoniezia) costalimai Fonseca e Ramos, 1940, novo nome e a redescri??o da espécie (Diptera-Culicidae)
Coutinho, J. O.;
Memórias do Instituto Oswaldo Cruz , 1943, DOI: 10.1590/S0074-02761943000600016
Abstract: the a. has identified several samples of a. (sh.) costalimai (=limai), working with material from paranaguá, paraná, brazil. he redescribed the species and gave a description of the larvae and pupa. the creators of the species were notified by the a. that the name limai is preoccupied by an identical name given to variety of a. (n.) albitarsis described by galv?o & lane in 1937, and suggested the new name for it, used in this paper. the a. has mantained the subgenus shannoniezia that was brought forth by fonseca and ramos in 1940. in this work the a. discusses the differential diagnosis between a. (sh.) costalimai and a. (sh.) mediopunctatus. he only refers incidently to a. (sh.) costai and does not give his opinion towards validity. he speaks about material with which bonne and bonne-webster worked and he thinks that they worked with more than one species because there is no agreement in their descriptions of specimens of different places.
Contribui??o para o estudo dos vetores de malaria no Brasil: Anopheles (Nyssorhynchus) Darlingi Root, em Campos, no Estado do Rio
Coutinho, J. O.;
Memórias do Instituto Oswaldo Cruz , 1945, DOI: 10.1590/S0074-02761945000100019
Abstract: we met with a. albitarsis, a. darlingi, a. triannulatus, a. oswaldoi, a. noroestensis, a. pessoai and a. intermedius in campos city, rio de janeiro state; indoors catches: darlingi, albitarsis and triannulatus, the last in small numbers in buildings where men and domestic animals cohabitate; as malaria vectors: darlingi (6.8% oocyst-, 4% sporozoit- indices) and albitarsis (2% oocyst, 0% sporozoit-indices). we are reporting a short study of the breeding places and pointing out that darlingi larvae breed in greater water collections, pond and channels as well as in small pools and drainage ditches under open sky. we are presenting a revision of the literature concerned with darlingi as a vector and with the ecology of their larvae.
Biomarkers of diffuse large B-cell lymphoma: impact on diagnosis, treatment, and prognosis
Coutinho R, Gribben J
Current Biomarker Findings , 2013, DOI: http://dx.doi.org/10.2147/CBF.S29208
Abstract: iomarkers of diffuse large B-cell lymphoma: impact on diagnosis, treatment, and prognosis Review (677) Total Article Views Authors: Coutinho R, Gribben J Published Date February 2013 Volume 2013:3 Pages 17 - 34 DOI: http://dx.doi.org/10.2147/CBF.S29208 Received: 01 October 2012 Accepted: 27 November 2012 Published: 01 February 2013 Rita Coutinho, John Gribben Centre for Haemato-Onocology, Barts Cancer Institute, Queen Mary, University of London, London, United Kingdom Abstract: Introduction of immunochemotherapy as frontline treatment for diffuse large B-cell lymphoma (DLBCL) has significantly increased survival. However, patients refractory to rituximab-containing regimens have a very poor survival. These differences in clinical behavior might lie behind the biological heterogeneity well recognized in this disease. Advanced molecular research has helped us to define DLBCL subgroups which harbor distinct oncogenic events and response to immunochemotherapy. The field of biomarker discovery in DLBCL has become more complex over the last decade and a broad up-to-date review on this topic is lacking. The aim for this review was to offer the hematology community a comprehensive overview of clinical and biological markers which have a diagnostic and prognostic potential and that might be amenable to therapeutic targeting. Some well known markers are reassessed in light of recent findings.
Biomarkers of diffuse large B-cell lymphoma: impact on diagnosis, treatment, and prognosis
Coutinho R,Gribben J
Current Biomarker Findings , 2013,
Abstract: Rita Coutinho, John GribbenCentre for Haemato-Onocology, Barts Cancer Institute, Queen Mary, University of London, London, United KingdomAbstract: Introduction of immunochemotherapy as frontline treatment for diffuse large B-cell lymphoma (DLBCL) has significantly increased survival. However, patients refractory to rituximab-containing regimens have a very poor survival. These differences in clinical behavior might lie behind the biological heterogeneity well recognized in this disease. Advanced molecular research has helped us to define DLBCL subgroups which harbor distinct oncogenic events and response to immunochemotherapy. The field of biomarker discovery in DLBCL has become more complex over the last decade and a broad up-to-date review on this topic is lacking. The aim for this review was to offer the hematology community a comprehensive overview of clinical and biological markers which have a diagnostic and prognostic potential and that might be amenable to therapeutic targeting. Some well known markers are reassessed in light of recent findings.Keywords: DLBCL, immunochemotherapy, rituximab, biomarkers
Self-Assembled Dextrin Nanogel as Curcumin Delivery System  [PDF]
Catarina Gon?alves, Paula Pereira, Peter Schellenberg, Paulo J. Coutinho, Francisco M. Gama
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.32024
Abstract: Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.
Replica Real Space Renormalization Group for Spin Glasses
J. R. L. de Almeida,S. Coutinho
Physics , 1993,
Abstract: We construct a real space renormalization group (RG) approach for Ising spin glasses on hypercubic lattices within the scheme of the Migdal-Kadanoff approximation using replicas. Our replica symmetric solution yields results consistent with simple decimation previously obtained and the introduction of breaking of replica symmetry within the RG is discussed, which inserts in a natural fashion non-linear RG into the problem.
Spin-Glass: An Unfinished Story
J. R. L. de Almeida,S. Coutinho
Physics , 1994,
Abstract: In this work a short overview of the development of spin glass theories, mainly long and short range Ising models, are presented.
Strain-induced structure transformations on Si(111) and Ge(111) surfaces: a combined density-functional and scannning tunnneling microscopy report
R. Zhachuk,S. Teys,J. Coutinho
Physics , 2013, DOI: 10.1063/1.4808356
Abstract: Si(111) and Ge(111) surface formation energies were calculated using density functional theory for various biaxial strain states ranging from -0.04 to 0.04, and for a wide set of experimentally observed surface reconstructions: 3x3, 5x5, 7x7 dimer-adatom-stacking fault reconstructions and c(2x8), 2x2 and \sqrt{3}x\sqrt{3} adatoms based surfaces. The calculations are compared with scanning tunneling microscopy data obtained on stepped Si(111) surfaces and on Ge islands grown on a Si(111) substrate. It is shown that the surface structure transformations observed in these strained systems are accounted for by a phase diagram that relates the equilibrium surface structure to the applied strain. The calculated formation energy of the unstrained Si(111)-9x9 dimer-adatom-stacking fault surface is reported for the first time and it is higher than corresponding energies of Si(111)-5x5 and Si(111)-7x7 dimer-adatom-stacking fault surfaces as expected. We predict that the Si(111) surface should adopt a c(2x8) reconstruction when tensile strain is above 0.03.
PRODU O E ESTADO NUTRICIONAL DA SOJA EM FUN O DA CALAGEM
COUTINHO, Edson Luiz Mendes,COUTINHO NETO, André Mendes,ORIOLI JúNIOR, Valdeci,SILVA, Alysson Roberto da
Nucleus , 2008,
Abstract: Tropical soils are acid and, in order to overcome these conditions to grow soybean, lime isnecessary. This experiment evaluated the effects of liming on some soil chemical attributes and on the yield, andnutritional status of soybean, under conventional till. The experiment was carried out on a Eutrustox soil, withthe application of lime at rates of 0 – 2.5 – 5.0 – 7.5 – 10.0, and 12.5 Mg ha-1. The soybean grain yield increasedwith lime levels, and maximum production was obtained at base saturation to approximately 70%. The raising ofsoil pH resulted in significant increments in leaves concentration of N and P, and reduced the contents of Mn andZn. In the plants those plots which did not receive lime, Mg deficiency symptoms were observed, which wereassociated with a 1.7 g kg-1 foliar content. The lime contributed to supply Mg to plants.A maioria dos solos tropicais apresenta alta acidez, requerendo a aplica o de calcário para obterboas produtividades de soja. O objetivo deste trabalho foi estudar os efeitos da calagem no sistema solo-planta ena produtividade da soja cultivada no sistema plantio convencional. O experimento foi conduzido num soloargiloso (Latossolo Vermelho distroférrico), empregando-se as seguintes doses de calcário: 0 – 2,5 – 5,0 – 7,5 –10,0 e 12,5 Mg ha-1. A produtividade de gr os de soja aumentou com a calagem, sendo a produ o mais elevadaobtida com uma satura o por bases ao redor de 70%. Em fun o da eleva o do pH, houve aumento nasconcentra es de N e P e redu o nos teores de Mn e Zn nas folhas. As plantas daquelas parcelas que n oreceberam calcário exibiram sintomas de deficiência de Mg, os quais estavam associados a uma concentra ofoliar de 1,7 g kg-1. O corretivo da acidez atuou também como fornecedor de Mg para as plantas.
PRODU O DE MATéRIA SECA E ESTADO NUTRICIONAL DO RABANETE EM FUN O DA ADUBA O NITROGENADA E POTáSSICA
COUTINHO NETO, André Mendes,ORIOLI JúNIOR, Valdeci,CARDOSO, Saulo Strazeio,COUTINHO, Edson Luiz Mendes
Nucleus , 2010,
Abstract: During a short growing period, the radish forms a large storage organ mass, which requires alarge amount of nutrients, mostly, nitrogen and potassium. Few researches on the effect of fertilizer applicationhave been performed with that crop in Brazil. So, we intended to evaluate, in two soils with very low contents ofpotassium, the effects of the nitrogen and potassium fertilization in the shoot dry matter yield, as well as, theinfluence of that fertilization in the contents of N, K, Ca and Mg in the shoot. A greenhouse experiment wascarried out, being used samples of the soils Quartzipsamment (“Neossolo Quartzarênico – RQ”) and TypicHaplustox (“Latossolo Vermelho – LV”). A completely randomized design in a factorial arrangement 5 x 3 x 2(five rates of nitrogen, three potassium rates, and two soils) was used. Five rates of nitrogen were used ( 30, 60,120, 180, and 240 mg kg-1) and three potassium rates (30, 80, and 120 mg kg-1). The part aboveground of plantswas cut 27 days after sowing. The shoot was weighed, being prepared later and analyzed for N, K, Ca, and Mg.The addition of N and K increased significantly the shoot dry matter of radish, but the nitrogen fertilization onlypresented maxim efficiency when the plants were also supplied with adequate amounts of K. The plantscultivated in LV soil presented a higher production than those of the sandy soil with low cation exchangecapacity - RQ. Symptoms of deficiency of N and K were observed when the plants presented concentrations of those nutrients lower than 29 and 38 g kg-1, respectively. The supply of K reduced the contents of Ca and Mg in the shoot.Durante um curto período de crescimento, o rabanete forma uma grande quantidade de massa noórg o de armazenamento, o qual requer uma grande quantidade de nutrientes, especialmente, nitrogênio epotássio. Em fun o da carência de trabalhos de pesquisa com essa cultura no Brasil, procurou-se avaliar em doissolos, os efeitos da aduba o nitrogenada e potássica na produ o de matéria seca da parte aérea, assim como, ainfluência dessa aduba o nas concentra es de N, K, Ca e Mg na parte aérea. O experimento foi conduzido emcasa de vegeta o, utilizando-se os solos Neossolo Quartzarênico e Latossolo Vermelho distrófico. Oexperimento consistiu de um fatorial 5 x 3 x 2 (cinco doses de nitrogênio, três doses de potássio e dois solos)com três repeti es de tratamentos dispostos em delineamento inteiramente casualizado. Foram utilizadas cincodoses de nitrogênio (30, 60, 120, 180 e 240 mg kg-1) e três doses de potássio (30, 80 e 120 mg kg-1). As plantasforam cortadas r
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