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Search Results: 1 - 10 of 23091 matches for " Itamar Romano Garcia;Festa Neto "
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Genética molecular aplicada ao cancer cutaneo n?o melanoma
Martinez, Marcos Antonio Rodrigues;Francisco, Guilherme;Cabral, Luciana Sanches;Ruiz, Itamar Romano Garcia;Festa Neto, Cyro;
Anais Brasileiros de Dermatologia , 2006, DOI: 10.1590/S0365-05962006000500003
Abstract: non-melanoma skin cancers are the most common malignant neoplasms in humans. about 95% of all non-melanoma skin cancers are represented by basal cell carcinoma and squamous cell carcinoma. their prevalences are still increasing worldwide, representing an important public health problem. the genetic alterations underlying basal cell carcinoma and squamous cell carcinoma development are only partly understood. much interest lies in determining the genetic basis of non-melanoma skin cancers, to explain their distinctive phenotypes, biological behaviors and metastatic potential. we present here a molecular genetic update, focusing on the most frequent genes and genomic instability involved in the development and progression of non-melanoma skin cancers.
Genomic instability in human actinic keratosis and squamous cell carcinoma
Cabral, Luciana Sanches;Festa Neto, Cyro;Sanches Jr, José A.;Ruiz, Itamar R. G.;
Clinics , 2011, DOI: 10.1590/S1807-59322011000400001
Abstract: objective: to compare the repetitive dna patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. introduction: cancer cells are prone to genomic instability, which is often due to dna polymerase slippage during the replication of repetitive dna and to mutations in the dna repair genes. the progression of benign actinic keratoses to malignant squamous cell carcinomas has been proposed by several authors. material and methods: eight actinic keratoses and 24 squamous cell carcinomas (scc), which were pair-matched to adjacent skin tissues and/or leucocytes, were studied. the presence of microsatellite instability (msi) and the loss of heterozygosity (loh) in chromosomes 6 and 9 were investigated using nine pcr primer pairs. random amplified polymorphic dna patterns were also evaluated using eight primers. results: msi was detected in two (d6s251, d9s50) of the eight actinic keratosis patients. among the 8 patients who had squamous cell carcinoma-i and provided informative results, a single patient exhibited two loh (d6s251, d9s287) and two instances of msi (d9s180, d9s280). two loh and one example of msi (d6s251) were detected in three out of the 10 patients with squamous cell carcinoma-ii. among the four patients with squamous cell carcinoma-iii, one patient displayed three msis (d6s251, d6s252, and d9s180) and another patient exhibited an msi (d9s280). the altered random amplified polymorphic dna ranged from 70% actinic keratoses, 76% squamous cell carcinoma-i, and 90% squamous cell carcinoma-ii, to 100% squamous cell carcinoma-iii. discussion: the increased levels of alterations in the microsatellites, particularly in d6s251, and the random amplified polymorphic dna fingerprints were statistically significant in squamous cell carcinomas, compared with actinic keratoses. conclusion: the overall alterations that were observed in the repetitive dna of actinic keratoses and s
Prognostic factors correlation between the cell cycle phases and apoptosis in basal cell carcinoma  [PDF]
Cyro Festa-Neto, Durvanei Augusto Maria
Open Journal of Internal Medicine (OJIM) , 2011, DOI: 10.4236/ojim.2011.13019
Abstract: Basal cell carcinoma (BCC) is the most common skin malignancy, are found in various forms depending on their clinical and biological behavior. The objective of study was analyzed the phases of the cell cycle and correlations between BCC of low and high risk of recurrence and correlation prognostic factors. The quantity of content DNA in tissues of normal skin, showed small amount of cells in apoptosis and mostly in phase quiescent and rare aneuploidy cells. In BCC, apoptosis was higher in the BCC at high risk than low risk, probably due to their high rates of cell proliferation, and present of aneuploidy cells, when compared to the average percentage of aneuploidy. The DNA content from cells of normal skin shows that the majority is in the quiescent phase; compatible with tissues that are is refreshing. There is presence of apoptosis in the epidermis by probable normal process of differentiation. The aneuploidy in BCC showed a direct correlation with the degree of tumor aggressiveness.
Tratamento tópico do carcinoma basocelular superficial e nodular pelo imiquimod creme a 5%: observa??o de 10 casos
Festa Neto, Cyro;
Anais Brasileiros de Dermatologia , 2002, DOI: 10.1590/S0365-05962002000600006
Abstract: background: topical treatment with 5% imiquimod cream has been demonstrated to be effective in patients with basal cell carcinoma. objectives: in the present study, efficacy and tolerability of this treatment was analyzed in 10 patients with 13 different types of superficial and nodular basal cell carcinomas. methods: imiquimod cream was applied daily for a mean period of 23 days. results and conclusions: all patients responded favorably to the drug with healing of the lesions. no recurrence was observed during two to three months of follow up.
Inpatient dermatological consultations in a university hospital
Mancusi, Suzana;Festa Neto, Cyro;
Clinics , 2010, DOI: 10.1590/S1807-59322010000900007
Abstract: introduction: dermatology is primarily an outpatient specialty, but it also plays an important role in the care of inpatients. methods: we conducted a prospective study that recorded data from inpatient dermatology consultation request forms over a period of four months. the study evaluated 313 requests that led to 566 visits, 86 biopsies, 35 laboratory exams, 41 direct microscopic studies, 18 direct immunofluorescence analyses, 14 skin cultures and a few other exams. results: the most frequent requesting service was internal medicine (24%), followed by neurology (12%), cardiology (11%), infectious diseases and pediatrics (8% each) and psychiatry and general surgery (6% each). the most frequent diagnostic groups were infectious diseases (25%, divided into fungal infections (13%), bacterial infections (7%) and viral infections (5%)), eczemas (15%) and drug reactions (14%). to our knowledge, this is the first study to attempt to evaluate the impact of the consultations by asking multiple-choice questions that were analyzed by the authors. in 31% of the cases, the consultation was considered extremely relevant because it aided in managing the disease that led to admission or treated a potentially severe dermatological disease. in 58% of the cases, the consultation was considered important because it facilitated diagnosis and/or treatment of a dermatological disease that was unrelated to the reason for admission.
Oral Manifestations, Gingival Index and Dental State of Vesiculobullous Diseases  [PDF]
Sergio Eduardo Migliorini, Vanessa Gallego Arias Pecorari, Marcio Zaffalon Casati, Claudia Giuli Santi, Cyro Festa Neto, Luciano Lauria Dib
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.95035
Abstract: Objective: To determine the occurrence of oral manifestations, gingival index, dental state and associated therapeutic aspects in patients with vesiculobullous diseases. Study design: Prospective and observational study conducted with 69 patients from May 2013 to May 2014 at the Dermatology Outpatient Clinic of the Clinical Hospital, University of São Paulo Medical School, Brazil. Data were analyzed for frequency in absolute values, percentage and correlation using the Chi-square test. Results: 84.1% of the patients had oral manifestations of vesiculobullous diseases (p = 0.001); 25% had gingival lesions; 18.2% had lesions in the buccal mucosa, and 17.6% in the lips, with no correlation between the location and the type of disease (p = 0.990). Among all patients with bullous pemphigoid, linear IgA dermatosis, and mucous membrane pemphigoid, 59 (93.6%) patients had gingival inflammation of dental origin but without significant correlation (p = 0.42). There was correlation between pemphigus vulgaris and periodontal disease (p = 0.05). Conclusion: Gingival inflammation seems to interfere negatively with the clinical course of these diseases. Further studies should be conducted to better clarify the interrelations between dental and gingival state, and between vesiculobullous diseases and oral involvement.
Terapia fotodinamica em dermatologia: princípios básicos e aplica??es
Torezan, Luís;Niwa, Ane Beatriz Mautari;Festa Neto, Cyro;
Anais Brasileiros de Dermatologia , 2009, DOI: 10.1590/S0365-05962009000500002
Abstract: photodynamic therapy involves the administration of a photosensitizing drug and its subsequent activation by light at wavelengths matching the absorption spectrum of the photosensitizer. currently, topical photodynamic therapy has received approval for the treatment of cutaneous oncologic conditions such as actinic keratoses, bowen’s disease and superficial basal cell carcinoma in many countries in the world. multicenter randomized controlled studies have demonstrated high efficacy and superior cosmetic outcome over standard therapies. for many non-oncologic dermatological diseases such as acne vulgaris, viral warts and localized scleroderma, case reports and small series have confirmed the potential of photodynamic therapy. after the development of topical photosensitizers 5-aminolevulinic acid (ala) or its methyl ester (mal), photodynamic therapy has gained worldwide popularity in dermatology, as these drugs do not induce prolonged phototoxicity as the systemic photosensitizing hematoporphyrin derivatives do. the production of reactive oxygen intermediates such as singlet oxygen depends on the concentration and localization of the photosensitizer in the diseased tissue as well as the applied light dose. either incoherent lamps or led arrays are suitable for the cytotoxic effects resulting in tumor destruction or immunomodulatory effects improving inflammatory condition.
Fatores preditivos do maior número de estádios na cirurgia micrográfica de Mohs para o tratamento do carcinoma espinocelular da cabe?a
Terzian, Luiz Roberto;Festa Neto, Cyro;Pimentel, Eugênio Raul de Almeida;
Anais Brasileiros de Dermatologia , 2008, DOI: 10.1590/S0365-05962008000300005
Abstract: background: squamous cell carcinomas of the skin of the head are better treated with mohs micrographic surgery which has the lowest recurrence rates and allows spare normal tissue. there are some characteristics of squamous cell carcinoma that can be related to a higher number of surgical stages. objective: to study characteristic of head squamous cell carcinoma that predicts a higher number of mohs surgical stages. methods: a retrospective analysis of 51 squamous cell carcinomas of the head treated with mohs surgery was performed to determine risk factors for a higher number of surgical stages. the characteristics analyzed were clinical limits, morphology, recurrence, histological differentiation and size and compared to the number of surgical stages. the analysis was performed by fisher's exact test and multivariate logistic regression. results: the recurrent squamous cell carcinomas showed a tendency for a higher number of stages (p=0,081). the odds ratio for a higher number of mohs stages was three for inaccurate limits; although not statistically significant,it corroborates clinical and previous publication. conclusion: clinical characteristics of squamous cell carcinoma as recurrence and inaccurate limits would not predict, but could indicate tendency of a higher number of mohs micrographic surgery stages.
Aspectos clínicos da epidermodisplasia verruciforme
Oliveira, Walmar Roncalli Pereira de;Festa Neto, Cyro;Tyring, Stephen K;
Anais Brasileiros de Dermatologia , 2002, DOI: 10.1590/S0365-05962002000500004
Abstract: background: epidermodysplasia verruciformis (ev) is a rare genodermatosis characterized by disseminated infection caused by specific types of human papillomavirus (hpv), development of cutaneous malignant tumors and immunological disturbances. objective: to correlate the clinical features of a group of 13 patients with ev aiming to contribute to knowledge of disease. method: the clinical evaluation of 13 ev patients during 3 years. the clinical diagnosis was confirmed by histopathological and immunohistochemical findings. results: the ev began in childhood with flat warts and/or erithematous macules on the face and neck. the parental consanguinity was observed in most patients (12/13). clinically the lesions were highly polymorphic with flat wart-like lesions, pityriasis versicolor-like lesions, erithematous macules and seborrheic keratoses-like lesions. the malignant conversion of lesions occured in 8 patients (62%). the tumor growth provoked heavy tissue loss in 50% of patients, and metastatic tumors caused death in 25%. conclusion: the ev presents high familial incidence and an autosomal recessive mode of inheritance. the high polymorphism clinical doesn't affect the scalp and mucous membrane. the most frequent clinical manifestation is the "malignant" (62%), followed by "benignant" (23%) and "mixed"(15%). the cutaneous tumors are frequent, multiple, destructive, metastasize and cause death.
Processos linfoproliferativos da pele: parte 2 - linfomas cutaneos de células T e de células NK
Sanches Jr, José Antonio;Moricz, Claudia Zavaloni M. de;Festa Neto, Cyro;
Anais Brasileiros de Dermatologia , 2006, DOI: 10.1590/S0365-05962006000100002
Abstract: the cutaneous nkt/cell lymphomas are a group of extranodal lymphoproliferative disorders currently classified and subdivided based on their clinical behavior, according to a consensus reached between the world health organization and the european organization for research and treatment of cancer. the cutaneous nkt/cell lymphomas of indolent clinical behavior comprise the classical mycosis fungoides, folliculotropic mycosis fungoides, pagetoid reticulosis, granulomatous slack skin, primary cutaneous anaplastic large cell lymphoma, lymphomatoid papulosis, subcutaneous panniculitis-like t-cell lymphoma and primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma. the aggressive clinical behavior cutaneous nkt/cell lymphomas include sézary syndrome, extranodal nk/t-cell lymphoma, nasal type, primary cutaneous aggressive epidermotropic cd8+t-cell lymphoma, cutaneous gamma-delta t-cell lymphoma and primary cutaneous peripheral t-cell lymphoma, unspecified. the adult t-cell leukemia lymphoma and cd4+ cd56+ hematodermic neoplasm are considered systemic lymphomas but are addressed in this article for their initial cutaneous manifestations in a significant number of patients. the diagnosis of these processes is based on histological examination complemented by phenotypic analysis of neoplastic cells, which is essential for classification. the recommended staging is based on type and extension of cutaneous involvement, clinical conditions and histological examination of lymph nodes and organs. hematological assessment is fundamental to characterize sézary syndrome. the recommended therapies include exclusively cutaneous treatment, biological response modifiers and systemic chemotherapy.
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