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Search Results: 1 - 10 of 297523 matches for " Jürgen Steinmeyer "
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Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
Jürgen Steinmeyer
Arthritis Research & Therapy , 2000, DOI: 10.1186/ar116
Abstract: With a total of 97 million prescriptions per year in Germany alone, analgesic and anti-rheumatic drugs are the foremost medication in terms of frequency of use. Every day they are taken by more than 30 million people worldwide; of these, 40% of consumers are older than 60. Only 4.5% of the prescriptions are for so-called centrally acting analgesics, namely the opioids. Population studies have shown that 10-20% of all people who are 65 years or older either are currently receiving or have recently received a prescription for nonsteroidal antirheumatic drugs. During the next 20 years the number of people over 65 is expected to increase from 380 million to 600 million. The very frequent use of NSAIDs is based on the fact that these agents have many indications for which a large number of patients exist. These indications include chronic polyarthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, gout, inflammatory soft tissue rheumatism, low back pain, postoperative and post-traumatic inflammation, thrombophlebitis and vasculitis.The history of analgesic and anti-inflammatory substances started with the use of decocted salicylate-containing plants by ancient Greek and Roman physicians. Willow bark was already mentioned in the Corpus Hippocraticum (a collection of medical scripts compiled by Alexandrian scholars in approximately 300 BC) as a substance for treating fever and pain conditions. Over the past 140 years other substances have been introduced for therapy, collectively termed nonsteroidal anti-inflammatory drugs (NSAIDs), after PS Hench discovered the anti-inflammatory properties of glucocorticoids in 1949. NSAIDs, which possess analgesic, anti-inflammatory and antipyretic properties, are a heterogeneous group of substances without any uniform chemical properties (although most are organic acids), but nevertheless share the same therapeutic and side effects. In the past few years there have been significant advances in explaining the mechanism of
Collagen Metabolism of Human Osteoarthritic Articular Cartilage as Modulated by Bovine Collagen Hydrolysates
Saskia Schadow, Hans-Christian Siebert, Günter Lochnit, Jens Kordelle, Markus Rickert, Jürgen Steinmeyer
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053955
Abstract: Destruction of articular cartilage is a characteristic feature of osteoarthritis (OA). Collagen hydrolysates are mixtures of collagen peptides and have gained huge public attention as nutriceuticals used for prophylaxis of OA. Here, we evaluated for the first time whether different bovine collagen hydrolysate preparations indeed modulate the metabolism of collagen and proteoglycans from human OA cartilage explants and determined the chemical composition of oligopeptides representing collagen fragments. Using biophysical techniques, like MALDI-TOF-MS, AFM, and NMR, the molecular weight distribution and aggregation behavior of collagen hydrolysates from bovine origin (CH-Alpha?, Peptan? B 5000, Peptan? B 2000) were determined. To investigate the metabolism of human femoral OA cartilage, explants were obtained during knee replacement surgery. Collagen synthesis of explants as modulated by 0–10 mg/ml collagen hydrolysates was determined using a novel dual radiolabeling procedure. Proteoglycans, NO, PGE2, MMP-1, -3, -13, TIMP-1, collagen type II, and cell viability were determined in explant cultures. Groups of data were analyzed using ANOVA and the Friedman test (n = 5–12). The significance was set to p≤0.05. We found that collagen hydrolysates obtained from different sources varied with respect to the width of molecular weight distribution, average molecular weight, and aggregation behavior. None of the collagen hydrolysates tested stimulated the biosynthesis of collagen. Peptan? B 5000 elevated NO and PGE2 levels significantly but had no effect on collagen or proteoglycan loss. All collagen hydrolysates tested proved not to be cytotoxic. Together, our data demonstrate for the first time that various collagen hydrolysates differ with respect to their chemical composition of collagen fragments as well as by their pharmacological efficacy on human chondrocytes. Our study underscores the importance that each collagen hydrolysate preparation should first demonstrate its pharmacological potential both in vitro and in vivo before being used for both regenerative medicine and prophylaxis of OA.
Vitamin D Analogs Differentially Control Antimicrobial Peptide/“Alarmin”Expression in Psoriasis
Mark Peric, Sarah Koglin, Yvonne Dombrowski, Katrin Gro?, Eva Bradac, Amanda Büchau, Andreas Steinmeyer, Ulrich Zügel, Thomas Ruzicka, Jürgen Schauber
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006340
Abstract: Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory “alarmins” in this chronic skin disease. Vitamin D analogs like calcipotriol have antipsoriatic effects and might mediate this effect by changing AMP expression. In this study, keratinocytes in lesional psoriatic plaques showed decreased expression of the AMPs β-defensin (HBD) 2 and HBD3 after topical treatment with calcipotriol. At the same time, calcipotriol normalized the proinflammatory cytokine milieu and decreased interleukin (IL)-17A, IL-17F and IL-8 transcript abundance in lesional psoriatic skin. In contrast, cathelicidin antimicrobial peptide expression was increased by calcipotriol while psoriasin expression remained unchanged. In cultured human epidermal keratinocytes the effect of different vitamin D analogs on the expression of AMPs was further analyzed. All vitamin D analogs tested blocked IL-17A induced HBD2 expression by increasing IκB-α protein and inhibition of NF-κB signaling. At the same time vitamin D analogs induced cathelicidin through activation of the vitamin D receptor and MEK/ERK signaling. These studies suggest that vitamin D analogs differentially alter AMP expression in lesional psoriatic skin and cultured keratinocytes. Balancing AMP “alarmin” expression might be a novel goal in treatment of chronic inflammatory skin diseases.
Operator Splitting Method for Coupled Problems:Transport and Maxwell Equations  [PDF]
Jürgen Geiser
American Journal of Computational Mathematics (AJCM) , 2011, DOI: 10.4236/ajcm.2011.13019
Abstract: In this article a new approach is considered for implementing operator splitting methods for transport problems, influenced by electric fields. Our motivation came to model PE-CVD (plasma-enhanced chemical vapor deposition) processes, means the flow of species to a gas-phase, which are influenced by an electric field. Such a field we can model by wave equations. The main contributions are to improve the standard discretization schemes of each part of the coupling equation. So we discuss an improvement with implicit Runge- Kutta methods instead of the Yee’s algorithm. Further we balance the solver method between the Maxwell and Transport equation.
Development of a computer vision system to monitor pig locomotion  [PDF]
Jrgen Kongsro
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.33038
Abstract: Avoiding lameness or leg weakness in pig production is crucial to reduce cost, improve animal welfare and meat quality. Detection of lameness detection by the use of vision systems may assist the farmer or breeder to obtain a more accurate and robust measurement of lameness. The paper presents a low-cost vision system for measuring the locomotion of moving pigs based on motion detection, frame-grabbing and multivariate image analysis. The first step is to set up a video system based on web camera technology and choose a test area. Secondly, a motion detection and data storage system are used to build a processing system of video data. The video data are analyzed measuring the properties of each image, stacking them for each animal and then analyze these stacks using multivariate image analysis. The system was able to obtain and decompose information from these stacks, where components could be extracted, representing a particular motion pattern. These components could be used to classify or score animals according to this pattern, which might be an indicator of lameness. However, further improvement is needed with respect to standardization of herding, test area and tracking of animals in order to have a robust system to be used in a farm environment.
The Motley World of “International Values”: Modes of Production on the World Market  [PDF]
Jrgen Sandemose
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.63058
Abstract: I venture to describe the world market from the viewpoint of those different extant modes of production which deliver commodities in “foreign” trade. The world market is, then, understood strictly in its basic feature, as a market for material products, all called commodities. The term “exchange”, which has to be used with some indeterminacy to begin with, is explained in greater detail as I proceed. In this regard, the most important sections are nos. 2 and 3. The term “modes of production” will also be clarified in due place, and primarily in Sections 9 and 10. I find such a concept necessary for an adequate background description of the products which are poured onto any market. I primarily analyze the capitalist mode of production through the concept of intensity of labour (cf. 4 and 9), which plays a main role even in Marx’s theory of the “modifications” of the law of value on the world market. Also, I find what is often labelled “Karl Marx’s theory of international values” to be correct in its foundations, and I will take a point of departure in it—especially apparent in sections 1, 2 and 3. A target for criticism in this article is the modern mainstream theory of “factors of production” in so far as it is found feasible for an analysis of the movements on the world market. This is briefly done in Section 8. In Section 6, I consider David Ricardo’s theory of “comparative advantages” as a counter-example to that theory. I use some terrain to show that the real historical and social background of the economic functioning of the so-called “factors”—capital, land and labour—must be a measuring rod for whether a factor theory is viable or not. To do this, I depend (cf. again Sections 9 and 10) to a high degree of Marx’s theory of those factors considered as forms of organized class forces—a viewpoint which played a central role in his preparing of the three volumes of Capital. While the Marxian theory insofar is adequate, it is also useful in analyzing the aborted or undeveloped state of those modes of production which, beneath the advanced capitalist one, supply the world market with material products. This ought to become clear especially in Sections 10 and 11. As my text expands, I try to show how the said inconsistency in the Ricardian model is based on
On the Exposition of the Transformation of Commodity-Values into Production Prices in the Third Volume of Capital—A Textual Analysis  [PDF]
Jrgen Sandemose
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65098
Abstract: The article is about the exposition of the Karl Marx’s concept of production prices in his main work Capital. It focuses on the structure of the central text in question, Chapter 9 of the third volume, on “transformation [Verwandlung] of commodity-values into production prices”. The actual content and structure of the chapter has to some degree been overlooked or distorted in the literature. The aim of the article is to establish (or re-establish) a sound view of the chapter, freed from prejudices nurtured by—especially—a theory of price formation which, albeit “modernized” by i.a. Walras, dates back to Steuart and Ricardo. These prejudices have had an immense significance for misunderstandings of the Marxian theory of measure of value and standard of prices reflected in the text of the chapter mentioned. For this reason, the article is furnished with an Appendix, underlining the difficult situation for Marxist-minded research today. It should be noted that it is not an objective of the article to discuss any extant interpretation of Marx’s exposition. However, the paradigm of criticism that was introduced early in the 20th century by Ladislaus von Bortkiewicz is used as a perspective. Specific references—other than to Marx’s own texts—are held at a minimum in the article proper. I have chosen such a mode of approach because I find that misunderstandings of the chapter are evenly distributed among authors regardless of how their views on the “transformation” collide. On the other hand, such a consciousness of “misunderstandings” among commentators certainly does imply that the author should at least shortly clarify his own view of the main problems in the paradigmatic criticism mentioned above. In the first section, I point out the importance of Marx’s way of presenting his concept of the composition of capital. In the next, I make some remarks on the concept of the socially necessary labour time and its relation to abstract labour. In the third and fourth, I investigate Marx’s different models of analysis. In the fifth section, it will be shown how Marx, contrary to
Paradoxes, Self-Referentiality, and Hybrid Systems: A Constructive Approach  [PDF]
Jürgen Klüver
Open Journal of Philosophy (OJPP) , 2017, DOI: 10.4236/ojpp.2017.71004
Abstract:
Since the discovery of the paradoxes of self-referentiality or self-reference respectively logicians and mathematicians tried to avoid self-reference when constructing formal systems. Yet “real” complex systems like the mind are characterized by self-reference and can accordingly only be modeled by formal systems that are also basically self-referential. In this article I show that and how self-referential computer programs, understood as algorithmic formal systems, are not only possible but also since some time quite common in special branches of computer science. Examples for this argument are neural networks and so-called hybrid systems, i.e. combination of different sub systems. The hybrid system SOCAIN, a combination of a cellular automaton, a neural network and a genetic algorithm is an example for the fruitfulness of using self-reference in a systematic way. In particular, such systems consist of mutually dependent sub systems, i.e. form no static hierarchy.
POST-TRAUMATIC AND POST-MODERN: A SOUTH AFRICAN “ELECTRA”
E. Steinmeyer
Akroterion , 2012, DOI: 10.7445/54-0-30
Abstract: The ancient myth of Electra seems to be of particular interest to South African writers and playwrights. This article focuses on the adaptation by Mervyn McMurtry, entitled Electra, which was produced in Durban in 2000. The underlying theme of his adaptation, which is based on the four Greek “Electra” tragedies by Aeschylus, Sophocles and Euripides, is the question of truth. This question — an important post-modern one — was of particular relevance for the Truth and Reconciliation Commission (TRC) in South Africa as it tried to deal with the legacy of the former apartheid regime. McMurtry’s play begins with a prologue six days after the matricide, while the actual play is performed as a sort of flashback. All the characters suffer from various symptoms of post-traumatic stress disorder. The chorus consists exclusively of women who all have been victims / survivors of male violence. This article proposes that McMurtry uses the ancient Electra myth to reflect on the situation of contemporary South African society (and particularly women), as it struggles to come to terms with a traumatic past.
Treatment of chronic vulvovaginal candidiasis with posaconazole and ciclopiroxolamine  [PDF]
Hans-Jürgen Tietz
Health (Health) , 2010, DOI: 10.4236/health.2010.26077
Abstract: Therapy of chronic recurrent vulvovaginal can- didiasis (VVC) caused by Candida glabrata is still rare in comparison to C. albicans infection, but therapy remains more difficult. Combination therapy with topical antifungals may improve therapy outcome, but still standard agents as fluconazole or itraconazole often fail. Posaconazole is a new systemic triazole with a wide antifungal spectrum including rare Candida species. Up to now, no clinical trials with posa- conazole in chronic recurrent VVC have been undertaken. Here, first results of the application of a new therapy regimen consisting of oral posaconazole in combination with topical ciclopiroxolamine are presented. 15 patients with chronic recurrent VVC caused by C. glabrata have been treated. 14 of these patients experienced successful therapy, clinical and mycological cure 30 days after begin of therapy has been observed. Long-term results are promising, as in 4 patients clinical and mycologic cure persists for more than 1 year up to now.
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