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Search Results: 1 - 10 of 310323 matches for " Júlio;Piron-Ruiz "
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Estudo retrospectivo do tratamento de leucemia mielóide aguda com o transplante de medula óssea: a experiência brasileira
Hamerschlak, Nelson;Barton, Débora;Pasquini, Ricardo;Sarquis, Yana N.;Ferreira, Eurípedes;Moreira, Frederico R.;Colturato, Vergilio A. R.;Souza, Carmino A.;Voltarelli, Júlio;Piron-Ruiz, Lilian;Setúbal, Daniela C.;Zanichelli, Maria A.;Castro, Cláudio G. de;Bueno, Nadjanara D.;Seber, Adriana;Rotolo, Marco A.;Silla, Lucia M. R.;Bittencourt, Henrique;Souza, Mair P.;Vigorito, Afonso C.;Brandalise, Silvia R.;Maiolino, Angelo;Nucci, Márcio;Coelho, érika;Ostronoff, Maurício;Sim?es, Belinda;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000100005
Abstract: data from the international bone marrow transplant registry (ibmtr) contribute for the improvement of bone marrow transplant (bmt) worldwide. we studied the brazilian experience in bmt for aml to compare this with international data. we performed a retrospective study by sending questionnaires to 16 bmt centers regarding clinical and treatment variables. statistical analyses concerning autologous bmt (autobmt) and allogeneic bmt (allobmt) were performed using the kaplan-meier method and the log-rank test. all p-values were two-tailed. we collected data from 731 patients (205 autobmt and 526 allobmt). median overall survival (os) for autobmt patients was longer than allobmt patients (1035 vs. 466 days, p=0.0012). allobmt stem cell source (scs): 73% bone marrow stem cell (bmsc), 23% peripheral blood stem cells (pbsc) and 4% umbilical cord blood. among the autobmt patients, the scs was 63% pbsc, 22% bmsc and 15% both. the scs did not impact on os. there was no difference in os between different fab classifications in the allobmt group, but in the autobmt the m3 patients had longer survival. as expected, the main cause of mortality among autobmt patients was related to disease relapse (60%), while in the allobmt, to infection (38%). in both groups we found longer os in first complete remission (1cr) compared to second (2cr) and other (p<0.0001), and longer os in de novo aml than in secondary. in the allobmt group we found more patients with advanced disease (60%), while in the autobmt group, we found more m3 patients (24%), which could explain the difference in os. most of our results are in accordance with ibmtr data. one should consider the fact that this is a retrospective study and our findings should be analysed with caution.
Linfoma ocular primário
Zola Paulo A.,Piron-Ruiz Lilian,Ricci Octávio
Revista Brasileira de Hematologia e Hemoterapia , 2000,
Varicela hemorrágica após transplante de medula óssea
Piron-Ruiz Lilian,Góngora-Rúbio Fernando,Rodrigues Renata Z.,Gallo Ana P.
Revista Brasileira de Hematologia e Hemoterapia , 2003,
O transplante de células-tronco hematopoéticas como op??o no tratamento de doen?as n?o hematológicas
Ruiz, Milton A.;Piron-Ruiz, Lilian;Lago, Mario R.;Maset, Angelo;Santos, Adriana B.;Greco, Oswaldo T.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009000700011
Abstract: in this report we discuss data and perspectives of hematopoietic stem cell transplantation in non-hematologic diseases. aspects related to the conditioning regimen and its relationship with toxicity and mortality are also presented. specific autoimmune diseases are discussed, in particular systemic lupus erythematosus, systemic sclerosis, multiple sclerosis and type 1 diabetes mellitus. the aim of the procedure in autoimmune diseases is immune reprogramming. apparently this procedure has indications for diseases in which conventional treatments have failed when organ damage is not definitive, but likely to occur if transplantation is not performed. the most promising method appears to be autologous stem cell transplantation with non-myeloablative conditioning regimens to obtain survival that is estimated at more than 50% for all autoimmune diseases, with low toxicity and no mortality related to transplantation. the controversial results of solid tumor treatment and particularities of breast cancer are also presented. hematopoietic stem cell transplantation is the apparent indication for solid tumors based on intensive treatment with myeloablative doses in order to induce the graft versus tumor effect. the myeloablative conditioning regimens are introduced with the purpose of reducing the toxicity and inducing immunosuppression but the data are insufficient and questionable requiring the introduction of new therapeutic strategies based on cellular and immune therapy.
O G-CSF na terapia do acidente vascular cerebral
Maset, Angelo L.;Piron-Ruiz, Lilian;Greco, Oswaldo T.;Lago, Mario;Poloni, Alana F. C.;Ruiz, Milton A.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000022
Abstract: the granulocyte colony-stimulating-factor (g-csf) is a glycoproteina which has been described for decades, and it is commonly utilized in the treatment of neutropenic states and bone marrow transplants. g-csf stimulates hematopoietic stem-cels e crucially regulates the survival of mature neutrophils through a mechanism of apoptosis inhibition. beyond its systemic effect, recently it has been shown its surprising activity in the central nervous system (cns). g-csf administration mobilizes bone marrow stem cells para systemic blood, and those cells cross the blood-brain-barrier e target brain's damaged area. g-csf's activity in the cns has been defined as multimodal, because additionally it has been demonstrated a direct neuroprotective action through different mechanisms such as antiapoptotic activity, angiogenesis, anti-inflamatory effect, and stimulation of endogenous neurogenesis. this paper sumarizes g-csf action in the cns and approaches its potential para use in stroke.
Bussulfano e melfalano como regime de condicionamento para o transplante autogênico de células-tronco hematopoéticas na leucemia mielóide aguda em primeira remiss?o completa
Bueno, Nadjanara D.;Dulley, Frederico L.;Saboya, Rosaura;Amigo Filho, José U.;Piron-Ruiz, Lílian;Sturaro, Daniel;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000500005
Abstract: twenty-two consecutive patients with acute myeloid leukemia in first complete remission submitted to autologous hematopoietic stem cells transplantation conditioned with busulfan and melphalan were evaluated between 1993 and 2006. the overall survival, according to the kaplan-meier curve, was 57.5% at 36 months, with a "plateau" at 20 months after transplant. factors such as gender, french-american-british (fab) classification of acute myeloid leukemia, induction therapy, intensive consolidation, remission after the first cycle of induction and source of cells had no impact on survival. one patient with poor prognosis before the procedure died a year after transplantation. nine patients died, eight by relapse and one because of bleeding. death before 100 days occurred for two patients, one due to relapse and the other bleeding caused by refractory thrombocytopenia related to the procedure. in conclusion, the conditioning regiment with busulfan and melphalan is a valid option compared to the other conditioning regimens, with an excellent overall survival.
Cancer de pulm?o: histologia, estádio, tratamento e sobrevida
Novaes, Fabiola Trocoli;Cataneo, Daniele Cristina;Ruiz Junior, Raul Lopes;Defaveri, Júlio;Michelin, Odair Carlito;Cataneo, Antonio José Maria;
Jornal Brasileiro de Pneumologia , 2008, DOI: 10.1590/S1806-37132008000800009
Abstract: objective: to analyze principal histological types of lung cancer, as well as the staging, treatment and survival of lung cancer patients. methods: this was a retrospective study based on the analysis of medical charts of patients treated at the botucatu school of medicine hospital das clínicas over a six-year period. results: from january of 2000 to january of 2006, 240 patients with lung cancer, most (64%) of whom were male, were treated. the most common histological type was squamous cell carcinoma (37.5%), followed by adenocarcinoma (30%), neuroendocrine carcinoma (19.6%) and large cell carcinoma (6.6%). only 131 patients (54.6%) were treated. of those, 52 patients (39.7%) received only chemotherapy, 32 (24.4%) were treated with chemotherapy combined with radiotherapy, and 47 (35.9%) were submitted to surgery alone or surgery accompanied by chemotherapy, with or without radiotherapy. only 27 patients (20.6%) were submitted to surgery alone. concerning staging, 34.4% presented stage iv at the time of diagnosis, 20.6% presented stage iiib, 16.8% presented stage iiia, and the remaining 28.2% were classified as stage i or ii. five-year survival was 65% for those in stage i and 25% for those in the remaining stages. conclusions: of the various histological types, the most common was squamous cell carcinoma and the least common was large cell carcinoma. most cases presented advanced stages at the moment of diagnosis, and less than 30% of the cases presented early stages. this accounts for the low survival rate and the small number of patients submitted to surgical treatment alone, the majority being submitted to chemotherapy alone.
Caracterización espacial de la sigatoka amarilla del banano e implicaciones en el muestreo
da Rocha Júnior, Otacílio M.;Saraiva Camara, Marcos P.;Michereff, Sami J.;J. de-Oliveira, Michelle;Mora-Aguilera, Gustavo;Ruiz-García, Noe;
Agrociencia , 2010,
Abstract: yellow sigatoka, caused by the fungus mycosphaerella musicola, is a major disease of banana (musa spp.) and is widely spread in brazil. this study was conducted to apply spatial dispersion criteria of yellow sigatoka in a sampling system to estimate the disease severity in the valley of siriji in northeastern brazil. the disease spatial pattern was characterized in three fields of cv pacovan bananas, where 30 contiguous rows, 30 plants per row were considered, giving a total of 900 plants. severity was analyzed by autocorrelation, lloyd index and geostatistical interpolative maps. in spite of the narrow range of severity among plantations (44.2-34.5 %), they exhibited a moderately to strongly aggregate pattern with continuous spatial dependencies of 2, 14, and 27 order, implicating contagious distances of 81, 42, and 6 m. the aggregates had an elongated predominance in direction of the rows with lateral contagious distances of 39 to 3 m in two of the fields. interpolations evidenced spatial generalization of aggregates, concurring with the low values of the lloyd index (1.01-1.04). systematic sampling was designed with intervals of selection of rows (k1) and plants (k2) of 6 units for a total n = 50, with which the entire production unit was explored, but giving priority to intra-row selection by the aggregative property. this sampling method was applied in an additional 30 i-fields to estimate the sample size using , where k is an estimator of aggregation of the negative binomial distribution and cv the acceptable error. with a 5 % error, ni had a range of 111-6 plants and was inversely proportional to the level of severity. in an epidemiological survey, systematic sampling (k1 =6, k2 = 6) is proposed with a 5 % error and n = 34 plants ha-1 , corresponding to 3.8 % of the population.
Estudo Prospectivo das Características Sonográficas no Diagnóstico de Nódulos Sólidos da Mama
Paulinelli, Régis Resende;Vidal,lio da Silva Rocha;Ruiz, Alessandro Naldi;Moraes, Vardeli Alves de;Bernardes Júnior, Júlio Roberto Macedo;Freitas Júnior, Ruffo de;
Revista Brasileira de Ginecologia e Obstetrícia , 2002, DOI: 10.1590/S0100-72032002000300008
Abstract: purpose: to evaluate, in a prospective way, the importance of ultrasound features of solid breast lesions in the differentiation between benign and malignant lumps. methods: one hundred and forty-two patients with solid breast lesions, from the department of gynecology and obstetrics of the federal university of goias (brazil), were included in the trial. all ultrasound examinations were performed by a training doctor, always supervised by an experienced professional. the characteristics of the lesions studied were: shape, retrotumoral echoes, internal echoes, oriented diameter, halo of bright echoes and cooper ligaments. each of the ultrasound features was compared to the results of the histological examination. results: among the 142 patients included in the trial, 90 (63%) had their lesions excised, and 77 (86%) had pathologic diagnoses of benign tumors and 13 (14%) of malignant tumors. the following characteristics were statistically significant in the diagnosis of the breast cancer (c2): masses with retrotumoral shadowing (p=0.0001), irregular shape (p=0.0007), heterogeneous internal echoes (p=0.0015) and vertically oriented - taller than wide (p<0.0001). the presence of halo of bright echoes anterior to the lump and the presence of wider cooper ligaments were not related to the correct diagnosis of malignancy in this trial. conclusion: ultrasound is a diagnostic method that can help physicians between the differentiation of benign and malignant breast lumps. the presence of retrotumoral shadowing, irregular shape, heterogeneous internal echoes and vertical orientation - lesions taller than wide - were related to the pathologic diagnosis of breast malignancies.
Condroma pulmonar isolado: caso incompleto da tríade de Carney?
Ruiz Júnior, Raul Lopes;Defaveri, Júlio;Cataneo, Antonio José Maria;Silva, Rogério Cardoso da;Ribeiro, Sérgio Marrone;Barros, Cristiano Ventorim de;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000400014
Abstract: a 45-year-old man presented with recurrent pulmonary infection for four years, cough, bloody sputum, yellowish excretion and nonpleuritic chest pain. tomography of the chest revealed a calcified nodule occluding the right lower lobe bronchus. a right lower and middle lobectomy was performed, and the histopathological examination of the bronchi revealed chondroma, a rare pulmonary tumor usually associated with the carney triad (pulmonary chondroma, gastric leiomyosarcoma and extra-adrenal paraganglioma), being the less common of the three components. in the present case, the other two components of the triad were not observed. since these components may appear years later, long-term follow-up care is necessary.
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