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Search Results: 1 - 10 of 600 matches for " Iska Moxon-Emre "
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The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro
Lyanne C Schlichter, Vikas Kaushal, Iska Moxon-Emre, Vishanthan Sivagnanam, Catherine Vincent
Journal of Neuroinflammation , 2010, DOI: 10.1186/1742-2094-7-4
Abstract: KCNN3 mRNA (real-time RT-PCR) and SK3 immunoreactivity were examined in rat microglia. Lipopolysaccharide was then used to activate microglia (monitored by iNOS, nitric oxide, activation of NF-κB and p38 MAPK) and transform them to a neurotoxic state. Microglia-mediated neuron damage (TUNEL, activated caspase 3) and nitrotyrosine levels were quantified using a two-chamber system that allowed microglia to be treated with channel blockers, washed and then added to neuron/astrocyte cultures. Contributions of SK3 to these processes were discriminated using a subtractive pharmacological approach with apamin and tamapin. ANOVA and post-hoc tests were used to assess the statistical significance of differences between treatment groups. SK3 immunoreactivity was then compared in the normal and damaged adult rat striatum, by injecting collagenase (a hemorrhagic stroke) or endothelin-1 (a transient ischemic stroke).KCNN3 mRNA was prevalent in cultured microglia and increased after lipopolysaccharide-induced activation; SK3 channel blockade inhibited microglial activation and reduced their ability to kill neurons. SK3 immunoreactivity was prevalent in cultured microglia and throughout the adult rat striatum (except white matter tracts). After strokes, SK3 was highly expressed in activated microglia/macrophages within the lesions, but reduced in other cells.SK3 is expressed in microglia in both the healthy and damaged adult striatum, and mechanistic in vitro studies show it contributes to transformation of microglia to an activated neurotoxic phenotype. Thus, SK3 might be a therapeutic target for reducing inflammation-mediated acute CNS damage. Moreover, its roles in microglia must be considered when targeting this channel for CNS diseases, disorders and reducing neuron hyper-excitability.After acute CNS injuries such as stroke or trauma, there is a prolonged inflammatory response involving microglial activation and infiltration of macrophages and neutrophils, which has the poten
Assessment of Vertical Magnetic Gradient Data of Tuzla Fault Using Boundary Analysis and 3-D Inversion Techniques  [PDF]
Emre Timur
Journal of Power and Energy Engineering (JPEE) , 2017, DOI: 10.4236/jpee.2017.512006
Abstract: The magnetic prospection is one of the most useful methods to determine buried geological structures such as shallow fracture zones. The investigation of vertical and horizontal gradient and total magnetic field variations over geological structures, which have been used for many years, may reveal their locations, geometries and physical characteristics. In this study, a proposed iterative 3-D rectangular prismatic model inversion algorithm was modified to interpret vertical magnetic gradient data defining the boundaries and the physical parameters of the anomalous structure. Vertical magnetic gradient measurements were carried out at the Tuzla fault, an active fault system located along NE-SW direction in Izmir (Turkey). Boundary analysis studies were applied to data in order to obtain boundaries of the structures, afterwards the inversion process was carried out considering these geometries. As a result, location, direction and other physical and geometrical features of the fault are achieved.
Determination of Shearing Properties for Tubular Pinewood under Torsion  [PDF]
Ezgi Günay, Emre Uludogan
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.61007
Abstract: In this study, tubular pinewood (Pinus sylvestris L.) specimens are tested and shear strain measurements are performed by applying torsion in z direction in the consideration of light weight aircraft engineering. The objective of this paper is to contribute and generate the nonlinear material model in terms of shear modulus presented with power functions under the consideration of nonlinear behavior of wood under torque. Strain gauge measurements are performed for the maximum shear stresses which develop on the tubular specimen, along the radial r(rin, rout), circumferential Φ(Φin, Φout) and z directions, in a point-wise manner. The data is gathered and examined for the determination of the local variations of empirical shear modulus functions on transversely isotropic surfaces of the specimens. The coordinate dependent shear modulus functions of GzΦ(r), GzΦ(Φ), GzΦ(z) are derived for GzΦ(r, Φ, z)as the function of r, Φ and z, respectively, by analyzing the gathered data. It is proposed to represent the shear modulus functions, GzΦ(Φ) and GzΦ(z) with the parabolic polynomials, and, to represent the shear modulus function GzΦ(r) with a linear equation.
Emergence and migration of trunk neural crest cells in a snake, the California Kingsnake (Lampropeltis getula californiae)
Michelle Reyes, Katrina Zandberg, Iska Desmawati, Maria E de Bellard
BMC Developmental Biology , 2010, DOI: 10.1186/1471-213x-10-52
Abstract: In this study, we show for the first time ever trunk neural crest migration in a snake by labeling it with DiI and immunofluorescence. As in birds and mammals, we find that early migrating trunk neural crest cells use both a ventromedial pathway and an inter-somitic pathway in the snake. However, unlike birds and mammals, we also observed large numbers of late migrating neural crest cells utilizing the inter-somitic pathway in snake.We found that while trunk neural crest migration in snakes is very similar to that of other amniotes, the inter-somitic pathway is used more extensively by late-migrating trunk neural crest cells in snake.The neural crest is a group of multipotent cells that emerge after an epithelial-to-mesenchymal transition from the dorsal neural tube early after neural tube closure. These cells give rise to a wide variety of neuronal and glial derivatives in the peripheral nervous system, as well as parts of the head skeleton and endocrine organs [1,2]. In jawed, anamniote vertebrates like sharks and teleosts, neural crest cells also give rise to electrosensory organs [3] and fin mesenchyme [4]. The neural crest in the trunk portion of an embryo has been found to follow different migratory pathways in different organisms. In amniotes trunk neural crest cells will follow two main courses: a ventromedial pathway through the rostral part of somites, and a dorsolateral pathway between somites and ectoderm [5]. In amphibians, trunk neural crest follows a dorsal pathway into the fin and a ventral pathway between the neural tube and the caudal portion of the somite [6]. In zebrafish, trunk neural crest predominantly migrates between the neural tube and somites as in amphibians [7,8].The origin of the neural crest was an important event in vertebrate given that it forms most of the craniofacial skeleton [9]. Agnathans (like lampreys) [10,11], teleosts (bony fish) and amphibians clearly possess identifiable cranial neural crest streams that are similar to tho
LHR effects in nonducted whistler propagation – new observations and numerical modelling
F. Ji i ek, D. R. Shklyar,P. T iska
Annales Geophysicae (ANGEO) , 2001,
Abstract: VLF-ELF broadband measurements onboard the MAGION 4 and 5 satellites at heights above 1 Re in plasmasphere provide new data on various known phenomena related to ducted and nonducted whistler wave propagation. Two examples are discussed: magnetospherically reflected (MR) whistlers and lower hybrid resonance (LHR) noise band. We present examples of rather complicated MR whistler spectrograms not reported previously and argue the conditions for their generation. Analytical consideration, together with numerical modelling, yield understanding of the main features of those spectrograms. LHR noise band, as well as MR whistlers, is a phenomenon whose source is the energy propagating in the nonducted way. At the plasmaspheric heights, where hydrogen (H+) is the prevailing ion, and electron plasma frequency is much larger than gyrofrequency, the LHR frequency is close to its maximumvalue in a given magnetic field. This frequency is well followed by the observed noise bands. The lower cutoff frequency of this band is somewhat below that maximum value. The reason for this, as well as the possibility of using the LHR noise bands for locating the plasma through position, are discussed. Key words. Magnetospheric physics (plasmasphere; wave propagation)
A scoring matrix approach to detecting miRNA target sites
Simon Moxon, Vincent Moulton, Jan T Kim
Algorithms for Molecular Biology , 2008, DOI: 10.1186/1748-7188-3-3
Abstract: We introduce a generic target prediction method, the Stacking Binding Matrix (SBM) that uses both information about the miRNA as well as experimentally validated target sequences in the search for candidate target sequences. We demonstrate the utility of our method by applying it to both animal and plant data sets and compare it with miRanda, a commonly used target prediction method.We show that SBM can be applied to target prediction in both plants and animals and performs well in terms of sensitivity and specificity. Open source code implementing the SBM method, together with documentation and examples are freely available for download from the address in the Availability and Requirements section.microRNAs (miRNAs) are small non-coding RNAs of around 21 nt in length, which are currently receiving a great deal of attention [1,2]. They are derived from a precursor RNA hairpin structure by RNAse III-like enzymes [3], and are incorporated into the RNA induced silencing complex (RISC). Via this complex, the microRNA guides either the cleavage or translational repression of messenger RNAs (mRNAs) by binding to a region of the mRNA known as the target site [4]. In this way, miRNAs regulate a variety of cellular and molecular functions [5,6], playing important roles in, for example, organism growth and development [7,8].New miRNAs are being discovered at an increasingly rapid rate [9]. Since they play an important role in eukaryotic gene regulation, the problem of determining their function is thus of utmost importance. Accordingly, several computational methods have been developed for miRNA target prediction – see e.g. [10-13]. These methods usually rely on finding target sequences based on a single miRNA input, and employ nucleotide complementarity and minimum free energy (MFE) calculations to identify candidate miRNA/target duplexes. Although these methods have been successfully used in target prediction e.g. [14], their specificity can be limited, i.e. they may produc
Edward Moxon-Browne,Cigdem Ustun
Romanian Journal of European Affairs (RJEA) , 2009,
Abstract: It has become almost axiomatic to argue that the prospect of Turkish accession to the European Union (EU) poses unprecedented challenges to its cohesion, its institutional structure, and to its identity.1 No country has waited longer to open negotiations with the EU, and no country has embarked on negotiations with such a distant prospect for those negotiations being concluded. Our purpose here is not to consider the wide range of problems faced by Turkey in these negotiations, or even to make a judgement on whether these negotiations will, or ought to be, successful. Our objective is to consider public opinion in the EU, and in Turkey with a view to isolating perceptions on both sides that may be complicating factors in an already intricate relationship.
External Rotation Brace Combined with a Physiotherapy Program for First Time Anterior Shoulder Dislocators; A 2 year Follow-up
Angus P. Moxon,Tim Walker,Angelo Rando
Australasian Medical Journal , 2010,
Abstract: BackgroundThere are a multitude of international studies that haveconsidered the rates of redislocation and instability ofshoulders managed non-operatively vs. operatively afterfirst time anterior dislocation. Initial management hasincluded no treatment, internal rotation slingimmobiliser, external rotation brace and early or latestabilisation. The majority of those managed in internalrotation or with no support initially have had poor longterm results.There are several small trials of the use of the ExternalRotation Brace that have shown promising resultscomparable to acute surgical stabilisation.The use of the External Rotation brace for first timeanterior dislocators in the 15-40 years age group wasinitiated to attempt to reduce the rates of redislocationand instability without requiring surgical intervention.MethodConsecutive patients that fit the selection criteria wereselected and followed over time. A physiotherapyprogram was initiated early in the management andregular clinic reviews undertaken. 2 years post first timeanterior dislocation, patients were reviewed subjectivelyand a Quick DASH score performed. They wereasked to give an estimate of their recovery andreport any redislocations, instability or subluxation.ResultsThere was 1 redislocation (3%) during this period inthe 32 patients. The majority were functioning atpredislocation levels at review and no surgicalintervention for instability was required. Quick-Dashresults were excellent, with a vast majority scoringless than 2/100 level of disability. Estimatedrecovery scores supported these findings with themajority of patients reporting 90-95% recoverycompared with the unaffected side.ConclusionThe external rotation brace has proven to be anexcellent alternative to early shoulder stabilisationfor first time anterior dislocators in the 15-40 yearsage group.
Corporate Governance Ratings and Market-based Financial Performance: Evidence from Turkey
Emre Ergin
International Journal of Economics and Finance , 2012, DOI: 10.5539/ijef.v4n9p61
Abstract: Corporate governance ranking is a recent issue for Turkish firms. Although the new regulations in Turkey encourage the firms to get corporate ratings, firms are not obliged to get them. It is those firms which trade their stocks in the Istanbul Stock Exchange (ISE) that are interested in governance ratings, while corporate governance rating is a luxury for firms that do not trade their stocks publicly. The objective of this paper is to investigate whether or not investors take the corporate governance rankings into account in their evaluation of stock price. Since the first rating was in 2006, all the rated firms quoted to ISE were examined for the years 2006 to 2010 using a price model. Further analysis is carried out in order to assess the total impact of corporate governance on stock price by eliminating any correlation between the independent accounting variables and corporate governance scores. The results suggest that the corporate governance rankings are positively and significantly associated not only with the financial performance but also with the accounting performance. The sub-components of corporate governance that have a positive association to the financial performance are stakeholders, and public disclosure and transparency.
Emre Aksoy
International Journal of Economics and Financial Issues , 2013,
Abstract: By using quarterly data this study applied Toda-Yamamoto (1995) method for the period 1988-2010 to uncover the relationship between growth and employment in aggregate and industrial respects and also to investigate the impacts of investment and employment incentives on employment for Turkish Economy. The findings showed that the relationship between growth and employment varied with the industries. The study covers ten industries and there were causalities detected for four out of ten industries, either one or two ways. For the rest six industries covered in the study, there was no causal relationship obtained. The incentives impacts on employment, similarly, vary with industries. The law numbered as 5084 had positive and statistically significant influences on social service, manufacturing, and transportation and communication industries while the law numbered as 5763 extracted positive and significant influences on energy production and distribution, and financial intermediation industries.
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