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Search Results: 1 - 10 of 1846 matches for " Ivvala Anand Shaker "
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Ivvala Anand Shaker1, Sailaja Inampudi2
International Journal of Bioassays , 2012,
Abstract: The In vitro antimicrobial activity of Cassia auriculata leaf extracts has been investigated against S. aureus, E. coli, K. pneumoniae, shigella and S. typhi. The fresh and methanol extracts Cassia auriculata showed high activity against nearly all test micro organisms. The zones of inhibition of extracts are very close and identical in magnitude and are comparable with that of standard antibiotic used.
G Raja1, Ivvala Anand Shaker1, Inampudi
International Journal of Bioassays , 2012,
Abstract: Juglans regia L. (Walnut) is the most widespread tree nut in the world. Nuts are used by mankind for food, edible oils, spices, condiments or beverages. They have been an important food source from prehistoric times and are among the most nutritionally concentrated of human foods, high in protein, oil, energy, minerals and vitamins. Nuts that are only rarely used as famine food have been excluded from this present study partly because of the paucity information available but mainly because they are not normally considered edible. Nuts used solely for spices or condiments have also been largely excluded since they are used sparingly, to flavor food and not as a food; traditionally they are considered separately from edible nuts. Nuts that are largely used as commercial sources of edible oil are not discussed in any great detail since they are already adequately dealt with in the literature. Present study is an attempt to determine the amount of biomolecules, mineral and vitamins present in nuts extract of Juglans regia L. The study was set up to determine the quantity of biomolecules, mineral and vitamins present in nuts extract of Juglans regia L. using various analytical models. Total carbohydrates, total protein, alkaloids, phosphorus, Iron, vitamin C, E and catalase activity of nuts extract of Juglans regia L. were determined using various biochemical experimental models. The nutritional analyses of nuts extract of Juglans regia L. were determined in different experimental models and it was observed that presence of the test compounds in all the models.
Extensively drug resistant tuberculosis (XDR-TB):A potential threat
Anaga Marwar,Nanadal,Ivvala Anand Shaker,Hemraz Palawan
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: Emergence of extensively drug resistant tuberculosis (XDR-TB) has been reported by more than 55 countries. XDR-TB is considered as untreatable and highly fatal disease. In developing countries like India, number of cases of multi-drug resistant tuberculosis (MDR-TB) and XDR-TB are increasing. Emergence of resistance to Isoniazid and Rifampicin, the two most effective and well tolerated agents, coupledwith resistance to second line agents pose limited treatment options for XDR-TB. The present minireview provides information about the seriousness of XDR-TB and the drugs available for its treatment. Although considered a fatal disorder, judicious use of combination of drugs, retaining their antimycobacterial activity, can improve theclinical outcome of XDR-TB. Only such an approach can provide some hope for the patients of XDR-TB.
Detection of inducible clindamycin resistance among clinical isolates of staphylococci from a rural tertiary care hospital
Makam Sri Rangakumar Manjunath, Vijaya Rayapu, Dhandapany Senthil Pragash, Ivvala Anand Shaker, Sandeep Kasukurthy
International Journal of Medical Research and Health Sciences , 2013, DOI: 10.5958/j.2319-5886.2.2.026
Abstract: Clindamycin has been used successfully to treat pneumonia and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. However, Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to Macrolide, Lincosamine and Streptogramin antibiotics. A total of 96 staphylococcal isolates from different clinical specimens were tested for inducible clindamycin resistance by the disk-diffusion induction test. Inducible clindamycin resistance was detected in 47.22% of methicillin-resistant Staphylococcus aureus isolates and in 21.67% of methicillin-sensitive Staphylococcus aureus isolates. In our setting, clindamycin is safe and effective agent to treat both systemic sand localized Staphylococcal infections, but we recommend that staphylococci isolates, particularly methicillin-resistant Staphylococcus aureus
G Raja, Ivvala Anand Shaker,Inampudi sailaja,R Swaminathan,S Saleem Basha,Kondaveeti Sureshbabu
International Journal of Bioassays , 2012,
Abstract: Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as lipid oxidative rancidity in foods. The role of antioxidants has protected effect against free radical damage that may cause many diseases including cancer. Primary sources of naturally occurring antioxidants are known as whole grains, fruits, and vegetables. Several studies suggest that regular consumption of nuts, mostly walnuts, may have beneficial effects against oxidative stress mediated diseases such as cardiovascular disease and cancer. The role of antioxidants has attracted much interest with respect to their protective effect against free radical damage that may cause many diseases including cancer. Juglans regia L. (walnut) contains antioxidant compounds, which are thought to contribute to their biological properties. Polyphenols, flavonoids and flavonols concentrations and antioxidant activity of Leaves, Stems and Nuts extract of Juglans regia L. as evaluated using DPPH, ABTS, Nitric acid, hydroxyl and superoxide radical scavenging activity, lipid peroxidation and total oxidation activity were determined. The antioxidant activities of Leaves, Stems and Nuts extract of Juglans regia L. were concentration dependent in different experimental models and it was observed that free radicals were scavenged by the test compounds in all the models.
Ivvala Anand Shaker1*, Sailaja Inampudi2, Vijaya Rayapu1
International Journal of Bioassays , 2012,
Abstract: The in vitro antimicrobial activity of Tabernaemontana coronaria leaf Fresh and Methanolic extracts has been investigated against E. coli, K. pneumonia, S. typhimurium, S. flexneri and S. aureus. The fresh and methanolic extract of Tabernaemontana coronaria showed activity against nearly all the test microorganisms. The inhibitory activities of methanolic extracts are highly significant in magnitude when compared with that of standard antibiotic used.
N Kannan*, R Aravind Kumar, Ramapraba P, P Naveen, Ivvala Anand Shaker
International Journal of Bioassays , 2013,
Abstract: Menstrual cycle is a physiological process that occurs in women. It is characterized by periodic vaginal bleeding due to shedding of uterine mucosa. This has its own effect on various systems and metabolisms. This study was attempted to understand the variations in hematological and respiratory parameters in different phases of menstrual cycle. The present study was conducted on 50 healthy female volunteers within the age group of 18 to 23 years having regular menstrual cycle of 28±3 days from the rural area of Chennai, South India. We analyzed various hematological parameters and pulmonary function parameters on three different phases of menstrual cycle (Menstrual phase-2nd day, Proliferative phase -12th day & Secretory phase-22nd day). The study reveals that there is an increase in total leucocyte count, absolute eosinophil count, and platelet count in secretory phase (P< 0.001). Neutrophil count is increased in secretory phase, when compared to proliferative phase and menstrual phase. There was a marked increase in lymphocyte count in all the three phases. No significant changes in eosinophil, monocyte, basophil counts (p<0.005).In Pulmonary function test parameters PEFR has not shown any significant difference. FEV1 and FVC were increased in mid secretory phase, FEV1/FVC ratio is higher in mid Secretory phase. This study was a moderate attempt to determine regular variations in different hematological and pulmonary function parameters, during different phases of menstrual cycle in normal healthy females and evaluate various conflicting reports on female subjects.
Suresh Babu Kondaveeti, Ivvala Anand Shaker, Aravind Kumar R, Hemraz Palwan, Raja G
International Journal of Bioassays , 2012,
Abstract: Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. An early intervention to normalize circulating lipids shown to reduce cardiovascular complications and mortality. Now a day’s Glycated albumin (GA) is a routinely used marker for short-term glycemic control. This investigation is an attempt to evaluate the association between GA and various lipid parameters. Venous blood samples collected from 100 type-2 diabetic patients (46 males, 44 females) and serum analyzed for GA, Fasting blood glucose, Total Cholesterol, Triacylglycerols, HDL-C and LDL-C. L/H risk ratio is also calculated. The levels of GA (%) did not differ significantly between males (8.51 ± 1.17) and females (8.24 ± 1.89), whereas male patients had higher mean values of FBG and various lipid parameters than in females. Patients with GA value >17.0 % showed direct and significant correlation with FBG, TC, LDL-C, L/H risk ratio as compared to patients with GA ≤ 17.0%. There was no significant difference in TG, HDL-C between two groups of glycated albumin. These findings indicate that GA is utilized for screening high risk diabetic patients for early diagnosis of dyslipidemia and timely intervention with lipid lowering drugs.
Kondaveeti Suresh Babu,Ivvala Anand Shaker,Dabburu Kumaraswamy,S.Saleem Basha
International Research Journal of Pharmacy , 2012,
Abstract: Cynodon dactylon is a perinneal grass,the plant is a rich source of metabolites such as proteins,carbohydrates mineral constituents, β-sitosterols, flavinoids, alkaloids, glycosides and triterpenoids the plant has been long used in traditional medicines to treat various alignments it also has antiviral and antimicrobial properties but none has proved its efficacy in evaluating gastro protective activity so we had made an attempt to evaluate the gastroprotective effect of extract of Cynodon dactylon in albino rats. The experiment was set up using male albino wistar rats weighing 150-180gms. These were further divided evenly into different treatment groups. The extract of Cynodon dactylon was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 100,200, 300mg/kg body weight. Histopathological assessment of rat stomach was carried out. A significant reduction (p<0.01) in ulcer index was seen in Cynodon dactylon extract treated rats of pylorus ligation, aspirin induced and ethanol induced gastric ulcer models. The gastroprotective effect was further confirmed by histopathological examination of rat stomach. Thus the present study concludes the Cynodon dactylon extract having potential gastroprotective effect in the three models tested.
Vinod Raveendran1, Dhandapany Senthil Pragash*2, Manju3, Ivvala Anand Shaker4, Vijaya Rayapu2
International Journal of Bioassays , 2012,
Abstract: Rubella is a mild self limiting vaccine preventable viral disease. Maternal Rubella infection during first trimester of pregnancy leads to abortion, still birth and Congenital Rubella Syndrome. Seroepidemiological studies conducted in different countries have shown that Rubella is a worldwide infection. The present study was conducted to assess the immunity status to Rubella among pregnant women in and around Kirumampakkam, Puducherry for a period of one year. A detailed history with special reference for previous bad obstetric history was collected after an informed consent. They were tested for Rubella IgG and IgM antibodies using commercially available kits. Overall seropositivity was 87.9% and 12% were susceptible to Rubella infection. 6.5% were positive to Rubella specific IgM antibodies. Percentage of seropositivity was seen to be increasing with age. The percentage of IgG negatives was higher among the cases with bad obstetric history. Cases from lower socioeconomic status had good immunity against Rubella. All the cases that had previous immunization record were positive for Rubella specific IgG antibodies. In conclusion, an action revamping the national immunization policy should be considered along with sero-surveillance of Rubella among adolescent girls and women of childbearing age before conception for the assessment and analysis of the situation, and take appropriate action to eradicate Rubella.
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